LeishMANIAdb
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Methyltransferase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Methyltransferase
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HLE5_LEIBR
TriTrypDb:
LbrM.33.1100 , LBRM2903_330015700 *
Length:
117

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HLE5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLE5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 74 78 PF00656 0.357
CLV_PCSK_SKI1_1 105 109 PF00082 0.420
CLV_PCSK_SKI1_1 110 114 PF00082 0.355
CLV_PCSK_SKI1_1 50 54 PF00082 0.463
CLV_PCSK_SKI1_1 62 66 PF00082 0.554
DEG_APCC_DBOX_1 104 112 PF00400 0.405
DEG_Nend_Nbox_1 1 3 PF02207 0.340
DOC_MAPK_HePTP_8 80 92 PF00069 0.463
DOC_MAPK_MEF2A_6 83 92 PF00069 0.458
DOC_PP4_FxxP_1 9 12 PF00568 0.357
DOC_USP7_MATH_1 99 103 PF00917 0.432
LIG_14-3-3_CanoR_1 110 116 PF00244 0.358
LIG_14-3-3_CanoR_1 97 107 PF00244 0.442
LIG_APCC_ABBA_1 3 8 PF00400 0.345
LIG_FHA_2 67 73 PF00498 0.544
LIG_LIR_Apic_2 8 12 PF02991 0.356
LIG_PDZ_Class_2 112 117 PF00595 0.405
LIG_SH2_STAT5 2 5 PF00017 0.334
LIG_TRAF2_1 38 41 PF00917 0.417
MOD_CK2_1 35 41 PF00069 0.424
MOD_CK2_1 66 72 PF00069 0.518
MOD_GlcNHglycan 101 104 PF01048 0.446
MOD_N-GLC_1 56 61 PF02516 0.572
MOD_N-GLC_1 75 80 PF02516 0.298
MOD_PIKK_1 75 81 PF00454 0.321
MOD_Plk_1 75 81 PF00069 0.337
MOD_Plk_2-3 66 72 PF00069 0.535
MOD_SUMO_for_1 18 21 PF00179 0.593
MOD_SUMO_rev_2 77 84 PF00179 0.443
TRG_ENDOCYTIC_2 2 5 PF00928 0.336
TRG_NES_CRM1_1 82 96 PF08389 0.452

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HU21 Leptomonas seymouri 74% 99%
A0A1X0P0S3 Trypanosomatidae 49% 100%
A0A3R7MVH5 Trypanosoma rangeli 49% 100%
A0A3S7X6L5 Leishmania donovani 87% 100%
A4I8V4 Leishmania infantum 87% 100%
E9B3S3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q4A1 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS