Chloride channel protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chloride channel protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HLG0_LEIBR

TriTrypDb:

LbrM.33.1260 , LBRM2903_330017600

Length:

911

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HLG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLG0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0005216	monoatomic ion channel activity	4	11
GO:0005244	voltage-gated monoatomic ion channel activity	4	11
GO:0005247	voltage-gated chloride channel activity	6	11
GO:0005253	monoatomic anion channel activity	5	11
GO:0005254	chloride channel activity	6	11
GO:0008308	voltage-gated monoatomic anion channel activity	5	11
GO:0008509	monoatomic anion transmembrane transporter activity	4	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0015103	inorganic anion transmembrane transporter activity	4	11
GO:0015108	chloride transmembrane transporter activity	5	11
GO:0015267	channel activity	4	11
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	11
GO:0022803	passive transmembrane transporter activity	3	11
GO:0022832	voltage-gated channel activity	6	11
GO:0022836	gated channel activity	5	11
GO:0022857	transmembrane transporter activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	524	528	PF00656	0.339
CLV_C14_Caspase3-7	726	730	PF00656	0.493
CLV_C14_Caspase3-7	73	77	PF00656	0.472
CLV_C14_Caspase3-7	856	860	PF00656	0.655
CLV_NRD_NRD_1	218	220	PF00675	0.474
CLV_NRD_NRD_1	239	241	PF00675	0.493
CLV_NRD_NRD_1	367	369	PF00675	0.258
CLV_NRD_NRD_1	653	655	PF00675	0.362
CLV_NRD_NRD_1	842	844	PF00675	0.278
CLV_NRD_NRD_1	880	882	PF00675	0.558
CLV_PCSK_FUR_1	237	241	PF00082	0.451
CLV_PCSK_KEX2_1	218	220	PF00082	0.473
CLV_PCSK_KEX2_1	239	241	PF00082	0.451
CLV_PCSK_KEX2_1	366	368	PF00082	0.259
CLV_PCSK_KEX2_1	653	655	PF00082	0.336
CLV_PCSK_SKI1_1	240	244	PF00082	0.490
CLV_PCSK_SKI1_1	276	280	PF00082	0.273
CLV_PCSK_SKI1_1	379	383	PF00082	0.248
CLV_PCSK_SKI1_1	459	463	PF00082	0.531
CLV_PCSK_SKI1_1	495	499	PF00082	0.436
CLV_PCSK_SKI1_1	640	644	PF00082	0.339
CLV_PCSK_SKI1_1	653	657	PF00082	0.339
CLV_PCSK_SKI1_1	70	74	PF00082	0.640
DEG_APCC_DBOX_1	378	386	PF00400	0.511
DEG_APCC_DBOX_1	639	647	PF00400	0.511
DEG_APCC_DBOX_1	737	745	PF00400	0.509
DEG_MDM2_SWIB_1	771	778	PF02201	0.667
DOC_CYCLIN_yCln2_LP_2	302	308	PF00134	0.182
DOC_CYCLIN_yCln2_LP_2	542	548	PF00134	0.288
DOC_CYCLIN_yCln2_LP_2	880	886	PF00134	0.714
DOC_MAPK_DCC_7	376	386	PF00069	0.473
DOC_MAPK_gen_1	234	244	PF00069	0.296
DOC_MAPK_gen_1	366	373	PF00069	0.481
DOC_MAPK_gen_1	376	386	PF00069	0.430
DOC_MAPK_gen_1	456	466	PF00069	0.370
