Putative 2,4-dienoyl-coa reductase fadh1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2,4-dienoyl-coa reductase fadh1, putative

Species:

Leishmania braziliensis

UniProt:

A4HLD7_LEIBR

TriTrypDb:

LbrM.33.1020 , LBRM2903_330014900

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HLD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLD7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0008670	2,4-dienoyl-CoA reductase (NADPH) activity	5	6
GO:0010181	FMN binding	4	10
GO:0016491	oxidoreductase activity	2	10
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	6
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	6
GO:0032553	ribonucleotide binding	3	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.485
CLV_C14_Caspase3-7	472	476	PF00656	0.228
CLV_MEL_PAP_1	225	231	PF00089	0.256
CLV_NRD_NRD_1	294	296	PF00675	0.302
CLV_NRD_NRD_1	521	523	PF00675	0.287
CLV_NRD_NRD_1	566	568	PF00675	0.333
CLV_PCSK_KEX2_1	151	153	PF00082	0.163
CLV_PCSK_KEX2_1	294	296	PF00082	0.284
CLV_PCSK_KEX2_1	521	523	PF00082	0.287
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.163
CLV_PCSK_PC7_1	290	296	PF00082	0.276
CLV_PCSK_SKI1_1	216	220	PF00082	0.276
CLV_PCSK_SKI1_1	330	334	PF00082	0.221
CLV_PCSK_SKI1_1	384	388	PF00082	0.483
CLV_PCSK_SKI1_1	458	462	PF00082	0.378
CLV_PCSK_SKI1_1	614	618	PF00082	0.243
CLV_PCSK_SKI1_1	694	698	PF00082	0.457
CLV_Separin_Metazoa	210	214	PF03568	0.456
DEG_APCC_DBOX_1	205	213	PF00400	0.421
DEG_APCC_DBOX_1	227	235	PF00400	0.504
DEG_SPOP_SBC_1	542	546	PF00917	0.374
DOC_CKS1_1	298	303	PF01111	0.460
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	333	339	PF00134	0.464
DOC_CYCLIN_yCln2_LP_2	604	610	PF00134	0.334
DOC_MAPK_gen_1	139	147	PF00069	0.363
DOC_MAPK_gen_1	204	211	PF00069	0.421
DOC_MAPK_gen_1	455	464	PF00069	0.274
DOC_MAPK_gen_1	57	66	PF00069	0.438
DOC_MAPK_gen_1	669	677	PF00069	0.379
DOC_MAPK_gen_1	713	721	PF00069	0.443
DOC_MAPK_MEF2A_6	140	149	PF00069	0.453
DOC_MAPK_MEF2A_6	455	464	PF00069	0.404
DOC_MAPK_MEF2A_6	59	68	PF00069	0.418
DOC_MAPK_MEF2A_6	6	15	PF00069	0.282
DOC_PP1_RVXF_1	202	208	PF00149	0.464
DOC_PP2B_PxIxI_1	300	306	PF00149	0.504
DOC_PP4_FxxP_1	185	188	PF00568	0.363
DOC_USP7_MATH_1	218	222	PF00917	0.504
DOC_USP7_MATH_1	236	240	PF00917	0.424
DOC_USP7_MATH_1	288	292	PF00917	0.530
DOC_USP7_MATH_1	37	41	PF00917	0.512
DOC_USP7_MATH_1	403	407	PF00917	0.393
DOC_USP7_MATH_1	587	591	PF00917	0.310
DOC_USP7_UBL2_3	2	6	PF12436	0.450
DOC_USP7_UBL2_3	569	573	PF12436	0.367
DOC_USP7_UBL2_3	57	61	PF12436	0.363
DOC_USP7_UBL2_3	690	694	PF12436	0.274
DOC_USP7_UBL2_3	714	718	PF12436	0.450
DOC_WW_Pin1_4	126	131	PF00397	0.466
DOC_WW_Pin1_4	297	302	PF00397	0.460
DOC_WW_Pin1_4	30	35	PF00397	0.504
DOC_WW_Pin1_4	538	543	PF00397	0.322
DOC_WW_Pin1_4	571	576	PF00397	0.236
DOC_WW_Pin1_4	694	699	PF00397	0.526
