Peptidase_S9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLF9_LEIBR

TriTrypDb:

LbrM.33.1250 , LBRM2903_330017500

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLF9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.660
CLV_C14_Caspase3-7	409	413	PF00656	0.378
CLV_NRD_NRD_1	14	16	PF00675	0.424
CLV_NRD_NRD_1	233	235	PF00675	0.457
CLV_PCSK_KEX2_1	14	16	PF00082	0.424
CLV_PCSK_KEX2_1	233	235	PF00082	0.466
CLV_PCSK_KEX2_1	74	76	PF00082	0.569
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.463
CLV_PCSK_SKI1_1	237	241	PF00082	0.565
CLV_PCSK_SKI1_1	276	280	PF00082	0.380
CLV_PCSK_SKI1_1	399	403	PF00082	0.334
CLV_PCSK_SKI1_1	77	81	PF00082	0.541
DEG_ODPH_VHL_1	288	301	PF01847	0.290
DOC_CYCLIN_yCln2_LP_2	351	357	PF00134	0.386
DOC_MAPK_gen_1	14	21	PF00069	0.380
DOC_MAPK_gen_1	266	272	PF00069	0.402
DOC_MAPK_gen_1	396	405	PF00069	0.357
DOC_MAPK_gen_1	74	80	PF00069	0.555
DOC_MAPK_MEF2A_6	116	125	PF00069	0.524
DOC_MAPK_MEF2A_6	14	23	PF00069	0.527
DOC_PP4_FxxP_1	211	214	PF00568	0.328
DOC_USP7_MATH_1	119	123	PF00917	0.710
DOC_USP7_MATH_1	256	260	PF00917	0.711
DOC_USP7_MATH_1	404	408	PF00917	0.455
DOC_WW_Pin1_4	108	113	PF00397	0.755
DOC_WW_Pin1_4	127	132	PF00397	0.547
DOC_WW_Pin1_4	166	171	PF00397	0.469
LIG_14-3-3_CanoR_1	116	122	PF00244	0.531
LIG_14-3-3_CanoR_1	276	286	PF00244	0.366
LIG_14-3-3_CanoR_1	365	375	PF00244	0.456
LIG_14-3-3_CanoR_1	399	404	PF00244	0.330
LIG_14-3-3_CanoR_1	420	426	PF00244	0.290
LIG_Actin_WH2_2	63	79	PF00022	0.561
LIG_BIR_III_4	61	65	PF00653	0.386
LIG_Clathr_ClatBox_1	298	302	PF01394	0.383
LIG_CtBP_PxDLS_1	69	74	PF00389	0.382
LIG_FHA_1	153	159	PF00498	0.444
LIG_FHA_1	217	223	PF00498	0.567
LIG_FHA_1	227	233	PF00498	0.500
LIG_FHA_1	369	375	PF00498	0.398
LIG_FHA_1	400	406	PF00498	0.534
LIG_FHA_1	52	58	PF00498	0.563
LIG_FHA_2	108	114	PF00498	0.750
LIG_FHA_2	190	196	PF00498	0.442
LIG_FHA_2	250	256	PF00498	0.715
LIG_FHA_2	35	41	PF00498	0.441
LIG_GBD_Chelix_1	72	80	PF00786	0.611
LIG_LIR_Apic_2	424	428	PF02991	0.322
LIG_LIR_Gen_1	280	290	PF02991	0.399
LIG_LIR_Gen_1	302	312	PF02991	0.476
LIG_LIR_Gen_1	412	422	PF02991	0.302
LIG_LIR_Nem_3	302	308	PF02991	0.391
LIG_LIR_Nem_3	412	417	PF02991	0.366
LIG_LIR_Nem_3	419	425	PF02991	0.411
LIG_Pex14_2	207	211	PF04695	0.314
LIG_Pex14_2	325	329	PF04695	0.478
LIG_SH2_CRK	181	185	PF00017	0.551
LIG_SH2_STAT5	36	39	PF00017	0.434
LIG_SH2_STAT5	414	417	PF00017	0.404
