PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania braziliensis

UniProt:

A4HLF5_LEIBR

TriTrypDb:

LbrM.33.1210 , LBRM2903_330017100

Length:

939

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLF5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.670
CLV_NRD_NRD_1	100	102	PF00675	0.821
CLV_NRD_NRD_1	141	143	PF00675	0.826
CLV_NRD_NRD_1	185	187	PF00675	0.808
CLV_NRD_NRD_1	632	634	PF00675	0.622
CLV_NRD_NRD_1	829	831	PF00675	0.433
CLV_NRD_NRD_1	882	884	PF00675	0.530
CLV_PCSK_KEX2_1	100	102	PF00082	0.821
CLV_PCSK_KEX2_1	140	142	PF00082	0.834
CLV_PCSK_KEX2_1	184	186	PF00082	0.831
CLV_PCSK_KEX2_1	348	350	PF00082	0.851
CLV_PCSK_KEX2_1	574	576	PF00082	0.573
CLV_PCSK_KEX2_1	598	600	PF00082	0.594
CLV_PCSK_KEX2_1	632	634	PF00082	0.622
CLV_PCSK_KEX2_1	828	830	PF00082	0.433
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.598
CLV_PCSK_PC1ET2_1	574	576	PF00082	0.573
CLV_PCSK_PC1ET2_1	598	600	PF00082	0.594
CLV_PCSK_PC1ET2_1	632	634	PF00082	0.622
CLV_PCSK_SKI1_1	16	20	PF00082	0.631
CLV_PCSK_SKI1_1	830	834	PF00082	0.530
CLV_PCSK_SKI1_1	847	851	PF00082	0.249
CLV_PCSK_SKI1_1	872	876	PF00082	0.530
CLV_PCSK_SKI1_1	883	887	PF00082	0.530
DEG_APCC_DBOX_1	828	836	PF00400	0.316
DEG_APCC_DBOX_1	99	107	PF00400	0.584
DEG_Kelch_Keap1_1	32	37	PF01344	0.698
DEG_Nend_UBRbox_1	1	4	PF02207	0.555
DEG_SCF_FBW7_2	832	837	PF00400	0.277
DEG_SPOP_SBC_1	162	166	PF00917	0.654
DEG_SPOP_SBC_1	82	86	PF00917	0.741
DOC_CDC14_PxL_1	18	26	PF14671	0.628
DOC_CKS1_1	289	294	PF01111	0.551
DOC_CYCLIN_RxL_1	879	888	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	363	369	PF00134	0.588
DOC_MAPK_gen_1	860	867	PF00069	0.530
DOC_MAPK_gen_1	869	878	PF00069	0.381
DOC_MAPK_gen_1	887	895	PF00069	0.530
DOC_MAPK_MEF2A_6	860	867	PF00069	0.530
DOC_MAPK_MEF2A_6	869	878	PF00069	0.381
DOC_MAPK_NFAT4_5	860	868	PF00069	0.530
DOC_PP1_SILK_1	700	705	PF00149	0.504
DOC_PP2B_LxvP_1	496	499	PF13499	0.685
DOC_SPAK_OSR1_1	616	620	PF12202	0.661
DOC_SPAK_OSR1_1	626	630	PF12202	0.432
DOC_USP7_MATH_1	162	166	PF00917	0.654
DOC_USP7_MATH_1	268	272	PF00917	0.635
DOC_USP7_MATH_1	305	309	PF00917	0.637
DOC_USP7_MATH_1	426	430	PF00917	0.699
DOC_USP7_MATH_1	470	474	PF00917	0.801
DOC_USP7_MATH_1	60	64	PF00917	0.698
DOC_USP7_MATH_1	600	604	PF00917	0.826
DOC_USP7_MATH_1	650	654	PF00917	0.637
DOC_USP7_MATH_1	75	79	PF00917	0.578
DOC_USP7_MATH_1	814	818	PF00917	0.610
DOC_USP7_MATH_1	82	86	PF00917	0.799
DOC_USP7_MATH_1	915	919	PF00917	0.786
