CW-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CW-type Zinc Finger, putative

Species:

Leishmania braziliensis

UniProt:

A4HLG4_LEIBR

TriTrypDb:

LbrM.33.1300 , LBRM2903_330018000

Length:

753

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLG4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.685
CLV_C14_Caspase3-7	168	172	PF00656	0.537
CLV_C14_Caspase3-7	372	376	PF00656	0.657
CLV_NRD_NRD_1	177	179	PF00675	0.557
CLV_NRD_NRD_1	206	208	PF00675	0.484
CLV_NRD_NRD_1	294	296	PF00675	0.652
CLV_NRD_NRD_1	335	337	PF00675	0.562
CLV_NRD_NRD_1	365	367	PF00675	0.577
CLV_NRD_NRD_1	545	547	PF00675	0.658
CLV_NRD_NRD_1	580	582	PF00675	0.709
CLV_NRD_NRD_1	625	627	PF00675	0.692
CLV_NRD_NRD_1	678	680	PF00675	0.644
CLV_NRD_NRD_1	77	79	PF00675	0.528
CLV_NRD_NRD_1	95	97	PF00675	0.774
CLV_PCSK_FUR_1	543	547	PF00082	0.630
CLV_PCSK_FUR_1	621	625	PF00082	0.712
CLV_PCSK_FUR_1	75	79	PF00082	0.382
CLV_PCSK_FUR_1	93	97	PF00082	0.639
CLV_PCSK_KEX2_1	177	179	PF00082	0.557
CLV_PCSK_KEX2_1	206	208	PF00082	0.484
CLV_PCSK_KEX2_1	294	296	PF00082	0.652
CLV_PCSK_KEX2_1	365	367	PF00082	0.569
CLV_PCSK_KEX2_1	423	425	PF00082	0.556
CLV_PCSK_KEX2_1	545	547	PF00082	0.633
CLV_PCSK_KEX2_1	582	584	PF00082	0.729
CLV_PCSK_KEX2_1	621	623	PF00082	0.712
CLV_PCSK_KEX2_1	624	626	PF00082	0.684
CLV_PCSK_KEX2_1	677	679	PF00082	0.657
CLV_PCSK_KEX2_1	718	720	PF00082	0.227
CLV_PCSK_KEX2_1	77	79	PF00082	0.380
CLV_PCSK_KEX2_1	95	97	PF00082	0.774
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.556
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.729
CLV_PCSK_PC1ET2_1	677	679	PF00082	0.667
CLV_PCSK_PC1ET2_1	718	720	PF00082	0.227
CLV_PCSK_PC7_1	621	627	PF00082	0.553
CLV_PCSK_PC7_1	714	720	PF00082	0.227
CLV_PCSK_SKI1_1	188	192	PF00082	0.460
CLV_PCSK_SKI1_1	383	387	PF00082	0.466
CLV_PCSK_SKI1_1	399	403	PF00082	0.510
CLV_PCSK_SKI1_1	78	82	PF00082	0.534
CLV_Separin_Metazoa	72	76	PF03568	0.387
DEG_APCC_DBOX_1	285	293	PF00400	0.605
DEG_SCF_FBW7_1	537	544	PF00400	0.666
DEG_SPOP_SBC_1	223	227	PF00917	0.603
DEG_SPOP_SBC_1	56	60	PF00917	0.619
DOC_CDC14_PxL_1	388	396	PF14671	0.553
DOC_CKS1_1	414	419	PF01111	0.585
DOC_CKS1_1	505	510	PF01111	0.554
DOC_CYCLIN_RxL_1	380	390	PF00134	0.416
DOC_CYCLIN_RxL_1	408	416	PF00134	0.583
DOC_CYCLIN_yCln2_LP_2	276	282	PF00134	0.591
DOC_MAPK_gen_1	423	429	PF00069	0.556
DOC_MAPK_gen_1	516	522	PF00069	0.572
DOC_MAPK_gen_1	718	726	PF00069	0.427
DOC_MAPK_RevD_3	408	424	PF00069	0.583
DOC_PP1_RVXF_1	721	727	PF00149	0.538
DOC_PP2B_LxvP_1	121	124	PF13499	0.670
DOC_PP2B_LxvP_1	3	6	PF13499	0.615
DOC_PP2B_LxvP_1	40	43	PF13499	0.720
DOC_PP2B_LxvP_1	658	661	PF13499	0.539
DOC_USP7_MATH_1	156	160	PF00917	0.578
DOC_USP7_MATH_1	284	288	PF00917	0.443
DOC_USP7_MATH_1	302	306	PF00917	0.570
DOC_USP7_MATH_1	354	358	PF00917	0.609
DOC_USP7_MATH_1	368	372	PF00917	0.660
DOC_USP7_MATH_1	41	45	PF00917	0.510
DOC_USP7_MATH_1	458	462	PF00917	0.686
DOC_USP7_MATH_1	476	480	PF00917	0.535
DOC_USP7_MATH_1	51	55	PF00917	0.666
DOC_USP7_MATH_1	541	545	PF00917	0.581
DOC_USP7_MATH_1	56	60	PF00917	0.677
DOC_USP7_MATH_1	594	598	PF00917	0.543
DOC_USP7_MATH_1	638	642	PF00917	0.672
DOC_USP7_MATH_1	670	674	PF00917	0.613
DOC_USP7_UBL2_3	363	367	PF12436	0.698
DOC_USP7_UBL2_3	517	521	PF12436	0.695
DOC_USP7_UBL2_3	629	633	PF12436	0.666
DOC_WW_Pin1_4	275	280	PF00397	0.594
DOC_WW_Pin1_4	336	341	PF00397	0.531
DOC_WW_Pin1_4	355	360	PF00397	0.668
DOC_WW_Pin1_4	413	418	PF00397	0.595
DOC_WW_Pin1_4	504	509	PF00397	0.568
DOC_WW_Pin1_4	537	542	PF00397	0.639
DOC_WW_Pin1_4	614	619	PF00397	0.559
DOC_WW_Pin1_4	62	67	PF00397	0.661
LIG_14-3-3_CanoR_1	104	112	PF00244	0.666
LIG_14-3-3_CanoR_1	136	142	PF00244	0.440
LIG_14-3-3_CanoR_1	294	300	PF00244	0.594
LIG_14-3-3_CanoR_1	325	335	PF00244	0.556
LIG_14-3-3_CanoR_1	365	373	PF00244	0.697
LIG_14-3-3_CanoR_1	404	413	PF00244	0.588
LIG_14-3-3_CanoR_1	737	746	PF00244	0.538
LIG_14-3-3_CanoR_1	75	85	PF00244	0.384
LIG_Actin_WH2_2	310	327	PF00022	0.611
LIG_BIR_III_2	375	379	PF00653	0.461
LIG_BIR_III_4	200	204	PF00653	0.495
LIG_BRCT_BRCA1_1	156	160	PF00533	0.511
LIG_BRCT_BRCA1_1	276	280	PF00533	0.596
LIG_BRCT_BRCA1_1	58	62	PF00533	0.490
LIG_FHA_2	163	169	PF00498	0.548
LIG_FHA_2	457	463	PF00498	0.555
LIG_FHA_2	505	511	PF00498	0.552
LIG_FHA_2	67	73	PF00498	0.418
LIG_FHA_2	739	745	PF00498	0.536
LIG_LIR_Gen_1	270	281	PF02991	0.588
LIG_LIR_Gen_1	69	74	PF02991	0.404
LIG_LIR_Nem_3	270	276	PF02991	0.587
LIG_LIR_Nem_3	277	283	PF02991	0.530
LIG_LIR_Nem_3	35	40	PF02991	0.553
LIG_LIR_Nem_3	69	73	PF02991	0.405
LIG_LIR_Nem_3	730	736	PF02991	0.433
LIG_NRBOX	428	434	PF00104	0.421
LIG_SH2_CRK	273	277	PF00017	0.590
LIG_SH2_CRK	37	41	PF00017	0.572
LIG_SH2_CRK	388	392	PF00017	0.556
LIG_SH2_NCK_1	169	173	PF00017	0.534
LIG_SH2_NCK_1	550	554	PF00017	0.577
LIG_SH2_SRC	169	172	PF00017	0.516
LIG_SH2_SRC	733	736	PF00017	0.427
LIG_SH2_STAT5	194	197	PF00017	0.498
LIG_SH2_STAT5	4	7	PF00017	0.609
LIG_SH3_2	487	492	PF14604	0.685
LIG_SH3_2	577	582	PF14604	0.604
LIG_SH3_3	205	211	PF00018	0.461
LIG_SH3_3	276	282	PF00018	0.720
LIG_SH3_3	296	302	PF00018	0.471
LIG_SH3_3	484	490	PF00018	0.696
LIG_SH3_3	527	533	PF00018	0.633
LIG_SH3_3	574	580	PF00018	0.658
LIG_SH3_3	60	66	PF00018	0.750
LIG_SH3_4	363	370	PF00018	0.674
LIG_SUMO_SIM_anti_2	69	75	PF11976	0.402
LIG_TRAF2_1	181	184	PF00917	0.692
LIG_TRAF2_1	507	510	PF00917	0.593
LIG_TYR_ITIM	271	276	PF00017	0.588
