Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLF8_LEIBR

TriTrypDb:

LbrM.33.1240 , LBRM2903_330017400

Length:

455

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLF8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.618
CLV_NRD_NRD_1	105	107	PF00675	0.533
CLV_NRD_NRD_1	159	161	PF00675	0.578
CLV_NRD_NRD_1	224	226	PF00675	0.522
CLV_NRD_NRD_1	66	68	PF00675	0.509
CLV_NRD_NRD_1	8	10	PF00675	0.503
CLV_PCSK_FUR_1	103	107	PF00082	0.530
CLV_PCSK_KEX2_1	102	104	PF00082	0.507
CLV_PCSK_KEX2_1	105	107	PF00082	0.531
CLV_PCSK_KEX2_1	158	160	PF00082	0.574
CLV_PCSK_KEX2_1	66	68	PF00082	0.517
CLV_PCSK_KEX2_1	8	10	PF00082	0.605
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.507
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.645
CLV_PCSK_PC7_1	4	10	PF00082	0.491
CLV_PCSK_SKI1_1	99	103	PF00082	0.428
CLV_Separin_Metazoa	81	85	PF03568	0.466
DEG_APCC_DBOX_1	266	274	PF00400	0.662
DEG_Nend_Nbox_1	1	3	PF02207	0.493
DEG_SCF_FBW7_1	241	246	PF00400	0.531
DOC_CKS1_1	314	319	PF01111	0.544
DOC_CKS1_1	402	407	PF01111	0.493
DOC_MAPK_gen_1	158	166	PF00069	0.621
DOC_MAPK_gen_1	199	208	PF00069	0.432
DOC_MAPK_gen_1	225	233	PF00069	0.490
DOC_MAPK_MEF2A_6	158	166	PF00069	0.447
DOC_MAPK_MEF2A_6	267	274	PF00069	0.441
DOC_MAPK_MEF2A_6	329	336	PF00069	0.603
DOC_MAPK_NFAT4_5	267	275	PF00069	0.445
DOC_PP4_FxxP_1	311	314	PF00568	0.542
DOC_PP4_FxxP_1	57	60	PF00568	0.610
DOC_USP7_MATH_1	129	133	PF00917	0.708
DOC_USP7_MATH_1	142	146	PF00917	0.763
DOC_USP7_MATH_1	201	205	PF00917	0.557
DOC_USP7_MATH_1	302	306	PF00917	0.690
DOC_USP7_MATH_1	307	311	PF00917	0.657
DOC_USP7_MATH_1	385	389	PF00917	0.602
DOC_WW_Pin1_4	123	128	PF00397	0.671
DOC_WW_Pin1_4	133	138	PF00397	0.710
DOC_WW_Pin1_4	239	244	PF00397	0.546
DOC_WW_Pin1_4	313	318	PF00397	0.549
DOC_WW_Pin1_4	401	406	PF00397	0.491
DOC_WW_Pin1_4	43	48	PF00397	0.600
LIG_14-3-3_CanoR_1	159	163	PF00244	0.602
LIG_14-3-3_CanoR_1	167	171	PF00244	0.493
LIG_14-3-3_CanoR_1	261	265	PF00244	0.578
LIG_14-3-3_CanoR_1	71	80	PF00244	0.456
LIG_Actin_WH2_2	83	101	PF00022	0.484
LIG_BIR_III_4	370	374	PF00653	0.634
LIG_BRCT_BRCA1_1	167	171	PF00533	0.456
LIG_FHA_1	110	116	PF00498	0.525
LIG_FHA_1	142	148	PF00498	0.650
LIG_FHA_1	181	187	PF00498	0.584
LIG_FHA_1	240	246	PF00498	0.535
LIG_FHA_1	267	273	PF00498	0.437
LIG_FHA_1	319	325	PF00498	0.453
LIG_FHA_1	48	54	PF00498	0.577
LIG_FHA_2	244	250	PF00498	0.482
LIG_FHA_2	342	348	PF00498	0.465
LIG_FHA_2	445	451	PF00498	0.595
LIG_FXI_DFP_1	54	58	PF00024	0.648
LIG_LIR_Apic_2	310	314	PF02991	0.443
LIG_LIR_Apic_2	56	60	PF02991	0.503
LIG_LIR_Gen_1	168	178	PF02991	0.341
LIG_LIR_Gen_1	260	270	PF02991	0.387
LIG_LIR_Gen_1	79	88	PF02991	0.458
LIG_LIR_Gen_1	91	101	PF02991	0.307
LIG_LIR_Nem_3	168	174	PF02991	0.552
LIG_LIR_Nem_3	260	265	PF02991	0.364
LIG_LIR_Nem_3	337	342	PF02991	0.410
LIG_LIR_Nem_3	79	83	PF02991	0.460
LIG_LIR_Nem_3	91	97	PF02991	0.307
LIG_NRBOX	269	275	PF00104	0.455
LIG_PCNA_PIPBox_1	251	260	PF02747	0.543
LIG_Pex14_2	311	315	PF04695	0.635
LIG_SH2_SRC	30	33	PF00017	0.694
LIG_SH2_STAP1	227	231	PF00017	0.536
LIG_SH2_STAP1	30	34	PF00017	0.694
LIG_SH2_STAT3	72	75	PF00017	0.424
LIG_SH2_STAT5	2	5	PF00017	0.638
LIG_SH2_STAT5	320	323	PF00017	0.488
LIG_SH2_STAT5	339	342	PF00017	0.286
LIG_SH2_STAT5	72	75	PF00017	0.424
LIG_SH2_STAT5	94	97	PF00017	0.439
LIG_SH3_3	134	140	PF00018	0.682
LIG_SH3_3	311	317	PF00018	0.615
LIG_SH3_3	399	405	PF00018	0.490
LIG_SUMO_SIM_anti_2	377	385	PF11976	0.463
LIG_SUMO_SIM_par_1	242	250	PF11976	0.518
LIG_TRAF2_1	237	240	PF00917	0.522
LIG_TRAF2_1	286	289	PF00917	0.800
LIG_TRAF2_1	37	40	PF00917	0.497
LIG_UBA3_1	219	226	PF00899	0.577
LIG_UBA3_1	97	102	PF00899	0.457
MOD_CK1_1	122	128	PF00069	0.643
MOD_CK1_1	145	151	PF00069	0.676
MOD_CK1_1	169	175	PF00069	0.498
MOD_CK1_1	260	266	PF00069	0.520
MOD_CK2_1	111	117	PF00069	0.468
MOD_CK2_1	243	249	PF00069	0.470
MOD_CK2_1	34	40	PF00069	0.541
MOD_CK2_1	376	382	PF00069	0.683
MOD_CK2_1	410	416	PF00069	0.643
MOD_GlcNHglycan	144	147	PF01048	0.697
MOD_GlcNHglycan	304	307	PF01048	0.714
MOD_GlcNHglycan	378	381	PF01048	0.525
MOD_GlcNHglycan	387	390	PF01048	0.508
MOD_GSK3_1	109	116	PF00069	0.483
MOD_GSK3_1	118	125	PF00069	0.570
MOD_GSK3_1	129	136	PF00069	0.572
MOD_GSK3_1	138	145	PF00069	0.591
MOD_GSK3_1	147	154	PF00069	0.596
MOD_GSK3_1	165	172	PF00069	0.566
MOD_GSK3_1	239	246	PF00069	0.528
MOD_GSK3_1	298	305	PF00069	0.689
MOD_GSK3_1	43	50	PF00069	0.538
MOD_N-GLC_1	119	124	PF02516	0.570
MOD_NEK2_1	111	116	PF00069	0.604
MOD_NEK2_1	165	170	PF00069	0.477
MOD_NEK2_1	353	358	PF00069	0.570
MOD_NEK2_2	24	29	PF00069	0.486
MOD_NEK2_2	47	52	PF00069	0.645
MOD_PIKK_1	207	213	PF00454	0.451
MOD_PIKK_1	353	359	PF00454	0.539
MOD_PIKK_1	71	77	PF00454	0.524
MOD_PK_1	158	164	PF00069	0.455
MOD_PKA_1	158	164	PF00069	0.560
MOD_PKA_2	158	164	PF00069	0.608
MOD_PKA_2	166	172	PF00069	0.547
MOD_PKA_2	201	207	PF00069	0.585
MOD_PKA_2	260	266	PF00069	0.472
MOD_Plk_2-3	410	416	PF00069	0.731
MOD_Plk_4	166	172	PF00069	0.503
MOD_Plk_4	24	30	PF00069	0.666
MOD_Plk_4	243	249	PF00069	0.503
MOD_Plk_4	307	313	PF00069	0.420
MOD_ProDKin_1	123	129	PF00069	0.676
MOD_ProDKin_1	133	139	PF00069	0.709
MOD_ProDKin_1	239	245	PF00069	0.547
MOD_ProDKin_1	313	319	PF00069	0.551
MOD_ProDKin_1	401	407	PF00069	0.493
MOD_ProDKin_1	43	49	PF00069	0.598
MOD_SUMO_rev_2	184	190	PF00179	0.578
TRG_DiLeu_BaEn_1	287	292	PF01217	0.638
TRG_DiLeu_LyEn_5	240	245	PF01217	0.535
TRG_ENDOCYTIC_2	80	83	PF00928	0.450
TRG_ENDOCYTIC_2	94	97	PF00928	0.292
TRG_ER_diArg_1	103	106	PF00400	0.491
TRG_ER_diArg_1	342	345	PF00400	0.400
TRG_NES_CRM1_1	323	338	PF08389	0.585
TRG_NLS_MonoExtC_3	101	106	PF00514	0.511
TRG_NLS_MonoExtN_4	99	106	PF00514	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCG4	Leptomonas seymouri	59%	100%
A0A1X0P2F5	Trypanosomatidae	29%	100%
A0A3R7P2X0	Trypanosoma rangeli	31%	100%
A0A3S7X6N5	Leishmania donovani	80%	100%
A4I8W9	Leishmania infantum	80%	100%
D0A4W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B3T8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q486	Leishmania major	79%	100%
V5AZU2	Trypanosoma cruzi	33%	100%