Dnaj chaperone-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dnaj chaperone-like protein

Species:

Leishmania braziliensis

UniProt:

A4HLE4_LEIBR

TriTrypDb:

LbrM.33.1090 , LBRM2903_330015600

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HLE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLE4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	512	516	PF00656	0.604
CLV_NRD_NRD_1	393	395	PF00675	0.658
CLV_NRD_NRD_1	56	58	PF00675	0.453
CLV_PCSK_KEX2_1	20	22	PF00082	0.453
CLV_PCSK_KEX2_1	393	395	PF00082	0.658
CLV_PCSK_KEX2_1	56	58	PF00082	0.428
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.453
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.428
CLV_PCSK_SKI1_1	12	16	PF00082	0.533
CLV_PCSK_SKI1_1	225	229	PF00082	0.548
CLV_PCSK_SKI1_1	25	29	PF00082	0.422
CLV_PCSK_SKI1_1	293	297	PF00082	0.542
DEG_APCC_DBOX_1	292	300	PF00400	0.342
DOC_CDC14_PxL_1	138	146	PF14671	0.304
DOC_MAPK_gen_1	20	28	PF00069	0.269
DOC_PP1_RVXF_1	240	246	PF00149	0.308
DOC_USP7_MATH_1	221	225	PF00917	0.301
DOC_USP7_MATH_1	241	245	PF00917	0.183
DOC_USP7_MATH_1	339	343	PF00917	0.563
DOC_USP7_MATH_1	349	353	PF00917	0.454
DOC_USP7_MATH_1	375	379	PF00917	0.440
DOC_USP7_MATH_1	380	384	PF00917	0.469
DOC_USP7_MATH_1	545	549	PF00917	0.623
DOC_WW_Pin1_4	127	132	PF00397	0.499
DOC_WW_Pin1_4	151	156	PF00397	0.508
DOC_WW_Pin1_4	562	567	PF00397	0.689
LIG_14-3-3_CanoR_1	225	230	PF00244	0.294
LIG_14-3-3_CanoR_1	242	246	PF00244	0.189
LIG_14-3-3_CanoR_1	293	299	PF00244	0.315
LIG_14-3-3_CanoR_1	347	355	PF00244	0.418
LIG_14-3-3_CanoR_1	537	543	PF00244	0.635
LIG_BRCT_BRCA1_1	129	133	PF00533	0.469
LIG_BRCT_BRCA1_1	243	247	PF00533	0.227
LIG_Clathr_ClatBox_1	132	136	PF01394	0.347
LIG_deltaCOP1_diTrp_1	194	200	PF00928	0.480
LIG_EH1_1	100	108	PF00400	0.225
LIG_eIF4E_1	101	107	PF01652	0.227
LIG_FHA_1	172	178	PF00498	0.304
LIG_FHA_1	285	291	PF00498	0.304
LIG_FHA_1	420	426	PF00498	0.355
LIG_FHA_1	432	438	PF00498	0.364
LIG_FHA_1	86	92	PF00498	0.361
LIG_FHA_1	95	101	PF00498	0.304
LIG_FHA_2	46	52	PF00498	0.269
LIG_FHA_2	486	492	PF00498	0.333
LIG_FHA_2	563	569	PF00498	0.697
LIG_IBAR_NPY_1	404	406	PF08397	0.450
LIG_LIR_Gen_1	122	133	PF02991	0.513
LIG_LIR_Gen_1	208	218	PF02991	0.304
LIG_LIR_Gen_1	244	255	PF02991	0.227
LIG_LIR_Gen_1	272	283	PF02991	0.258
LIG_LIR_Gen_1	3	10	PF02991	0.269
LIG_LIR_Nem_3	122	128	PF02991	0.519
LIG_LIR_Nem_3	208	213	PF02991	0.304
LIG_LIR_Nem_3	244	250	PF02991	0.227
LIG_LIR_Nem_3	271	277	PF02991	0.308
LIG_LIR_Nem_3	3	8	PF02991	0.269
LIG_LIR_Nem_3	449	453	PF02991	0.469
LIG_LIR_Nem_3	47	53	PF02991	0.270
LIG_LIR_Nem_3	60	65	PF02991	0.268
LIG_NRBOX	163	169	PF00104	0.365
LIG_Pex14_2	111	115	PF04695	0.477
LIG_Pex14_2	129	133	PF04695	0.395
LIG_SH2_CRK	125	129	PF00017	0.448
LIG_SH2_CRK	23	27	PF00017	0.269
LIG_SH2_CRK	240	244	PF00017	0.316
LIG_SH2_CRK	450	454	PF00017	0.469
LIG_SH2_NCK_1	125	129	PF00017	0.448
LIG_SH2_NCK_1	240	244	PF00017	0.316
LIG_SH2_STAP1	101	105	PF00017	0.227
LIG_SH2_STAP1	125	129	PF00017	0.448
LIG_SH2_STAT3	406	409	PF00017	0.434
LIG_SH2_STAT5	125	128	PF00017	0.549
LIG_SH2_STAT5	205	208	PF00017	0.265
LIG_SH2_STAT5	274	277	PF00017	0.304
LIG_SH2_STAT5	302	305	PF00017	0.379
LIG_SH2_STAT5	406	409	PF00017	0.422
LIG_SH2_STAT5	445	448	PF00017	0.508
LIG_SH3_3	125	131	PF00018	0.503
LIG_SH3_3	136	142	PF00018	0.304
LIG_SH3_3	215	221	PF00018	0.227
LIG_SH3_3	527	533	PF00018	0.691
LIG_SUMO_SIM_anti_2	422	428	PF11976	0.226
LIG_SUMO_SIM_par_1	214	219	PF11976	0.275
LIG_SUMO_SIM_par_1	222	231	PF11976	0.332
LIG_SUMO_SIM_par_1	294	300	PF11976	0.336
LIG_SUMO_SIM_par_1	451	457	PF11976	0.308
LIG_SUMO_SIM_par_1	6	11	PF11976	0.251
LIG_SUMO_SIM_par_1	91	97	PF11976	0.292
LIG_TRAF2_1	14	17	PF00917	0.214
LIG_TYR_ITSM	270	277	PF00017	0.222
LIG_UBA3_1	226	230	PF00899	0.409
LIG_WRC_WIRS_1	82	87	PF05994	0.545
MOD_CDK_SPxxK_3	562	569	PF00069	0.626
MOD_CK1_1	124	130	PF00069	0.267
MOD_CK1_1	154	160	PF00069	0.483
MOD_CK1_1	219	225	PF00069	0.470
MOD_CK1_1	297	303	PF00069	0.409
MOD_CK1_1	419	425	PF00069	0.248
MOD_CK1_1	485	491	PF00069	0.227
MOD_CK1_1	548	554	PF00069	0.634
MOD_CK2_1	45	51	PF00069	0.304
MOD_CK2_1	485	491	PF00069	0.333
MOD_CK2_1	492	498	PF00069	0.622
MOD_CK2_1	506	512	PF00069	0.580
MOD_CMANNOS	197	200	PF00535	0.383
MOD_DYRK1A_RPxSP_1	562	566	PF00069	0.549
MOD_GlcNHglycan	207	210	PF01048	0.222
MOD_GlcNHglycan	299	302	PF01048	0.345
MOD_GlcNHglycan	351	354	PF01048	0.525
MOD_GlcNHglycan	467	470	PF01048	0.262
MOD_GlcNHglycan	484	487	PF01048	0.325
MOD_GlcNHglycan	547	550	PF01048	0.639
MOD_GSK3_1	119	126	PF00069	0.309
MOD_GSK3_1	221	228	PF00069	0.440
MOD_GSK3_1	297	304	PF00069	0.424
MOD_GSK3_1	339	346	PF00069	0.620
MOD_GSK3_1	416	423	PF00069	0.265
MOD_GSK3_1	543	550	PF00069	0.688
MOD_GSK3_1	80	87	PF00069	0.509
MOD_N-GLC_2	458	460	PF02516	0.227
MOD_NEK2_1	163	168	PF00069	0.341
MOD_NEK2_1	284	289	PF00069	0.369
MOD_NEK2_1	294	299	PF00069	0.375
MOD_NEK2_1	420	425	PF00069	0.479
MOD_NEK2_1	430	435	PF00069	0.339
MOD_NEK2_1	454	459	PF00069	0.437
MOD_NEK2_1	85	90	PF00069	0.492
MOD_NEK2_2	94	99	PF00069	0.227
MOD_PIKK_1	12	18	PF00454	0.222
MOD_PIKK_1	519	525	PF00454	0.499
MOD_PKA_2	241	247	PF00069	0.215
MOD_PKA_2	536	542	PF00069	0.544
MOD_PKA_2	574	580	PF00069	0.681
MOD_Plk_1	519	525	PF00069	0.499
MOD_Plk_1	571	577	PF00069	0.681
MOD_Plk_4	124	130	PF00069	0.375
MOD_Plk_4	163	169	PF00069	0.336
MOD_Plk_4	171	177	PF00069	0.254
MOD_Plk_4	241	247	PF00069	0.227
MOD_Plk_4	284	290	PF00069	0.304
MOD_Plk_4	294	300	PF00069	0.409
MOD_Plk_4	416	422	PF00069	0.359
MOD_Plk_4	470	476	PF00069	0.241
MOD_Plk_4	94	100	PF00069	0.261
MOD_ProDKin_1	127	133	PF00069	0.348
MOD_ProDKin_1	151	157	PF00069	0.505
MOD_ProDKin_1	562	568	PF00069	0.611
TRG_ENDOCYTIC_2	101	104	PF00928	0.227
TRG_ENDOCYTIC_2	125	128	PF00928	0.356
TRG_ENDOCYTIC_2	23	26	PF00928	0.304
TRG_ENDOCYTIC_2	240	243	PF00928	0.393
TRG_ENDOCYTIC_2	274	277	PF00928	0.304
TRG_ENDOCYTIC_2	450	453	PF00928	0.304
TRG_ENDOCYTIC_2	5	8	PF00928	0.304
TRG_ENDOCYTIC_2	50	53	PF00928	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0P4	Leptomonas seymouri	50%	100%
A0A3S7X6M9	Leishmania donovani	67%	100%
A4I8V3	Leishmania infantum	67%	100%
E9B3S2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4Q4A2	Leishmania major	66%	100%