Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLG5_LEIBR

TriTrypDb:

LbrM.33.1310 , LBRM2903_330018100

Length:

753

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.356
CLV_C14_Caspase3-7	642	646	PF00656	0.504
CLV_NRD_NRD_1	162	164	PF00675	0.668
CLV_NRD_NRD_1	20	22	PF00675	0.517
CLV_NRD_NRD_1	433	435	PF00675	0.535
CLV_NRD_NRD_1	515	517	PF00675	0.462
CLV_NRD_NRD_1	574	576	PF00675	0.554
CLV_NRD_NRD_1	86	88	PF00675	0.570
CLV_PCSK_KEX2_1	162	164	PF00082	0.624
CLV_PCSK_KEX2_1	339	341	PF00082	0.734
CLV_PCSK_KEX2_1	433	435	PF00082	0.535
CLV_PCSK_KEX2_1	458	460	PF00082	0.554
CLV_PCSK_KEX2_1	515	517	PF00082	0.550
CLV_PCSK_KEX2_1	574	576	PF00082	0.552
CLV_PCSK_KEX2_1	581	583	PF00082	0.499
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.723
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.554
CLV_PCSK_PC1ET2_1	581	583	PF00082	0.499
CLV_PCSK_SKI1_1	17	21	PF00082	0.389
CLV_PCSK_SKI1_1	249	253	PF00082	0.640
CLV_PCSK_SKI1_1	269	273	PF00082	0.549
CLV_PCSK_SKI1_1	340	344	PF00082	0.747
CLV_PCSK_SKI1_1	484	488	PF00082	0.519
CLV_PCSK_SKI1_1	606	610	PF00082	0.497
CLV_Separin_Metazoa	222	226	PF03568	0.580
DEG_APCC_DBOX_1	170	178	PF00400	0.420
DEG_Nend_UBRbox_4	1	3	PF02207	0.419
DEG_SPOP_SBC_1	136	140	PF00917	0.718
DEG_SPOP_SBC_1	154	158	PF00917	0.746
DEG_SPOP_SBC_1	224	228	PF00917	0.601
DOC_CKS1_1	730	735	PF01111	0.624
DOC_CYCLIN_RxL_1	478	491	PF00134	0.520
DOC_CYCLIN_RxL_1	496	507	PF00134	0.454
DOC_MAPK_gen_1	267	275	PF00069	0.616
DOC_MAPK_RevD_3	74	88	PF00069	0.538
DOC_PP4_FxxP_1	69	72	PF00568	0.552
DOC_USP7_MATH_1	126	130	PF00917	0.645
DOC_USP7_MATH_1	137	141	PF00917	0.598
DOC_USP7_MATH_1	154	158	PF00917	0.751
DOC_USP7_MATH_1	256	260	PF00917	0.667
DOC_USP7_MATH_1	341	345	PF00917	0.805
DOC_USP7_MATH_1	359	363	PF00917	0.780
DOC_USP7_MATH_1	396	400	PF00917	0.618
DOC_USP7_MATH_1	60	64	PF00917	0.578
DOC_USP7_MATH_1	646	650	PF00917	0.700
DOC_USP7_MATH_1	722	726	PF00917	0.682
DOC_USP7_MATH_1	741	745	PF00917	0.732
DOC_USP7_MATH_1	79	83	PF00917	0.345
DOC_WW_Pin1_4	129	134	PF00397	0.743
DOC_WW_Pin1_4	155	160	PF00397	0.507
DOC_WW_Pin1_4	199	204	PF00397	0.630
DOC_WW_Pin1_4	259	264	PF00397	0.583
DOC_WW_Pin1_4	355	360	PF00397	0.693
DOC_WW_Pin1_4	693	698	PF00397	0.766
DOC_WW_Pin1_4	710	715	PF00397	0.683
DOC_WW_Pin1_4	729	734	PF00397	0.712
LIG_14-3-3_CanoR_1	225	230	PF00244	0.499
LIG_14-3-3_CanoR_1	277	287	PF00244	0.436
LIG_14-3-3_CanoR_1	463	468	PF00244	0.598
LIG_14-3-3_CanoR_1	478	484	PF00244	0.428
LIG_14-3-3_CanoR_1	504	513	PF00244	0.440
LIG_14-3-3_CanoR_1	534	539	PF00244	0.454
LIG_14-3-3_CanoR_1	575	584	PF00244	0.561
LIG_14-3-3_CanoR_1	695	701	PF00244	0.708
LIG_14-3-3_CanoR_1	705	709	PF00244	0.700
LIG_14-3-3_CanoR_1	745	751	PF00244	0.719
LIG_APCC_ABBA_1	467	472	PF00400	0.583
LIG_BIR_III_2	144	148	PF00653	0.651
LIG_Clathr_ClatBox_1	39	43	PF01394	0.497
LIG_deltaCOP1_diTrp_1	257	266	PF00928	0.563
LIG_eIF4E_1	34	40	PF01652	0.498
LIG_EVH1_1	69	73	PF00568	0.593
LIG_FHA_1	156	162	PF00498	0.607
LIG_FHA_1	196	202	PF00498	0.668
LIG_FHA_1	333	339	PF00498	0.818
LIG_FHA_1	464	470	PF00498	0.700
LIG_FHA_1	558	564	PF00498	0.532
LIG_FHA_1	56	62	PF00498	0.491
LIG_FHA_1	653	659	PF00498	0.770
LIG_FHA_1	725	731	PF00498	0.620
LIG_FHA_2	110	116	PF00498	0.699
LIG_FHA_2	137	143	PF00498	0.809
LIG_FHA_2	386	392	PF00498	0.677
LIG_FHA_2	403	409	PF00498	0.496
LIG_FHA_2	480	486	PF00498	0.533
LIG_FHA_2	503	509	PF00498	0.439
LIG_FHA_2	535	541	PF00498	0.446
LIG_FHA_2	613	619	PF00498	0.562
LIG_FHA_2	676	682	PF00498	0.674
LIG_FHA_2	730	736	PF00498	0.796
LIG_LIR_Apic_2	257	263	PF02991	0.566
LIG_LIR_Gen_1	237	248	PF02991	0.629
LIG_LIR_Gen_1	270	280	PF02991	0.564
LIG_LIR_Gen_1	495	503	PF02991	0.457
LIG_LIR_Gen_1	507	514	PF02991	0.399
LIG_LIR_Nem_3	237	243	PF02991	0.637
LIG_LIR_Nem_3	270	275	PF02991	0.455
LIG_LIR_Nem_3	289	293	PF02991	0.531
LIG_LIR_Nem_3	450	455	PF02991	0.447
LIG_LIR_Nem_3	482	486	PF02991	0.538
LIG_LIR_Nem_3	495	500	PF02991	0.462
LIG_LIR_Nem_3	507	513	PF02991	0.397
LIG_LYPXL_yS_3	632	635	PF13949	0.471
LIG_NRBOX	35	41	PF00104	0.559
LIG_PCNA_yPIPBox_3	581	590	PF02747	0.480
LIG_Pex14_1	286	290	PF04695	0.413
LIG_Pex14_2	483	487	PF04695	0.502
LIG_SH2_CRK	290	294	PF00017	0.556
LIG_SH2_CRK	497	501	PF00017	0.462
LIG_SH2_CRK	510	514	PF00017	0.392
LIG_SH2_NCK_1	50	54	PF00017	0.517
LIG_SH2_STAP1	30	34	PF00017	0.569
LIG_SH2_STAP1	497	501	PF00017	0.506
LIG_SH2_STAP1	510	514	PF00017	0.481
LIG_SH2_STAP1	538	542	PF00017	0.443
LIG_SH3_1	21	27	PF00018	0.371
LIG_SH3_3	130	136	PF00018	0.816
LIG_SH3_3	197	203	PF00018	0.658
LIG_SH3_3	21	27	PF00018	0.371
LIG_SH3_3	293	299	PF00018	0.522
LIG_SH3_3	322	328	PF00018	0.639
LIG_SH3_3	335	341	PF00018	0.690
LIG_SH3_3	42	48	PF00018	0.508
LIG_SH3_3	67	73	PF00018	0.484
LIG_Sin3_3	231	238	PF02671	0.637
LIG_SUMO_SIM_anti_2	169	176	PF11976	0.432
LIG_SUMO_SIM_anti_2	587	593	PF11976	0.583
LIG_SUMO_SIM_par_1	37	44	PF11976	0.510
