Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLE8_LEIBR

TriTrypDb:

LbrM.33.1130 , LBRM2903_330016000

Length:

550

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.542
CLV_NRD_NRD_1	126	128	PF00675	0.589
CLV_NRD_NRD_1	191	193	PF00675	0.645
CLV_NRD_NRD_1	236	238	PF00675	0.537
CLV_NRD_NRD_1	280	282	PF00675	0.599
CLV_NRD_NRD_1	283	285	PF00675	0.571
CLV_NRD_NRD_1	287	289	PF00675	0.558
CLV_NRD_NRD_1	293	295	PF00675	0.558
CLV_NRD_NRD_1	300	302	PF00675	0.535
CLV_NRD_NRD_1	33	35	PF00675	0.528
CLV_NRD_NRD_1	337	339	PF00675	0.524
CLV_NRD_NRD_1	392	394	PF00675	0.554
CLV_PCSK_FUR_1	189	193	PF00082	0.655
CLV_PCSK_FUR_1	281	285	PF00082	0.580
CLV_PCSK_FUR_1	291	295	PF00082	0.564
CLV_PCSK_KEX2_1	111	113	PF00082	0.539
CLV_PCSK_KEX2_1	191	193	PF00082	0.664
CLV_PCSK_KEX2_1	222	224	PF00082	0.481
CLV_PCSK_KEX2_1	254	256	PF00082	0.541
CLV_PCSK_KEX2_1	280	282	PF00082	0.580
CLV_PCSK_KEX2_1	283	285	PF00082	0.580
CLV_PCSK_KEX2_1	286	288	PF00082	0.582
CLV_PCSK_KEX2_1	291	293	PF00082	0.574
CLV_PCSK_KEX2_1	33	35	PF00082	0.528
CLV_PCSK_KEX2_1	392	394	PF00082	0.566
CLV_PCSK_KEX2_1	518	520	PF00082	0.632
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.573
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.467
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.632
CLV_PCSK_PC7_1	283	289	PF00082	0.579
CLV_PCSK_SKI1_1	179	183	PF00082	0.514
CLV_PCSK_SKI1_1	198	202	PF00082	0.585
CLV_PCSK_SKI1_1	205	209	PF00082	0.499
CLV_PCSK_SKI1_1	219	223	PF00082	0.534
CLV_PCSK_SKI1_1	267	271	PF00082	0.444
CLV_PCSK_SKI1_1	302	306	PF00082	0.481
CLV_PCSK_SKI1_1	331	335	PF00082	0.682
CLV_PCSK_SKI1_1	382	386	PF00082	0.694
CLV_PCSK_SKI1_1	502	506	PF00082	0.718
CLV_Separin_Metazoa	499	503	PF03568	0.546
DEG_APCC_DBOX_1	144	152	PF00400	0.573
DEG_APCC_DBOX_1	178	186	PF00400	0.668
DEG_APCC_DBOX_1	204	212	PF00400	0.591
DEG_SPOP_SBC_1	420	424	PF00917	0.709
DEG_SPOP_SBC_1	465	469	PF00917	0.611
DEG_SPOP_SBC_1	473	477	PF00917	0.638
DEG_SPOP_SBC_1	6	10	PF00917	0.487
DOC_CYCLIN_yCln2_LP_2	114	120	PF00134	0.556
DOC_MAPK_gen_1	301	308	PF00069	0.483
DOC_MAPK_gen_1	381	387	PF00069	0.637
DOC_MAPK_MEF2A_6	45	53	PF00069	0.588
DOC_PP4_FxxP_1	83	86	PF00568	0.488
DOC_USP7_MATH_1	132	136	PF00917	0.507
DOC_USP7_MATH_1	193	197	PF00917	0.513
DOC_USP7_MATH_1	32	36	PF00917	0.637
DOC_USP7_MATH_1	367	371	PF00917	0.728
DOC_USP7_MATH_1	402	406	PF00917	0.691
DOC_USP7_MATH_1	430	434	PF00917	0.710
DOC_USP7_MATH_1	465	469	PF00917	0.694
DOC_USP7_MATH_1	474	478	PF00917	0.638
DOC_USP7_MATH_1	506	510	PF00917	0.702
DOC_USP7_MATH_1	6	10	PF00917	0.509
DOC_WW_Pin1_4	137	142	PF00397	0.649
DOC_WW_Pin1_4	166	171	PF00397	0.500
DOC_WW_Pin1_4	2	7	PF00397	0.641
DOC_WW_Pin1_4	338	343	PF00397	0.621
DOC_WW_Pin1_4	393	398	PF00397	0.600
DOC_WW_Pin1_4	408	413	PF00397	0.739
DOC_WW_Pin1_4	461	466	PF00397	0.566
DOC_WW_Pin1_4	469	474	PF00397	0.657
DOC_WW_Pin1_4	513	518	PF00397	0.749
