Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HLD9_LEIBR

TriTrypDb:

LbrM.33.1040 , LBRM2903_330015100

Length:

917

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLD9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	378	382	PF00656	0.813
CLV_C14_Caspase3-7	485	489	PF00656	0.585
CLV_C14_Caspase3-7	521	525	PF00656	0.579
CLV_C14_Caspase3-7	556	560	PF00656	0.749
CLV_NRD_NRD_1	134	136	PF00675	0.765
CLV_NRD_NRD_1	173	175	PF00675	0.375
CLV_NRD_NRD_1	188	190	PF00675	0.306
CLV_NRD_NRD_1	293	295	PF00675	0.524
CLV_NRD_NRD_1	397	399	PF00675	0.608
CLV_NRD_NRD_1	413	415	PF00675	0.723
CLV_NRD_NRD_1	420	422	PF00675	0.514
CLV_NRD_NRD_1	612	614	PF00675	0.594
CLV_NRD_NRD_1	764	766	PF00675	0.544
CLV_NRD_NRD_1	774	776	PF00675	0.723
CLV_NRD_NRD_1	782	784	PF00675	0.625
CLV_NRD_NRD_1	831	833	PF00675	0.647
CLV_PCSK_FUR_1	772	776	PF00082	0.475
CLV_PCSK_KEX2_1	173	175	PF00082	0.375
CLV_PCSK_KEX2_1	188	190	PF00082	0.306
CLV_PCSK_KEX2_1	293	295	PF00082	0.520
CLV_PCSK_KEX2_1	397	399	PF00082	0.605
CLV_PCSK_KEX2_1	412	414	PF00082	0.726
CLV_PCSK_KEX2_1	420	422	PF00082	0.495
CLV_PCSK_KEX2_1	439	441	PF00082	0.482
CLV_PCSK_KEX2_1	763	765	PF00082	0.519
CLV_PCSK_KEX2_1	774	776	PF00082	0.727
CLV_PCSK_KEX2_1	782	784	PF00082	0.666
CLV_PCSK_KEX2_1	831	833	PF00082	0.647
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.633
CLV_PCSK_SKI1_1	173	177	PF00082	0.368
CLV_PCSK_SKI1_1	188	192	PF00082	0.320
CLV_PCSK_SKI1_1	718	722	PF00082	0.499
CLV_PCSK_SKI1_1	764	768	PF00082	0.507
DEG_APCC_DBOX_1	187	195	PF00400	0.382
DEG_APCC_DBOX_1	315	323	PF00400	0.402
DEG_Nend_UBRbox_3	1	3	PF02207	0.527
DEG_SCF_FBW7_1	271	278	PF00400	0.543
DEG_SCF_FBW7_1	453	460	PF00400	0.733
DEG_SCF_FBW7_1	896	902	PF00400	0.752
DEG_SPOP_SBC_1	623	627	PF00917	0.569
DEG_SPOP_SBC_1	68	72	PF00917	0.495
DOC_CDC14_PxL_1	124	132	PF14671	0.723
DOC_CKS1_1	272	277	PF01111	0.493
DOC_CKS1_1	823	828	PF01111	0.760
DOC_CKS1_1	896	901	PF01111	0.656
DOC_CYCLIN_yCln2_LP_2	108	114	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	694	700	PF00134	0.743
DOC_CYCLIN_yCln2_LP_2	823	829	PF00134	0.716
DOC_MAPK_DCC_7	188	196	PF00069	0.386
DOC_MAPK_DCC_7	688	696	PF00069	0.667
DOC_MAPK_gen_1	188	196	PF00069	0.386
DOC_MAPK_gen_1	290	300	PF00069	0.509
DOC_MAPK_gen_1	361	371	PF00069	0.574
DOC_MAPK_gen_1	397	403	PF00069	0.756
DOC_MAPK_HePTP_8	186	198	PF00069	0.520
DOC_MAPK_HePTP_8	884	896	PF00069	0.543
DOC_MAPK_MEF2A_6	117	124	PF00069	0.527
DOC_MAPK_MEF2A_6	188	196	PF00069	0.538