DOC_USP7_UBL2_3	606	610	PF12436	0.815
DOC_WW_Pin1_4	165	170	PF00397	0.796
DOC_WW_Pin1_4	273	278	PF00397	0.732
DOC_WW_Pin1_4	288	293	PF00397	0.488
DOC_WW_Pin1_4	428	433	PF00397	0.576
DOC_WW_Pin1_4	440	445	PF00397	0.599
DOC_WW_Pin1_4	458	463	PF00397	0.710
DOC_WW_Pin1_4	541	546	PF00397	0.825
DOC_WW_Pin1_4	830	835	PF00397	0.369
LIG_14-3-3_CanoR_1	100	104	PF00244	0.765
LIG_14-3-3_CanoR_1	141	147	PF00244	0.817
LIG_14-3-3_CanoR_1	209	219	PF00244	0.797
LIG_14-3-3_CanoR_1	302	311	PF00244	0.583
LIG_14-3-3_CanoR_1	487	496	PF00244	0.551
LIG_14-3-3_CanoR_1	599	608	PF00244	0.792
LIG_14-3-3_CanoR_1	83	89	PF00244	0.766
LIG_Actin_WH2_2	689	706	PF00022	0.458
LIG_APCC_ABBA_1	463	468	PF00400	0.556
LIG_BIR_III_2	216	220	PF00653	0.665
LIG_BRCT_BRCA1_1	174	178	PF00533	0.575
LIG_BRCT_BRCA1_1	199	203	PF00533	0.680
LIG_BRCT_BRCA1_1	909	913	PF00533	0.728
LIG_CtBP_PxDLS_1	219	223	PF00389	0.549
LIG_FHA_1	260	266	PF00498	0.713
LIG_FHA_1	274	280	PF00498	0.755
LIG_FHA_1	289	295	PF00498	0.582
LIG_FHA_1	330	336	PF00498	0.560
LIG_FHA_1	503	509	PF00498	0.559
LIG_FHA_1	578	584	PF00498	0.567
LIG_FHA_1	592	598	PF00498	0.649
LIG_FHA_1	698	704	PF00498	0.495
LIG_FHA_1	862	868	PF00498	0.445
LIG_FHA_2	166	172	PF00498	0.799
LIG_FHA_2	227	233	PF00498	0.776
LIG_FHA_2	25	31	PF00498	0.572
LIG_FHA_2	704	710	PF00498	0.522
LIG_FHA_2	743	749	PF00498	0.641
LIG_FHA_2	848	854	PF00498	0.530
LIG_FHA_2	926	932	PF00498	0.825
LIG_IBAR_NPY_1	112	114	PF08397	0.797
LIG_LIR_Apic_2	354	360	PF02991	0.688
LIG_LIR_Apic_2	585	589	PF02991	0.554
LIG_LIR_Gen_1	23	33	PF02991	0.661
LIG_LIR_Gen_1	468	478	PF02991	0.744
LIG_LIR_Gen_1	492	502	PF02991	0.535
LIG_LIR_Gen_1	653	660	PF02991	0.365
LIG_LIR_Gen_1	909	919	PF02991	0.758
LIG_LIR_Nem_3	23	28	PF02991	0.659
LIG_LIR_Nem_3	412	418	PF02991	0.625
LIG_LIR_Nem_3	468	474	PF02991	0.742
LIG_LIR_Nem_3	491	496	PF02991	0.537
LIG_LIR_Nem_3	653	657	PF02991	0.352
LIG_LIR_Nem_3	737	741	PF02991	0.612
LIG_LIR_Nem_3	909	914	PF02991	0.722
LIG_LYPXL_yS_3	415	418	PF13949	0.772
LIG_PCNA_yPIPBox_3	686	696	PF02747	0.586
LIG_PDZ_Class_3	934	939	PF00595	0.830
LIG_SH2_CRK	369	373	PF00017	0.572
LIG_SH2_CRK	425	429	PF00017	0.779
LIG_SH2_CRK	442	446	PF00017	0.829
LIG_SH2_CRK	471	475	PF00017	0.593
LIG_SH2_CRK	493	497	PF00017	0.805
LIG_SH2_CRK	586	590	PF00017	0.558
LIG_SH2_CRK	640	644	PF00017	0.349
LIG_SH2_GRB2like	146	149	PF00017	0.814
LIG_SH2_NCK_1	425	429	PF00017	0.779
LIG_SH2_NCK_1	471	475	PF00017	0.583
LIG_SH2_NCK_1	586	590	PF00017	0.558
