UBC core domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

YEATS family, putative

Species:

Leishmania braziliensis

UniProt:

A4HLG2_LEIBR

TriTrypDb:

LbrM.33.1280 , LBRM2903_330017800

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	10
GO:0000123	histone acetyltransferase complex	4	1
GO:0005654	nucleoplasm	2	1
GO:0031248	protein acetyltransferase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0035267	NuA4 histone acetyltransferase complex	7	1
GO:0043189	H4/H2A histone acetyltransferase complex	6	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902493	acetyltransferase complex	4	1
GO:1902494	catalytic complex	2	1
GO:1902562	H4 histone acetyltransferase complex	5	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HLG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLG2

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	10
GO:0009889	regulation of biosynthetic process	4	10
GO:0010468	regulation of gene expression	5	10
GO:0010556	regulation of macromolecule biosynthetic process	5	10
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	10
GO:0019222	regulation of metabolic process	3	10
GO:0031323	regulation of cellular metabolic process	4	10
GO:0031326	regulation of cellular biosynthetic process	5	10
GO:0050789	regulation of biological process	2	10
GO:0050794	regulation of cellular process	3	10
GO:0051171	regulation of nitrogen compound metabolic process	4	10
GO:0051252	regulation of RNA metabolic process	5	10
GO:0060255	regulation of macromolecule metabolic process	4	10
GO:0065007	biological regulation	1	10
GO:0080090	regulation of primary metabolic process	4	10
GO:1903506	regulation of nucleic acid-templated transcription	7	10
GO:2001141	regulation of RNA biosynthetic process	6	10
GO:0006325	chromatin organization	4	1
GO:0006338	chromatin remodeling	5	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006473	protein acetylation	6	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016570	histone modification	5	1
GO:0016573	histone acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0018393	internal peptidyl-lysine acetylation	8	1
GO:0018394	peptidyl-lysine acetylation	7	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.723
CLV_NRD_NRD_1	171	173	PF00675	0.638
CLV_NRD_NRD_1	269	271	PF00675	0.290
CLV_NRD_NRD_1	314	316	PF00675	0.697
CLV_NRD_NRD_1	545	547	PF00675	0.535
CLV_PCSK_KEX2_1	159	161	PF00082	0.723
CLV_PCSK_KEX2_1	171	173	PF00082	0.639
CLV_PCSK_KEX2_1	269	271	PF00082	0.291
CLV_PCSK_KEX2_1	314	316	PF00082	0.622
CLV_PCSK_KEX2_1	505	507	PF00082	0.557