DOC_MAPK_MEF2A_6	237	245	PF00069	0.226
DOC_MAPK_MEF2A_6	29	38	PF00069	0.473
DOC_MAPK_MEF2A_6	366	373	PF00069	0.494
DOC_MAPK_MEF2A_6	379	386	PF00069	0.413
DOC_MAPK_MEF2A_6	640	647	PF00069	0.511
DOC_MAPK_MEF2A_6	738	745	PF00069	0.509
DOC_MAPK_NFAT4_5	640	648	PF00069	0.511
DOC_MAPK_NFAT4_5	738	746	PF00069	0.574
DOC_PP1_RVXF_1	355	361	PF00149	0.355
DOC_PP2B_LxvP_1	302	305	PF13499	0.182
DOC_PP4_FxxP_1	233	236	PF00568	0.259
DOC_PP4_FxxP_1	472	475	PF00568	0.339
DOC_USP7_MATH_1	143	147	PF00917	0.467
DOC_USP7_MATH_1	410	414	PF00917	0.242
DOC_USP7_MATH_1	421	425	PF00917	0.297
DOC_USP7_MATH_1	475	479	PF00917	0.366
DOC_USP7_MATH_1	517	521	PF00917	0.339
DOC_USP7_MATH_1	588	592	PF00917	0.399
DOC_USP7_MATH_1	697	701	PF00917	0.390
DOC_USP7_MATH_1	723	727	PF00917	0.438
DOC_USP7_MATH_1	81	85	PF00917	0.512
DOC_USP7_MATH_1	876	880	PF00917	0.688
DOC_USP7_MATH_1	889	893	PF00917	0.707
DOC_USP7_MATH_1	895	899	PF00917	0.715
DOC_WW_Pin1_4	120	125	PF00397	0.438
DOC_WW_Pin1_4	441	446	PF00397	0.250
DOC_WW_Pin1_4	693	698	PF00397	0.524
DOC_WW_Pin1_4	857	862	PF00397	0.709
DOC_WW_Pin1_4	904	909	PF00397	0.786
LIG_14-3-3_CanoR_1	357	361	PF00244	0.473
LIG_14-3-3_CanoR_1	459	467	PF00244	0.311
LIG_14-3-3_CanoR_1	508	513	PF00244	0.368
LIG_14-3-3_CanoR_1	70	75	PF00244	0.424
LIG_14-3-3_CanoR_1	712	722	PF00244	0.499
LIG_14-3-3_CanoR_1	754	762	PF00244	0.599
LIG_14-3-3_CanoR_1	788	797	PF00244	0.585
LIG_14-3-3_CanoR_1	896	901	PF00244	0.694
LIG_Actin_WH2_2	700	717	PF00022	0.403
LIG_AP2alpha_1	229	233	PF02296	0.339
LIG_APCC_ABBA_1	564	569	PF00400	0.204
LIG_APCC_ABBA_1	796	801	PF00400	0.537
LIG_BIR_II_1	1	5	PF00653	0.487
LIG_BIR_III_2	489	493	PF00653	0.182
LIG_BRCT_BRCA1_1	287	291	PF00533	0.335
LIG_BRCT_BRCA1_1	519	523	PF00533	0.259
LIG_BRCT_BRCA1_1	869	873	PF00533	0.569
LIG_Clathr_ClatBox_1	263	267	PF01394	0.385
LIG_Clathr_ClatBox_1	828	832	PF01394	0.562
LIG_deltaCOP1_diTrp_1	27	35	PF00928	0.542
LIG_DLG_GKlike_1	896	903	PF00625	0.579
LIG_EH1_1	329	337	PF00400	0.265
LIG_EH1_1	625	633	PF00400	0.331
LIG_eIF4E_1	380	386	PF01652	0.385
LIG_FAT_LD_1	741	749	PF03623	0.504
LIG_FHA_1	139	145	PF00498	0.424
LIG_FHA_1	176	182	PF00498	0.511
LIG_FHA_1	373	379	PF00498	0.490
LIG_FHA_1	41	47	PF00498	0.390
LIG_FHA_1	410	416	PF00498	0.359
LIG_FHA_1	442	448	PF00498	0.283
LIG_FHA_1	509	515	PF00498	0.301
LIG_FHA_1	536	542	PF00498	0.308
LIG_FHA_1	547	553	PF00498	0.394
LIG_FHA_1	619	625	PF00498	0.318
LIG_FHA_1	663	669	PF00498	0.515
LIG_FHA_1	757	763	PF00498	0.601
LIG_FHA_1	779	785	PF00498	0.617
LIG_FHA_1	789	795	PF00498	0.425
LIG_FHA_1	808	814	PF00498	0.483
LIG_FHA_1	820	826	PF00498	0.436
LIG_FHA_1	862	868	PF00498	0.582
LIG_FHA_1	886	892	PF00498	0.671
