Skp1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SKP1-like protein

Species:

Leishmania braziliensis

UniProt:

A4HLF3_LEIBR

TriTrypDb:

LbrM.33.1180 , LBRM2903_330016500

Length:

193

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLF3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006511	ubiquitin-dependent protein catabolic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009057	macromolecule catabolic process	4	7
GO:0009987	cellular process	1	7
GO:0019538	protein metabolic process	3	7
GO:0019941	modification-dependent protein catabolic process	6	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043632	modification-dependent macromolecule catabolic process	5	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044248	cellular catabolic process	3	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0044265	obsolete cellular macromolecule catabolic process	4	7
GO:0051603	proteolysis involved in protein catabolic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901575	organic substance catabolic process	3	7
GO:0010498	proteasomal protein catabolic process	5	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0016310	phosphorylation	5	1
GO:0016567	protein ubiquitination	7	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0070647	protein modification by small protein conjugation or removal	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0097602	cullin family protein binding	3	1
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	104	108	PF00082	0.421
CLV_PCSK_SKI1_1	135	139	PF00082	0.334
CLV_PCSK_SKI1_1	166	170	PF00082	0.255
DEG_MDM2_SWIB_1	121	129	PF02201	0.283
DEG_SPOP_SBC_1	40	44	PF00917	0.635
DOC_MAPK_JIP1_4	104	110	PF00069	0.354
DOC_USP7_MATH_1	24	28	PF00917	0.687
DOC_USP7_UBL2_3	172	176	PF12436	0.518
DOC_WW_Pin1_4	11	16	PF00397	0.539
DOC_WW_Pin1_4	25	30	PF00397	0.623
DOC_WW_Pin1_4	44	49	PF00397	0.494
DOC_WW_Pin1_4	5	10	PF00397	0.506
LIG_14-3-3_CanoR_1	104	109	PF00244	0.569
LIG_14-3-3_CanoR_1	74	79	PF00244	0.399
LIG_14-3-3_CanoR_1	81	86	PF00244	0.487
LIG_BRCT_BRCA1_1	13	17	PF00533	0.622
LIG_BRCT_BRCA1_1	76	80	PF00533	0.341
LIG_deltaCOP1_diTrp_1	124	128	PF00928	0.255
LIG_FHA_1	105	111	PF00498	0.319
LIG_FHA_1	63	69	PF00498	0.305
LIG_FHA_1	97	103	PF00498	0.350
LIG_LIR_Gen_1	112	121	PF02991	0.355
LIG_LIR_Gen_1	124	133	PF02991	0.285
LIG_LIR_Nem_3	124	128	PF02991	0.365
LIG_LIR_Nem_3	58	64	PF02991	0.441
LIG_LIR_Nem_3	89	95	PF02991	0.507
LIG_Pex14_2	121	125	PF04695	0.280
LIG_SH2_STAP1	142	146	PF00017	0.251
LIG_SH2_STAT5	113	116	PF00017	0.381
LIG_SH2_STAT5	156	159	PF00017	0.415
LIG_SH2_STAT5	63	66	PF00017	0.417
LIG_SH3_3	30	36	PF00018	0.493
LIG_SH3_3	43	49	PF00018	0.637
LIG_SH3_3	54	60	PF00018	0.530
LIG_TYR_ITIM	140	145	PF00017	0.315
LIG_UBA3_1	145	152	PF00899	0.457
LIG_WRC_WIRS_1	82	87	PF05994	0.399
LIG_WW_2	52	55	PF00397	0.396
MOD_CDK_SPK_2	11	16	PF00069	0.441
MOD_CDK_SPxK_1	25	31	PF00069	0.461
MOD_CK1_1	25	31	PF00069	0.457
MOD_CK1_1	44	50	PF00069	0.718
MOD_CK1_1	8	14	PF00069	0.555
MOD_CK1_1	84	90	PF00069	0.483
MOD_GlcNHglycan	149	152	PF01048	0.205
MOD_GSK3_1	1	8	PF00069	0.671
MOD_GSK3_1	40	47	PF00069	0.633
MOD_GSK3_1	80	87	PF00069	0.550
MOD_NEK2_1	80	85	PF00069	0.566
MOD_PKA_2	80	86	PF00069	0.495
MOD_PKB_1	79	87	PF00069	0.360
MOD_Plk_4	135	141	PF00069	0.308
MOD_Plk_4	152	158	PF00069	0.352
MOD_ProDKin_1	25	31	PF00069	0.694
MOD_ProDKin_1	44	50	PF00069	0.491
MOD_ProDKin_1	5	11	PF00069	0.503
MOD_SUMO_for_1	183	186	PF00179	0.488
TRG_DiLeu_BaEn_1	164	169	PF01217	0.364
TRG_DiLeu_BaEn_4	143	149	PF01217	0.251
TRG_ENDOCYTIC_2	113	116	PF00928	0.416
TRG_ENDOCYTIC_2	142	145	PF00928	0.304
TRG_NES_CRM1_1	161	174	PF08389	0.420
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.185

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J0Y1	Bodo saltans	42%	100%
A0A1X0P0U8	Trypanosomatidae	52%	79%
D0A4V7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	84%
E9B3T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
O81058	Arabidopsis thaliana	27%	96%
Q4Q493	Leishmania major	88%	100%