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.563
CLV_PCSK_SKI1_1	222	226	PF00082	0.562
CLV_PCSK_SKI1_1	269	273	PF00082	0.305
CLV_PCSK_SKI1_1	409	413	PF00082	0.541
CLV_PCSK_SKI1_1	424	428	PF00082	0.557
CLV_PCSK_SKI1_1	540	544	PF00082	0.588
DEG_SPOP_SBC_1	209	213	PF00917	0.522
DEG_SPOP_SBC_1	446	450	PF00917	0.539
DOC_CDC14_PxL_1	414	422	PF14671	0.343
DOC_CKS1_1	223	228	PF01111	0.811
DOC_CKS1_1	431	436	PF01111	0.570
DOC_CKS1_1	466	471	PF01111	0.657
DOC_CYCLIN_RxL_1	308	322	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	466	472	PF00134	0.617
DOC_MAPK_gen_1	29	38	PF00069	0.455
DOC_MAPK_JIP1_4	352	358	PF00069	0.707
DOC_MAPK_MEF2A_6	29	38	PF00069	0.455
DOC_PP1_RVXF_1	253	260	PF00149	0.495
DOC_PP2B_LxvP_1	299	302	PF13499	0.561
DOC_PP2B_LxvP_1	57	60	PF13499	0.442
DOC_PP2B_LxvP_1	67	70	PF13499	0.419
DOC_PP4_FxxP_1	118	121	PF00568	0.499
DOC_PP4_FxxP_1	259	262	PF00568	0.476
DOC_PP4_FxxP_1	265	268	PF00568	0.476
DOC_PP4_FxxP_1	53	56	PF00568	0.448
DOC_PP4_FxxP_1	71	74	PF00568	0.386
DOC_USP7_MATH_1	103	107	PF00917	0.470
DOC_USP7_MATH_1	123	127	PF00917	0.452
DOC_USP7_MATH_1	152	156	PF00917	0.727
DOC_USP7_MATH_1	235	239	PF00917	0.753
DOC_USP7_MATH_1	24	28	PF00917	0.462
DOC_USP7_MATH_1	439	443	PF00917	0.709
DOC_USP7_MATH_1	446	450	PF00917	0.569
DOC_USP7_MATH_1	490	494	PF00917	0.544
DOC_USP7_UBL2_3	543	547	PF12436	0.625
DOC_WW_Pin1_4	135	140	PF00397	0.660
DOC_WW_Pin1_4	150	155	PF00397	0.679
DOC_WW_Pin1_4	211	216	PF00397	0.741
DOC_WW_Pin1_4	222	227	PF00397	0.780
DOC_WW_Pin1_4	243	248	PF00397	0.508
DOC_WW_Pin1_4	430	435	PF00397	0.547
DOC_WW_Pin1_4	454	459	PF00397	0.746
DOC_WW_Pin1_4	465	470	PF00397	0.525
DOC_WW_Pin1_4	70	75	PF00397	0.435
LIG_14-3-3_CanoR_1	159	167	PF00244	0.696
LIG_14-3-3_CanoR_1	17	21	PF00244	0.458
LIG_14-3-3_CanoR_1	171	180	PF00244	0.387
LIG_14-3-3_CanoR_1	314	319	PF00244	0.747
LIG_14-3-3_CanoR_1	489	495	PF00244	0.595
LIG_Actin_WH2_2	410	426	PF00022	0.338
LIG_BIR_II_1	1	5	PF00653	0.439
LIG_BRCT_BRCA1_1	466	470	PF00533	0.604
LIG_BRCT_BRCA1_1	474	478	PF00533	0.557
LIG_BRCT_BRCA1_1	83	87	PF00533	0.457
LIG_CSL_BTD_1	340	343	PF09270	0.694
LIG_eIF4E_1	350	356	PF01652	0.723
LIG_EVH1_1	71	75	PF00568	0.435
LIG_EVH1_1	99	103	PF00568	0.470
LIG_FHA_1	115	121	PF00498	0.528
LIG_FHA_1	225	231	PF00498	0.550
LIG_FHA_1	361	367	PF00498	0.496
LIG_FHA_1	392	398	PF00498	0.495
LIG_FHA_1	455	461	PF00498	0.730
LIG_FHA_1	525	531	PF00498	0.553
LIG_FHA_2	281	287	PF00498	0.476
LIG_FHA_2	372	378	PF00498	0.532
LIG_FHA_2	448	454	PF00498	0.715
LIG_FHA_2	479	485	PF00498	0.356
LIG_GBD_Chelix_1	404	412	PF00786	0.317
