Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLE2_LEIBR

TriTrypDb:

LbrM.33.1070 , LBRM2903_330015400

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HLE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.608
CLV_NRD_NRD_1	251	253	PF00675	0.537
CLV_NRD_NRD_1	79	81	PF00675	0.424
CLV_NRD_NRD_1	92	94	PF00675	0.511
CLV_PCSK_FUR_1	92	96	PF00082	0.449
CLV_PCSK_KEX2_1	251	253	PF00082	0.606
CLV_PCSK_KEX2_1	79	81	PF00082	0.482
CLV_PCSK_KEX2_1	92	94	PF00082	0.524
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.425
CLV_PCSK_SKI1_1	192	196	PF00082	0.448
CLV_PCSK_SKI1_1	42	46	PF00082	0.375
CLV_PCSK_SKI1_1	79	83	PF00082	0.424
CLV_Separin_Metazoa	222	226	PF03568	0.371
DEG_COP1_1	238	246	PF00400	0.261
DEG_ODPH_VHL_1	232	243	PF01847	0.261
DOC_CYCLIN_RxL_1	37	49	PF00134	0.623
DOC_CYCLIN_RxL_1	74	87	PF00134	0.661
DOC_MAPK_gen_1	76	84	PF00069	0.702
DOC_MAPK_MEF2A_6	37	45	PF00069	0.553
DOC_USP7_MATH_1	111	115	PF00917	0.672
DOC_USP7_MATH_1	156	160	PF00917	0.690
DOC_USP7_MATH_1	255	259	PF00917	0.651
DOC_USP7_MATH_1	278	282	PF00917	0.671
DOC_USP7_MATH_1	290	294	PF00917	0.718
DOC_WW_Pin1_4	152	157	PF00397	0.784
DOC_WW_Pin1_4	251	256	PF00397	0.628
LIG_14-3-3_CanoR_1	104	109	PF00244	0.681
LIG_14-3-3_CanoR_1	121	129	PF00244	0.574
LIG_14-3-3_CanoR_1	184	194	PF00244	0.639
LIG_14-3-3_CanoR_1	262	271	PF00244	0.773
LIG_APCC_ABBA_1	43	48	PF00400	0.555
LIG_APCC_ABBAyCdc20_2	42	48	PF00400	0.559
LIG_BIR_II_1	1	5	PF00653	0.610
LIG_BIR_III_2	277	281	PF00653	0.615
LIG_eIF4E_1	325	331	PF01652	0.513
LIG_FHA_1	101	107	PF00498	0.575
LIG_FHA_1	186	192	PF00498	0.655
LIG_FHA_1	22	28	PF00498	0.261
LIG_FHA_1	243	249	PF00498	0.368
LIG_FHA_1	316	322	PF00498	0.261
LIG_FHA_1	66	72	PF00498	0.658
LIG_FHA_2	6	12	PF00498	0.410
LIG_LIR_Gen_1	147	157	PF02991	0.638
LIG_LIR_Gen_1	219	228	PF02991	0.518
LIG_LIR_Gen_1	318	327	PF02991	0.280
LIG_LIR_Gen_1	328	335	PF02991	0.457
LIG_LIR_Nem_3	147	152	PF02991	0.639
LIG_LIR_Nem_3	219	223	PF02991	0.520
LIG_LIR_Nem_3	24	29	PF02991	0.448
LIG_LIR_Nem_3	328	332	PF02991	0.374
LIG_NRBOX	105	111	PF00104	0.577
LIG_PCNA_APIM_2	190	196	PF02747	0.299
LIG_Pex14_2	115	119	PF04695	0.742
LIG_SH2_CRK	149	153	PF00017	0.641
LIG_SH2_CRK	265	269	PF00017	0.620
LIG_SH2_NCK_1	149	153	PF00017	0.641
LIG_SH2_NCK_1	265	269	PF00017	0.620
LIG_SH2_SRC	329	332	PF00017	0.513
LIG_SH2_STAP1	29	33	PF00017	0.513
LIG_SH2_STAP1	98	102	PF00017	0.750
LIG_SH2_STAT5	149	152	PF00017	0.688
LIG_SH2_STAT5	193	196	PF00017	0.465
LIG_SH2_STAT5	226	229	PF00017	0.481