DOC_WW_Pin1_4	74	79	PF00397	0.571
DOC_WW_Pin1_4	82	87	PF00397	0.495
LIG_14-3-3_CanoR_1	14	18	PF00244	0.547
LIG_14-3-3_CanoR_1	198	207	PF00244	0.479
LIG_14-3-3_CanoR_1	223	228	PF00244	0.634
LIG_14-3-3_CanoR_1	243	251	PF00244	0.670
LIG_14-3-3_CanoR_1	26	32	PF00244	0.591
LIG_14-3-3_CanoR_1	338	342	PF00244	0.595
LIG_14-3-3_CanoR_1	45	53	PF00244	0.441
LIG_Actin_WH2_2	367	383	PF00022	0.712
LIG_BRCT_BRCA1_1	54	58	PF00533	0.521
LIG_BRCT_BRCA1_1	8	12	PF00533	0.612
LIG_eIF4E_1	143	149	PF01652	0.578
LIG_FHA_1	327	333	PF00498	0.638
LIG_FHA_1	338	344	PF00498	0.575
LIG_FHA_1	422	428	PF00498	0.699
LIG_FHA_1	473	479	PF00498	0.688
LIG_FHA_1	59	65	PF00498	0.473
LIG_FHA_1	86	92	PF00498	0.464
LIG_FHA_2	169	175	PF00498	0.627
LIG_FHA_2	182	188	PF00498	0.546
LIG_FHA_2	261	267	PF00498	0.453
LIG_LIR_Apic_2	82	86	PF02991	0.491
LIG_LIR_Gen_1	140	151	PF02991	0.616
LIG_LIR_Gen_1	9	17	PF02991	0.659
LIG_LIR_Nem_3	140	146	PF02991	0.624
LIG_LIR_Nem_3	9	15	PF02991	0.657
LIG_NRBOX	268	274	PF00104	0.438
LIG_PCNA_yPIPBox_3	365	375	PF02747	0.545
LIG_PDZ_Class_2	545	550	PF00595	0.546
LIG_SH3_1	426	432	PF00018	0.609
LIG_SH3_2	376	381	PF14604	0.639
LIG_SH3_2	497	502	PF14604	0.628
LIG_SH3_3	114	120	PF00018	0.556
LIG_SH3_3	187	193	PF00018	0.480
LIG_SH3_3	373	379	PF00018	0.611
LIG_SH3_3	422	428	PF00018	0.623
LIG_SH3_3	475	481	PF00018	0.807
LIG_SH3_3	491	497	PF00018	0.660
LIG_SH3_3	517	523	PF00018	0.565
LIG_SH3_3	75	81	PF00018	0.611
LIG_TRAF2_1	296	299	PF00917	0.494
LIG_TRAF2_1	452	455	PF00917	0.546
LIG_UBA3_1	181	186	PF00899	0.492
LIG_WW_2	429	432	PF00397	0.604
LIG_WW_3	499	503	PF00397	0.546
MOD_CDC14_SPxK_1	396	399	PF00782	0.550
MOD_CDK_SPK_2	393	398	PF00069	0.557
MOD_CDK_SPK_2	513	518	PF00069	0.564
MOD_CDK_SPxK_1	393	399	PF00069	0.551
MOD_CDK_SPxK_1	513	519	PF00069	0.603
MOD_CK1_1	168	174	PF00069	0.689
MOD_CK1_1	250	256	PF00069	0.693
MOD_CK1_1	323	329	PF00069	0.573
MOD_CK1_1	349	355	PF00069	0.560
MOD_CK1_1	356	362	PF00069	0.553
MOD_CK1_1	411	417	PF00069	0.677
MOD_CK1_1	469	475	PF00069	0.625
MOD_CK1_1	47	53	PF00069	0.423
MOD_CK1_1	479	485	PF00069	0.705
MOD_CK1_1	488	494	PF00069	0.683
MOD_CK1_1	5	11	PF00069	0.656
MOD_CK1_1	82	88	PF00069	0.642
MOD_CK2_1	168	174	PF00069	0.625
MOD_CK2_1	181	187	PF00069	0.556
MOD_CK2_1	223	229	PF00069	0.469
MOD_CK2_1	260	266	PF00069	0.462
MOD_CK2_1	293	299	PF00069	0.644
MOD_CK2_1	403	409	PF00069	0.673
MOD_CK2_1	7	13	PF00069	0.575
MOD_GlcNHglycan	100	104	PF01048	0.460
MOD_GlcNHglycan	311	314	PF01048	0.639
MOD_GlcNHglycan	323	326	PF01048	0.563
MOD_GlcNHglycan	348	351	PF01048	0.600
MOD_GlcNHglycan	355	358	PF01048	0.623
MOD_GlcNHglycan	376	379	PF01048	0.612
MOD_GlcNHglycan	382	385	PF01048	0.631
MOD_GlcNHglycan	387	390	PF01048	0.660
MOD_GlcNHglycan	405	408	PF01048	0.680
MOD_GlcNHglycan	478	481	PF01048	0.655
MOD_GlcNHglycan	54	57	PF01048	0.545
MOD_GlcNHglycan	69	72	PF01048	0.504
MOD_GSK3_1	133	140	PF00069	0.495
MOD_GSK3_1	15	22	PF00069	0.522
