Beta-tubulin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Beta-tubulin

Gene product:

beta-tubulin

Species:

Leishmania braziliensis

UniProt:

A4HLD1_LEIBR

TriTrypDb:

LbrM.33.0950 , LBRM2903_330014300

Length:

223

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	4
GO:0099080	supramolecular complex	2	4
GO:0099081	supramolecular polymer	3	4
GO:0099512	supramolecular fiber	4	4
GO:0099513	polymeric cytoskeletal fiber	5	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HLD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLD1

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	4
GO:0009987	cellular process	1	4

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	4
GO:0003824	catalytic activity	1	4
GO:0003924	GTPase activity	7	4
GO:0005198	structural molecule activity	1	4
GO:0005200	structural constituent of cytoskeleton	2	4
GO:0005488	binding	1	4
GO:0005525	GTP binding	5	4
GO:0016462	pyrophosphatase activity	5	4
GO:0016787	hydrolase activity	2	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	4
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	4
GO:0017076	purine nucleotide binding	4	4
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	4
GO:0019001	guanyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032561	guanyl ribonucleotide binding	5	4
GO:0035639	purine ribonucleoside triphosphate binding	4	4
GO:0036094	small molecule binding	2	4
GO:0043167	ion binding	2	4
GO:0043168	anion binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:0097367	carbohydrate derivative binding	2	4
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.439
CLV_NRD_NRD_1	170	172	PF00675	0.472
CLV_NRD_NRD_1	30	32	PF00675	0.629
CLV_PCSK_KEX2_1	159	161	PF00082	0.439
CLV_PCSK_KEX2_1	170	172	PF00082	0.472
CLV_PCSK_SKI1_1	139	143	PF00082	0.439
CLV_PCSK_SKI1_1	171	175	PF00082	0.619
CLV_PCSK_SKI1_1	89	93	PF00082	0.439
DEG_Nend_Nbox_1	1	3	PF02207	0.355
DOC_MAPK_gen_1	139	147	PF00069	0.621
DOC_MAPK_gen_1	31	37	PF00069	0.594
DOC_MAPK_MEF2A_6	139	147	PF00069	0.621
DOC_PP1_RVXF_1	40	46	PF00149	0.502
DOC_USP7_MATH_1	11	15	PF00917	0.541
DOC_USP7_MATH_1	52	56	PF00917	0.627
LIG_14-3-3_CanoR_1	62	67	PF00244	0.627
LIG_14-3-3_CanoR_1	89	97	PF00244	0.639
LIG_14-3-3_CanoR_1	98	106	PF00244	0.539
LIG_Actin_WH2_2	126	144	PF00022	0.639
LIG_BRCT_BRCA1_1	117	121	PF00533	0.639
LIG_BRCT_BRCA1_1	143	147	PF00533	0.639
LIG_BRCT_BRCA1_1	93	97	PF00533	0.639
LIG_CAP-Gly_1	215	223	PF01302	0.801
LIG_FHA_1	101	107	PF00498	0.639
LIG_FHA_1	15	21	PF00498	0.571
LIG_FHA_2	187	193	PF00498	0.644
LIG_FHA_2	207	213	PF00498	0.409
LIG_LIR_Nem_3	156	161	PF02991	0.639
LIG_LIR_Nem_3	200	205	PF02991	0.628
LIG_LIR_Nem_3	58	64	PF02991	0.627
LIG_MLH1_MIPbox_1	117	121	PF16413	0.639
LIG_PCNA_yPIPBox_3	151	160	PF02747	0.639
LIG_Pex14_2	165	169	PF04695	0.596
LIG_Pex14_2	46	50	PF04695	0.621
LIG_SH2_CRK	61	65	PF00017	0.627
LIG_SH2_SRC	205	208	PF00017	0.636
LIG_SH2_STAT5	120	123	PF00017	0.639
LIG_SH2_STAT5	178	181	PF00017	0.640
LIG_SH2_STAT5	90	93	PF00017	0.639
LIG_SH3_3	35	41	PF00018	0.576
LIG_TRAF2_1	209	212	PF00917	0.737
MOD_CK1_1	14	20	PF00069	0.565
MOD_CK1_1	55	61	PF00069	0.627
MOD_CK2_1	186	192	PF00069	0.646
MOD_CK2_1	206	212	PF00069	0.389
MOD_CK2_1	62	68	PF00069	0.627
MOD_CK2_1	99	105	PF00069	0.639
MOD_GlcNHglycan	13	16	PF01048	0.562
MOD_GlcNHglycan	93	96	PF01048	0.439
MOD_GSK3_1	186	193	PF00069	0.649
MOD_GSK3_1	51	58	PF00069	0.627
MOD_LATS_1	87	93	PF00433	0.639
MOD_N-GLC_1	116	121	PF02516	0.439
MOD_N-GLC_1	149	154	PF02516	0.439
MOD_N-GLC_2	151	153	PF02516	0.439
MOD_NEK2_1	141	146	PF00069	0.639
MOD_NEK2_1	91	96	PF00069	0.639
MOD_PIKK_1	55	61	PF00454	0.627
MOD_PIKK_1	67	73	PF00454	0.501
MOD_PK_1	62	68	PF00069	0.627
MOD_PKA_2	55	61	PF00069	0.627
MOD_PKA_2	99	105	PF00069	0.639
MOD_PKB_1	98	106	PF00069	0.639
MOD_Plk_1	116	122	PF00069	0.639
MOD_Plk_1	149	155	PF00069	0.639
MOD_Plk_1	206	212	PF00069	0.696
MOD_Plk_4	116	122	PF00069	0.639
MOD_Plk_4	143	149	PF00069	0.639
TRG_ENDOCYTIC_2	61	64	PF00928	0.627
TRG_ER_diArg_1	158	160	PF00400	0.639
TRG_ER_diArg_1	169	171	PF00400	0.455
TRG_ER_diArg_1	97	100	PF00400	0.639

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IVQ1	Bodo saltans	31%	100%
A0A0S4KMQ2	Bodo saltans	35%	100%
A0A1X0NW87	Trypanosomatidae	35%	100%
A0A3S7X6J0	Leishmania donovani	100%	91%
A0AAL4	Dictyostelium purpureum	33%	67%
A4HHS1	Leishmania braziliensis	34%	86%
A4HLD6	Leishmania braziliensis	100%	100%
C9ZIG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZIG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	74%
E8NHQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
P02556	Lytechinus pictus	85%	100%
P09642	Gallus gallus	34%	69%
P09643	Gallus gallus	35%	69%
P09645	Gallus gallus	34%	69%
P18700	Strongylocentrotus purpuratus	86%	76%
P20364	Daucus carota	86%	71%
P24635	Octopus vulgaris	36%	93%
P33632	Anemia phyllitidis	84%	93%
P86221	Mesocricetus auratus	58%	77%
Q07972	Pneumocystis carinii	37%	100%