LIG_FHA_2	600	606	PF00498	0.339
LIG_FHA_2	704	710	PF00498	0.540
LIG_FHA_2	71	77	PF00498	0.484
LIG_FHA_2	804	810	PF00498	0.539
LIG_FHA_2	840	846	PF00498	0.503
LIG_FHA_2	860	866	PF00498	0.528
LIG_HP1_1	697	701	PF01393	0.493
LIG_HP1_1	723	727	PF01393	0.382
LIG_LIR_Apic_2	231	236	PF02991	0.259
LIG_LIR_Apic_2	602	606	PF02991	0.260
LIG_LIR_Gen_1	106	116	PF02991	0.405
LIG_LIR_Gen_1	359	364	PF02991	0.484
LIG_LIR_Gen_1	387	398	PF02991	0.318
LIG_LIR_Gen_1	516	526	PF02991	0.275
LIG_LIR_Gen_1	549	557	PF02991	0.445
LIG_LIR_Gen_1	759	766	PF02991	0.619
LIG_LIR_Gen_1	773	780	PF02991	0.641
LIG_LIR_Gen_1	802	813	PF02991	0.492
LIG_LIR_Gen_1	816	825	PF02991	0.473
LIG_LIR_Nem_3	106	111	PF02991	0.386
LIG_LIR_Nem_3	198	204	PF02991	0.372
LIG_LIR_Nem_3	292	298	PF02991	0.330
LIG_LIR_Nem_3	359	363	PF02991	0.484
LIG_LIR_Nem_3	387	393	PF02991	0.318
LIG_LIR_Nem_3	478	482	PF02991	0.317
LIG_LIR_Nem_3	516	521	PF02991	0.285
LIG_LIR_Nem_3	549	553	PF02991	0.383
LIG_LIR_Nem_3	558	564	PF02991	0.242
LIG_LIR_Nem_3	636	642	PF02991	0.511
LIG_LIR_Nem_3	729	735	PF02991	0.471
LIG_LIR_Nem_3	773	778	PF02991	0.647
LIG_LIR_Nem_3	795	800	PF02991	0.564
LIG_LIR_Nem_3	802	808	PF02991	0.371
LIG_LIR_Nem_3	816	820	PF02991	0.400
LIG_LYPXL_S_1	796	800	PF13949	0.390
LIG_LYPXL_yS_3	172	175	PF13949	0.473
LIG_LYPXL_yS_3	479	482	PF13949	0.182
LIG_LYPXL_yS_3	797	800	PF13949	0.594
LIG_LYPXL_yS_3	80	83	PF13949	0.486
LIG_NRBOX	384	390	PF00104	0.204
LIG_NRBOX	529	535	PF00104	0.311
LIG_NRBOX	740	746	PF00104	0.520
LIG_PCNA_yPIPBox_3	322	336	PF02747	0.265
LIG_Pex14_1	360	364	PF04695	0.539
LIG_Pex14_2	229	233	PF04695	0.339
LIG_Pex14_2	31	35	PF04695	0.473
LIG_Pex14_2	338	342	PF04695	0.395
LIG_Pex14_2	771	775	PF04695	0.636
LIG_SH2_CRK	518	522	PF00017	0.264
LIG_SH2_CRK	561	565	PF00017	0.424
LIG_SH2_GRB2like	166	169	PF00017	0.389
LIG_SH2_NCK_1	4	8	PF00017	0.535
LIG_SH2_NCK_1	488	492	PF00017	0.335
LIG_SH2_PTP2	380	383	PF00017	0.343
LIG_SH2_PTP2	390	393	PF00017	0.312
LIG_SH2_SRC	166	169	PF00017	0.389
LIG_SH2_SRC	525	528	PF00017	0.305
LIG_SH2_SRC	667	670	PF00017	0.578
LIG_SH2_STAP1	131	135	PF00017	0.204
LIG_SH2_STAP1	298	302	PF00017	0.210
LIG_SH2_STAP1	518	522	PF00017	0.259
LIG_SH2_STAT5	150	153	PF00017	0.436
LIG_SH2_STAT5	166	169	PF00017	0.392
LIG_SH2_STAT5	280	283	PF00017	0.312
LIG_SH2_STAT5	364	367	PF00017	0.498
LIG_SH2_STAT5	380	383	PF00017	0.208
LIG_SH2_STAT5	390	393	PF00017	0.296
LIG_SH2_STAT5	453	456	PF00017	0.360
LIG_SH2_STAT5	554	557	PF00017	0.313
LIG_SH2_STAT5	667	670	PF00017	0.578
LIG_SH2_STAT5	681	684	PF00017	0.631
LIG_SH2_STAT5	799	802	PF00017	0.580
LIG_SH3_3	167	173	PF00018	0.467
LIG_SH3_3	444	450	PF00018	0.271
