Geranylgeranyl transferase type-2 subunit alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein prenyltransferase alpha subunit repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HLF6_LEIBR

TriTrypDb:

LbrM.33.1220 , LBRM2903_330017200

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005968	Rab-protein geranylgeranyltransferase complex	4	12
GO:0032991	protein-containing complex	1	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLF6

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0018342	protein prenylation	4	12
GO:0018344	protein geranylgeranylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0097354	prenylation	3	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004659	prenyltransferase activity	4	12
GO:0004661	protein geranylgeranyltransferase activity	4	12
GO:0004663	Rab geranylgeranyltransferase activity	5	12
GO:0008318	protein prenyltransferase activity	3	12
GO:0016740	transferase activity	2	12
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.546
CLV_C14_Caspase3-7	358	362	PF00656	0.235
CLV_NRD_NRD_1	102	104	PF00675	0.392
CLV_NRD_NRD_1	173	175	PF00675	0.313
CLV_NRD_NRD_1	197	199	PF00675	0.209
CLV_NRD_NRD_1	342	344	PF00675	0.494
CLV_NRD_NRD_1	451	453	PF00675	0.454
CLV_NRD_NRD_1	462	464	PF00675	0.447
CLV_NRD_NRD_1	469	471	PF00675	0.477
CLV_NRD_NRD_1	67	69	PF00675	0.281
CLV_PCSK_KEX2_1	102	104	PF00082	0.421
CLV_PCSK_KEX2_1	197	199	PF00082	0.220
CLV_PCSK_KEX2_1	342	344	PF00082	0.484
CLV_PCSK_KEX2_1	451	453	PF00082	0.456
CLV_PCSK_KEX2_1	469	471	PF00082	0.435
CLV_PCSK_KEX2_1	67	69	PF00082	0.281
CLV_PCSK_SKI1_1	116	120	PF00082	0.253
CLV_PCSK_SKI1_1	198	202	PF00082	0.220
CLV_PCSK_SKI1_1	421	425	PF00082	0.464
CLV_PCSK_SKI1_1	68	72	PF00082	0.283
CLV_PCSK_SKI1_1	8	12	PF00082	0.584
DEG_APCC_DBOX_1	67	75	PF00400	0.302
DEG_SPOP_SBC_1	401	405	PF00917	0.381
DOC_CKS1_1	10	15	PF01111	0.330
DOC_CYCLIN_RxL_1	177	188	PF00134	0.353
DOC_MAPK_JIP1_4	215	221	PF00069	0.403
DOC_MAPK_MEF2A_6	25	33	PF00069	0.223
DOC_PP2B_LxvP_1	55	58	PF13499	0.365
DOC_PP4_FxxP_1	239	242	PF00568	0.367
DOC_PP4_FxxP_1	332	335	PF00568	0.433
DOC_USP7_MATH_1	220	224	PF00917	0.640
DOC_USP7_MATH_1	229	233	PF00917	0.689
DOC_USP7_MATH_1	271	275	PF00917	0.458
DOC_USP7_MATH_1	81	85	PF00917	0.513
DOC_USP7_UBL2_3	112	116	PF12436	0.460
DOC_WW_Pin1_4	231	236	PF00397	0.639
DOC_WW_Pin1_4	238	243	PF00397	0.418
DOC_WW_Pin1_4	9	14	PF00397	0.576