LIG_SUMO_SIM_par_1	76	82	PF11976	0.503
LIG_TRAF2_1	405	408	PF00917	0.689
LIG_TRAF2_1	678	681	PF00917	0.810
LIG_WRC_WIRS_1	480	485	PF05994	0.524
LIG_WRC_WIRS_1	747	752	PF05994	0.663
MOD_CDK_SPxxK_3	155	162	PF00069	0.497
MOD_CK1_1	128	134	PF00069	0.719
MOD_CK1_1	239	245	PF00069	0.611
MOD_CK1_1	259	265	PF00069	0.645
MOD_CK1_1	276	282	PF00069	0.307
MOD_CK1_1	399	405	PF00069	0.658
MOD_CK1_1	495	501	PF00069	0.453
MOD_CK1_1	724	730	PF00069	0.687
MOD_CK2_1	109	115	PF00069	0.663
MOD_CK2_1	124	130	PF00069	0.608
MOD_CK2_1	3	9	PF00069	0.398
MOD_CK2_1	318	324	PF00069	0.753
MOD_CK2_1	385	391	PF00069	0.677
MOD_CK2_1	402	408	PF00069	0.529
MOD_CK2_1	413	419	PF00069	0.775
MOD_CK2_1	433	439	PF00069	0.643
MOD_CK2_1	479	485	PF00069	0.553
MOD_CK2_1	48	54	PF00069	0.404
MOD_CK2_1	502	508	PF00069	0.434
MOD_CK2_1	534	540	PF00069	0.462
MOD_CK2_1	597	603	PF00069	0.410
MOD_CK2_1	612	618	PF00069	0.470
MOD_CK2_1	675	681	PF00069	0.697
MOD_CK2_1	729	735	PF00069	0.764
MOD_CMANNOS	403	406	PF00535	0.467
MOD_GlcNHglycan	192	196	PF01048	0.583
MOD_GlcNHglycan	398	401	PF01048	0.747
MOD_GlcNHglycan	415	418	PF01048	0.588
MOD_GlcNHglycan	435	438	PF01048	0.703
MOD_GlcNHglycan	50	53	PF01048	0.413
MOD_GlcNHglycan	58	61	PF01048	0.435
MOD_GlcNHglycan	661	664	PF01048	0.718
MOD_GlcNHglycan	702	705	PF01048	0.714
MOD_GlcNHglycan	710	713	PF01048	0.628
MOD_GlcNHglycan	724	727	PF01048	0.693
MOD_GSK3_1	122	129	PF00069	0.706
MOD_GSK3_1	131	138	PF00069	0.762
MOD_GSK3_1	149	156	PF00069	0.691
MOD_GSK3_1	187	194	PF00069	0.522
MOD_GSK3_1	195	202	PF00069	0.583
MOD_GSK3_1	223	230	PF00069	0.628
MOD_GSK3_1	255	262	PF00069	0.553
MOD_GSK3_1	275	282	PF00069	0.528
MOD_GSK3_1	328	335	PF00069	0.676
MOD_GSK3_1	348	355	PF00069	0.577
MOD_GSK3_1	360	367	PF00069	0.639
MOD_GSK3_1	398	405	PF00069	0.612
MOD_GSK3_1	504	511	PF00069	0.495
MOD_GSK3_1	56	63	PF00069	0.461
MOD_GSK3_1	696	703	PF00069	0.649
MOD_GSK3_1	704	711	PF00069	0.623
MOD_GSK3_1	720	727	PF00069	0.694
MOD_GSK3_1	741	748	PF00069	0.745
MOD_GSK3_1	79	86	PF00069	0.536
MOD_N-GLC_1	359	364	PF02516	0.565
MOD_NEK2_1	3	8	PF00069	0.417
MOD_NEK2_1	329	334	PF00069	0.733
MOD_NEK2_1	509	514	PF00069	0.519
MOD_NEK2_1	527	532	PF00069	0.350
MOD_NEK2_1	569	574	PF00069	0.534
MOD_NEK2_1	612	617	PF00069	0.637
MOD_NEK2_2	465	470	PF00069	0.586
MOD_PIKK_1	332	338	PF00454	0.725
MOD_PIKK_1	377	383	PF00454	0.723
MOD_PIKK_1	502	508	PF00454	0.434
MOD_PIKK_1	576	582	PF00454	0.432
MOD_PIKK_1	597	603	PF00454	0.419
MOD_PIKK_1	646	652	PF00454	0.651
MOD_PKA_1	433	439	PF00069	0.537
MOD_PKA_2	224	230	PF00069	0.503
MOD_PKA_2	276	282	PF00069	0.439
MOD_PKA_2	319	325	PF00069	0.627
MOD_PKA_2	433	439	PF00069	0.802
MOD_PKA_2	472	478	PF00069	0.602
MOD_PKA_2	704	710	PF00069	0.609
MOD_Plk_1	191	197	PF00069	0.603
MOD_Plk_1	236	242	PF00069	0.687
MOD_Plk_1	256	262	PF00069	0.630
MOD_Plk_1	329	335	PF00069	0.732
MOD_Plk_1	359	365	PF00069	0.676
MOD_Plk_1	377	383	PF00069	0.689
MOD_Plk_1	646	652	PF00069	0.502
MOD_Plk_1	736	742	PF00069	0.620
MOD_Plk_4	177	183	PF00069	0.553
MOD_Plk_4	196	202	PF00069	0.661
MOD_Plk_4	465	471	PF00069	0.685
MOD_Plk_4	492	498	PF00069	0.529
MOD_Plk_4	509	515	PF00069	0.484
MOD_Plk_4	62	68	PF00069	0.523
MOD_Plk_4	653	659	PF00069	0.485
MOD_Plk_4	79	85	PF00069	0.393
MOD_ProDKin_1	129	135	PF00069	0.750
MOD_ProDKin_1	155	161	PF00069	0.499
MOD_ProDKin_1	199	205	PF00069	0.632
MOD_ProDKin_1	259	265	PF00069	0.578
MOD_ProDKin_1	355	361	PF00069	0.693
MOD_ProDKin_1	693	699	PF00069	0.766
MOD_ProDKin_1	710	716	PF00069	0.685
MOD_ProDKin_1	729	735	PF00069	0.712
MOD_SUMO_for_1	684	687	PF00179	0.529
MOD_SUMO_rev_2	450	460	PF00179	0.509
MOD_SUMO_rev_2	533	542	PF00179	0.418
MOD_SUMO_rev_2	677	686	PF00179	0.525
TRG_AP2beta_CARGO_1	450	459	PF09066	0.558
TRG_DiLeu_BaEn_1	587	592	PF01217	0.546
TRG_DiLeu_BaEn_1	603	608	PF01217	0.335
TRG_DiLeu_BaEn_1	653	658	PF01217	0.487
TRG_DiLeu_BaEn_4	491	497	PF01217	0.497
TRG_DiLeu_BaLyEn_6	496	501	PF01217	0.548
TRG_DiLeu_BaLyEn_6	630	635	PF01217	0.624
TRG_DiLeu_LyEn_5	603	608	PF01217	0.545
TRG_ENDOCYTIC_2	290	293	PF00928	0.564
TRG_ENDOCYTIC_2	497	500	PF00928	0.474
TRG_ENDOCYTIC_2	510	513	PF00928	0.388
TRG_ENDOCYTIC_2	632	635	PF00928	0.471
TRG_ER_diArg_1	161	163	PF00400	0.676
TRG_ER_diArg_1	266	269	PF00400	0.584
TRG_ER_diArg_1	514	516	PF00400	0.550
TRG_ER_diArg_1	624	627	PF00400	0.513
TRG_NLS_MonoExtC_3	385	391	PF00514	0.707
TRG_NLS_MonoExtN_4	383	390	PF00514	0.714
TRG_Pf-PMV_PEXEL_1	484	489	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	606	610	PF00026	0.348

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S9	Leptomonas seymouri	56%	94%
A0A1X0P0V9	Trypanosomatidae	36%	94%
A0A3Q8IDP5	Leishmania donovani	83%	99%
A4I8X6	Leishmania infantum	83%	99%
D0A4X2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B3U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4Q479	Leishmania major	83%	100%
V5BPB5	Trypanosoma cruzi	35%	100%