LIG_SH2_STAT5	425	428	PF00017	0.439
LIG_SH3_3	101	107	PF00018	0.556
LIG_SH3_3	18	24	PF00018	0.443
LIG_SH3_3	298	304	PF00018	0.463
LIG_SH3_3	50	56	PF00018	0.589
LIG_SUMO_SIM_anti_2	297	302	PF11976	0.429
LIG_SUMO_SIM_anti_2	391	396	PF11976	0.504
LIG_SUMO_SIM_par_1	189	195	PF11976	0.346
LIG_SUMO_SIM_par_1	297	302	PF11976	0.416
LIG_TRAF2_1	289	292	PF00917	0.567
LIG_WRC_WIRS_1	326	331	PF05994	0.433
LIG_WW_3	11	15	PF00397	0.537
MOD_CK1_1	124	130	PF00069	0.483
MOD_CK1_1	259	265	PF00069	0.684
MOD_CK1_1	28	34	PF00069	0.442
MOD_CK1_1	92	98	PF00069	0.727
MOD_CK2_1	189	195	PF00069	0.454
MOD_CK2_1	249	255	PF00069	0.660
MOD_GlcNHglycan	152	155	PF01048	0.307
MOD_GlcNHglycan	283	286	PF01048	0.470
MOD_GSK3_1	117	124	PF00069	0.525
MOD_GSK3_1	126	133	PF00069	0.390
MOD_GSK3_1	24	31	PF00069	0.389
MOD_GSK3_1	256	263	PF00069	0.644
MOD_GSK3_1	272	279	PF00069	0.352
MOD_GSK3_1	357	364	PF00069	0.349
MOD_GSK3_1	395	402	PF00069	0.527
MOD_N-GLC_1	249	254	PF02516	0.589
MOD_N-GLC_1	46	51	PF02516	0.589
MOD_NEK2_1	272	277	PF00069	0.349
MOD_NEK2_1	325	330	PF00069	0.433
MOD_NEK2_1	357	362	PF00069	0.398
MOD_NEK2_1	395	400	PF00069	0.427
MOD_NEK2_1	421	426	PF00069	0.484
MOD_NEK2_2	152	157	PF00069	0.442
MOD_NEK2_2	189	194	PF00069	0.469
MOD_NEK2_2	200	205	PF00069	0.496
MOD_NEK2_2	25	30	PF00069	0.499
MOD_NEK2_2	277	282	PF00069	0.412
MOD_PIKK_1	28	34	PF00454	0.413
MOD_PIKK_1	368	374	PF00454	0.444
MOD_PKA_2	256	262	PF00069	0.642
MOD_PKA_2	34	40	PF00069	0.432
MOD_PKA_2	65	71	PF00069	0.533
MOD_Plk_1	312	318	PF00069	0.465
MOD_Plk_4	17	23	PF00069	0.514
MOD_Plk_4	294	300	PF00069	0.465
MOD_ProDKin_1	108	114	PF00069	0.752
MOD_ProDKin_1	127	133	PF00069	0.537
MOD_ProDKin_1	166	172	PF00069	0.468
MOD_SUMO_rev_2	291	296	PF00179	0.493
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.427
TRG_ENDOCYTIC_2	181	184	PF00928	0.559
TRG_ENDOCYTIC_2	283	286	PF00928	0.389
TRG_ENDOCYTIC_2	414	417	PF00928	0.404
TRG_ER_diArg_1	13	15	PF00400	0.423
TRG_ER_diArg_1	232	234	PF00400	0.453
TRG_ER_diArg_1	75	78	PF00400	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5H7	Leptomonas seymouri	55%	94%
A0A1X0P162	Trypanosomatidae	43%	100%
A0A3Q8IGI7	Leishmania donovani	78%	100%
A4I8X0	Leishmania infantum	76%	100%
D0A4W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B3T9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q485	Leishmania major	76%	100%