LIG_SH2_PTP2	114	117	PF00017	0.814
LIG_SH2_PTP2	654	657	PF00017	0.350
LIG_SH2_SRC	369	372	PF00017	0.834
LIG_SH2_SRC	405	408	PF00017	0.820
LIG_SH2_SRC	621	624	PF00017	0.403
LIG_SH2_STAP1	388	392	PF00017	0.591
LIG_SH2_STAT3	371	374	PF00017	0.569
LIG_SH2_STAT3	388	391	PF00017	0.805
LIG_SH2_STAT3	395	398	PF00017	0.737
LIG_SH2_STAT3	424	427	PF00017	0.816
LIG_SH2_STAT5	114	117	PF00017	0.814
LIG_SH2_STAT5	405	408	PF00017	0.820
LIG_SH2_STAT5	471	474	PF00017	0.559
LIG_SH2_STAT5	495	498	PF00017	0.806
LIG_SH2_STAT5	504	507	PF00017	0.658
LIG_SH2_STAT5	654	657	PF00017	0.350
LIG_SH2_STAT5	731	734	PF00017	0.613
LIG_SH2_STAT5	779	782	PF00017	0.543
LIG_SH2_STAT5	866	869	PF00017	0.530
LIG_SH2_STAT5	897	900	PF00017	0.350
LIG_SH3_3	193	199	PF00018	0.808
LIG_SH3_3	262	268	PF00018	0.559
LIG_SH3_3	441	447	PF00018	0.826
LIG_SH3_3	528	534	PF00018	0.813
LIG_SH3_3	594	600	PF00018	0.677
LIG_SH3_3	807	813	PF00018	0.547
LIG_SH3_3	864	870	PF00018	0.384
LIG_SH3_3	909	915	PF00018	0.741
LIG_SH3_4	768	775	PF00018	0.613
LIG_SUMO_SIM_anti_2	848	853	PF11976	0.530
LIG_SUMO_SIM_par_1	841	846	PF11976	0.444
LIG_TRAF2_1	125	128	PF00917	0.763
LIG_TRAF2_1	645	648	PF00917	0.645
LIG_TRAF2_1	836	839	PF00917	0.530
LIG_TYR_ITIM	469	474	PF00017	0.589
LIG_WRC_WIRS_1	1	6	PF05994	0.576
LIG_WRC_WIRS_1	25	30	PF05994	0.697
LIG_WRC_WIRS_1	886	891	PF05994	0.384
MOD_CK1_1	144	150	PF00069	0.737
MOD_CK1_1	161	167	PF00069	0.497
MOD_CK1_1	221	227	PF00069	0.585
MOD_CK1_1	248	254	PF00069	0.793
MOD_CK1_1	255	261	PF00069	0.765
MOD_CK1_1	298	304	PF00069	0.799
MOD_CK1_1	306	312	PF00069	0.762
MOD_CK1_1	317	323	PF00069	0.586
MOD_CK1_1	449	455	PF00069	0.623
MOD_CK1_1	56	62	PF00069	0.580
MOD_CK1_1	587	593	PF00069	0.590
MOD_CK1_1	6	12	PF00069	0.586
MOD_CK1_1	670	676	PF00069	0.362
MOD_CK1_1	70	76	PF00069	0.610
MOD_CK1_1	734	740	PF00069	0.629
MOD_CK1_1	800	806	PF00069	0.479
MOD_CK1_1	817	823	PF00069	0.502
MOD_CK1_1	84	90	PF00069	0.790
MOD_CK1_1	868	874	PF00069	0.530
MOD_CK1_1	96	102	PF00069	0.571
MOD_CK2_1	122	128	PF00069	0.747
MOD_CK2_1	281	287	PF00069	0.722
MOD_CK2_1	306	312	PF00069	0.840
MOD_CK2_1	31	37	PF00069	0.698
MOD_CK2_1	347	353	PF00069	0.807
MOD_CK2_1	642	648	PF00069	0.492
MOD_CK2_1	742	748	PF00069	0.531
MOD_CK2_1	833	839	PF00069	0.530
MOD_CK2_1	925	931	PF00069	0.574
MOD_Cter_Amidation	608	611	PF01082	0.545
MOD_GlcNHglycan	160	163	PF01048	0.653
MOD_GlcNHglycan	179	182	PF01048	0.814
MOD_GlcNHglycan	247	250	PF01048	0.673
MOD_GlcNHglycan	270	273	PF01048	0.673
