Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLC7_LEIBR

TriTrypDb:

LbrM.33.0910 , LBRM2903_210027200

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HLC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	335	339	PF00656	0.451
CLV_C14_Caspase3-7	49	53	PF00656	0.563
CLV_MEL_PAP_1	303	309	PF00089	0.433
CLV_NRD_NRD_1	188	190	PF00675	0.555
CLV_NRD_NRD_1	46	48	PF00675	0.522
CLV_NRD_NRD_1	462	464	PF00675	0.454
CLV_NRD_NRD_1	567	569	PF00675	0.410
CLV_NRD_NRD_1	643	645	PF00675	0.556
CLV_NRD_NRD_1	646	648	PF00675	0.516
CLV_NRD_NRD_1	694	696	PF00675	0.547
CLV_NRD_NRD_1	79	81	PF00675	0.555
CLV_PCSK_FUR_1	401	405	PF00082	0.438
CLV_PCSK_FUR_1	644	648	PF00082	0.396
CLV_PCSK_FUR_1	77	81	PF00082	0.555
CLV_PCSK_KEX2_1	188	190	PF00082	0.662
CLV_PCSK_KEX2_1	221	223	PF00082	0.554
CLV_PCSK_KEX2_1	250	252	PF00082	0.476
CLV_PCSK_KEX2_1	281	283	PF00082	0.419
CLV_PCSK_KEX2_1	311	313	PF00082	0.603
CLV_PCSK_KEX2_1	403	405	PF00082	0.434
CLV_PCSK_KEX2_1	46	48	PF00082	0.522
CLV_PCSK_KEX2_1	462	464	PF00082	0.454
CLV_PCSK_KEX2_1	566	568	PF00082	0.434
CLV_PCSK_KEX2_1	643	645	PF00082	0.541
CLV_PCSK_KEX2_1	646	648	PF00082	0.506
CLV_PCSK_KEX2_1	694	696	PF00082	0.623
CLV_PCSK_KEX2_1	77	79	PF00082	0.557
CLV_PCSK_KEX2_1	907	909	PF00082	0.539
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.554
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.476
CLV_PCSK_PC1ET2_1	281	283	PF00082	0.426
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.598
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.434
CLV_PCSK_PC1ET2_1	907	909	PF00082	0.471
CLV_PCSK_PC7_1	246	252	PF00082	0.472
CLV_PCSK_PC7_1	277	283	PF00082	0.405
CLV_PCSK_PC7_1	639	645	PF00082	0.538
CLV_PCSK_SKI1_1	134	138	PF00082	0.527
CLV_PCSK_SKI1_1	246	250	PF00082	0.467
CLV_PCSK_SKI1_1	270	274	PF00082	0.367
CLV_PCSK_SKI1_1	391	395	PF00082	0.537
CLV_PCSK_SKI1_1	428	432	PF00082	0.486
CLV_PCSK_SKI1_1	610	614	PF00082	0.456
CLV_PCSK_SKI1_1	672	676	PF00082	0.454
CLV_PCSK_SKI1_1	688	692	PF00082	0.612
CLV_PCSK_SKI1_1	694	698	PF00082	0.620
CLV_PCSK_SKI1_1	828	832	PF00082	0.621
DEG_APCC_DBOX_1	327	335	PF00400	0.490
DEG_COP1_1	788	798	PF00400	0.542
DEG_Nend_UBRbox_1	1	4	PF02207	0.498
DEG_SCF_FBW7_1	392	398	PF00400	0.446
DEG_SPOP_SBC_1	17	21	PF00917	0.494
DEG_SPOP_SBC_1	51	55	PF00917	0.576
DEG_SPOP_SBC_1	698	702	PF00917	0.528
DEG_SPOP_SBC_1	787	791	PF00917	0.591
DOC_CDC14_PxL_1	508	516	PF14671	0.308
DOC_CKS1_1	392	397	PF01111	0.484
DOC_CKS1_1	742	747	PF01111	0.576
DOC_CYCLIN_RxL_1	38	49	PF00134	0.539
DOC_CYCLIN_yClb5_NLxxxL_5	224	233	PF00134	0.536