LIG_LIR_Apic_2	117	121	PF02991	0.511
LIG_LIR_Apic_2	264	268	PF02991	0.509
LIG_LIR_Apic_2	348	353	PF02991	0.685
LIG_LIR_Apic_2	428	434	PF02991	0.519
LIG_LIR_Apic_2	473	477	PF02991	0.601
LIG_LIR_Apic_2	51	56	PF02991	0.449
LIG_LIR_Apic_2	7	11	PF02991	0.455
LIG_LIR_Gen_1	248	259	PF02991	0.344
LIG_LIR_Nem_3	190	196	PF02991	0.529
LIG_LIR_Nem_3	248	254	PF02991	0.369
LIG_LIR_Nem_3	65	71	PF02991	0.451
LIG_MYND_1	56	60	PF01753	0.439
LIG_MYND_3	417	421	PF01753	0.597
LIG_OCRL_FandH_1	13	25	PF00620	0.460
LIG_Pex14_1	474	478	PF04695	0.447
LIG_Pex14_2	470	474	PF04695	0.599
LIG_Pex14_2	49	53	PF04695	0.452
LIG_SH2_CRK	178	182	PF00017	0.428
LIG_SH2_CRK	251	255	PF00017	0.444
LIG_SH2_CRK	350	354	PF00017	0.728
LIG_SH2_CRK	431	435	PF00017	0.559
LIG_SH2_CRK	8	12	PF00017	0.456
LIG_SH2_NCK_1	431	435	PF00017	0.559
LIG_SH2_SRC	122	125	PF00017	0.478
LIG_SH2_STAT3	485	488	PF00017	0.593
LIG_SH2_STAT5	178	181	PF00017	0.414
LIG_SH2_STAT5	78	81	PF00017	0.453
LIG_SH3_3	124	130	PF00018	0.410
LIG_SH3_3	217	223	PF00018	0.800
LIG_SH3_3	238	244	PF00018	0.664
LIG_SH3_3	337	343	PF00018	0.702
LIG_SH3_3	361	367	PF00018	0.614
LIG_SH3_3	525	531	PF00018	0.611
LIG_SH3_3	69	75	PF00018	0.437
LIG_SH3_3	94	100	PF00018	0.461
LIG_SUMO_SIM_anti_2	401	406	PF11976	0.465
LIG_SUMO_SIM_anti_2	491	498	PF11976	0.600
LIG_SUMO_SIM_par_1	354	360	PF11976	0.597
LIG_SUMO_SIM_par_1	383	390	PF11976	0.565
LIG_SUMO_SIM_par_1	520	527	PF11976	0.546
LIG_TYR_ITIM	249	254	PF00017	0.525
LIG_WW_3	138	142	PF00397	0.517
MOD_CDC14_SPxK_1	138	141	PF00782	0.768
MOD_CDK_SPxK_1	135	141	PF00069	0.748
MOD_CK1_1	106	112	PF00069	0.661
MOD_CK1_1	153	159	PF00069	0.684
MOD_CK1_1	19	25	PF00069	0.461
MOD_CK1_1	210	216	PF00069	0.692
MOD_CK1_1	357	363	PF00069	0.574
MOD_CK1_1	442	448	PF00069	0.711
MOD_CK1_1	449	455	PF00069	0.611
MOD_CK1_1	465	471	PF00069	0.622
MOD_CK2_1	24	30	PF00069	0.715
MOD_CK2_1	280	286	PF00069	0.476
MOD_CK2_1	449	455	PF00069	0.600
MOD_CK2_1	478	484	PF00069	0.612
MOD_DYRK1A_RPxSP_1	222	226	PF00069	0.562
MOD_GlcNHglycan	105	108	PF01048	0.723
MOD_GlcNHglycan	163	166	PF01048	0.686
MOD_GlcNHglycan	237	240	PF01048	0.622
MOD_GlcNHglycan	324	327	PF01048	0.780
MOD_GlcNHglycan	328	331	PF01048	0.716
MOD_GlcNHglycan	41	44	PF01048	0.460
MOD_GlcNHglycan	444	447	PF01048	0.792
MOD_GlcNHglycan	50	53	PF01048	0.425
MOD_GSK3_1	150	157	PF00069	0.739
MOD_GSK3_1	16	23	PF00069	0.458
MOD_GSK3_1	161	168	PF00069	0.754
MOD_GSK3_1	207	214	PF00069	0.673
MOD_GSK3_1	224	231	PF00069	0.614
MOD_GSK3_1	314	321	PF00069	0.651
MOD_GSK3_1	322	329	PF00069	0.748
MOD_GSK3_1	365	372	PF00069	0.543
MOD_GSK3_1	376	383	PF00069	0.715
MOD_GSK3_1	44	51	PF00069	0.601
MOD_GSK3_1	440	447	PF00069	0.720
MOD_GSK3_1	461	468	PF00069	0.735
MOD_GSK3_1	511	518	PF00069	0.604
MOD_GSK3_1	77	84	PF00069	0.722
MOD_N-GLC_1	165	170	PF02516	0.636
MOD_N-GLC_1	233	238	PF02516	0.543
MOD_N-GLC_1	360	365	PF02516	0.407
MOD_N-GLC_1	439	444	PF02516	0.680
MOD_NEK2_1	134	139	PF00069	0.699
MOD_NEK2_1	20	25	PF00069	0.625
MOD_NEK2_1	228	233	PF00069	0.670
MOD_NEK2_1	250	255	PF00069	0.481
MOD_NEK2_1	345	350	PF00069	0.592
MOD_NEK2_1	412	417	PF00069	0.518
MOD_NEK2_1	470	475	PF00069	0.631
MOD_NEK2_1	478	483	PF00069	0.468
MOD_NEK2_1	62	67	PF00069	0.629
MOD_NEK2_1	81	86	PF00069	0.445
MOD_NEK2_2	154	159	PF00069	0.516
MOD_PIKK_1	106	112	PF00454	0.684
MOD_PIKK_1	185	191	PF00454	0.436
MOD_PIKK_1	24	30	PF00454	0.461
MOD_PIKK_1	319	325	PF00454	0.516
MOD_PIKK_1	529	535	PF00454	0.580
MOD_PK_1	354	360	PF00069	0.592
MOD_PKA_1	171	177	PF00069	0.580
MOD_PKA_1	314	320	PF00069	0.498
MOD_PKA_2	16	22	PF00069	0.456
MOD_PKA_2	171	177	PF00069	0.481
MOD_PKA_2	314	320	PF00069	0.498
MOD_PKA_2	488	494	PF00069	0.553
MOD_Plk_1	165	171	PF00069	0.634
MOD_Plk_1	280	286	PF00069	0.476
MOD_Plk_1	360	366	PF00069	0.412
MOD_Plk_1	462	468	PF00069	0.655
MOD_Plk_1	478	484	PF00069	0.541
MOD_Plk_2-3	280	286	PF00069	0.561
MOD_Plk_4	16	22	PF00069	0.557
MOD_Plk_4	245	251	PF00069	0.518
MOD_Plk_4	302	308	PF00069	0.561
MOD_Plk_4	45	51	PF00069	0.607
MOD_ProDKin_1	135	141	PF00069	0.667
MOD_ProDKin_1	150	156	PF00069	0.679
MOD_ProDKin_1	211	217	PF00069	0.746
MOD_ProDKin_1	222	228	PF00069	0.780
MOD_ProDKin_1	243	249	PF00069	0.502
MOD_ProDKin_1	430	436	PF00069	0.559
MOD_ProDKin_1	454	460	PF00069	0.744
MOD_ProDKin_1	465	471	PF00069	0.523
MOD_ProDKin_1	70	76	PF00069	0.438
MOD_SUMO_for_1	504	507	PF00179	0.537
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.450
TRG_ENDOCYTIC_2	178	181	PF00928	0.405
TRG_ENDOCYTIC_2	193	196	PF00928	0.536
TRG_ENDOCYTIC_2	251	254	PF00928	0.378
TRG_ENDOCYTIC_2	78	81	PF00928	0.453
TRG_ER_diArg_1	170	172	PF00400	0.624
TRG_ER_diArg_1	268	270	PF00400	0.486
TRG_ER_diArg_1	314	316	PF00400	0.738
TRG_NES_CRM1_1	119	132	PF08389	0.557
TRG_NES_CRM1_1	520	533	PF08389	0.614
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S1	Leptomonas seymouri	45%	100%
A0A3R7LCY2	Trypanosoma rangeli	28%	100%
A0A3S7X6P8	Leishmania donovani	80%	100%
A4I8X3	Leishmania infantum	80%	100%
D0A4W8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B3U2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q482	Leishmania major	80%	100%
V5DG54	Trypanosoma cruzi	30%	100%