LIG_SH3_3	696	702	PF00018	0.539
LIG_SH3_3	880	886	PF00018	0.714
LIG_SUMO_SIM_anti_2	316	321	PF11976	0.293
LIG_SUMO_SIM_par_1	261	267	PF11976	0.333
LIG_SUMO_SIM_par_1	723	729	PF11976	0.493
LIG_SUMO_SIM_par_1	827	832	PF11976	0.562
LIG_TRAF2_1	491	494	PF00917	0.182
LIG_TYR_ITIM	388	393	PF00017	0.385
LIG_TYR_ITIM	60	65	PF00017	0.225
LIG_WRC_WIRS_1	547	552	PF05994	0.424
MOD_CDK_SPK_2	120	125	PF00069	0.438
MOD_CDK_SPxxK_3	904	911	PF00069	0.789
MOD_CK1_1	155	161	PF00069	0.515
MOD_CK1_1	413	419	PF00069	0.267
MOD_CK1_1	429	435	PF00069	0.305
MOD_CK1_1	44	50	PF00069	0.424
MOD_CK1_1	535	541	PF00069	0.279
MOD_CK1_1	6	12	PF00069	0.529
MOD_CK1_1	616	622	PF00069	0.371
MOD_CK1_1	756	762	PF00069	0.506
MOD_CK1_1	803	809	PF00069	0.539
MOD_CK1_1	857	863	PF00069	0.718
MOD_CK1_1	898	904	PF00069	0.628
MOD_CMANNOS	30	33	PF00535	0.334
MOD_GlcNHglycan	101	104	PF01048	0.630
MOD_GlcNHglycan	128	131	PF01048	0.588
MOD_GlcNHglycan	141	144	PF01048	0.307
MOD_GlcNHglycan	145	148	PF01048	0.222
MOD_GlcNHglycan	157	160	PF01048	0.199
MOD_GlcNHglycan	193	196	PF01048	0.312
MOD_GlcNHglycan	269	272	PF01048	0.347
MOD_GlcNHglycan	347	350	PF01048	0.399
MOD_GlcNHglycan	401	404	PF01048	0.480
MOD_GlcNHglycan	412	415	PF01048	0.459
MOD_GlcNHglycan	418	422	PF01048	0.438
MOD_GlcNHglycan	423	426	PF01048	0.532
MOD_GlcNHglycan	43	46	PF01048	0.385
MOD_GlcNHglycan	456	459	PF01048	0.527
MOD_GlcNHglycan	557	560	PF01048	0.299
MOD_GlcNHglycan	561	564	PF01048	0.293
MOD_GlcNHglycan	590	593	PF01048	0.469
MOD_GlcNHglycan	618	621	PF01048	0.390
MOD_GlcNHglycan	772	775	PF01048	0.463
MOD_GlcNHglycan	801	805	PF01048	0.344
MOD_GlcNHglycan	851	854	PF01048	0.427
MOD_GlcNHglycan	869	872	PF01048	0.547
MOD_GlcNHglycan	94	97	PF01048	0.741
MOD_GSK3_1	139	146	PF00069	0.327
MOD_GSK3_1	191	198	PF00069	0.341
MOD_GSK3_1	285	292	PF00069	0.323
MOD_GSK3_1	40	47	PF00069	0.424
MOD_GSK3_1	404	411	PF00069	0.204
MOD_GSK3_1	413	420	PF00069	0.258
MOD_GSK3_1	426	433	PF00069	0.342
MOD_GSK3_1	517	524	PF00069	0.282
MOD_GSK3_1	525	532	PF00069	0.243
MOD_GSK3_1	555	562	PF00069	0.411
MOD_GSK3_1	567	574	PF00069	0.438
MOD_GSK3_1	618	625	PF00069	0.355
MOD_GSK3_1	693	700	PF00069	0.535
MOD_GSK3_1	710	717	PF00069	0.557
MOD_GSK3_1	748	755	PF00069	0.574
MOD_GSK3_1	770	777	PF00069	0.609
MOD_GSK3_1	788	795	PF00069	0.627
MOD_GSK3_1	799	806	PF00069	0.423
MOD_GSK3_1	809	816	PF00069	0.402
MOD_GSK3_1	857	864	PF00069	0.714
MOD_GSK3_1	885	892	PF00069	0.734
MOD_GSK3_1	92	99	PF00069	0.527
MOD_N-GLC_1	429	434	PF02516	0.429
MOD_N-GLC_1	459	464	PF02516	0.477
MOD_N-GLC_1	81	86	PF02516	0.662
MOD_NEK2_1	174	179	PF00069	0.460
MOD_NEK2_1	255	260	PF00069	0.312
MOD_NEK2_1	286	291	PF00069	0.381
