Tubulin beta chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Tubulin beta chain

Gene product:

beta-tubulin

Species:

Leishmania braziliensis

UniProt:

A4HLD5_LEIBR

TriTrypDb:

LbrM.33.0990 , LBRM2903_330014300

Length:

175

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	7
GO:0099080	supramolecular complex	2	7
GO:0099081	supramolecular polymer	3	7
GO:0099512	supramolecular fiber	4	7
GO:0099513	polymeric cytoskeletal fiber	5	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HLD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLD5

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	7
GO:0009987	cellular process	1	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	4
GO:0003924	GTPase activity	7	4
GO:0005198	structural molecule activity	1	5
GO:0005200	structural constituent of cytoskeleton	2	5
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0016462	pyrophosphatase activity	5	4
GO:0016787	hydrolase activity	2	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	4
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	4
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	4
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.454
CLV_NRD_NRD_1	120	122	PF00675	0.226
CLV_PCSK_SKI1_1	62	66	PF00082	0.240
DEG_APCC_DBOX_1	61	69	PF00400	0.462
DEG_Nend_UBRbox_1	1	4	PF02207	0.375
DOC_USP7_MATH_1	32	36	PF00917	0.445
DOC_WW_Pin1_4	169	174	PF00397	0.480
LIG_14-3-3_CanoR_1	162	168	PF00244	0.452
LIG_APCC_ABBA_1	47	52	PF00400	0.429
LIG_APCC_ABBAyCdc20_2	46	52	PF00400	0.429
LIG_Clathr_ClatBox_1	65	69	PF01394	0.462
LIG_FHA_1	164	170	PF00498	0.498
LIG_LIR_Gen_1	166	173	PF02991	0.437
LIG_LIR_Gen_1	18	25	PF02991	0.462
LIG_LIR_Nem_3	166	170	PF02991	0.437
LIG_LIR_Nem_3	18	24	PF02991	0.462
LIG_SH2_CRK	81	85	PF00017	0.498
LIG_SH2_STAT5	106	109	PF00017	0.503
LIG_SH2_STAT5	50	53	PF00017	0.462
LIG_SH2_STAT5	59	62	PF00017	0.462
LIG_SxIP_EBH_1	163	174	PF03271	0.483
LIG_WRC_WIRS_1	164	169	PF05994	0.480
MOD_CDK_SPK_2	169	174	PF00069	0.480
MOD_GlcNHglycan	144	147	PF01048	0.281
MOD_GlcNHglycan	52	56	PF01048	0.208
MOD_GlcNHglycan	94	97	PF01048	0.244
MOD_GSK3_1	165	172	PF00069	0.440
MOD_NEK2_1	112	117	PF00069	0.497
MOD_NEK2_1	133	138	PF00069	0.574
MOD_NEK2_1	150	155	PF00069	0.420
MOD_NEK2_1	165	170	PF00069	0.382
MOD_NEK2_1	51	56	PF00069	0.505
MOD_NEK2_1	92	97	PF00069	0.497
MOD_OFUCOSY	120	127	PF10250	0.262
MOD_Plk_2-3	69	75	PF00069	0.462
MOD_Plk_4	112	118	PF00069	0.518
MOD_ProDKin_1	169	175	PF00069	0.480
TRG_DiLeu_BaEn_1	108	113	PF01217	0.462
TRG_ENDOCYTIC_2	81	84	PF00928	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IWF9	Bodo saltans	93%	100%
A0A0S4J1M4	Bodo saltans	92%	82%
A0A1X0P3S8	Trypanosomatidae	30%	68%
C9ZIG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
V5AP72	Trypanosoma cruzi	31%	74%