Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HLG1_LEIBR

TriTrypDb:

LbrM.33.1270 , LBRM2903_330017700

Length:

243

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HLG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLG1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	217	219	PF00675	0.644
CLV_NRD_NRD_1	223	225	PF00675	0.605
CLV_PCSK_KEX2_1	217	219	PF00082	0.644
CLV_PCSK_SKI1_1	122	126	PF00082	0.669
CLV_PCSK_SKI1_1	25	29	PF00082	0.495
DOC_MAPK_DCC_7	161	171	PF00069	0.312
DOC_MAPK_gen_1	92	100	PF00069	0.546
DOC_PP1_RVXF_1	120	126	PF00149	0.364
DOC_PP1_RVXF_1	49	56	PF00149	0.580
DOC_PP1_RVXF_1	78	85	PF00149	0.613
DOC_PP4_FxxP_1	125	128	PF00568	0.376
DOC_USP7_MATH_1	236	240	PF00917	0.531
DOC_WW_Pin1_4	210	215	PF00397	0.405
DOC_WW_Pin1_4	46	51	PF00397	0.562
LIG_BIR_II_1	1	5	PF00653	0.677
LIG_BRCT_BRCA1_1	68	72	PF00533	0.705
LIG_deltaCOP1_diTrp_1	52	59	PF00928	0.578
LIG_eIF4E_1	164	170	PF01652	0.320
LIG_FHA_2	210	216	PF00498	0.338
LIG_FHA_2	33	39	PF00498	0.600
LIG_IBAR_NPY_1	30	32	PF08397	0.576
LIG_IBAR_NPY_1	76	78	PF08397	0.629
LIG_LIR_Gen_1	109	117	PF02991	0.267
LIG_LIR_Gen_1	99	108	PF02991	0.383
LIG_LIR_Nem_3	109	114	PF02991	0.304
LIG_LIR_Nem_3	116	121	PF02991	0.387
LIG_LIR_Nem_3	158	163	PF02991	0.480
LIG_LIR_Nem_3	99	103	PF02991	0.485
LIG_PCNA_yPIPBox_3	165	179	PF02747	0.297
LIG_PDZ_Class_2	238	243	PF00595	0.582
LIG_Pex14_1	55	59	PF04695	0.616
LIG_Pex14_2	111	115	PF04695	0.266
LIG_PTB_Apo_2	16	23	PF02174	0.503
LIG_PTB_Phospho_1	16	22	PF10480	0.500
LIG_REV1ctd_RIR_1	70	76	PF16727	0.607
LIG_SH2_CRK	61	65	PF00017	0.638
LIG_SH2_STAT5	209	212	PF00017	0.433
LIG_SH2_STAT5	23	26	PF00017	0.618
LIG_SH2_STAT5	32	35	PF00017	0.598
LIG_SH2_STAT5	81	84	PF00017	0.625
LIG_SH3_3	136	142	PF00018	0.445
LIG_SH3_4	141	148	PF00018	0.456
LIG_TRFH_1	22	26	PF08558	0.670
LIG_TRFH_1	61	65	PF08558	0.672
LIG_WRC_WIRS_1	97	102	PF05994	0.494
MOD_CDK_SPK_2	46	51	PF00069	0.562
MOD_CDK_SPxxK_3	210	217	PF00069	0.318
MOD_CK1_1	106	112	PF00069	0.475
MOD_CK1_1	230	236	PF00069	0.433
MOD_CK1_1	99	105	PF00069	0.561
MOD_CK2_1	85	91	PF00069	0.606
MOD_GlcNHglycan	234	237	PF01048	0.708
MOD_GlcNHglycan	68	71	PF01048	0.430
MOD_GlcNHglycan	8	11	PF01048	0.482
MOD_GSK3_1	227	234	PF00069	0.535
MOD_GSK3_1	99	106	PF00069	0.532
MOD_NEK2_1	85	90	PF00069	0.593
MOD_NEK2_2	128	133	PF00069	0.375
MOD_PIKK_1	32	38	PF00454	0.685
MOD_PKA_2	6	12	PF00069	0.641
MOD_Plk_1	128	134	PF00069	0.363
MOD_Plk_1	200	206	PF00069	0.426
MOD_Plk_1	85	91	PF00069	0.594
MOD_Plk_2-3	86	92	PF00069	0.587
MOD_Plk_4	103	109	PF00069	0.321
MOD_Plk_4	13	19	PF00069	0.572
MOD_Plk_4	236	242	PF00069	0.429
MOD_ProDKin_1	210	216	PF00069	0.399
MOD_ProDKin_1	46	52	PF00069	0.566
TRG_ENDOCYTIC_2	160	163	PF00928	0.430
TRG_ENDOCYTIC_2	61	64	PF00928	0.633
TRG_ER_diArg_1	216	218	PF00400	0.434
TRG_NES_CRM1_1	173	187	PF08389	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYK0	Leptomonas seymouri	70%	100%
A0A0S4IVH5	Bodo saltans	54%	100%
A0A0S4IXX7	Bodo saltans	43%	92%
A0A1X0NYZ9	Trypanosomatidae	62%	100%
A0A3Q8IGT4	Leishmania donovani	80%	100%
A0A422MZK8	Trypanosoma rangeli	60%	100%
A4HGE2	Leishmania braziliensis	57%	98%
A4I3H5	Leishmania infantum	60%	100%
A4I8X2	Leishmania infantum	80%	100%
E9AZR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
E9B3U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
I1ZAQ0	Leishmania donovani	60%	100%
Q4Q483	Leishmania major	81%	100%
Q4Q8G9	Leishmania major	59%	100%
V5AL49	Trypanosoma cruzi	60%	95%