Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLE1_LEIBR

TriTrypDb:

LbrM.33.1060 , LBRM2903_330015300

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLE1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.609
CLV_C14_Caspase3-7	69	73	PF00656	0.717
CLV_MEL_PAP_1	259	265	PF00089	0.642
CLV_NRD_NRD_1	19	21	PF00675	0.513
CLV_NRD_NRD_1	319	321	PF00675	0.728
CLV_NRD_NRD_1	325	327	PF00675	0.785
CLV_NRD_NRD_1	40	42	PF00675	0.547
CLV_NRD_NRD_1	426	428	PF00675	0.494
CLV_NRD_NRD_1	467	469	PF00675	0.487
CLV_PCSK_KEX2_1	119	121	PF00082	0.737
CLV_PCSK_KEX2_1	261	263	PF00082	0.615
CLV_PCSK_KEX2_1	277	279	PF00082	0.398
CLV_PCSK_KEX2_1	319	321	PF00082	0.736
CLV_PCSK_KEX2_1	338	340	PF00082	0.509
CLV_PCSK_KEX2_1	39	41	PF00082	0.545
CLV_PCSK_KEX2_1	467	469	PF00082	0.487
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.737
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.649
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.398
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.583
CLV_PCSK_SKI1_1	206	210	PF00082	0.477
CLV_PCSK_SKI1_1	21	25	PF00082	0.434
CLV_PCSK_SKI1_1	255	259	PF00082	0.624
CLV_PCSK_SKI1_1	277	281	PF00082	0.536
CLV_PCSK_SKI1_1	312	316	PF00082	0.667
CLV_PCSK_SKI1_1	339	343	PF00082	0.676
CLV_PCSK_SKI1_1	446	450	PF00082	0.349
CLV_PCSK_SKI1_1	9	13	PF00082	0.732
DEG_APCC_DBOX_1	205	213	PF00400	0.479
DEG_Nend_UBRbox_2	1	3	PF02207	0.653
DEG_SCF_FBW7_1	371	377	PF00400	0.538
DEG_SCF_FBW7_1	84	91	PF00400	0.577
DEG_SPOP_SBC_1	282	286	PF00917	0.520
DOC_CKS1_1	150	155	PF01111	0.572
DOC_CKS1_1	371	376	PF01111	0.541
DOC_CKS1_1	85	90	PF01111	0.682
DOC_CYCLIN_RxL_1	203	210	PF00134	0.475
DOC_CYCLIN_RxL_1	467	478	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	141	147	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	435	441	PF00134	0.425
DOC_MAPK_gen_1	427	435	PF00069	0.452
DOC_MAPK_MEF2A_6	226	234	PF00069	0.574
DOC_MAPK_RevD_3	433	447	PF00069	0.438
DOC_PP1_RVXF_1	470	477	PF00149	0.597
DOC_PP2B_LxvP_1	220	223	PF13499	0.462
DOC_PP2B_LxvP_1	330	333	PF13499	0.557
DOC_PP4_FxxP_1	391	394	PF00568	0.584
DOC_USP7_MATH_1	11	15	PF00917	0.736
DOC_USP7_MATH_1	183	187	PF00917	0.801
DOC_USP7_MATH_1	298	302	PF00917	0.707
DOC_USP7_MATH_1	374	378	PF00917	0.533
DOC_USP7_MATH_1	392	396	PF00917	0.679
DOC_USP7_MATH_1	68	72	PF00917	0.587
DOC_USP7_MATH_1	98	102	PF00917	0.762
