Beta-tubulin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Beta-tubulin

Gene product:

beta-tubulin

Species:

Leishmania braziliensis

UniProt:

A4HLD6_LEIBR

TriTrypDb:

LbrM.33.1010 , LBRM2903_330014300

Length:

177

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	7
GO:0099080	supramolecular complex	2	7
GO:0099081	supramolecular polymer	3	7
GO:0099512	supramolecular fiber	4	7
GO:0099513	polymeric cytoskeletal fiber	5	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HLD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLD6

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	7
GO:0009987	cellular process	1	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0003924	GTPase activity	7	7
GO:0005198	structural molecule activity	1	7
GO:0005200	structural constituent of cytoskeleton	2	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.336
CLV_NRD_NRD_1	124	126	PF00675	0.566
CLV_PCSK_KEX2_1	113	115	PF00082	0.326
CLV_PCSK_KEX2_1	124	126	PF00082	0.608
CLV_PCSK_SKI1_1	125	129	PF00082	0.609
CLV_PCSK_SKI1_1	43	47	PF00082	0.288
CLV_PCSK_SKI1_1	93	97	PF00082	0.326
DOC_MAPK_gen_1	93	101	PF00069	0.509
DOC_MAPK_MEF2A_6	93	101	PF00069	0.509
DOC_USP7_MATH_1	6	10	PF00917	0.495
LIG_14-3-3_CanoR_1	16	21	PF00244	0.495
LIG_14-3-3_CanoR_1	43	51	PF00244	0.509
LIG_14-3-3_CanoR_1	52	60	PF00244	0.508
LIG_Actin_WH2_2	80	98	PF00022	0.526
LIG_BRCT_BRCA1_1	47	51	PF00533	0.509
LIG_BRCT_BRCA1_1	71	75	PF00533	0.526
LIG_BRCT_BRCA1_1	97	101	PF00533	0.565
LIG_CAP-Gly_1	169	177	PF01302	0.726
LIG_FHA_1	55	61	PF00498	0.518
LIG_FHA_2	141	147	PF00498	0.625
LIG_FHA_2	161	167	PF00498	0.632
LIG_LIR_Nem_3	110	115	PF02991	0.526
LIG_LIR_Nem_3	12	18	PF02991	0.495
LIG_LIR_Nem_3	154	159	PF02991	0.599
LIG_MLH1_MIPbox_1	71	75	PF16413	0.526
LIG_PCNA_yPIPBox_3	105	114	PF02747	0.526
LIG_Pex14_2	119	123	PF04695	0.586
LIG_SH2_CRK	15	19	PF00017	0.495
LIG_SH2_SRC	159	162	PF00017	0.625
LIG_SH2_STAT5	132	135	PF00017	0.595
LIG_SH2_STAT5	44	47	PF00017	0.493
LIG_SH2_STAT5	74	77	PF00017	0.511
LIG_TRAF2_1	163	166	PF00917	0.652
MOD_CK1_1	9	15	PF00069	0.495
MOD_CK2_1	140	146	PF00069	0.628
MOD_CK2_1	16	22	PF00069	0.495
MOD_CK2_1	160	166	PF00069	0.624
MOD_CK2_1	53	59	PF00069	0.509
MOD_GlcNHglycan	47	50	PF01048	0.309
MOD_GSK3_1	140	147	PF00069	0.600
MOD_GSK3_1	5	12	PF00069	0.495
MOD_LATS_1	41	47	PF00433	0.509
MOD_N-GLC_1	103	108	PF02516	0.326
MOD_N-GLC_1	70	75	PF02516	0.326
MOD_N-GLC_2	105	107	PF02516	0.326
MOD_NEK2_1	45	50	PF00069	0.509
MOD_NEK2_1	95	100	PF00069	0.509
MOD_PIKK_1	21	27	PF00454	0.428
MOD_PIKK_1	9	15	PF00454	0.495
MOD_PK_1	16	22	PF00069	0.495
MOD_PKA_2	53	59	PF00069	0.509
MOD_PKA_2	9	15	PF00069	0.495
MOD_PKB_1	52	60	PF00069	0.509
MOD_Plk_1	103	109	PF00069	0.526
MOD_Plk_1	160	166	PF00069	0.610
MOD_Plk_1	70	76	PF00069	0.526
MOD_Plk_4	70	76	PF00069	0.526
MOD_Plk_4	97	103	PF00069	0.509
TRG_ENDOCYTIC_2	15	18	PF00928	0.495
TRG_ER_diArg_1	112	114	PF00400	0.545
TRG_ER_diArg_1	123	125	PF00400	0.562
TRG_ER_diArg_1	51	54	PF00400	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IVQ1	Bodo saltans	31%	96%
A0A0S4J902	Bodo saltans	98%	100%
A0A0S4KMQ2	Bodo saltans	34%	92%
A0A1X0NW87	Trypanosomatidae	35%	100%
A0A3S7X6J0	Leishmania donovani	100%	73%
A0A3S7X6K6	Leishmania donovani	100%	100%
A4HHS1	Leishmania braziliensis	32%	68%
A4HLD1	Leishmania braziliensis	100%	100%
C9ZIG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	93%
E8NHQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
P02553	Lytechinus pictus	33%	100%
P02556	Lytechinus pictus	85%	100%
P24635	Octopus vulgaris	33%	74%
P33632	Anemia phyllitidis	83%	74%
Q07972	Pneumocystis carinii	33%	83%
V5AN49	Trypanosoma cruzi	97%	100%