MOD_NEK2_1	320	325	PF00069	0.274
MOD_NEK2_1	389	394	PF00069	0.288
MOD_NEK2_1	521	526	PF00069	0.320
MOD_NEK2_1	548	553	PF00069	0.399
MOD_NEK2_1	555	560	PF00069	0.209
MOD_NEK2_1	571	576	PF00069	0.126
MOD_NEK2_1	714	719	PF00069	0.437
MOD_NEK2_1	808	813	PF00069	0.454
MOD_NEK2_1	819	824	PF00069	0.494
MOD_NEK2_1	92	97	PF00069	0.474
MOD_NEK2_2	876	881	PF00069	0.553
MOD_PIKK_1	289	295	PF00454	0.424
MOD_PIKK_1	532	538	PF00454	0.315
MOD_PIKK_1	778	784	PF00454	0.647
MOD_PIKK_1	854	860	PF00454	0.706
MOD_PK_1	3	9	PF00069	0.542
MOD_PKA_2	175	181	PF00069	0.539
MOD_PKA_2	356	362	PF00069	0.473
MOD_PKA_2	714	720	PF00069	0.403
MOD_PKA_2	753	759	PF00069	0.603
MOD_PKA_2	895	901	PF00069	0.692
MOD_PKA_2	96	102	PF00069	0.429
MOD_Plk_1	459	465	PF00069	0.273
MOD_Plk_1	526	532	PF00069	0.336
MOD_Plk_1	800	806	PF00069	0.591
MOD_Plk_1	808	814	PF00069	0.326
MOD_Plk_4	11	17	PF00069	0.534
MOD_Plk_4	286	292	PF00069	0.280
MOD_Plk_4	529	535	PF00069	0.292
MOD_Plk_4	567	573	PF00069	0.460
MOD_Plk_4	613	619	PF00069	0.383
MOD_Plk_4	662	668	PF00069	0.516
MOD_Plk_4	677	683	PF00069	0.576
MOD_Plk_4	792	798	PF00069	0.544
MOD_ProDKin_1	120	126	PF00069	0.436
MOD_ProDKin_1	441	447	PF00069	0.250
MOD_ProDKin_1	693	699	PF00069	0.524
MOD_ProDKin_1	857	863	PF00069	0.713
MOD_ProDKin_1	904	910	PF00069	0.787
TRG_DiLeu_BaEn_2	26	32	PF01217	0.561
TRG_DiLeu_BaLyEn_6	671	676	PF01217	0.580
TRG_ENDOCYTIC_2	172	175	PF00928	0.473
TRG_ENDOCYTIC_2	201	204	PF00928	0.311
TRG_ENDOCYTIC_2	390	393	PF00928	0.331
TRG_ENDOCYTIC_2	4	7	PF00928	0.525
TRG_ENDOCYTIC_2	479	482	PF00928	0.336
TRG_ENDOCYTIC_2	518	521	PF00928	0.268
TRG_ENDOCYTIC_2	561	564	PF00928	0.401
TRG_ENDOCYTIC_2	62	65	PF00928	0.308
TRG_ENDOCYTIC_2	685	688	PF00928	0.560
TRG_ENDOCYTIC_2	760	763	PF00928	0.604
TRG_ENDOCYTIC_2	797	800	PF00928	0.575
TRG_ENDOCYTIC_2	80	83	PF00928	0.368
TRG_ENDOCYTIC_2	817	820	PF00928	0.492
TRG_ER_diArg_1	239	241	PF00400	0.203
TRG_ER_diArg_1	366	368	PF00400	0.462
TRG_ER_diArg_1	653	655	PF00400	0.562
TRG_NES_CRM1_1	740	752	PF08389	0.425
TRG_Pf-PMV_PEXEL_1	654	658	PF00026	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC56	Leptomonas seymouri	66%	79%
A0A0S4JNP7	Bodo saltans	38%	100%
A0A1X0P0Y6	Trypanosomatidae	47%	84%
A0A3Q8IK21	Leishmania donovani	84%	95%
A4I8X1	Leishmania infantum	83%	83%
D0A4W6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	92%
E9B3U0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	95%
P92941	Arabidopsis thaliana	23%	100%
P92942	Arabidopsis thaliana	23%	100%
Q4Q484	Leishmania major	81%	100%
Q54AX6	Dictyostelium discoideum	26%	100%
Q86AZ6	Dictyostelium discoideum	23%	100%
V5BPC2	Trypanosoma cruzi	47%	100%