LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HLE0_LEIBR
TriTrypDb:
LbrM.33.1050 , LBRM2903_330015200
Length:
417

Annotations

LeishMANIAdb annotations

A small folded protein with a long C-terminal TM segment. Very unclear topology.. Expanded on multiple lineages, especially Strigomonas.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 5, no: 12
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A4HLE0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLE0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016491 oxidoreductase activity 2 1
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 1
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 262 268 PF00089 0.180
CLV_NRD_NRD_1 201 203 PF00675 0.307
CLV_NRD_NRD_1 356 358 PF00675 0.594
CLV_NRD_NRD_1 55 57 PF00675 0.549
CLV_PCSK_KEX2_1 179 181 PF00082 0.261
CLV_PCSK_KEX2_1 201 203 PF00082 0.295
CLV_PCSK_KEX2_1 356 358 PF00082 0.533
CLV_PCSK_KEX2_1 390 392 PF00082 0.628
CLV_PCSK_PC1ET2_1 179 181 PF00082 0.331
CLV_PCSK_PC1ET2_1 390 392 PF00082 0.654
CLV_PCSK_PC7_1 352 358 PF00082 0.445
CLV_PCSK_SKI1_1 151 155 PF00082 0.265
CLV_PCSK_SKI1_1 201 205 PF00082 0.295
CLV_PCSK_SKI1_1 305 309 PF00082 0.241
CLV_PCSK_SKI1_1 379 383 PF00082 0.545
CLV_PCSK_SKI1_1 59 63 PF00082 0.505
CLV_Separin_Metazoa 80 84 PF03568 0.180
DEG_APCC_DBOX_1 304 312 PF00400 0.437
DEG_Nend_Nbox_1 1 3 PF02207 0.603
DEG_SCF_FBW7_1 113 120 PF00400 0.180
DEG_SPOP_SBC_1 218 222 PF00917 0.419
DOC_CYCLIN_RxL_1 21 29 PF00134 0.468
DOC_CYCLIN_yCln2_LP_2 277 283 PF00134 0.532
DOC_MAPK_gen_1 316 324 PF00069 0.484
DOC_MAPK_gen_1 72 81 PF00069 0.259
DOC_MAPK_MEF2A_6 189 197 PF00069 0.532
DOC_PP1_RVXF_1 158 164 PF00149 0.532
DOC_PP2B_LxvP_1 17 20 PF13499 0.560
DOC_PP2B_LxvP_1 277 280 PF13499 0.491
DOC_PP2B_LxvP_1 82 85 PF13499 0.332
DOC_USP7_MATH_1 138 142 PF00917 0.402
DOC_USP7_MATH_1 219 223 PF00917 0.509
DOC_USP7_MATH_1 286 290 PF00917 0.474
DOC_USP7_MATH_1 320 324 PF00917 0.242
DOC_USP7_MATH_1 402 406 PF00917 0.467
DOC_USP7_MATH_1 95 99 PF00917 0.334
DOC_USP7_UBL2_3 386 390 PF12436 0.315
DOC_WW_Pin1_4 107 112 PF00397 0.254
DOC_WW_Pin1_4 113 118 PF00397 0.213
DOC_WW_Pin1_4 12 17 PF00397 0.590
DOC_WW_Pin1_4 203 208 PF00397 0.466
DOC_WW_Pin1_4 93 98 PF00397 0.239
LIG_14-3-3_CanoR_1 10 19 PF00244 0.594
LIG_14-3-3_CanoR_1 180 185 PF00244 0.567
LIG_14-3-3_CanoR_1 240 248 PF00244 0.444
LIG_14-3-3_CanoR_1 59 64 PF00244 0.296
LIG_Actin_WH2_2 186 203 PF00022 0.532
LIG_APCC_ABBA_1 359 364 PF00400 0.438
LIG_BRCT_BRCA1_1 322 326 PF00533 0.242
LIG_BRCT_BRCA1_1 388 392 PF00533 0.307
LIG_deltaCOP1_diTrp_1 268 276 PF00928 0.472
LIG_EVH1_1 17 21 PF00568 0.524
LIG_FHA_1 148 154 PF00498 0.469
LIG_FHA_1 236 242 PF00498 0.532
LIG_FHA_2 301 307 PF00498 0.532
LIG_FHA_2 48 54 PF00498 0.305
LIG_LIR_Apic_2 168 173 PF02991 0.532
LIG_LIR_Gen_1 136 147 PF02991 0.326
LIG_LIR_Gen_1 275 284 PF02991 0.547
LIG_LIR_Gen_1 323 334 PF02991 0.314
LIG_LIR_Gen_1 341 351 PF02991 0.341
LIG_LIR_Gen_1 66 71 PF02991 0.266
LIG_LIR_Nem_3 136 142 PF02991 0.326
LIG_LIR_Nem_3 268 273 PF02991 0.478
LIG_LIR_Nem_3 275 279 PF02991 0.483
LIG_LIR_Nem_3 323 329 PF02991 0.314
LIG_LIR_Nem_3 341 347 PF02991 0.329
LIG_LIR_Nem_3 350 354 PF02991 0.331
LIG_LIR_Nem_3 66 70 PF02991 0.266
LIG_NRBOX 331 337 PF00104 0.372
LIG_SH2_CRK 312 316 PF00017 0.465
LIG_SH2_STAP1 344 348 PF00017 0.377
LIG_SH2_STAT5 344 347 PF00017 0.369
LIG_SH2_STAT5 354 357 PF00017 0.389
LIG_SH2_STAT5 49 52 PF00017 0.263
LIG_SH3_2 19 24 PF14604 0.591
LIG_SH3_3 118 124 PF00018 0.292
LIG_SH3_3 128 134 PF00018 0.281