LIG_14-3-3_CanoR_1	215	220	PF00244	0.664
LIG_14-3-3_CanoR_1	402	411	PF00244	0.669
LIG_14-3-3_CanoR_1	414	420	PF00244	0.448
LIG_Actin_WH2_2	303	320	PF00022	0.295
LIG_APCC_ABBAyCdc20_2	318	324	PF00400	0.384
LIG_APCC_ABBAyCdc20_2	469	475	PF00400	0.465
LIG_Clathr_ClatBox_1	183	187	PF01394	0.420
LIG_EVH1_2	235	239	PF00568	0.390
LIG_FHA_1	163	169	PF00498	0.467
LIG_FHA_1	232	238	PF00498	0.616
LIG_FHA_1	250	256	PF00498	0.442
LIG_FHA_1	42	48	PF00498	0.471
LIG_FHA_2	154	160	PF00498	0.561
LIG_LIR_Apic_2	238	242	PF02991	0.397
LIG_LIR_Gen_1	165	173	PF02991	0.442
LIG_LIR_LC3C_4	388	392	PF02991	0.200
LIG_LIR_Nem_3	165	169	PF02991	0.452
LIG_LIR_Nem_3	257	262	PF02991	0.418
LIG_LIR_Nem_3	377	383	PF02991	0.237
LIG_LIR_Nem_3	59	64	PF02991	0.304
LIG_NRBOX	168	174	PF00104	0.446
LIG_OCRL_FandH_1	127	139	PF00620	0.512
LIG_OCRL_FandH_1	454	466	PF00620	0.438
LIG_PCNA_yPIPBox_3	16	30	PF02747	0.406
LIG_Pex14_2	332	336	PF04695	0.430
LIG_RPA_C_Fungi	440	452	PF08784	0.339
LIG_SH2_CRK	166	170	PF00017	0.236
LIG_SH2_STAP1	125	129	PF00017	0.178
LIG_SH2_STAP1	473	477	PF00017	0.432
LIG_SH2_STAT5	250	253	PF00017	0.364
LIG_SH2_STAT5	30	33	PF00017	0.222
LIG_SH2_STAT5	322	325	PF00017	0.323
LIG_SH2_STAT5	380	383	PF00017	0.303
LIG_SH2_STAT5	384	387	PF00017	0.305
LIG_SH2_STAT5	457	460	PF00017	0.450
LIG_SH2_STAT5	61	64	PF00017	0.321
LIG_SH3_3	7	13	PF00018	0.594
LIG_SH3_3	73	79	PF00018	0.422
LIG_SH3_CIN85_PxpxPR_1	97	102	PF14604	0.345
LIG_SUMO_SIM_anti_2	388	394	PF11976	0.484
LIG_SUMO_SIM_par_1	181	188	PF11976	0.298
LIG_SUMO_SIM_par_1	53	59	PF11976	0.468
LIG_TRAF2_1	19	22	PF00917	0.353
LIG_TRAF2_1	241	244	PF00917	0.547
LIG_TRAF2_1	396	399	PF00917	0.387
LIG_TYR_ITIM	381	386	PF00017	0.295
LIG_UBA3_1	168	175	PF00899	0.451
LIG_UBA3_1	306	311	PF00899	0.224
MOD_CDK_SPxxK_3	9	16	PF00069	0.565
MOD_CK1_1	257	263	PF00069	0.256
MOD_CK1_1	274	280	PF00069	0.396
MOD_CK1_1	415	421	PF00069	0.285
MOD_CK1_1	83	89	PF00069	0.566
MOD_CK2_1	238	244	PF00069	0.424
MOD_GlcNHglycan	125	128	PF01048	0.240
MOD_GlcNHglycan	229	232	PF01048	0.590
MOD_GlcNHglycan	262	265	PF01048	0.245
MOD_GlcNHglycan	273	276	PF01048	0.463
MOD_GlcNHglycan	289	292	PF01048	0.348
MOD_GlcNHglycan	407	410	PF01048	0.618
MOD_GlcNHglycan	415	418	PF01048	0.439
MOD_GlcNHglycan	435	438	PF01048	0.315
MOD_GlcNHglycan	85	88	PF01048	0.548
MOD_GlcNHglycan	91	94	PF01048	0.435
MOD_GSK3_1	158	165	PF00069	0.622
MOD_GSK3_1	220	227	PF00069	0.643
MOD_GSK3_1	231	238	PF00069	0.594
MOD_GSK3_1	274	281	PF00069	0.342
MOD_GSK3_1	29	36	PF00069	0.396
MOD_GSK3_1	401	408	PF00069	0.661
MOD_GSK3_1	429	436	PF00069	0.508
MOD_GSK3_1	43	50	PF00069	0.376
MOD_GSK3_1	81	88	PF00069	0.718
MOD_N-GLC_1	123	128	PF02516	0.166
MOD_N-GLC_1	257	262	PF02516	0.277
MOD_NEK2_1	158	163	PF00069	0.521
MOD_NEK2_1	210	215	PF00069	0.400
MOD_NEK2_1	248	253	PF00069	0.260
MOD_NEK2_1	29	34	PF00069	0.387
MOD_NEK2_1	355	360	PF00069	0.452
MOD_NEK2_1	400	405	PF00069	0.523
MOD_PIKK_1	224	230	PF00454	0.479
MOD_PIKK_1	278	284	PF00454	0.452
MOD_PIKK_1	305	311	PF00454	0.259
MOD_PIKK_1	394	400	PF00454	0.419
MOD_PK_1	429	435	PF00069	0.267
MOD_PKA_2	401	407	PF00069	0.656
MOD_PKA_2	413	419	PF00069	0.477
MOD_Plk_1	123	129	PF00069	0.166
MOD_Plk_1	246	252	PF00069	0.166
MOD_Plk_1	260	266	PF00069	0.265
MOD_Plk_1	355	361	PF00069	0.361
MOD_Plk_4	235	241	PF00069	0.377
MOD_Plk_4	29	35	PF00069	0.395
MOD_Plk_4	355	361	PF00069	0.439
MOD_Plk_4	429	435	PF00069	0.414
MOD_Plk_4	59	65	PF00069	0.338
MOD_ProDKin_1	231	237	PF00069	0.634
MOD_ProDKin_1	238	244	PF00069	0.409
MOD_ProDKin_1	9	15	PF00069	0.568
MOD_SUMO_rev_2	104	113	PF00179	0.180
MOD_SUMO_rev_2	348	352	PF00179	0.296
MOD_SUMO_rev_2	9	18	PF00179	0.461
TRG_DiLeu_BaEn_4	243	249	PF01217	0.313
TRG_ENDOCYTIC_2	125	128	PF00928	0.245
TRG_ENDOCYTIC_2	166	169	PF00928	0.384
TRG_ENDOCYTIC_2	30	33	PF00928	0.322
TRG_ENDOCYTIC_2	333	336	PF00928	0.288
TRG_ENDOCYTIC_2	383	386	PF00928	0.325
TRG_ENDOCYTIC_2	473	476	PF00928	0.306
TRG_ER_diArg_1	101	103	PF00400	0.331
TRG_ER_diArg_1	196	198	PF00400	0.245
TRG_ER_diArg_1	341	343	PF00400	0.480
TRG_ER_diArg_1	468	470	PF00400	0.557
TRG_ER_diArg_1	67	69	PF00400	0.298
TRG_NES_CRM1_1	136	147	PF08389	0.321
TRG_Pf-PMV_PEXEL_1	268	273	PF00026	0.237
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6W4	Leptomonas seymouri	50%	100%
A0A0S4JI96	Bodo saltans	32%	100%
A0A1X0P0V1	Trypanosomatidae	27%	87%
A0A3S7X6L4	Leishmania donovani	75%	99%
A0A422P2I9	Trypanosoma rangeli	32%	96%
A4I8W7	Leishmania infantum	75%	99%
A5A779	Sus scrofa	25%	86%
D0A4W1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	99%
E9B3T6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%
Q08602	Rattus norvegicus	25%	86%
Q4Q488	Leishmania major	74%	100%
Q5EA80	Bos taurus	24%	86%
Q5NVK5	Pongo abelii	26%	86%
Q92696	Homo sapiens	26%	86%
Q9JHK4	Mus musculus	25%	86%
V5BJU9	Trypanosoma cruzi	34%	100%