LIG_TYR_ITIM	548	553	PF00017	0.544
LIG_UBA3_1	393	402	PF00899	0.558
LIG_WRC_WIRS_1	67	72	PF05994	0.422
LIG_WW_3	585	589	PF00397	0.619
LIG_WW_3	660	664	PF00397	0.561
MOD_CDC14_SPxK_1	619	622	PF00782	0.549
MOD_CDK_SPK_2	616	621	PF00069	0.550
MOD_CDK_SPxK_1	336	342	PF00069	0.528
MOD_CDK_SPxK_1	537	543	PF00069	0.639
MOD_CDK_SPxK_1	616	622	PF00069	0.553
MOD_CDK_SPxxK_3	614	621	PF00069	0.555
MOD_CK1_1	243	249	PF00069	0.485
MOD_CK1_1	287	293	PF00069	0.452
MOD_CK1_1	431	437	PF00069	0.588
MOD_CK1_1	445	451	PF00069	0.571
MOD_CK1_1	54	60	PF00069	0.649
MOD_CK1_1	597	603	PF00069	0.662
MOD_CK1_1	61	67	PF00069	0.490
MOD_CK1_1	681	687	PF00069	0.536
MOD_CK2_1	152	158	PF00069	0.640
MOD_CK2_1	177	183	PF00069	0.712
MOD_CK2_1	249	255	PF00069	0.702
MOD_CK2_1	327	333	PF00069	0.624
MOD_CK2_1	366	372	PF00069	0.700
MOD_CK2_1	41	47	PF00069	0.455
MOD_CK2_1	456	462	PF00069	0.590
MOD_CK2_1	504	510	PF00069	0.557
MOD_CK2_1	523	529	PF00069	0.510
MOD_CK2_1	66	72	PF00069	0.520
MOD_CK2_1	681	687	PF00069	0.536
MOD_GlcNHglycan	125	128	PF01048	0.511
MOD_GlcNHglycan	154	157	PF01048	0.672
MOD_GlcNHglycan	180	183	PF01048	0.614
MOD_GlcNHglycan	191	194	PF01048	0.557
MOD_GlcNHglycan	242	245	PF01048	0.617
MOD_GlcNHglycan	304	307	PF01048	0.564
MOD_GlcNHglycan	350	353	PF01048	0.703
MOD_GlcNHglycan	368	371	PF01048	0.523
MOD_GlcNHglycan	406	409	PF01048	0.581
MOD_GlcNHglycan	445	448	PF01048	0.696
MOD_GlcNHglycan	525	528	PF01048	0.700
MOD_GlcNHglycan	599	602	PF01048	0.541
MOD_GlcNHglycan	672	675	PF01048	0.713
MOD_GlcNHglycan	78	81	PF01048	0.377
MOD_GSK3_1	119	126	PF00069	0.535
MOD_GSK3_1	150	157	PF00069	0.570
MOD_GSK3_1	222	229	PF00069	0.613
MOD_GSK3_1	284	291	PF00069	0.444
MOD_GSK3_1	323	330	PF00069	0.609
MOD_GSK3_1	336	343	PF00069	0.559
MOD_GSK3_1	354	361	PF00069	0.571
MOD_GSK3_1	439	446	PF00069	0.643
MOD_GSK3_1	458	465	PF00069	0.501
MOD_GSK3_1	46	53	PF00069	0.637
MOD_GSK3_1	488	495	PF00069	0.713
MOD_GSK3_1	537	544	PF00069	0.611
MOD_GSK3_1	54	61	PF00069	0.659
MOD_GSK3_1	549	556	PF00069	0.578
MOD_GSK3_1	588	595	PF00069	0.617
MOD_GSK3_1	599	606	PF00069	0.669
MOD_GSK3_1	62	69	PF00069	0.534
MOD_GSK3_1	634	641	PF00069	0.688
MOD_LATS_1	176	182	PF00433	0.708
MOD_N-GLC_1	564	569	PF02516	0.569
MOD_NEK2_1	137	142	PF00069	0.688
MOD_NEK2_1	150	155	PF00069	0.501
MOD_NEK2_1	222	227	PF00069	0.600
MOD_NEK2_1	323	328	PF00069	0.606
MOD_NEK2_1	387	392	PF00069	0.556
MOD_NEK2_1	397	402	PF00069	0.465
MOD_NEK2_1	428	433	PF00069	0.574
MOD_NEK2_1	654	659	PF00069	0.561
MOD_NEK2_1	91	96	PF00069	0.522
MOD_NEK2_2	32	37	PF00069	0.519
MOD_NEK2_2	727	732	PF00069	0.427
MOD_PIKK_1	183	189	PF00454	0.659
MOD_PIKK_1	284	290	PF00454	0.547
MOD_PIKK_1	490	496	PF00454	0.563