DOC_MAPK_MEF2A_6	26	34	PF00069	0.475
DOC_MAPK_MEF2A_6	316	323	PF00069	0.404
DOC_MAPK_MEF2A_6	688	696	PF00069	0.667
DOC_MAPK_MEF2A_6	887	896	PF00069	0.540
DOC_PP1_RVXF_1	222	229	PF00149	0.507
DOC_PP2B_LxvP_1	108	111	PF13499	0.479
DOC_PP2B_LxvP_1	198	201	PF13499	0.473
DOC_PP2B_LxvP_1	471	474	PF13499	0.751
DOC_PP2B_LxvP_1	694	697	PF13499	0.747
DOC_PP2B_LxvP_1	894	897	PF13499	0.670
DOC_PP4_FxxP_1	148	151	PF00568	0.690
DOC_PP4_FxxP_1	228	231	PF00568	0.487
DOC_PP4_FxxP_1	720	723	PF00568	0.642
DOC_PP4_MxPP_1	103	106	PF00568	0.548
DOC_USP7_MATH_1	144	148	PF00917	0.718
DOC_USP7_MATH_1	241	245	PF00917	0.688
DOC_USP7_MATH_1	249	253	PF00917	0.538
DOC_USP7_MATH_1	25	29	PF00917	0.658
DOC_USP7_MATH_1	396	400	PF00917	0.607
DOC_USP7_MATH_1	457	461	PF00917	0.692
DOC_USP7_MATH_1	51	55	PF00917	0.533
DOC_USP7_MATH_1	520	524	PF00917	0.610
DOC_USP7_MATH_1	564	568	PF00917	0.556
DOC_USP7_MATH_1	68	72	PF00917	0.530
DOC_USP7_MATH_1	701	705	PF00917	0.706
DOC_USP7_MATH_1	795	799	PF00917	0.667
DOC_USP7_MATH_1	80	84	PF00917	0.619
DOC_USP7_MATH_2	360	366	PF00917	0.572
DOC_WW_Pin1_4	106	111	PF00397	0.675
DOC_WW_Pin1_4	271	276	PF00397	0.490
DOC_WW_Pin1_4	338	343	PF00397	0.571
DOC_WW_Pin1_4	442	447	PF00397	0.721
DOC_WW_Pin1_4	453	458	PF00397	0.761
DOC_WW_Pin1_4	791	796	PF00397	0.689
DOC_WW_Pin1_4	822	827	PF00397	0.765
DOC_WW_Pin1_4	874	879	PF00397	0.659
DOC_WW_Pin1_4	895	900	PF00397	0.599
LIG_14-3-3_CanoR_1	174	183	PF00244	0.344
LIG_14-3-3_CanoR_1	203	211	PF00244	0.457
LIG_14-3-3_CanoR_1	224	229	PF00244	0.502
LIG_14-3-3_CanoR_1	26	34	PF00244	0.475
LIG_14-3-3_CanoR_1	364	371	PF00244	0.676
LIG_14-3-3_CanoR_1	397	404	PF00244	0.741
LIG_14-3-3_CanoR_1	440	446	PF00244	0.597
LIG_14-3-3_CanoR_1	494	504	PF00244	0.714
LIG_14-3-3_CanoR_1	599	606	PF00244	0.675
LIG_14-3-3_CanoR_1	874	878	PF00244	0.523
LIG_14-3-3_CanoR_1	911	917	PF00244	0.483
LIG_Actin_WH2_2	699	717	PF00022	0.706
LIG_APCC_ABBA_1	116	121	PF00400	0.507
LIG_APCC_ABBA_1	812	817	PF00400	0.660
LIG_APCC_ABBAyCdc20_2	811	817	PF00400	0.506
LIG_BIR_III_2	472	476	PF00653	0.713
LIG_BIR_III_2	620	624	PF00653	0.592
LIG_BRCT_BRCA1_1	206	210	PF00533	0.450
LIG_BRCT_BRCA1_1	224	228	PF00533	0.506
LIG_BRCT_BRCA1_1	833	837	PF00533	0.765
LIG_BRCT_BRCA1_1	889	893	PF00533	0.542
LIG_CSL_BTD_1	737	740	PF09270	0.573
LIG_CtBP_PxDLS_1	105	109	PF00389	0.514
LIG_deltaCOP1_diTrp_1	221	228	PF00928	0.611
LIG_FHA_1	160	166	PF00498	0.416
LIG_FHA_1	200	206	PF00498	0.469
LIG_FHA_1	214	220	PF00498	0.469
LIG_FHA_1	231	237	PF00498	0.641