LIG_SH2_STAT5	242	245	PF00017	0.199
LIG_SH2_STAT5	325	328	PF00017	0.411
LIG_SH2_STAT5	329	332	PF00017	0.411
LIG_SH3_3	228	234	PF00018	0.419
LIG_SH3_3	243	249	PF00018	0.250
LIG_TRAF2_1	219	222	PF00917	0.462
LIG_TRAF2_2	156	161	PF00917	0.639
MOD_CK1_1	145	151	PF00069	0.706
MOD_CK1_1	185	191	PF00069	0.456
MOD_CK1_1	2	8	PF00069	0.500
MOD_CK1_1	283	289	PF00069	0.700
MOD_CK1_1	75	81	PF00069	0.375
MOD_CK2_1	216	222	PF00069	0.600
MOD_CK2_1	46	52	PF00069	0.490
MOD_CK2_1	5	11	PF00069	0.510
MOD_GlcNHglycan	124	127	PF01048	0.615
MOD_GlcNHglycan	140	143	PF01048	0.618
MOD_GlcNHglycan	144	147	PF01048	0.653
MOD_GlcNHglycan	237	240	PF01048	0.261
MOD_GlcNHglycan	265	268	PF01048	0.507
MOD_GlcNHglycan	280	283	PF01048	0.516
MOD_GSK3_1	1	8	PF00069	0.608
MOD_GSK3_1	100	107	PF00069	0.574
MOD_GSK3_1	138	145	PF00069	0.748
MOD_GSK3_1	147	154	PF00069	0.747
MOD_GSK3_1	182	189	PF00069	0.438
MOD_GSK3_1	251	258	PF00069	0.670
MOD_GSK3_1	280	287	PF00069	0.657
MOD_N-GLC_1	138	143	PF02516	0.539
MOD_N-GLC_1	185	190	PF02516	0.551
MOD_NEK2_1	1	6	PF00069	0.619
MOD_NEK2_1	144	149	PF00069	0.759
MOD_NEK2_1	235	240	PF00069	0.286
MOD_NEK2_1	284	289	PF00069	0.511
MOD_NEK2_2	29	34	PF00069	0.411
MOD_PKA_2	120	126	PF00069	0.653
MOD_PKA_2	130	136	PF00069	0.546
MOD_PKA_2	46	52	PF00069	0.393
MOD_PKA_2	75	81	PF00069	0.375
MOD_Plk_1	185	191	PF00069	0.489
MOD_Plk_1	35	41	PF00069	0.653
MOD_Plk_1	47	53	PF00069	0.441
MOD_Plk_1	72	78	PF00069	0.592
MOD_Plk_1	98	104	PF00069	0.607
MOD_Plk_4	104	110	PF00069	0.529
MOD_Plk_4	186	192	PF00069	0.467
MOD_Plk_4	22	28	PF00069	0.459
MOD_Plk_4	237	243	PF00069	0.308
MOD_Plk_4	29	35	PF00069	0.495
MOD_Plk_4	316	322	PF00069	0.411
MOD_Plk_4	325	331	PF00069	0.411
MOD_ProDKin_1	152	158	PF00069	0.747
MOD_ProDKin_1	251	257	PF00069	0.527
MOD_SUMO_rev_2	155	165	PF00179	0.536
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.433
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.427
TRG_ENDOCYTIC_2	149	152	PF00928	0.544
TRG_ENDOCYTIC_2	265	268	PF00928	0.517
TRG_ENDOCYTIC_2	329	332	PF00928	0.429
TRG_ER_diArg_1	251	253	PF00400	0.523
TRG_ER_diArg_1	82	85	PF00400	0.579
TRG_ER_diArg_1	92	95	PF00400	0.455
TRG_NLS_Bipartite_1	79	97	PF00514	0.393
TRG_NLS_MonoExtN_4	92	97	PF00514	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X6H6	Leishmania donovani	62%	99%
A0A422P2P2	Trypanosoma rangeli	26%	100%
A4I8V1	Leishmania infantum	62%	99%
E9B3S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	99%
Q4Q4A4	Leishmania major	60%	100%