MOD_PIKK_1	599	605	PF00454	0.700
MOD_PIKK_1	678	684	PF00454	0.695
MOD_PK_1	295	301	PF00069	0.507
MOD_PK_1	402	408	PF00069	0.568
MOD_PKA_1	177	183	PF00069	0.549
MOD_PKA_1	294	300	PF00069	0.658
MOD_PKA_1	366	372	PF00069	0.560
MOD_PKA_1	678	684	PF00069	0.695
MOD_PKA_2	150	156	PF00069	0.667
MOD_PKA_2	177	183	PF00069	0.727
MOD_PKA_2	294	300	PF00069	0.658
MOD_PKA_2	307	313	PF00069	0.525
MOD_PKA_2	327	333	PF00069	0.450
MOD_PKA_2	348	354	PF00069	0.573
MOD_PKA_2	437	443	PF00069	0.557
MOD_PKA_2	678	684	PF00069	0.553
MOD_PKA_2	738	744	PF00069	0.538
MOD_PKA_2	76	82	PF00069	0.379
MOD_PKB_1	737	745	PF00069	0.538
MOD_Plk_1	46	52	PF00069	0.544
MOD_Plk_1	606	612	PF00069	0.558
MOD_Plk_1	727	733	PF00069	0.427
MOD_Plk_4	137	143	PF00069	0.594
MOD_Plk_4	32	38	PF00069	0.581
MOD_Plk_4	428	434	PF00069	0.576
MOD_Plk_4	594	600	PF00069	0.544
MOD_Plk_4	606	612	PF00069	0.535
MOD_Plk_4	638	644	PF00069	0.538
MOD_Plk_4	66	72	PF00069	0.582
MOD_Plk_4	7	13	PF00069	0.609
MOD_ProDKin_1	275	281	PF00069	0.590
MOD_ProDKin_1	336	342	PF00069	0.536
MOD_ProDKin_1	355	361	PF00069	0.667
MOD_ProDKin_1	413	419	PF00069	0.589
MOD_ProDKin_1	504	510	PF00069	0.571
MOD_ProDKin_1	537	543	PF00069	0.642
MOD_ProDKin_1	614	620	PF00069	0.555
MOD_ProDKin_1	62	68	PF00069	0.654
MOD_SUMO_for_1	422	425	PF00179	0.552
MOD_SUMO_for_1	470	473	PF00179	0.706
MOD_SUMO_for_1	515	518	PF00179	0.616
MOD_SUMO_for_1	520	523	PF00179	0.597
MOD_SUMO_rev_2	628	638	PF00179	0.688
MOD_SUMO_rev_2	684	694	PF00179	0.660
TRG_DiLeu_BaEn_1	255	260	PF01217	0.588
TRG_DiLeu_BaEn_2	381	387	PF01217	0.573
TRG_DiLeu_BaEn_4	47	53	PF01217	0.574
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.597
TRG_ENDOCYTIC_2	273	276	PF00928	0.589
TRG_ENDOCYTIC_2	37	40	PF00928	0.566
TRG_ENDOCYTIC_2	388	391	PF00928	0.557
TRG_ENDOCYTIC_2	550	553	PF00928	0.549
TRG_ENDOCYTIC_2	733	736	PF00928	0.427
TRG_ER_diArg_1	205	207	PF00400	0.499
TRG_ER_diArg_1	364	366	PF00400	0.568
TRG_ER_diArg_1	543	546	PF00400	0.631
TRG_ER_diArg_1	580	583	PF00400	0.716
TRG_ER_diArg_1	620	623	PF00400	0.706
TRG_ER_diArg_1	624	626	PF00400	0.674
TRG_ER_diArg_1	662	665	PF00400	0.701
TRG_ER_diArg_1	666	669	PF00400	0.675
TRG_ER_diArg_1	736	739	PF00400	0.427
TRG_ER_diArg_1	74	77	PF00400	0.544
TRG_ER_diArg_1	93	96	PF00400	0.656
TRG_NES_CRM1_1	255	270	PF08389	0.493
TRG_NLS_MonoExtC_3	580	585	PF00514	0.721
TRG_NLS_MonoExtN_4	580	586	PF00514	0.716
TRG_Pf-PMV_PEXEL_1	546	551	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	555	560	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6I4	Leishmania donovani	72%	78%
A4I8X5	Leishmania infantum	72%	78%
E9B3U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	78%
Q4Q480	Leishmania major	71%	100%