DOC_WW_Pin1_4	70	75	PF00397	0.439
LIG_14-3-3_CanoR_1	228	232	PF00244	0.424
LIG_14-3-3_CanoR_1	279	285	PF00244	0.449
LIG_14-3-3_CanoR_1	330	336	PF00244	0.439
LIG_14-3-3_CanoR_1	39	44	PF00244	0.363
LIG_14-3-3_CanoR_1	467	471	PF00244	0.467
LIG_14-3-3_CanoR_1	596	600	PF00244	0.386
LIG_Actin_WH2_2	198	215	PF00022	0.464
LIG_BIR_III_4	217	221	PF00653	0.476
LIG_CtBP_PxDLS_1	10	14	PF00389	0.439
LIG_CtBP_PxDLS_1	142	146	PF00389	0.504
LIG_eIF4E_1	81	87	PF01652	0.363
LIG_FHA_1	136	142	PF00498	0.502
LIG_FHA_1	284	290	PF00498	0.510
LIG_FHA_1	298	304	PF00498	0.486
LIG_FHA_1	449	455	PF00498	0.326
LIG_FHA_1	459	465	PF00498	0.339
LIG_FHA_1	632	638	PF00498	0.271
LIG_FHA_1	672	678	PF00498	0.382
LIG_FHA_1	695	701	PF00498	0.475
LIG_FHA_1	710	716	PF00498	0.546
LIG_FHA_2	151	157	PF00498	0.433
LIG_FHA_2	238	244	PF00498	0.439
LIG_FHA_2	27	33	PF00498	0.439
LIG_FHA_2	40	46	PF00498	0.439
LIG_FHA_2	408	414	PF00498	0.293
LIG_FHA_2	417	423	PF00498	0.222
LIG_FHA_2	467	473	PF00498	0.307
LIG_FHA_2	543	549	PF00498	0.386
LIG_FHA_2	557	563	PF00498	0.435
LIG_IBAR_NPY_1	47	49	PF08397	0.504
LIG_LIR_Gen_1	12	23	PF02991	0.464
LIG_LIR_Gen_1	155	164	PF02991	0.504
LIG_LIR_Gen_1	221	231	PF02991	0.360
LIG_LIR_Gen_1	475	484	PF02991	0.311
LIG_LIR_LC3C_4	672	677	PF02991	0.177
LIG_LIR_Nem_3	12	18	PF02991	0.464
LIG_LIR_Nem_3	155	160	PF02991	0.467
LIG_LIR_Nem_3	221	226	PF02991	0.369
LIG_LIR_Nem_3	475	481	PF02991	0.311
LIG_LIR_Nem_3	654	658	PF02991	0.282
LIG_LYPXL_yS_3	4	7	PF13949	0.251
LIG_PCNA_yPIPBox_3	358	368	PF02747	0.276
LIG_PCNA_yPIPBox_3	430	440	PF02747	0.292
LIG_PDZ_Class_2	726	731	PF00595	0.300
LIG_Pex14_2	223	227	PF04695	0.439
LIG_Pex14_2	566	570	PF04695	0.258
LIG_SH2_CRK	49	53	PF00017	0.504
LIG_SH2_GRB2like	119	122	PF00017	0.418
LIG_SH2_SRC	119	122	PF00017	0.368
LIG_SH2_SRC	478	481	PF00017	0.318
LIG_SH2_SRC	509	512	PF00017	0.171
LIG_SH2_STAP1	421	425	PF00017	0.253
LIG_SH2_STAP1	478	482	PF00017	0.318
LIG_SH2_STAP1	49	53	PF00017	0.504
LIG_SH2_STAT5	180	183	PF00017	0.421
LIG_SH2_STAT5	282	285	PF00017	0.490
LIG_SH2_STAT5	337	340	PF00017	0.504
LIG_SH2_STAT5	509	512	PF00017	0.258
LIG_SH2_STAT5	555	558	PF00017	0.451
LIG_SH2_STAT5	665	668	PF00017	0.318
LIG_SH3_3	604	610	PF00018	0.334
LIG_SH3_4	2	9	PF00018	0.273
LIG_SUMO_SIM_anti_2	170	178	PF11976	0.421
LIG_SUMO_SIM_anti_2	230	236	PF11976	0.424
LIG_SUMO_SIM_par_1	672	678	PF11976	0.334
LIG_TRAF2_1	379	382	PF00917	0.323
LIG_TRAF2_1	559	562	PF00917	0.182
LIG_UBA3_1	131	140	PF00899	0.253
LIG_WRC_WIRS_1	655	660	PF05994	0.248
MOD_CK1_1	133	139	PF00069	0.325
MOD_CK1_1	26	32	PF00069	0.282
MOD_CK1_1	541	547	PF00069	0.374
MOD_CK1_1	595	601	PF00069	0.177
MOD_CK2_1	237	243	PF00069	0.284
MOD_CK2_1	26	32	PF00069	0.282
MOD_CK2_1	39	45	PF00069	0.282
MOD_CK2_1	416	422	PF00069	0.258
MOD_CK2_1	505	511	PF00069	0.440