DOC_MAPK_gen_1	246	256	PF00069	0.472
DOC_MAPK_gen_1	328	336	PF00069	0.494
DOC_MAPK_gen_1	401	410	PF00069	0.352
DOC_MAPK_MEF2A_6	401	410	PF00069	0.352
DOC_MAPK_RevD_3	390	404	PF00069	0.460
DOC_MAPK_RevD_3	448	463	PF00069	0.426
DOC_PP2B_LxvP_1	135	138	PF13499	0.524
DOC_PP2B_LxvP_1	334	337	PF13499	0.510
DOC_PP2B_LxvP_1	509	512	PF13499	0.309
DOC_SPAK_OSR1_1	47	51	PF12202	0.518
DOC_USP7_MATH_1	106	110	PF00917	0.552
DOC_USP7_MATH_1	145	149	PF00917	0.542
DOC_USP7_MATH_1	17	21	PF00917	0.629
DOC_USP7_MATH_1	203	207	PF00917	0.590
DOC_USP7_MATH_1	232	236	PF00917	0.517
DOC_USP7_MATH_1	305	309	PF00917	0.495
DOC_USP7_MATH_1	341	345	PF00917	0.475
DOC_USP7_MATH_1	478	482	PF00917	0.486
DOC_USP7_MATH_1	633	637	PF00917	0.581
DOC_USP7_MATH_1	690	694	PF00917	0.543
DOC_USP7_MATH_1	698	702	PF00917	0.526
DOC_USP7_MATH_1	737	741	PF00917	0.701
DOC_USP7_MATH_1	766	770	PF00917	0.572
DOC_USP7_MATH_1	775	779	PF00917	0.538
DOC_USP7_MATH_1	800	804	PF00917	0.535
DOC_USP7_MATH_1	846	850	PF00917	0.586
DOC_USP7_MATH_1	867	871	PF00917	0.637
DOC_USP7_UBL2_3	668	672	PF12436	0.409
DOC_WW_Pin1_4	102	107	PF00397	0.559
DOC_WW_Pin1_4	116	121	PF00397	0.545
DOC_WW_Pin1_4	13	18	PF00397	0.679
DOC_WW_Pin1_4	164	169	PF00397	0.535
DOC_WW_Pin1_4	197	202	PF00397	0.547
DOC_WW_Pin1_4	301	306	PF00397	0.484
DOC_WW_Pin1_4	345	350	PF00397	0.553
DOC_WW_Pin1_4	391	396	PF00397	0.525
DOC_WW_Pin1_4	533	538	PF00397	0.447
DOC_WW_Pin1_4	65	70	PF00397	0.543
DOC_WW_Pin1_4	699	704	PF00397	0.671
DOC_WW_Pin1_4	715	720	PF00397	0.530
DOC_WW_Pin1_4	733	738	PF00397	0.535
DOC_WW_Pin1_4	741	746	PF00397	0.596
DOC_WW_Pin1_4	779	784	PF00397	0.622
DOC_WW_Pin1_4	794	799	PF00397	0.564
DOC_WW_Pin1_4	849	854	PF00397	0.561
LIG_14-3-3_CanoR_1	188	195	PF00244	0.565
LIG_14-3-3_CanoR_1	236	242	PF00244	0.535
LIG_14-3-3_CanoR_1	277	285	PF00244	0.545
LIG_14-3-3_CanoR_1	350	359	PF00244	0.481
LIG_14-3-3_CanoR_1	46	51	PF00244	0.542
LIG_14-3-3_CanoR_1	462	469	PF00244	0.462
LIG_14-3-3_CanoR_1	67	76	PF00244	0.564
LIG_14-3-3_CanoR_1	688	698	PF00244	0.547
LIG_BIR_III_4	125	129	PF00653	0.541
LIG_BRCT_BRCA1_1	781	785	PF00533	0.640
LIG_Clathr_ClatBox_1	806	810	PF01394	0.519
LIG_deltaCOP1_diTrp_1	472	476	PF00928	0.443
LIG_EH_1	557	561	PF12763	0.339
LIG_FHA_1	156	162	PF00498	0.519
LIG_FHA_1	31	37	PF00498	0.534
LIG_FHA_1	346	352	PF00498	0.569
LIG_FHA_1	725	731	PF00498	0.763
LIG_FHA_1	787	793	PF00498	0.576
LIG_FHA_1	876	882	PF00498	0.429
LIG_FHA_2	108	114	PF00498	0.522
LIG_FHA_2	161	167	PF00498	0.583
LIG_FHA_2	384	390	PF00498	0.360
LIG_FHA_2	575	581	PF00498	0.453
LIG_FHA_2	809	815	PF00498	0.474
LIG_FHA_2	97	103	PF00498	0.535
LIG_Integrin_RGD_1	707	709	PF01839	0.544
LIG_Integrin_RGD_1	80	82	PF01839	0.550
LIG_LIR_Apic_2	778	783	PF02991	0.532
LIG_LIR_Gen_1	235	242	PF02991	0.507
LIG_LIR_Nem_3	235	241	PF02991	0.513
LIG_LIR_Nem_3	374	380	PF02991	0.447
LIG_MYND_1	585	589	PF01753	0.526
LIG_NRBOX	527	533	PF00104	0.343
LIG_NRBOX	826	832	PF00104	0.465
LIG_NRBOX	912	918	PF00104	0.456
LIG_Pex14_1	499	503	PF04695	0.334
LIG_PTAP_UEV_1	744	749	PF05743	0.552
LIG_SH2_CRK	238	242	PF00017	0.497
LIG_SH2_NCK_1	238	242	PF00017	0.497
LIG_SH2_PTP2	443	446	PF00017	0.436
LIG_SH2_SRC	443	446	PF00017	0.436
LIG_SH2_STAP1	529	533	PF00017	0.305
LIG_SH2_STAT3	382	385	PF00017	0.443
LIG_SH2_STAT5	238	241	PF00017	0.514
LIG_SH2_STAT5	255	258	PF00017	0.660
LIG_SH2_STAT5	347	350	PF00017	0.479
LIG_SH2_STAT5	380	383	PF00017	0.427
LIG_SH2_STAT5	443	446	PF00017	0.436
LIG_SH2_STAT5	502	505	PF00017	0.471
LIG_SH2_STAT5	662	665	PF00017	0.363
LIG_SH3_3	144	150	PF00018	0.567
LIG_SH3_3	212	218	PF00018	0.682
LIG_SH3_3	390	396	PF00018	0.433
LIG_SH3_3	472	478	PF00018	0.448
LIG_SH3_3	731	737	PF00018	0.749
LIG_SH3_3	742	748	PF00018	0.590
LIG_SH3_3	792	798	PF00018	0.556
LIG_SH3_3	831	837	PF00018	0.474
LIG_SUMO_SIM_anti_2	142	148	PF11976	0.520
LIG_SUMO_SIM_anti_2	729	734	PF11976	0.535
LIG_SUMO_SIM_anti_2	878	884	PF11976	0.482
LIG_SUMO_SIM_par_1	332	338	PF11976	0.517
LIG_SUMO_SIM_par_1	805	811	PF11976	0.517
LIG_TRAF2_1	371	374	PF00917	0.506
LIG_WRC_WIRS_1	514	519	PF05994	0.425
MOD_CDC14_SPxK_1	119	122	PF00782	0.535
MOD_CDC14_SPxK_1	536	539	PF00782	0.438
MOD_CDC14_SPxK_1	702	705	PF00782	0.577
MOD_CDK_SPK_2	197	202	PF00069	0.536
MOD_CDK_SPK_2	301	306	PF00069	0.484
MOD_CDK_SPK_2	345	350	PF00069	0.553
MOD_CDK_SPK_2	715	720	PF00069	0.640
MOD_CDK_SPxK_1	116	122	PF00069	0.545
MOD_CDK_SPxK_1	533	539	PF00069	0.442
MOD_CDK_SPxK_1	699	705	PF00069	0.582
MOD_CDK_SPxxK_3	197	204	PF00069	0.536
MOD_CK1_1	148	154	PF00069	0.553
MOD_CK1_1	16	22	PF00069	0.493
MOD_CK1_1	237	243	PF00069	0.545
MOD_CK1_1	352	358	PF00069	0.471
MOD_CK1_1	53	59	PF00069	0.541
MOD_CK1_1	579	585	PF00069	0.507
MOD_CK1_1	68	74	PF00069	0.767
MOD_CK1_1	699	705	PF00069	0.613
MOD_CK1_1	712	718	PF00069	0.545
MOD_CK1_1	722	728	PF00069	0.602
MOD_CK1_1	757	763	PF00069	0.555
MOD_CK1_1	770	776	PF00069	0.558
MOD_CK1_1	808	814	PF00069	0.515
MOD_CK1_1	845	851	PF00069	0.632
MOD_CK2_1	107	113	PF00069	0.547
MOD_CK2_1	160	166	PF00069	0.623
MOD_CK2_1	383	389	PF00069	0.550
MOD_CK2_1	51	57	PF00069	0.515
MOD_CK2_1	540	546	PF00069	0.376
MOD_CK2_1	574	580	PF00069	0.455
MOD_CK2_1	808	814	PF00069	0.485
MOD_CK2_1	96	102	PF00069	0.535
MOD_DYRK1A_RPxSP_1	735	739	PF00069	0.592
MOD_GlcNHglycan	185	188	PF01048	0.574
MOD_GlcNHglycan	190	193	PF01048	0.552
MOD_GlcNHglycan	20	23	PF01048	0.541
MOD_GlcNHglycan	278	281	PF01048	0.491
MOD_GlcNHglycan	30	33	PF01048	0.525
MOD_GlcNHglycan	307	310	PF01048	0.579
MOD_GlcNHglycan	312	315	PF01048	0.741
MOD_GlcNHglycan	322	326	PF01048	0.476
MOD_GlcNHglycan	432	435	PF01048	0.491
MOD_GlcNHglycan	480	483	PF01048	0.462
MOD_GlcNHglycan	541	545	PF01048	0.349
MOD_GlcNHglycan	590	593	PF01048	0.404
MOD_GlcNHglycan	70	73	PF01048	0.551
MOD_GlcNHglycan	709	712	PF01048	0.635
MOD_GlcNHglycan	745	748	PF01048	0.686
MOD_GlcNHglycan	769	772	PF01048	0.632
MOD_GlcNHglycan	773	776	PF01048	0.641
MOD_GlcNHglycan	800	803	PF01048	0.580
MOD_GlcNHglycan	844	847	PF01048	0.617
MOD_GlcNHglycan	895	898	PF01048	0.512
MOD_GSK3_1	126	133	PF00069	0.590
MOD_GSK3_1	13	20	PF00069	0.502
MOD_GSK3_1	151	158	PF00069	0.605
MOD_GSK3_1	160	167	PF00069	0.549
MOD_GSK3_1	179	186	PF00069	0.551
MOD_GSK3_1	232	239	PF00069	0.534
MOD_GSK3_1	295	302	PF00069	0.531
MOD_GSK3_1	341	348	PF00069	0.538
MOD_GSK3_1	391	398	PF00069	0.442
MOD_GSK3_1	451	458	PF00069	0.491
MOD_GSK3_1	46	53	PF00069	0.596
MOD_GSK3_1	503	510	PF00069	0.285
MOD_GSK3_1	533	540	PF00069	0.504
MOD_GSK3_1	572	579	PF00069	0.567
MOD_GSK3_1	59	66	PF00069	0.550
MOD_GSK3_1	67	74	PF00069	0.566
MOD_GSK3_1	672	679	PF00069	0.546
MOD_GSK3_1	686	693	PF00069	0.594
MOD_GSK3_1	709	716	PF00069	0.618
MOD_GSK3_1	722	729	PF00069	0.590
MOD_GSK3_1	733	740	PF00069	0.594
MOD_GSK3_1	743	750	PF00069	0.580
MOD_GSK3_1	757	764	PF00069	0.630
MOD_GSK3_1	766	773	PF00069	0.616
MOD_GSK3_1	775	782	PF00069	0.601
MOD_GSK3_1	794	801	PF00069	0.516
MOD_GSK3_1	838	845	PF00069	0.629
MOD_GSK3_1	916	923	PF00069	0.490
MOD_GSK3_1	98	105	PF00069	0.532
MOD_LATS_1	686	692	PF00433	0.533
MOD_N-GLC_1	13	18	PF02516	0.495
MOD_N-GLC_1	455	460	PF02516	0.453
MOD_N-GLC_1	672	677	PF02516	0.461
MOD_N-GLC_1	757	762	PF02516	0.589
MOD_N-GLC_1	767	772	PF02516	0.567
MOD_NEK2_1	18	23	PF00069	0.523
MOD_NEK2_1	254	259	PF00069	0.489
MOD_NEK2_1	432	437	PF00069	0.404
MOD_NEK2_1	714	719	PF00069	0.540
MOD_NEK2_1	916	921	PF00069	0.489
MOD_NEK2_2	295	300	PF00069	0.577
MOD_PIKK_1	457	463	PF00454	0.510
MOD_PIKK_1	618	624	PF00454	0.439
MOD_PIKK_1	838	844	PF00454	0.605
MOD_PIKK_1	846	852	PF00454	0.627
MOD_PK_1	46	52	PF00069	0.520
MOD_PKA_1	188	194	PF00069	0.637
MOD_PKA_1	46	52	PF00069	0.520