MOD_GlcNHglycan	316	319	PF01048	0.625
MOD_GlcNHglycan	34	37	PF01048	0.697
MOD_GlcNHglycan	349	352	PF01048	0.598
MOD_GlcNHglycan	38	43	PF01048	0.669
MOD_GlcNHglycan	407	410	PF01048	0.584
MOD_GlcNHglycan	428	431	PF01048	0.572
MOD_GlcNHglycan	516	519	PF01048	0.807
MOD_GlcNHglycan	525	528	PF01048	0.740
MOD_GlcNHglycan	549	552	PF01048	0.660
MOD_GlcNHglycan	55	58	PF01048	0.740
MOD_GlcNHglycan	644	647	PF01048	0.403
MOD_GlcNHglycan	69	72	PF01048	0.644
MOD_GlcNHglycan	815	819	PF01048	0.795
MOD_GlcNHglycan	919	922	PF01048	0.542
MOD_GSK3_1	122	129	PF00069	0.597
MOD_GSK3_1	144	151	PF00069	0.790
MOD_GSK3_1	157	164	PF00069	0.536
MOD_GSK3_1	16	23	PF00069	0.686
MOD_GSK3_1	198	205	PF00069	0.665
MOD_GSK3_1	220	227	PF00069	0.589
MOD_GSK3_1	245	252	PF00069	0.670
MOD_GSK3_1	255	262	PF00069	0.677
MOD_GSK3_1	268	275	PF00069	0.611
MOD_GSK3_1	281	288	PF00069	0.585
MOD_GSK3_1	294	301	PF00069	0.677
MOD_GSK3_1	3	10	PF00069	0.577
MOD_GSK3_1	303	310	PF00069	0.670
MOD_GSK3_1	313	320	PF00069	0.613
MOD_GSK3_1	347	354	PF00069	0.690
MOD_GSK3_1	405	412	PF00069	0.555
MOD_GSK3_1	454	461	PF00069	0.577
MOD_GSK3_1	485	492	PF00069	0.614
MOD_GSK3_1	504	511	PF00069	0.596
MOD_GSK3_1	537	544	PF00069	0.604
MOD_GSK3_1	553	560	PF00069	0.674
MOD_GSK3_1	56	63	PF00069	0.566
MOD_GSK3_1	578	585	PF00069	0.649
MOD_GSK3_1	587	594	PF00069	0.617
MOD_GSK3_1	598	605	PF00069	0.560
MOD_GSK3_1	66	73	PF00069	0.568
MOD_GSK3_1	800	807	PF00069	0.643
MOD_GSK3_1	819	826	PF00069	0.568
MOD_GSK3_1	843	850	PF00069	0.530
MOD_GSK3_1	861	868	PF00069	0.216
MOD_GSK3_1	925	932	PF00069	0.610
MOD_GSK3_1	95	102	PF00069	0.591
MOD_N-GLC_1	106	111	PF02516	0.705
MOD_N-GLC_1	122	127	PF02516	0.572
MOD_N-GLC_1	133	138	PF02516	0.695
MOD_N-GLC_1	147	152	PF02516	0.743
MOD_N-GLC_1	249	254	PF02516	0.668
MOD_N-GLC_1	256	261	PF02516	0.685
MOD_N-GLC_1	298	303	PF02516	0.595
MOD_N-GLC_1	312	317	PF02516	0.562
MOD_N-GLC_1	601	606	PF02516	0.586
MOD_N-GLC_1	830	835	PF02516	0.369
MOD_NEK2_1	106	111	PF00069	0.700
MOD_NEK2_1	157	162	PF00069	0.595
MOD_NEK2_1	177	182	PF00069	0.750
MOD_NEK2_1	210	215	PF00069	0.818
MOD_NEK2_1	24	29	PF00069	0.695
MOD_NEK2_1	256	261	PF00069	0.833
MOD_NEK2_1	293	298	PF00069	0.755
MOD_NEK2_1	4	9	PF00069	0.631
MOD_NEK2_1	417	422	PF00069	0.539
MOD_NEK2_1	44	49	PF00069	0.806
MOD_NEK2_1	489	494	PF00069	0.547
MOD_NEK2_1	66	71	PF00069	0.549
MOD_NEK2_1	865	870	PF00069	0.369
MOD_NEK2_1	885	890	PF00069	0.530
MOD_NEK2_2	731	736	PF00069	0.621
MOD_PIKK_1	148	154	PF00454	0.801
