Putative 40S ribosomal protein S3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S3, putative

Species:

Leishmania braziliensis

UniProt:

A4HLE6_LEIBR

TriTrypDb:

LbrM.33.1110 , LBRM2903_330015800

Length:

219

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 24

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0015935	small ribosomal subunit	4	11
GO:0032991	protein-containing complex	1	12
GO:0044391	ribosomal subunit	3	11
GO:1990904	ribonucleoprotein complex	2	12
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0022627	cytosolic small ribosomal subunit	5	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005840	ribosome	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4HLE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLE6

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.477
CLV_C14_Caspase3-7	165	169	PF00656	0.477
CLV_NRD_NRD_1	115	117	PF00675	0.277
CLV_NRD_NRD_1	63	65	PF00675	0.290
CLV_PCSK_KEX2_1	115	117	PF00082	0.277
CLV_PCSK_KEX2_1	25	27	PF00082	0.290
CLV_PCSK_KEX2_1	63	65	PF00082	0.290
CLV_PCSK_KEX2_1	7	9	PF00082	0.431
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.290
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.431
CLV_PCSK_SKI1_1	147	151	PF00082	0.277
CLV_PCSK_SKI1_1	186	190	PF00082	0.373
CLV_PCSK_SKI1_1	213	217	PF00082	0.619
CLV_PCSK_SKI1_1	55	59	PF00082	0.298
CLV_PCSK_SKI1_1	66	70	PF00082	0.304
DOC_MAPK_gen_1	105	114	PF00069	0.315
DOC_MAPK_gen_1	115	121	PF00069	0.477
DOC_MAPK_gen_1	142	151	PF00069	0.477
DOC_MAPK_gen_1	50	60	PF00069	0.570
DOC_MAPK_gen_1	79	87	PF00069	0.570
DOC_MAPK_MEF2A_6	177	185	PF00069	0.477
DOC_MAPK_MEF2A_6	79	87	PF00069	0.572
DOC_USP7_MATH_1	162	166	PF00917	0.567
DOC_USP7_MATH_1	190	194	PF00917	0.557
LIG_14-3-3_CanoR_1	145	150	PF00244	0.477
LIG_14-3-3_CanoR_1	93	101	PF00244	0.484
LIG_APCC_ABBA_1	83	88	PF00400	0.477
LIG_APCC_ABBAyCdc20_2	82	88	PF00400	0.477
LIG_BRCT_BRCA1_1	102	106	PF00533	0.360
LIG_BRCT_BRCA1_1	147	151	PF00533	0.477
LIG_FHA_1	43	49	PF00498	0.490
LIG_FHA_1	52	58	PF00498	0.483
LIG_FHA_1	67	73	PF00498	0.451
LIG_FHA_2	148	154	PF00498	0.477
LIG_FHA_2	206	212	PF00498	0.473
LIG_Integrin_isoDGR_2	61	63	PF01839	0.370
LIG_LIR_Gen_1	19	29	PF02991	0.334
LIG_LIR_Nem_3	103	109	PF02991	0.315
LIG_LIR_Nem_3	19	24	PF02991	0.334
LIG_LIR_Nem_3	30	36	PF02991	0.490
LIG_SH2_STAP1	17	21	PF00017	0.382
LIG_SH2_STAT5	124	127	PF00017	0.490
LIG_SH2_STAT5	86	89	PF00017	0.570
LIG_SH3_1	196	202	PF00018	0.595
LIG_SH3_3	196	202	PF00018	0.523
LIG_SH3_3	206	212	PF00018	0.436
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.473
LIG_SUMO_SIM_par_1	205	211	PF11976	0.473
LIG_TYR_ITIM	15	20	PF00017	0.384
LIG_UBA3_1	20	25	PF00899	0.334
MOD_CK1_1	191	197	PF00069	0.372
MOD_CK1_1	34	40	PF00069	0.557
MOD_CK2_1	205	211	PF00069	0.536
MOD_CK2_1	213	219	PF00069	0.523
MOD_Cter_Amidation	61	64	PF01082	0.290
MOD_GlcNHglycan	127	130	PF01048	0.290
MOD_GlcNHglycan	158	161	PF01048	0.279
MOD_GlcNHglycan	168	171	PF01048	0.305
MOD_GlcNHglycan	33	36	PF01048	0.370
MOD_GlcNHglycan	95	98	PF01048	0.345
MOD_GSK3_1	158	165	PF00069	0.536
MOD_GSK3_1	34	41	PF00069	0.508
MOD_NEK2_1	156	161	PF00069	0.477
MOD_NEK2_1	166	171	PF00069	0.477
MOD_PKB_1	64	72	PF00069	0.490
MOD_Plk_1	133	139	PF00069	0.477
MOD_Plk_2-3	205	211	PF00069	0.473
MOD_Plk_4	162	168	PF00069	0.536
MOD_SUMO_for_1	24	27	PF00179	0.506
MOD_SUMO_rev_2	205	215	PF00179	0.475
TRG_DiLeu_BaEn_2	18	24	PF01217	0.334
TRG_ENDOCYTIC_2	17	20	PF00928	0.418
TRG_ER_diArg_1	114	116	PF00400	0.477
TRG_ER_diArg_1	63	66	PF00400	0.490
TRG_NLS_MonoExtN_4	3	10	PF00514	0.441
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.290
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.290