LIG_FHA_1	448	454	PF00498	0.611
LIG_FHA_1	896	902	PF00498	0.650
LIG_FHA_2	374	380	PF00498	0.839
LIG_FHA_2	512	518	PF00498	0.705
LIG_FHA_2	519	525	PF00498	0.638
LIG_FHA_2	532	538	PF00498	0.576
LIG_LIR_Apic_2	147	151	PF02991	0.698
LIG_LIR_Apic_2	225	231	PF02991	0.489
LIG_LIR_Gen_1	263	272	PF02991	0.540
LIG_LIR_Gen_1	274	283	PF02991	0.537
LIG_LIR_Gen_1	627	636	PF02991	0.579
LIG_LIR_Gen_1	890	901	PF02991	0.520
LIG_LIR_Nem_3	221	226	PF02991	0.520
LIG_LIR_Nem_3	263	269	PF02991	0.546
LIG_LIR_Nem_3	274	279	PF02991	0.519
LIG_LIR_Nem_3	402	407	PF02991	0.558
LIG_LIR_Nem_3	627	633	PF02991	0.614
LIG_LIR_Nem_3	71	77	PF02991	0.638
LIG_LIR_Nem_3	870	875	PF02991	0.521
LIG_LIR_Nem_3	890	896	PF02991	0.738
LIG_LIR_Nem_3	909	913	PF02991	0.590
LIG_MYND_1	106	110	PF01753	0.508
LIG_NRBOX	213	219	PF00104	0.462
LIG_NRBOX	549	555	PF00104	0.628
LIG_Pex14_1	667	671	PF04695	0.628
LIG_Pex14_2	633	637	PF04695	0.584
LIG_RPA_C_Fungi	409	421	PF08784	0.563
LIG_SH2_CRK	699	703	PF00017	0.710
LIG_SH2_STAP1	237	241	PF00017	0.735
LIG_SH2_STAP1	304	308	PF00017	0.562
LIG_SH2_STAT3	608	611	PF00017	0.588
LIG_SH2_STAT5	338	341	PF00017	0.744
LIG_SH2_STAT5	822	825	PF00017	0.542
LIG_SH2_STAT5	84	87	PF00017	0.596
LIG_SH3_1	189	195	PF00018	0.419
LIG_SH3_3	189	195	PF00018	0.419
LIG_SH3_3	31	37	PF00018	0.663
LIG_SH3_3	513	519	PF00018	0.542
LIG_SH3_3	74	80	PF00018	0.664
LIG_SH3_3	784	790	PF00018	0.556
LIG_SH3_3	872	878	PF00018	0.522
LIG_SH3_3	886	892	PF00018	0.690
LIG_SH3_3	893	899	PF00018	0.663
LIG_SUMO_SIM_anti_2	318	326	PF11976	0.675
LIG_SUMO_SIM_par_1	215	221	PF11976	0.358
LIG_TRAF2_1	330	333	PF00917	0.777
LIG_TRAF2_1	348	351	PF00917	0.515
LIG_TRAF2_1	728	731	PF00917	0.627
LIG_TRAF2_1	868	871	PF00917	0.754
LIG_TRFH_1	822	826	PF08558	0.667
MOD_CDC14_SPxK_1	877	880	PF00782	0.530
MOD_CDK_SPxK_1	874	880	PF00069	0.526
MOD_CK1_1	341	347	PF00069	0.533
MOD_CK1_1	373	379	PF00069	0.709
MOD_CK1_1	447	453	PF00069	0.751
MOD_CK1_1	523	529	PF00069	0.825
MOD_CK1_1	531	537	PF00069	0.602
MOD_CK1_1	54	60	PF00069	0.666
MOD_CK1_1	585	591	PF00069	0.745
MOD_CK1_1	612	618	PF00069	0.760
MOD_CK1_1	794	800	PF00069	0.617
MOD_CK1_1	83	89	PF00069	0.679
MOD_CK2_1	249	255	PF00069	0.576
MOD_CK2_1	345	351	PF00069	0.796
MOD_CK2_1	442	448	PF00069	0.687
MOD_CK2_1	511	517	PF00069	0.695
MOD_CK2_1	565	571	PF00069	0.614
MOD_CK2_1	725	731	PF00069	0.703
MOD_CK2_1	783	789	PF00069	0.769
MOD_CK2_1	798	804	PF00069	0.630
MOD_Cter_Amidation	186	189	PF01082	0.350
MOD_DYRK1A_RPxSP_1	874	878	PF00069	0.659
MOD_GlcNHglycan	100	103	PF01048	0.634
MOD_GlcNHglycan	167	170	PF01048	0.534
MOD_GlcNHglycan	177	180	PF01048	0.444
MOD_GlcNHglycan	245	248	PF01048	0.676
MOD_GlcNHglycan	251	254	PF01048	0.783
MOD_GlcNHglycan	27	30	PF01048	0.556
MOD_GlcNHglycan	347	350	PF01048	0.785
MOD_GlcNHglycan	416	419	PF01048	0.722
MOD_GlcNHglycan	462	466	PF01048	0.605
MOD_GlcNHglycan	524	528	PF01048	0.805
MOD_GlcNHglycan	630	633	PF01048	0.653
MOD_GlcNHglycan	677	680	PF01048	0.620
MOD_GlcNHglycan	703	706	PF01048	0.695
MOD_GlcNHglycan	797	800	PF01048	0.557
MOD_GlcNHglycan	846	849	PF01048	0.552
MOD_GlcNHglycan	862	865	PF01048	0.427
MOD_GlcNHglycan	88	91	PF01048	0.740
MOD_GSK3_1	21	28	PF00069	0.765
MOD_GSK3_1	271	278	PF00069	0.572
MOD_GSK3_1	341	348	PF00069	0.757
MOD_GSK3_1	363	370	PF00069	0.686
MOD_GSK3_1	373	380	PF00069	0.758
MOD_GSK3_1	392	399	PF00069	0.580
MOD_GSK3_1	440	447	PF00069	0.677
MOD_GSK3_1	453	460	PF00069	0.649
MOD_GSK3_1	461	468	PF00069	0.708
MOD_GSK3_1	518	525	PF00069	0.729
MOD_GSK3_1	54	61	PF00069	0.730
MOD_GSK3_1	581	588	PF00069	0.712
MOD_GSK3_1	624	631	PF00069	0.591
MOD_GSK3_1	671	678	PF00069	0.525
MOD_GSK3_1	749	756	PF00069	0.472
MOD_GSK3_1	791	798	PF00069	0.769
MOD_GSK3_1	852	859	PF00069	0.656
MOD_GSK3_1	86	93	PF00069	0.587
MOD_GSK3_1	895	902	PF00069	0.688
MOD_N-GLC_1	539	544	PF02516	0.633
MOD_NEK2_1	12	17	PF00069	0.748
MOD_NEK2_1	165	170	PF00069	0.517
MOD_NEK2_1	204	209	PF00069	0.458
MOD_NEK2_1	285	290	PF00069	0.590
MOD_NEK2_1	317	322	PF00069	0.548
MOD_NEK2_1	32	37	PF00069	0.552
MOD_NEK2_1	363	368	PF00069	0.573
MOD_NEK2_1	371	376	PF00069	0.535
MOD_NEK2_1	441	446	PF00069	0.675
MOD_NEK2_1	461	466	PF00069	0.735
MOD_NEK2_1	511	516	PF00069	0.547
MOD_NEK2_1	581	586	PF00069	0.492
MOD_NEK2_1	652	657	PF00069	0.604
MOD_NEK2_1	906	911	PF00069	0.617
MOD_PIKK_1	12	18	PF00454	0.741
MOD_PIKK_1	204	210	PF00454	0.455
MOD_PIKK_1	371	377	PF00454	0.585
MOD_PIKK_1	495	501	PF00454	0.734
MOD_PIKK_1	582	588	PF00454	0.721
MOD_PIKK_1	671	677	PF00454	0.752
MOD_PIKK_1	831	837	PF00454	0.576
MOD_PK_1	783	789	PF00069	0.769
MOD_PKA_1	135	141	PF00069	0.684
MOD_PKA_1	831	837	PF00069	0.648
MOD_PKA_2	144	150	PF00069	0.709
MOD_PKA_2	25	31	PF00069	0.518
MOD_PKA_2	363	369	PF00069	0.781
MOD_PKA_2	396	402	PF00069	0.663
MOD_PKA_2	581	587	PF00069	0.668
MOD_PKA_2	598	604	PF00069	0.526
MOD_PKA_2	612	618	PF00069	0.588
MOD_PKA_2	831	837	PF00069	0.648
MOD_PKA_2	873	879	PF00069	0.552
MOD_PKB_1	412	420	PF00069	0.820
MOD_Plk_1	120	126	PF00069	0.558
MOD_Plk_1	317	323	PF00069	0.550
MOD_Plk_1	482	488	PF00069	0.584
MOD_Plk_1	523	529	PF00069	0.579
MOD_Plk_1	539	545	PF00069	0.633
MOD_Plk_4	144	150	PF00069	0.748
MOD_Plk_4	213	219	PF00069	0.300
MOD_Plk_4	317	323	PF00069	0.550
MOD_Plk_4	482	488	PF00069	0.775
MOD_Plk_4	734	740	PF00069	0.586
MOD_Plk_4	783	789	PF00069	0.634
MOD_Plk_4	80	86	PF00069	0.604
MOD_ProDKin_1	106	112	PF00069	0.672
MOD_ProDKin_1	271	277	PF00069	0.492
MOD_ProDKin_1	338	344	PF00069	0.569
MOD_ProDKin_1	442	448	PF00069	0.723
MOD_ProDKin_1	453	459	PF00069	0.760
MOD_ProDKin_1	791	797	PF00069	0.691
MOD_ProDKin_1	822	828	PF00069	0.763
MOD_ProDKin_1	874	880	PF00069	0.662
MOD_ProDKin_1	895	901	PF00069	0.592
MOD_SUMO_for_1	543	546	PF00179	0.745
TRG_DiLeu_BaEn_1	549	554	PF01217	0.589
TRG_DiLeu_BaEn_1	709	714	PF01217	0.584
TRG_DiLeu_BaEn_1	762	767	PF01217	0.717
TRG_DiLeu_BaEn_4	730	736	PF01217	0.631
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.502
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.473
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.406
TRG_DiLeu_BaLyEn_6	499	504	PF01217	0.630
TRG_DiLeu_BaLyEn_6	690	695	PF01217	0.508
TRG_DiLeu_BaLyEn_6	721	726	PF01217	0.496
TRG_DiLeu_LyEn_5	549	554	PF01217	0.688
TRG_DiLeu_LyEn_5	709	714	PF01217	0.584
TRG_DiLeu_LyEn_5	762	767	PF01217	0.717
TRG_ENDOCYTIC_2	699	702	PF00928	0.670
TRG_ENDOCYTIC_2	74	77	PF00928	0.605
TRG_ENDOCYTIC_2	872	875	PF00928	0.523
TRG_ER_diArg_1	142	145	PF00400	0.651
TRG_ER_diArg_1	172	174	PF00400	0.388
TRG_ER_diArg_1	188	190	PF00400	0.302
TRG_ER_diArg_1	292	294	PF00400	0.532
TRG_ER_diArg_1	411	414	PF00400	0.749
TRG_ER_diArg_1	500	503	PF00400	0.691
TRG_ER_diArg_1	763	765	PF00400	0.640
TRG_ER_diArg_1	772	775	PF00400	0.625
TRG_ER_diArg_1	782	784	PF00400	0.484
TRG_ER_diArg_1	810	813	PF00400	0.540
TRG_NES_CRM1_1	107	121	PF08389	0.415
TRG_NES_CRM1_1	209	221	PF08389	0.571
TRG_Pf-PMV_PEXEL_1	188	193	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	203	208	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	287	291	PF00026	0.648
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.695
TRG_Pf-PMV_PEXEL_1	552	556	PF00026	0.730
TRG_Pf-PMV_PEXEL_1	712	716	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	764	769	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IH80	Leptomonas seymouri	41%	92%
A0A3S7X6H4	Leishmania donovani	64%	100%
A4I8U8	Leishmania infantum	64%	100%
E9B3R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	99%
Q4Q4A7	Leishmania major	66%	96%