LIG_SH3_3 13 19 PF00018 0.689
LIG_SH3_3 152 158 PF00018 0.491
LIG_SH3_3 212 218 PF00018 0.484
LIG_SH3_3 276 282 PF00018 0.526
LIG_SH3_3 289 295 PF00018 0.542
LIG_SH3_CIN85_PxpxPR_1 19 24 PF14604 0.497
LIG_SUMO_SIM_anti_2 149 157 PF11976 0.462
LIG_SUMO_SIM_anti_2 78 83 PF11976 0.202
LIG_SUMO_SIM_par_1 149 157 PF11976 0.462
LIG_SUMO_SIM_par_1 172 177 PF11976 0.380
LIG_SUMO_SIM_par_1 24 29 PF11976 0.491
LIG_SUMO_SIM_par_1 333 339 PF11976 0.451
LIG_SxIP_EBH_1 24 37 PF03271 0.449
LIG_WRC_WIRS_1 321 326 PF05994 0.447
LIG_WRC_WIRS_1 337 342 PF05994 0.480
LIG_WW_3 21 25 PF00397 0.607
MOD_CDK_SPK_2 107 112 PF00069 0.210
MOD_CK1_1 106 112 PF00069 0.390
MOD_CK1_1 206 212 PF00069 0.407
MOD_CK1_1 338 344 PF00069 0.389
MOD_CK1_1 374 380 PF00069 0.455
MOD_CK1_1 96 102 PF00069 0.308
MOD_CK2_1 300 306 PF00069 0.420
MOD_GlcNHglycan 117 120 PF01048 0.476
MOD_GlcNHglycan 12 15 PF01048 0.437
MOD_GlcNHglycan 211 214 PF01048 0.318
MOD_GlcNHglycan 221 224 PF01048 0.292
MOD_GlcNHglycan 242 245 PF01048 0.288
MOD_GlcNHglycan 317 320 PF01048 0.409
MOD_GlcNHglycan 372 376 PF01048 0.668
MOD_GlcNHglycan 98 101 PF01048 0.545
MOD_GSK3_1 103 110 PF00069 0.401
MOD_GSK3_1 111 118 PF00069 0.249
MOD_GSK3_1 205 212 PF00069 0.467
MOD_GSK3_1 219 226 PF00069 0.566
MOD_GSK3_1 230 237 PF00069 0.588
MOD_GSK3_1 338 345 PF00069 0.458
MOD_GSK3_1 382 389 PF00069 0.366
MOD_GSK3_1 47 54 PF00069 0.288
MOD_GSK3_1 95 102 PF00069 0.364
MOD_N-GLC_1 185 190 PF02516 0.276
MOD_N-GLC_1 300 305 PF02516 0.338
MOD_NEK2_1 126 131 PF00069 0.367
MOD_NEK2_1 26 31 PF00069 0.327
MOD_NEK2_1 315 320 PF00069 0.504
MOD_NEK2_1 335 340 PF00069 0.326
MOD_NEK2_1 382 387 PF00069 0.269
MOD_NEK2_1 51 56 PF00069 0.275
MOD_PIKK_1 206 212 PF00454 0.380
MOD_PIKK_1 342 348 PF00454 0.329
MOD_PKA_1 179 185 PF00069 0.520
MOD_PKA_1 386 392 PF00069 0.408
MOD_PKA_2 111 117 PF00069 0.370
MOD_PKA_2 147 153 PF00069 0.544
MOD_PKA_2 179 185 PF00069 0.479
MOD_Plk_1 342 348 PF00069 0.284
MOD_Plk_1 371 377 PF00069 0.389
MOD_Plk_1 51 57 PF00069 0.313
MOD_Plk_4 103 109 PF00069 0.180
MOD_Plk_4 126 132 PF00069 0.280
MOD_Plk_4 138 144 PF00069 0.276
MOD_Plk_4 180 186 PF00069 0.475
MOD_Plk_4 26 32 PF00069 0.318
MOD_Plk_4 320 326 PF00069 0.398
MOD_ProDKin_1 107 113 PF00069 0.254
MOD_ProDKin_1 117 123 PF00069 0.201
MOD_ProDKin_1 12 18 PF00069 0.583
MOD_ProDKin_1 203 209 PF00069 0.466
MOD_ProDKin_1 93 99 PF00069 0.239
TRG_DiLeu_BaEn_2 305 311 PF01217 0.440
TRG_DiLeu_BaEn_4 156 162 PF01217 0.532
TRG_DiLeu_BaLyEn_6 21 26 PF01217 0.484
TRG_DiLeu_BaLyEn_6 257 262 PF01217 0.427
TRG_DiLeu_BaLyEn_6 56 61 PF01217 0.247
TRG_ENDOCYTIC_2 312 315 PF00928 0.461
TRG_ENDOCYTIC_2 344 347 PF00928 0.363
TRG_ER_diArg_1 200 202 PF00400 0.532
TRG_ER_diArg_1 214 217 PF00400 0.546
TRG_ER_diArg_1 355 357 PF00400 0.392

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P304 Leptomonas seymouri 55% 96%
A0A0N0P958 Leptomonas seymouri 28% 100%
A0A0S4JG88 Bodo saltans 32% 100%
A0A1X0NP69 Trypanosomatidae 29% 100%
A0A1X0P126 Trypanosomatidae 33% 100%
A0A3Q8IGS5 Leishmania donovani 82% 96%
A0A3S7X466 Leishmania donovani 27% 100%
A4I6E8 Leishmania infantum 27% 100%
A4I8U9 Leishmania infantum 82% 96%
D0A4U6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E8NHM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B1J8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B3R8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4Q4A6 Leishmania major 80% 100%
Q4Q6L5 Leishmania major 27% 88%
V5BPD5 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS