Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLD8_LEIBR

TriTrypDb:

LbrM.33.1030 , LBRM2903_330015000

Length:

710

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLD8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	618	622	PF00656	0.627
CLV_NRD_NRD_1	112	114	PF00675	0.728
CLV_NRD_NRD_1	23	25	PF00675	0.699
CLV_NRD_NRD_1	283	285	PF00675	0.647
CLV_NRD_NRD_1	316	318	PF00675	0.562
CLV_NRD_NRD_1	350	352	PF00675	0.430
CLV_NRD_NRD_1	601	603	PF00675	0.667
CLV_NRD_NRD_1	665	667	PF00675	0.536
CLV_NRD_NRD_1	67	69	PF00675	0.719
CLV_NRD_NRD_1	683	685	PF00675	0.494
CLV_NRD_NRD_1	705	707	PF00675	0.691
CLV_PCSK_FUR_1	110	114	PF00082	0.754
CLV_PCSK_FUR_1	280	284	PF00082	0.658
CLV_PCSK_FUR_1	703	707	PF00082	0.773
CLV_PCSK_KEX2_1	112	114	PF00082	0.728
CLV_PCSK_KEX2_1	23	25	PF00082	0.699
CLV_PCSK_KEX2_1	280	282	PF00082	0.643
CLV_PCSK_KEX2_1	283	285	PF00082	0.675
CLV_PCSK_KEX2_1	350	352	PF00082	0.430
CLV_PCSK_KEX2_1	601	603	PF00082	0.667
CLV_PCSK_KEX2_1	665	667	PF00082	0.543
CLV_PCSK_KEX2_1	67	69	PF00082	0.719
CLV_PCSK_KEX2_1	685	687	PF00082	0.407
CLV_PCSK_KEX2_1	705	707	PF00082	0.736
CLV_PCSK_PC1ET2_1	685	687	PF00082	0.585
CLV_PCSK_SKI1_1	317	321	PF00082	0.507
CLV_PCSK_SKI1_1	394	398	PF00082	0.532
CLV_PCSK_SKI1_1	462	466	PF00082	0.427
CLV_PCSK_SKI1_1	602	606	PF00082	0.652
CLV_PCSK_SKI1_1	8	12	PF00082	0.727
DEG_Nend_Nbox_1	1	3	PF02207	0.697
DEG_SPOP_SBC_1	46	50	PF00917	0.807
DOC_AGCK_PIF_2	486	491	PF00069	0.571
DOC_CDC14_PxL_1	10	18	PF14671	0.510
DOC_CKS1_1	132	137	PF01111	0.697
DOC_CKS1_1	27	32	PF01111	0.710
DOC_CYCLIN_RxL_1	311	322	PF00134	0.687
DOC_CYCLIN_RxL_1	456	469	PF00134	0.523
DOC_CYCLIN_RxL_1	598	607	PF00134	0.695
DOC_CYCLIN_yCln2_LP_2	136	142	PF00134	0.509
DOC_MAPK_gen_1	494	503	PF00069	0.455
DOC_MAPK_gen_1	529	537	PF00069	0.608
DOC_MAPK_MEF2A_6	4	11	PF00069	0.625
DOC_MAPK_MEF2A_6	497	505	PF00069	0.423
DOC_PP1_RVXF_1	6	12	PF00149	0.680
DOC_PP2B_LxvP_1	299	302	PF13499	0.719
DOC_PP2B_LxvP_1	370	373	PF13499	0.456
DOC_PP4_FxxP_1	11	14	PF00568	0.725
DOC_USP7_MATH_1	154	158	PF00917	0.634
DOC_USP7_MATH_1	207	211	PF00917	0.529
DOC_USP7_MATH_1	255	259	PF00917	0.732
DOC_USP7_MATH_1	381	385	PF00917	0.515
DOC_USP7_MATH_1	46	50	PF00917	0.663
DOC_USP7_UBL2_3	681	685	PF12436	0.586
DOC_WW_Pin1_4	119	124	PF00397	0.689
DOC_WW_Pin1_4	131	136	PF00397	0.555
DOC_WW_Pin1_4	14	19	PF00397	0.678
DOC_WW_Pin1_4	26	31	PF00397	0.723
DOC_WW_Pin1_4	3	8	PF00397	0.696
DOC_WW_Pin1_4	457	462	PF00397	0.420
DOC_WW_Pin1_4	58	63	PF00397	0.631
DOC_WW_Pin1_4	616	621	PF00397	0.699
LIG_14-3-3_CanoR_1	227	232	PF00244	0.592
LIG_14-3-3_CanoR_1	311	315	PF00244	0.586
LIG_14-3-3_CanoR_1	52	58	PF00244	0.754
LIG_14-3-3_CanoR_1	566	573	PF00244	0.505
LIG_14-3-3_CanoR_1	615	620	PF00244	0.662
LIG_eIF4E_1	314	320	PF01652	0.625
LIG_eIF4E_1	499	505	PF01652	0.469
LIG_EVH1_2	53	57	PF00568	0.532
LIG_FHA_1	439	445	PF00498	0.521
LIG_FHA_1	511	517	PF00498	0.517
LIG_FHA_1	532	538	PF00498	0.590
LIG_FHA_1	590	596	PF00498	0.659
LIG_FHA_2	330	336	PF00498	0.463
LIG_FHA_2	513	519	PF00498	0.590
LIG_FHA_2	553	559	PF00498	0.711
LIG_Integrin_RGD_1	587	589	PF01839	0.547
LIG_LIR_Gen_1	210	219	PF02991	0.504
LIG_LIR_Gen_1	502	511	PF02991	0.445
LIG_LIR_Nem_3	131	136	PF02991	0.738
LIG_LIR_Nem_3	416	420	PF02991	0.618
LIG_LIR_Nem_3	431	435	PF02991	0.399
LIG_LIR_Nem_3	502	508	PF02991	0.416
LIG_LIR_Nem_3	76	80	PF02991	0.525
LIG_LYPXL_yS_3	454	457	PF13949	0.558
LIG_MYND_1	14	18	PF01753	0.511
LIG_NRBOX	342	348	PF00104	0.429
LIG_PCNA_PIPBox_1	389	398	PF02747	0.406
LIG_PTB_Apo_2	211	218	PF02174	0.642
LIG_PTB_Phospho_1	211	217	PF10480	0.646
LIG_RPA_C_Fungi	661	673	PF08784	0.678
LIG_SH2_CRK	327	331	PF00017	0.495
LIG_SH2_CRK	77	81	PF00017	0.690
LIG_SH2_NCK_1	674	678	PF00017	0.401
LIG_SH2_PTP2	432	435	PF00017	0.256
LIG_SH2_STAP1	366	370	PF00017	0.420
LIG_SH2_STAP1	491	495	PF00017	0.557
LIG_SH2_STAT3	102	105	PF00017	0.743
LIG_SH2_STAT3	525	528	PF00017	0.377
LIG_SH2_STAT5	102	105	PF00017	0.760
LIG_SH2_STAT5	354	357	PF00017	0.489
LIG_SH2_STAT5	361	364	PF00017	0.407
LIG_SH2_STAT5	432	435	PF00017	0.369
LIG_SH2_STAT5	55	58	PF00017	0.552
LIG_SH3_1	24	30	PF00018	0.714
LIG_SH3_1	449	455	PF00018	0.581
LIG_SH3_2	18	23	PF14604	0.698
LIG_SH3_3	12	18	PF00018	0.651
LIG_SH3_3	150	156	PF00018	0.512
LIG_SH3_3	24	30	PF00018	0.556
LIG_SH3_3	304	310	PF00018	0.703
LIG_SH3_3	399	405	PF00018	0.403
LIG_SH3_3	449	455	PF00018	0.472
LIG_SH3_3	464	470	PF00018	0.413
LIG_SH3_3	79	85	PF00018	0.652
LIG_SUMO_SIM_par_1	287	294	PF11976	0.512
LIG_SxIP_EBH_1	199	208	PF03271	0.552
LIG_TRAF2_1	168	171	PF00917	0.422
LIG_TRAF2_1	302	305	PF00917	0.702
LIG_TRAF2_1	582	585	PF00917	0.725
LIG_TYR_ITIM	325	330	PF00017	0.567
LIG_WRC_WIRS_1	414	419	PF05994	0.620
MOD_CDK_SPK_2	3	8	PF00069	0.478
MOD_CDK_SPK_2	457	462	PF00069	0.410
MOD_CDK_SPxxK_3	131	138	PF00069	0.669
MOD_CK1_1	131	137	PF00069	0.682
MOD_CK1_1	36	42	PF00069	0.778
MOD_CK1_1	384	390	PF00069	0.488
MOD_CK1_1	428	434	PF00069	0.512
MOD_CK1_1	559	565	PF00069	0.578
MOD_CK1_1	656	662	PF00069	0.689
MOD_CK1_1	76	82	PF00069	0.561
MOD_CK2_1	165	171	PF00069	0.578
MOD_CK2_1	172	178	PF00069	0.519
MOD_CK2_1	329	335	PF00069	0.468
MOD_CK2_1	512	518	PF00069	0.597
MOD_CK2_1	552	558	PF00069	0.676
MOD_GlcNHglycan	174	177	PF01048	0.651
MOD_GlcNHglycan	209	212	PF01048	0.551
MOD_GlcNHglycan	253	256	PF01048	0.736
MOD_GlcNHglycan	257	260	PF01048	0.728
MOD_GlcNHglycan	417	420	PF01048	0.456
MOD_GlcNHglycan	42	45	PF01048	0.637
MOD_GlcNHglycan	558	561	PF01048	0.586
MOD_GlcNHglycan	635	638	PF01048	0.761
MOD_GlcNHglycan	655	658	PF01048	0.749
MOD_GlcNHglycan	660	663	PF01048	0.669
MOD_GSK3_1	124	131	PF00069	0.690
MOD_GSK3_1	221	228	PF00069	0.557
MOD_GSK3_1	251	258	PF00069	0.707
MOD_GSK3_1	29	36	PF00069	0.775
MOD_GSK3_1	380	387	PF00069	0.491
MOD_GSK3_1	424	431	PF00069	0.550
MOD_GSK3_1	510	517	PF00069	0.569
MOD_GSK3_1	552	559	PF00069	0.748
MOD_GSK3_1	611	618	PF00069	0.660
MOD_GSK3_1	651	658	PF00069	0.669
MOD_GSK3_1	96	103	PF00069	0.703
MOD_N-GLC_1	245	250	PF02516	0.723
MOD_N-GLC_2	406	408	PF02516	0.378
MOD_NEK2_1	212	217	PF00069	0.604
MOD_NEK2_1	251	256	PF00069	0.682
MOD_NEK2_1	303	308	PF00069	0.738
MOD_NEK2_1	380	385	PF00069	0.513
MOD_NEK2_1	413	418	PF00069	0.613
MOD_NEK2_1	438	443	PF00069	0.409
MOD_NEK2_1	623	628	PF00069	0.594
MOD_NEK2_1	655	660	PF00069	0.515
MOD_NEK2_1	680	685	PF00069	0.593
MOD_PIKK_1	101	107	PF00454	0.617
MOD_PIKK_1	552	558	PF00454	0.552
MOD_PKA_2	154	160	PF00069	0.611
MOD_PKA_2	165	171	PF00069	0.682
MOD_PKA_2	310	316	PF00069	0.584
MOD_PKA_2	36	42	PF00069	0.669
MOD_PKA_2	493	499	PF00069	0.498
MOD_PKA_2	73	79	PF00069	0.595
MOD_PKB_1	225	233	PF00069	0.589
MOD_PKB_1	613	621	PF00069	0.793
MOD_Plk_1	124	130	PF00069	0.667
MOD_Plk_1	335	341	PF00069	0.516
MOD_Plk_1	611	617	PF00069	0.629
MOD_Plk_1	651	657	PF00069	0.544
MOD_Plk_2-3	335	341	PF00069	0.521
MOD_Plk_4	128	134	PF00069	0.749
MOD_Plk_4	212	218	PF00069	0.577
MOD_Plk_4	428	434	PF00069	0.449
MOD_Plk_4	439	445	PF00069	0.351
MOD_ProDKin_1	119	125	PF00069	0.691
MOD_ProDKin_1	131	137	PF00069	0.554
MOD_ProDKin_1	14	20	PF00069	0.681
MOD_ProDKin_1	26	32	PF00069	0.723
MOD_ProDKin_1	3	9	PF00069	0.700
MOD_ProDKin_1	457	463	PF00069	0.414
MOD_ProDKin_1	58	64	PF00069	0.633
MOD_ProDKin_1	616	622	PF00069	0.702
MOD_SUMO_rev_2	524	530	PF00179	0.481
TRG_DiLeu_BaEn_1	342	347	PF01217	0.428
TRG_DiLeu_BaEn_1	692	697	PF01217	0.503
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.578
TRG_DiLeu_LyEn_5	692	697	PF01217	0.503
TRG_ENDOCYTIC_2	143	146	PF00928	0.670
TRG_ENDOCYTIC_2	213	216	PF00928	0.533
TRG_ENDOCYTIC_2	327	330	PF00928	0.428
TRG_ENDOCYTIC_2	393	396	PF00928	0.512
TRG_ENDOCYTIC_2	432	435	PF00928	0.369
TRG_ENDOCYTIC_2	454	457	PF00928	0.537
TRG_ENDOCYTIC_2	77	80	PF00928	0.524
TRG_ER_diArg_1	109	112	PF00400	0.721
TRG_ER_diArg_1	23	25	PF00400	0.700
TRG_ER_diArg_1	280	283	PF00400	0.642
TRG_ER_diArg_1	565	568	PF00400	0.654
TRG_ER_diArg_1	600	602	PF00400	0.673
TRG_ER_diArg_1	613	616	PF00400	0.788
TRG_ER_diArg_1	665	667	PF00400	0.543
TRG_ER_diArg_1	67	69	PF00400	0.719
TRG_ER_diArg_1	705	707	PF00400	0.754
TRG_Pf-PMV_PEXEL_1	317	322	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	602	607	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3E3	Leptomonas seymouri	61%	99%
A0A1X0P130	Trypanosomatidae	51%	100%
A0A3Q8IK12	Leishmania donovani	81%	100%
A0A422P2K6	Trypanosoma rangeli	50%	100%
A4I8U7	Leishmania infantum	81%	100%
D0A4U5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B3R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q4A8	Leishmania major	81%	100%
V5AZV9	Trypanosoma cruzi	49%	100%