Putative histone deacetylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone deacetylase, putative

Species:

Leishmania braziliensis

UniProt:

A4HLD0_LEIBR

TriTrypDb:

LbrM.33.0940 , LBRM2903_330014100

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000118	histone deacetylase complex	3	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4HLD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLD0

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006476	protein deacetylation	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0016570	histone modification	5	1
GO:0016575	histone deacetylation	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0035601	protein deacylation	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0098732	macromolecule deacylation	5	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004407	histone deacetylase activity	4	1
GO:0016787	hydrolase activity	2	2
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	1
GO:0019213	deacetylase activity	3	1
GO:0033558	protein lysine deacetylase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	423	427	PF00656	0.584
CLV_NRD_NRD_1	153	155	PF00675	0.288
CLV_NRD_NRD_1	157	159	PF00675	0.306
CLV_NRD_NRD_1	23	25	PF00675	0.487
CLV_NRD_NRD_1	310	312	PF00675	0.547
CLV_NRD_NRD_1	435	437	PF00675	0.641
CLV_PCSK_KEX2_1	153	155	PF00082	0.288
CLV_PCSK_KEX2_1	23	25	PF00082	0.519
CLV_PCSK_KEX2_1	3	5	PF00082	0.654
CLV_PCSK_KEX2_1	435	437	PF00082	0.641
CLV_PCSK_KEX2_1	612	614	PF00082	0.441
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.654
CLV_PCSK_PC1ET2_1	612	614	PF00082	0.476
CLV_PCSK_SKI1_1	145	149	PF00082	0.344
CLV_PCSK_SKI1_1	581	585	PF00082	0.253
CLV_Separin_Metazoa	355	359	PF03568	0.543
DEG_APCC_DBOX_1	516	524	PF00400	0.583
DEG_SCF_FBW7_1	48	55	PF00400	0.680
DEG_SCF_FBW7_1	64	71	PF00400	0.703
DEG_SPOP_SBC_1	406	410	PF00917	0.685
DEG_SPOP_SBC_1	68	72	PF00917	0.649
DOC_ANK_TNKS_1	176	183	PF00023	0.527
DOC_CDC14_PxL_1	50	58	PF14671	0.671
DOC_CKS1_1	49	54	PF01111	0.672
DOC_CYCLIN_RxL_1	267	277	PF00134	0.518
DOC_CYCLIN_RxL_1	578	587	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	46	49	PF00134	0.664
DOC_MAPK_gen_1	514	523	PF00069	0.527
DOC_MAPK_MEF2A_6	514	522	PF00069	0.453
DOC_PIKK_1	330	337	PF02985	0.734
DOC_PP2B_LxvP_1	46	49	PF13499	0.735
DOC_PP2B_PxIxI_1	268	274	PF00149	0.544
DOC_USP7_MATH_1	208	212	PF00917	0.394
DOC_USP7_MATH_1	406	410	PF00917	0.666
DOC_USP7_MATH_1	573	577	PF00917	0.453
DOC_USP7_MATH_1	69	73	PF00917	0.682
DOC_WW_Pin1_4	108	113	PF00397	0.526
DOC_WW_Pin1_4	36	41	PF00397	0.693
DOC_WW_Pin1_4	365	370	PF00397	0.601
DOC_WW_Pin1_4	449	454	PF00397	0.739
DOC_WW_Pin1_4	48	53	PF00397	0.654
DOC_WW_Pin1_4	538	543	PF00397	0.483
DOC_WW_Pin1_4	64	69	PF00397	0.567
DOC_WW_Pin1_4	84	89	PF00397	0.673
LIG_14-3-3_CanoR_1	122	130	PF00244	0.462
LIG_14-3-3_CanoR_1	311	317	PF00244	0.682
LIG_14-3-3_CanoR_1	374	381	PF00244	0.534
LIG_14-3-3_CanoR_1	4	12	PF00244	0.602
LIG_14-3-3_CanoR_1	435	439	PF00244	0.518
LIG_Actin_WH2_2	556	572	PF00022	0.411
LIG_BRCT_BRCA1_1	418	422	PF00533	0.623
LIG_BRCT_BRCA1_1	523	527	PF00533	0.455
LIG_BRCT_BRCA1_1	585	589	PF00533	0.317
LIG_Clathr_ClatBox_1	399	403	PF01394	0.662
LIG_EH1_1	545	553	PF00400	0.544
LIG_eIF4E_1	546	552	PF01652	0.544
LIG_EVH1_1	353	357	PF00568	0.543
LIG_FHA_1	147	153	PF00498	0.415
LIG_FHA_1	204	210	PF00498	0.391
LIG_FHA_1	282	288	PF00498	0.453
LIG_FHA_1	442	448	PF00498	0.546
LIG_FHA_1	466	472	PF00498	0.468
LIG_FHA_1	96	102	PF00498	0.379
LIG_FHA_2	256	262	PF00498	0.490
LIG_FHA_2	331	337	PF00498	0.629
LIG_FHA_2	366	372	PF00498	0.543
LIG_FHA_2	375	381	PF00498	0.477
LIG_FHA_2	455	461	PF00498	0.664
LIG_Integrin_isoDGR_2	433	435	PF01839	0.549
LIG_IRF3_LxIS_1	292	298	PF10401	0.544
LIG_LIR_Apic_2	116	120	PF02991	0.298
LIG_LIR_Apic_2	286	292	PF02991	0.450
LIG_LIR_Gen_1	215	224	PF02991	0.487
LIG_LIR_Gen_1	378	388	PF02991	0.563
LIG_LIR_Gen_1	498	509	PF02991	0.453
LIG_LIR_Nem_3	168	173	PF02991	0.512
LIG_LIR_Nem_3	215	221	PF02991	0.487
LIG_LIR_Nem_3	378	384	PF02991	0.590
LIG_LIR_Nem_3	498	504	PF02991	0.453
LIG_MYND_1	44	48	PF01753	0.696
LIG_NRBOX	336	342	PF00104	0.656
LIG_SH2_CRK	239	243	PF00017	0.544
LIG_SH2_CRK	381	385	PF00017	0.642
LIG_SH2_NCK_1	117	121	PF00017	0.279
LIG_SH2_NCK_1	239	243	PF00017	0.544
LIG_SH2_NCK_1	289	293	PF00017	0.453
LIG_SH2_SRC	289	292	PF00017	0.453
LIG_SH2_STAT5	28	31	PF00017	0.475
LIG_SH2_STAT5	501	504	PF00017	0.453
LIG_SH2_STAT5	546	549	PF00017	0.453
LIG_SH2_STAT5	82	85	PF00017	0.468
LIG_SH3_3	218	224	PF00018	0.496
LIG_SH3_3	34	40	PF00018	0.584
LIG_SH3_3	343	349	PF00018	0.579
LIG_SH3_3	351	357	PF00018	0.628
LIG_SH3_3	435	441	PF00018	0.667
LIG_SH3_3	46	52	PF00018	0.553
LIG_SUMO_SIM_anti_2	293	298	PF11976	0.453
LIG_SUMO_SIM_anti_2	519	525	PF11976	0.527
LIG_SUMO_SIM_par_1	270	275	PF11976	0.509
LIG_SUMO_SIM_par_1	293	298	PF11976	0.453
LIG_SUMO_SIM_par_1	519	525	PF11976	0.527
LIG_SUMO_SIM_par_1	559	564	PF11976	0.454
LIG_TRAF2_1	459	462	PF00917	0.665
LIG_TYR_ITIM	379	384	PF00017	0.580
LIG_TYR_ITIM	499	504	PF00017	0.453
LIG_WW_3	355	359	PF00397	0.543
MOD_CDK_SPxxK_3	36	43	PF00069	0.469
MOD_CK1_1	18	24	PF00069	0.616
MOD_CK1_1	188	194	PF00069	0.512
MOD_CK1_1	314	320	PF00069	0.671
MOD_CK1_1	408	414	PF00069	0.615
MOD_CK1_1	416	422	PF00069	0.609
MOD_CK1_1	620	626	PF00069	0.538
MOD_CK1_1	78	84	PF00069	0.653
MOD_CK1_1	95	101	PF00069	0.306
MOD_CK2_1	365	371	PF00069	0.674
MOD_CK2_1	445	451	PF00069	0.580
MOD_CK2_1	454	460	PF00069	0.581
MOD_Cter_Amidation	21	24	PF01082	0.581
MOD_Cter_Amidation	433	436	PF01082	0.546
MOD_GlcNHglycan	20	23	PF01048	0.602
MOD_GlcNHglycan	210	213	PF01048	0.366
MOD_GlcNHglycan	316	319	PF01048	0.793
MOD_GlcNHglycan	341	344	PF01048	0.715
MOD_GlcNHglycan	428	431	PF01048	0.806
MOD_GlcNHglycan	524	527	PF01048	0.271
MOD_GlcNHglycan	528	531	PF01048	0.262
MOD_GlcNHglycan	542	545	PF01048	0.251
MOD_GlcNHglycan	585	589	PF01048	0.435
MOD_GlcNHglycan	61	64	PF01048	0.658
MOD_GlcNHglycan	71	74	PF01048	0.602
MOD_GlcNHglycan	89	92	PF01048	0.622
MOD_GSK3_1	185	192	PF00069	0.544
MOD_GSK3_1	208	215	PF00069	0.563
MOD_GSK3_1	405	412	PF00069	0.622
MOD_GSK3_1	413	420	PF00069	0.598
MOD_GSK3_1	421	428	PF00069	0.623
MOD_GSK3_1	441	448	PF00069	0.571
MOD_GSK3_1	48	55	PF00069	0.618
MOD_GSK3_1	522	529	PF00069	0.500
MOD_GSK3_1	534	541	PF00069	0.463
MOD_GSK3_1	64	71	PF00069	0.500
MOD_N-GLC_1	454	459	PF02516	0.515
MOD_NEK2_1	295	300	PF00069	0.544
MOD_NEK2_1	522	527	PF00069	0.478
MOD_NEK2_1	534	539	PF00069	0.446
MOD_NEK2_1	583	588	PF00069	0.392
MOD_NEK2_2	283	288	PF00069	0.450
MOD_NEK2_2	434	439	PF00069	0.520
MOD_NEK2_2	617	622	PF00069	0.491
MOD_PIKK_1	620	626	PF00454	0.533
MOD_PKA_1	311	317	PF00069	0.682
MOD_PKA_2	42	48	PF00069	0.701
MOD_PKA_2	434	440	PF00069	0.649
MOD_Plk_1	15	21	PF00069	0.629
MOD_Plk_1	78	84	PF00069	0.706
MOD_Plk_4	102	108	PF00069	0.478
MOD_Plk_4	283	289	PF00069	0.452
MOD_Plk_4	290	296	PF00069	0.454
MOD_Plk_4	42	48	PF00069	0.665
MOD_Plk_4	78	84	PF00069	0.566
MOD_ProDKin_1	108	114	PF00069	0.537
MOD_ProDKin_1	36	42	PF00069	0.697
MOD_ProDKin_1	365	371	PF00069	0.599
MOD_ProDKin_1	449	455	PF00069	0.739
MOD_ProDKin_1	48	54	PF00069	0.654
MOD_ProDKin_1	538	544	PF00069	0.483
MOD_ProDKin_1	64	70	PF00069	0.568
MOD_ProDKin_1	84	90	PF00069	0.673
MOD_SUMO_rev_2	605	614	PF00179	0.494
MOD_SUMO_rev_2	7	12	PF00179	0.653
TRG_DiLeu_BaEn_1	500	505	PF01217	0.527
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.735
TRG_ENDOCYTIC_2	239	242	PF00928	0.544
TRG_ENDOCYTIC_2	381	384	PF00928	0.566
TRG_ENDOCYTIC_2	501	504	PF00928	0.453
TRG_ER_diArg_1	152	154	PF00400	0.484
TRG_ER_diArg_1	23	25	PF00400	0.575
TRG_NES_CRM1_1	162	175	PF08389	0.518
TRG_NLS_MonoExtC_3	2	8	PF00514	0.688
TRG_NLS_MonoExtN_4	2	7	PF00514	0.697
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.344
TRG_Pf-PMV_PEXEL_1	270	275	PF00026	0.246
TRG_Pf-PMV_PEXEL_1	581	585	PF00026	0.253
TRG_Pf-PMV_PEXEL_1	598	603	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0R2	Leptomonas seymouri	60%	93%
A0A1X0NJV3	Trypanosomatidae	46%	95%
A0A3S7WWW4	Leishmania donovani	81%	100%
A0A422N700	Trypanosoma rangeli	50%	99%
A4HTR2	Leishmania infantum	82%	99%
C9ZIZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	91%
E9AVI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	89%
Q4QBZ5	Leishmania major	81%	100%
V5BFA4	Trypanosoma cruzi	48%	100%