DOC_USP7_UBL2_3	338	342	PF12436	0.667
DOC_USP7_UBL2_3	56	60	PF12436	0.785
DOC_WW_Pin1_4	125	130	PF00397	0.831
DOC_WW_Pin1_4	149	154	PF00397	0.572
DOC_WW_Pin1_4	370	375	PF00397	0.542
DOC_WW_Pin1_4	79	84	PF00397	0.822
DOC_WW_Pin1_4	93	98	PF00397	0.588
LIG_14-3-3_CanoR_1	120	129	PF00244	0.701
LIG_14-3-3_CanoR_1	262	269	PF00244	0.727
LIG_14-3-3_CanoR_1	278	283	PF00244	0.475
LIG_14-3-3_CanoR_1	326	331	PF00244	0.560
LIG_APCC_ABBA_1	232	237	PF00400	0.614
LIG_APCC_ABBAyCdc20_2	472	478	PF00400	0.492
LIG_BRCT_BRCA1_1	163	167	PF00533	0.523
LIG_EH_1	2	6	PF12763	0.656
LIG_FHA_1	107	113	PF00498	0.577
LIG_FHA_1	167	173	PF00498	0.793
LIG_FHA_1	301	307	PF00498	0.658
LIG_FHA_1	438	444	PF00498	0.442
LIG_FHA_1	97	103	PF00498	0.596
LIG_FHA_2	153	159	PF00498	0.813
LIG_FHA_2	173	179	PF00498	0.541
LIG_FHA_2	213	219	PF00498	0.614
LIG_FHA_2	265	271	PF00498	0.636
LIG_LIR_Apic_2	417	423	PF02991	0.577
LIG_LIR_Gen_1	2	12	PF02991	0.668
LIG_LIR_Nem_3	2	8	PF02991	0.627
LIG_LIR_Nem_3	351	357	PF02991	0.797
LIG_MYND_3	422	426	PF01753	0.509
LIG_Rb_pABgroove_1	430	438	PF01858	0.573
LIG_SH2_CRK	245	249	PF00017	0.459
LIG_SH2_CRK	386	390	PF00017	0.768
LIG_SH2_CRK	436	440	PF00017	0.448
LIG_SH2_GRB2like	357	360	PF00017	0.538
LIG_SH2_GRB2like	477	480	PF00017	0.476
LIG_SH2_NCK_1	436	440	PF00017	0.550
LIG_SH2_SRC	436	439	PF00017	0.553
LIG_SH2_SRC	477	480	PF00017	0.476
LIG_SH2_STAP1	245	249	PF00017	0.459
LIG_SH2_STAT5	252	255	PF00017	0.504
LIG_SH2_STAT5	354	357	PF00017	0.702
LIG_SH3_3	141	147	PF00018	0.568
LIG_SH3_3	168	174	PF00018	0.567
LIG_SH3_3	368	374	PF00018	0.796
LIG_SUMO_SIM_anti_2	440	445	PF11976	0.458
LIG_TRAF2_1	108	111	PF00917	0.806
LIG_TRAF2_1	35	38	PF00917	0.648
MOD_CDK_SPxxK_3	79	86	PF00069	0.732
MOD_CK1_1	125	131	PF00069	0.699
MOD_CK1_1	264	270	PF00069	0.631
MOD_CK1_1	281	287	PF00069	0.636
MOD_CK1_1	395	401	PF00069	0.740
MOD_CK1_1	71	77	PF00069	0.667
MOD_CK1_1	96	102	PF00069	0.747
MOD_CK2_1	120	126	PF00069	0.670
MOD_CK2_1	152	158	PF00069	0.815
MOD_CK2_1	172	178	PF00069	0.546
MOD_CK2_1	185	191	PF00069	0.642
MOD_CK2_1	193	199	PF00069	0.596
MOD_CK2_1	264	270	PF00069	0.698
MOD_CK2_1	32	38	PF00069	0.649
MOD_CK2_1	457	463	PF00069	0.618
MOD_Cter_Amidation	259	262	PF01082	0.633
MOD_GlcNHglycan	137	140	PF01048	0.658
MOD_GlcNHglycan	180	183	PF01048	0.679
MOD_GlcNHglycan	285	288	PF01048	0.761
MOD_GlcNHglycan	330	333	PF01048	0.730
MOD_GlcNHglycan	408	412	PF01048	0.724
MOD_GlcNHglycan	62	65	PF01048	0.661
MOD_GlcNHglycan	76	79	PF01048	0.576
MOD_GlcNHglycan	93	96	PF01048	0.815
MOD_GSK3_1	120	127	PF00069	0.647
MOD_GSK3_1	157	164	PF00069	0.773
MOD_GSK3_1	233	240	PF00069	0.444
MOD_GSK3_1	277	284	PF00069	0.651
MOD_GSK3_1	298	305	PF00069	0.794
MOD_GSK3_1	370	377	PF00069	0.569
MOD_GSK3_1	395	402	PF00069	0.702
MOD_GSK3_1	67	74	PF00069	0.685
MOD_GSK3_1	84	91	PF00069	0.672
MOD_N-GLC_1	395	400	PF02516	0.658
MOD_NEK2_1	251	256	PF00069	0.521
MOD_PIKK_1	106	112	PF00454	0.554
MOD_PIKK_1	161	167	PF00454	0.784
MOD_PIKK_1	22	28	PF00454	0.609
MOD_PIKK_1	446	452	PF00454	0.507
MOD_PK_1	278	284	PF00069	0.494
MOD_PK_1	428	434	PF00069	0.473
MOD_PKA_1	261	267	PF00069	0.644
MOD_PKA_1	277	283	PF00069	0.408
MOD_PKA_1	326	332	PF00069	0.559
MOD_PKA_1	446	452	PF00069	0.507
MOD_PKA_2	135	141	PF00069	0.634
MOD_PKA_2	261	267	PF00069	0.600
MOD_PKA_2	277	283	PF00069	0.408
MOD_PKA_2	392	398	PF00069	0.717
MOD_PKA_2	46	52	PF00069	0.453
MOD_PKB_1	120	128	PF00069	0.698
MOD_Plk_1	157	163	PF00069	0.707
MOD_Plk_1	193	199	PF00069	0.627
MOD_Plk_1	395	401	PF00069	0.558
MOD_Plk_1	416	422	PF00069	0.602
MOD_Plk_4	157	163	PF00069	0.552
MOD_Plk_4	243	249	PF00069	0.416
MOD_Plk_4	302	308	PF00069	0.525
MOD_Plk_4	395	401	PF00069	0.558
MOD_Plk_4	428	434	PF00069	0.473
MOD_Plk_4	98	104	PF00069	0.569
MOD_ProDKin_1	125	131	PF00069	0.832
MOD_ProDKin_1	149	155	PF00069	0.573
MOD_ProDKin_1	370	376	PF00069	0.542
MOD_ProDKin_1	79	85	PF00069	0.825
MOD_ProDKin_1	93	99	PF00069	0.588
MOD_SUMO_for_1	314	317	PF00179	0.756
MOD_SUMO_for_1	355	358	PF00179	0.698
MOD_SUMO_for_1	405	408	PF00179	0.717
MOD_SUMO_rev_2	284	294	PF00179	0.695
MOD_SUMO_rev_2	322	329	PF00179	0.553
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.627
TRG_ENDOCYTIC_2	245	248	PF00928	0.405
TRG_ENDOCYTIC_2	436	439	PF00928	0.451
TRG_ER_diArg_1	318	320	PF00400	0.551
TRG_ER_diArg_1	39	41	PF00400	0.647
TRG_ER_diArg_1	466	468	PF00400	0.488
TRG_NLS_Bipartite_1	40	62	PF00514	0.709
TRG_NLS_MonoExtC_3	118	124	PF00514	0.835
TRG_NLS_MonoExtN_4	56	62	PF00514	0.782
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBA2	Leptomonas seymouri	40%	100%
A0A3Q8ITX1	Leishmania donovani	76%	99%
A4I8V0	Leishmania infantum	75%	99%
E9B3R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4Q4A5	Leishmania major	74%	100%