MOD_CK2_1	542	548	PF00069	0.386
MOD_CK2_1	556	562	PF00069	0.435
MOD_CK2_1	685	691	PF00069	0.334
MOD_Cter_Amidation	519	522	PF01082	0.299
MOD_GlcNHglycan	253	256	PF01048	0.355
MOD_GlcNHglycan	260	263	PF01048	0.180
MOD_GlcNHglycan	343	346	PF01048	0.378
MOD_GlcNHglycan	405	408	PF01048	0.322
MOD_GlcNHglycan	422	426	PF01048	0.374
MOD_GlcNHglycan	545	548	PF01048	0.400
MOD_GlcNHglycan	590	593	PF01048	0.409
MOD_GlcNHglycan	74	77	PF01048	0.274
MOD_GSK3_1	126	133	PF00069	0.244
MOD_GSK3_1	187	194	PF00069	0.380
MOD_GSK3_1	26	33	PF00069	0.374
MOD_GSK3_1	269	276	PF00069	0.257
MOD_GSK3_1	35	42	PF00069	0.374
MOD_GSK3_1	403	410	PF00069	0.381
MOD_GSK3_1	537	544	PF00069	0.329
MOD_GSK3_1	583	590	PF00069	0.426
MOD_GSK3_1	66	73	PF00069	0.282
MOD_GSK3_1	681	688	PF00069	0.374
MOD_GSK3_1	694	701	PF00069	0.485
MOD_LATS_1	490	496	PF00433	0.177
MOD_N-GLC_1	236	241	PF02516	0.250
MOD_N-GLC_1	458	463	PF02516	0.370
MOD_N-GLC_1	592	597	PF02516	0.177
MOD_N-GLC_1	709	714	PF02516	0.458
MOD_N-GLC_2	351	353	PF02516	0.281
MOD_NEK2_1	13	18	PF00069	0.248
MOD_NEK2_1	227	232	PF00069	0.282
MOD_NEK2_1	619	624	PF00069	0.330
MOD_NEK2_1	66	71	PF00069	0.282
MOD_NEK2_2	450	455	PF00069	0.380
MOD_PIKK_1	133	139	PF00454	0.311
MOD_PIKK_1	237	243	PF00454	0.318
MOD_PK_1	492	498	PF00069	0.177
MOD_PKA_2	227	233	PF00069	0.258
MOD_PKA_2	38	44	PF00069	0.177
MOD_PKA_2	466	472	PF00069	0.373
MOD_PKA_2	595	601	PF00069	0.313
MOD_PKA_2	642	648	PF00069	0.298
MOD_Plk_1	143	149	PF00069	0.343
MOD_Plk_1	339	345	PF00069	0.177
MOD_Plk_1	421	427	PF00069	0.252
MOD_Plk_1	458	464	PF00069	0.355
MOD_Plk_1	592	598	PF00069	0.177
MOD_Plk_1	614	620	PF00069	0.318
MOD_Plk_1	671	677	PF00069	0.334
MOD_Plk_4	219	225	PF00069	0.189
MOD_Plk_4	227	233	PF00069	0.282
MOD_Plk_4	416	422	PF00069	0.258
MOD_Plk_4	492	498	PF00069	0.196
MOD_Plk_4	614	620	PF00069	0.290
MOD_Plk_4	671	677	PF00069	0.299
MOD_ProDKin_1	126	132	PF00069	0.321
MOD_ProDKin_1	297	303	PF00069	0.313
MOD_ProDKin_1	30	36	PF00069	0.374
MOD_ProDKin_1	538	544	PF00069	0.322
MOD_ProDKin_1	571	577	PF00069	0.236
MOD_ProDKin_1	694	700	PF00069	0.519
MOD_ProDKin_1	70	76	PF00069	0.282
MOD_SUMO_rev_2	580	584	PF00179	0.322
TRG_DiLeu_BaEn_4	382	388	PF01217	0.286
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.365
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.374
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.177
TRG_ENDOCYTIC_2	4	7	PF00928	0.357
TRG_ENDOCYTIC_2	478	481	PF00928	0.318
TRG_ENDOCYTIC_2	49	52	PF00928	0.374
TRG_ENDOCYTIC_2	555	558	PF00928	0.451
TRG_ENDOCYTIC_2	613	616	PF00928	0.334
TRG_ENDOCYTIC_2	655	658	PF00928	0.258
TRG_ER_diArg_1	18	21	PF00400	0.282
TRG_ER_diArg_1	204	207	PF00400	0.258
TRG_ER_diArg_1	293	295	PF00400	0.346
TRG_ER_diArg_1	521	523	PF00400	0.287
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.177

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P302	Leptomonas seymouri	74%	100%
A0A0N0P5L6	Leptomonas seymouri	31%	100%
A0A0S4JCH5	Bodo saltans	33%	100%
A0A0S4JST7	Bodo saltans	46%	100%
A0A1X0NKW1	Trypanosomatidae	30%	100%
A0A1X0NU55	Trypanosomatidae	53%	100%
A0A3S5H5T4	Leishmania donovani	31%	100%
A0A3S7X6G9	Leishmania donovani	87%	100%
A4H4Q6	Leishmania braziliensis	31%	100%
A4HSY5	Leishmania infantum	31%	100%
A4I8U6	Leishmania infantum	87%	100%
A4J778	Desulforamulus reducens (strain ATCC BAA-1160 / DSM 100696 / MI-1)	34%	100%
C9ZTL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AKX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B3R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
G9F1Y9	Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679)	30%	100%
O87278	Rhizobium meliloti (strain 1021)	29%	100%
P16099	Methylophilus methylotrophus	28%	100%
P19410	Clostridium scindens (strain JCM 10418 / VPI 12708)	31%	100%
P32370	Clostridium scindens (strain JCM 10418 / VPI 12708)	29%	100%
P32382	Thermoanaerobacter brockii	33%	100%
P42593	Escherichia coli (strain K12)	43%	100%
Q48303	Hyphomicrobium sp. (strain x)	26%	99%
Q4Q4A9	Leishmania major	86%	100%
Q4QIY4	Leishmania major	31%	100%
V5AR23	Trypanosoma cruzi	53%	100%
V5BNI9	Trypanosoma cruzi	32%	100%