MOD_GSK3_1	162	169	PF00069	0.538
MOD_GSK3_1	177	184	PF00069	0.603
MOD_GSK3_1	194	201	PF00069	0.548
MOD_GSK3_1	2	9	PF00069	0.656
MOD_GSK3_1	225	232	PF00069	0.587
MOD_GSK3_1	319	326	PF00069	0.685
MOD_GSK3_1	346	353	PF00069	0.765
MOD_GSK3_1	356	363	PF00069	0.781
MOD_GSK3_1	461	468	PF00069	0.667
MOD_GSK3_1	469	476	PF00069	0.683
MOD_GSK3_1	479	486	PF00069	0.693
MOD_GSK3_1	506	513	PF00069	0.709
MOD_GSK3_1	528	535	PF00069	0.594
MOD_GSK3_1	81	88	PF00069	0.539
MOD_N-GLC_1	247	252	PF02516	0.605
MOD_NEK2_1	15	20	PF00069	0.585
MOD_NEK2_1	194	199	PF00069	0.546
MOD_NEK2_1	319	324	PF00069	0.592
MOD_NEK2_1	332	337	PF00069	0.592
MOD_NEK2_1	380	385	PF00069	0.776
MOD_NEK2_1	485	490	PF00069	0.559
MOD_NEK2_1	511	516	PF00069	0.547
MOD_NEK2_1	541	546	PF00069	0.610
MOD_NEK2_1	58	63	PF00069	0.525
MOD_NEK2_1	7	12	PF00069	0.655
MOD_PIKK_1	15	21	PF00454	0.527
MOD_PIKK_1	286	292	PF00454	0.493
MOD_PIKK_1	32	38	PF00454	0.602
MOD_PIKK_1	323	329	PF00454	0.665
MOD_PIKK_1	44	50	PF00454	0.454
MOD_PKA_1	222	228	PF00069	0.625
MOD_PKA_1	286	292	PF00069	0.661
MOD_PKA_1	293	299	PF00069	0.415
MOD_PKA_1	532	538	PF00069	0.591
MOD_PKA_2	13	19	PF00069	0.595
MOD_PKA_2	165	171	PF00069	0.555
MOD_PKA_2	194	200	PF00069	0.683
MOD_PKA_2	222	228	PF00069	0.503
MOD_PKA_2	242	248	PF00069	0.716
MOD_PKA_2	260	266	PF00069	0.491
MOD_PKA_2	286	292	PF00069	0.593
MOD_PKA_2	293	299	PF00069	0.454
MOD_PKA_2	32	38	PF00069	0.514
MOD_PKA_2	337	343	PF00069	0.715
MOD_PKA_2	385	391	PF00069	0.614
MOD_PKA_2	44	50	PF00069	0.425
MOD_PKA_2	488	494	PF00069	0.560
MOD_PKA_2	511	517	PF00069	0.720
MOD_PKB_1	284	292	PF00069	0.665
MOD_Plk_1	247	253	PF00069	0.643
MOD_Plk_4	332	338	PF00069	0.607
MOD_Plk_4	7	13	PF00069	0.652
MOD_ProDKin_1	137	143	PF00069	0.648
MOD_ProDKin_1	166	172	PF00069	0.504
MOD_ProDKin_1	2	8	PF00069	0.638
MOD_ProDKin_1	338	344	PF00069	0.622
MOD_ProDKin_1	393	399	PF00069	0.603
MOD_ProDKin_1	408	414	PF00069	0.738
MOD_ProDKin_1	461	467	PF00069	0.567
MOD_ProDKin_1	469	475	PF00069	0.658
MOD_ProDKin_1	513	519	PF00069	0.752
MOD_ProDKin_1	74	80	PF00069	0.569
MOD_ProDKin_1	82	88	PF00069	0.494
MOD_SUMO_rev_2	168	178	PF00179	0.513
MOD_SUMO_rev_2	451	461	PF00179	0.551
TRG_ENDOCYTIC_2	143	146	PF00928	0.530
TRG_ER_diArg_1	110	112	PF00400	0.526
TRG_ER_diArg_1	189	192	PF00400	0.573
TRG_ER_diArg_1	203	206	PF00400	0.628
TRG_ER_diArg_1	279	281	PF00400	0.587
TRG_ER_diArg_1	283	286	PF00400	0.568
TRG_ER_diArg_1	291	294	PF00400	0.554
TRG_ER_diArg_1	391	393	PF00400	0.555
TRG_NES_CRM1_1	41	52	PF08389	0.561
TRG_NLS_Bipartite_1	111	131	PF00514	0.468
TRG_NLS_MonoExtC_3	537	543	PF00514	0.600
TRG_NLS_MonoExtN_4	124	131	PF00514	0.475
TRG_PTS2	1	42	PF00400	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S3	Leptomonas seymouri	39%	100%
A0A3S7X6K5	Leishmania donovani	61%	100%
A4I8V7	Leishmania infantum	62%	100%
E9B3S6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4Q498	Leishmania major	61%	100%