MOD_PKA_2	148	154	PF00069	0.532
MOD_PKA_2	188	194	PF00069	0.604
MOD_PKA_2	259	265	PF00069	0.630
MOD_PKA_2	276	282	PF00069	0.353
MOD_PKA_2	305	311	PF00069	0.472
MOD_PKA_2	320	326	PF00069	0.452
MOD_PKA_2	349	355	PF00069	0.498
MOD_PKA_2	451	457	PF00069	0.486
MOD_PKA_2	46	52	PF00069	0.568
MOD_PKA_2	461	467	PF00069	0.517
MOD_PKB_1	705	713	PF00069	0.546
MOD_Plk_1	130	136	PF00069	0.601
MOD_Plk_1	295	301	PF00069	0.530
MOD_Plk_1	455	461	PF00069	0.556
MOD_Plk_1	56	62	PF00069	0.574
MOD_Plk_1	572	578	PF00069	0.461
MOD_Plk_1	579	585	PF00069	0.455
MOD_Plk_4	168	174	PF00069	0.553
MOD_Plk_4	395	401	PF00069	0.440
MOD_Plk_4	726	732	PF00069	0.545
MOD_Plk_4	737	743	PF00069	0.533
MOD_ProDKin_1	102	108	PF00069	0.559
MOD_ProDKin_1	116	122	PF00069	0.546
MOD_ProDKin_1	13	19	PF00069	0.680
MOD_ProDKin_1	164	170	PF00069	0.535
MOD_ProDKin_1	197	203	PF00069	0.546
MOD_ProDKin_1	301	307	PF00069	0.483
MOD_ProDKin_1	345	351	PF00069	0.546
MOD_ProDKin_1	391	397	PF00069	0.528
MOD_ProDKin_1	533	539	PF00069	0.442
MOD_ProDKin_1	65	71	PF00069	0.543
MOD_ProDKin_1	699	705	PF00069	0.673
MOD_ProDKin_1	715	721	PF00069	0.527
MOD_ProDKin_1	733	739	PF00069	0.535
MOD_ProDKin_1	741	747	PF00069	0.595
MOD_ProDKin_1	779	785	PF00069	0.623
MOD_ProDKin_1	794	800	PF00069	0.564
MOD_ProDKin_1	849	855	PF00069	0.562
MOD_SUMO_for_1	280	283	PF00179	0.466
MOD_SUMO_for_1	287	290	PF00179	0.459
MOD_SUMO_for_1	538	541	PF00179	0.338
MOD_SUMO_rev_2	119	129	PF00179	0.539
TRG_DiLeu_BaEn_1	912	917	PF01217	0.453
TRG_DiLeu_BaEn_4	629	635	PF01217	0.473
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.537
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.502
TRG_DiLeu_LyEn_5	912	917	PF01217	0.453
TRG_ENDOCYTIC_2	238	241	PF00928	0.506
TRG_ENDOCYTIC_2	529	532	PF00928	0.297
TRG_ER_diArg_1	258	261	PF00400	0.488
TRG_ER_diArg_1	45	47	PF00400	0.522
TRG_ER_diArg_1	565	568	PF00400	0.422
TRG_ER_diArg_1	643	646	PF00400	0.546
TRG_ER_diArg_1	694	696	PF00400	0.597
TRG_ER_diArg_1	76	79	PF00400	0.601
TRG_NES_CRM1_1	326	338	PF08389	0.522
TRG_Pf-PMV_PEXEL_1	134	139	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	485	490	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	545	549	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	828	833	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	908	912	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRK6	Leptomonas seymouri	43%	98%
A0A3Q8IC18	Leishmania donovani	69%	100%
A4HZJ1	Leishmania infantum	65%	92%
E9AVI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QBZ8	Leishmania major	69%	100%