MOD_PIKK_1	185	191	PF00454	0.825
MOD_PIKK_1	318	324	PF00454	0.832
MOD_PIKK_1	409	415	PF00454	0.572
MOD_PIKK_1	417	423	PF00454	0.565
MOD_PIKK_1	557	563	PF00454	0.812
MOD_PKA_1	141	147	PF00069	0.829
MOD_PKA_1	185	191	PF00069	0.592
MOD_PKA_1	598	604	PF00069	0.592
MOD_PKA_2	141	147	PF00069	0.829
MOD_PKA_2	185	191	PF00069	0.592
MOD_PKA_2	245	251	PF00069	0.697
MOD_PKA_2	502	508	PF00069	0.564
MOD_PKA_2	598	604	PF00069	0.701
MOD_PKA_2	703	709	PF00069	0.519
MOD_PKA_2	82	88	PF00069	0.762
MOD_PKA_2	868	874	PF00069	0.530
MOD_PKA_2	99	105	PF00069	0.819
MOD_PKB_1	140	148	PF00069	0.827
MOD_Plk_1	252	258	PF00069	0.711
MOD_Plk_1	259	265	PF00069	0.677
MOD_Plk_1	298	304	PF00069	0.595
MOD_Plk_1	306	312	PF00069	0.661
MOD_Plk_1	847	853	PF00069	0.530
MOD_Plk_2-3	307	313	PF00069	0.590
MOD_Plk_2-3	929	935	PF00069	0.573
MOD_Plk_4	126	132	PF00069	0.637
MOD_Plk_4	20	26	PF00069	0.688
MOD_Plk_4	504	510	PF00069	0.608
MOD_Plk_4	650	656	PF00069	0.371
MOD_Plk_4	698	704	PF00069	0.495
MOD_Plk_4	84	90	PF00069	0.568
MOD_Plk_4	847	853	PF00069	0.530
MOD_Plk_4	907	913	PF00069	0.720
MOD_ProDKin_1	165	171	PF00069	0.798
MOD_ProDKin_1	273	279	PF00069	0.735
MOD_ProDKin_1	288	294	PF00069	0.491
MOD_ProDKin_1	428	434	PF00069	0.575
MOD_ProDKin_1	440	446	PF00069	0.598
MOD_ProDKin_1	458	464	PF00069	0.708
MOD_ProDKin_1	541	547	PF00069	0.827
MOD_ProDKin_1	830	836	PF00069	0.369
MOD_SUMO_rev_2	693	701	PF00179	0.451
MOD_SUMO_rev_2	836	843	PF00179	0.433
TRG_DiLeu_BaEn_1	126	131	PF01217	0.571
TRG_DiLeu_BaEn_2	908	914	PF01217	0.729
TRG_DiLeu_BaEn_3	837	843	PF01217	0.277
TRG_DiLeu_BaEn_4	838	844	PF01217	0.530
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.551
TRG_DiLeu_BaLyEn_6	737	742	PF01217	0.360
TRG_ENDOCYTIC_2	114	117	PF00928	0.814
TRG_ENDOCYTIC_2	415	418	PF00928	0.772
TRG_ENDOCYTIC_2	425	428	PF00928	0.651
TRG_ENDOCYTIC_2	466	469	PF00928	0.758
TRG_ENDOCYTIC_2	471	474	PF00928	0.783
TRG_ENDOCYTIC_2	493	496	PF00928	0.803
TRG_ENDOCYTIC_2	654	657	PF00928	0.350
TRG_ER_diArg_1	139	142	PF00400	0.829
TRG_ER_diArg_1	183	186	PF00400	0.822
TRG_ER_diArg_1	244	247	PF00400	0.827
TRG_ER_diArg_1	687	690	PF00400	0.655
TRG_ER_diArg_1	828	830	PF00400	0.433
TRG_ER_diArg_1	889	892	PF00400	0.530
TRG_NES_CRM1_1	664	675	PF08389	0.610
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IM55	Leishmania donovani	64%	100%
A4I8W6	Leishmania infantum	64%	98%
E9B3T5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4Q489	Leishmania major	65%	99%