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZM6	Leptomonas seymouri	96%	100%
A0A1D8PSV5	Candida albicans (strain SC5314 / ATCC MYA-2876)	50%	87%
A0A1X0P0T7	Trypanosomatidae	82%	100%
A0A3Q8IHP3	Leishmania donovani	99%	100%
A0A3R7KSG8	Trypanosoma rangeli	83%	100%
A0B9W4	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	31%	79%
A0Q4I9	Francisella tularensis subsp. novicida (strain U112)	28%	98%
A0RVX9	Cenarchaeum symbiosum (strain A)	28%	84%
A1RV98	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	25%	100%
A1RXG6	Thermofilum pendens (strain DSM 2475 / Hrk 5)	27%	100%
A2BMC5	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	27%	89%
A2SPK9	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	33%	95%
A3CT03	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	31%	94%
A3DNB3	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	29%	98%
A3MTL3	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	27%	100%
A4FWB6	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	32%	100%
A4H868	Leishmania braziliensis	100%	100%
A4HWJ3	Leishmania infantum	99%	100%
A4IZS8	Francisella tularensis subsp. tularensis (strain WY96-3418)	28%	98%
A4VSG0	Streptococcus suis (strain 05ZYH33)	26%	100%
A4VYP9	Streptococcus suis (strain 98HAH33)	26%	100%
A4WIY8	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	26%	100%
A4YCX2	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	31%	91%
A5UL83	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	30%	88%
A6UQ49	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	29%	100%
A6UWU3	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	31%	100%
A6VGZ0	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	31%	100%
A7I5P5	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	32%	95%
A7N9T2	Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA)	28%	98%
A8AA20	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	27%	91%
A9A9Q9	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	31%	100%
B2SDX9	Francisella tularensis subsp. mediasiatica (strain FSC147)	28%	98%
B6YSL9	Thermococcus onnurineus (strain NA1)	36%	100%
B9L6M7	Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH)	31%	91%
C4ZBS5	Agathobacter rectalis (strain ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835 / VPI 0990)	26%	100%
C5A280	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	35%	100%
C6A165	Thermococcus sibiricus (strain DSM 12597 / MM 739)	34%	100%
C9ZXU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	82%
D0A4V0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	82%	100%
E2RH47	Canis lupus familiaris	60%	90%
E9AQ94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O26116	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	29%	85%
O28360	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	30%	96%
O59424	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	34%	100%
O60128	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	57%	88%
P02350	Xenopus laevis	60%	89%
P05750	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	59%	91%
P15009	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	31%	73%
P20281	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	32%	72%
P23396	Homo sapiens	60%	90%
P47835	Xenopus laevis	59%	89%
P48152	Caenorhabditis elegans	53%	89%
P48153	Manduca sexta	58%	90%
P54034	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	35%	100%
P62908	Mus musculus	60%	90%
P62909	Rattus norvegicus	60%	90%
P79891	Ambystoma mexicanum	59%	87%
P90526	Dictyostelium discoideum	54%	100%
Q06559	Drosophila melanogaster	59%	89%
Q0BNS1	Francisella tularensis subsp. holarctica (strain OSU18)	28%	98%
Q0W1Y3	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	31%	78%
Q0Z8U2	Sus scrofa	60%	90%
Q12ZU5	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	27%	72%
Q14JB4	Francisella tularensis subsp. tularensis (strain FSC 198)	28%	99%
Q18GF5	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	31%	68%
Q2A5G4	Francisella tularensis subsp. holarctica (strain LVS)	28%	98%
Q2FT39	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	31%	92%
Q2NFW2	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	29%	87%
Q3IMY2	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	32%	72%
Q3T169	Bos taurus	60%	90%
Q46GA1	Methanosarcina barkeri (strain Fusaro / DSM 804)	32%	70%
Q4A5C7	Mycoplasmopsis synoviae (strain 53)	28%	97%
Q4JB46	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	28%	95%
Q4Q4A0	Leishmania major	99%	100%
Q5JDH5	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	36%	100%
Q5NHW2	Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)	28%	99%
Q5R465	Pongo abelii	60%	90%
Q6L1C1	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	27%	100%
Q6LXE7	Methanococcus maripaludis (strain S2 / LL)	31%	100%
Q74MZ4	Nanoarchaeum equitans (strain Kin4-M)	24%	95%
Q8PV44	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	30%	71%
Q8SQM3	Encephalitozoon cuniculi (strain GB-M1)	37%	100%
Q8TRU1	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	29%	69%
Q8U004	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	35%	100%
Q8ZWI0	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	26%	100%
Q90YS2	Ictalurus punctatus	59%	89%
Q975I7	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	29%	97%
Q97BX1	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	24%	97%
Q9FJA6	Arabidopsis thaliana	58%	88%
Q9HIR5	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	23%	97%
Q9M339	Arabidopsis thaliana	58%	88%
Q9SIP7	Arabidopsis thaliana	58%	88%
Q9UXA0	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	27%	96%
Q9V1U1	Pyrococcus abyssi (strain GE5 / Orsay)	34%	100%
Q9YF78	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	30%	89%