Peroxisomal membrane protein PEX14

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxin 14, putative

Species:

Leishmania braziliensis

UniProt:

A4HLC6_LEIBR

TriTrypDb:

LbrM.33.0900 , LBRM2903_210027100

Length:

461

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	9
GO:0016020	membrane	2	9
GO:0031090	organelle membrane	3	9
GO:0031903	microbody membrane	5	9
GO:0042579	microbody	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0098588	bounding membrane of organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0032991	protein-containing complex	1	1
GO:1990351	transporter complex	2	1
GO:1990429	peroxisomal importomer complex	3	1

Expansion

Sequence features

A4HLC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLC6

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	9
GO:0009987	cellular process	1	9
GO:0016560	protein import into peroxisome matrix, docking	5	9
GO:0033036	macromolecule localization	2	9
GO:0051179	localization	1	9
GO:0051641	cellular localization	2	9
GO:0070727	cellular macromolecule localization	3	9

Molecular functions
Term	Name	Level	Count
GO:0005102	signaling receptor binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.675
CLV_C14_Caspase3-7	26	30	PF00656	0.512
CLV_C14_Caspase3-7	423	427	PF00656	0.499
CLV_C14_Caspase3-7	62	66	PF00656	0.257
CLV_NRD_NRD_1	182	184	PF00675	0.519
CLV_NRD_NRD_1	267	269	PF00675	0.524
CLV_NRD_NRD_1	348	350	PF00675	0.508
CLV_NRD_NRD_1	47	49	PF00675	0.464
CLV_PCSK_FUR_1	145	149	PF00082	0.443
CLV_PCSK_FUR_1	45	49	PF00082	0.271
CLV_PCSK_KEX2_1	147	149	PF00082	0.437
CLV_PCSK_KEX2_1	182	184	PF00082	0.519
CLV_PCSK_KEX2_1	47	49	PF00082	0.427
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.437
CLV_PCSK_SKI1_1	251	255	PF00082	0.551
CLV_PCSK_SKI1_1	261	265	PF00082	0.501
CLV_PCSK_SKI1_1	56	60	PF00082	0.319
CLV_PCSK_SKI1_1	69	73	PF00082	0.291
CLV_PCSK_SKI1_1	77	81	PF00082	0.471
DEG_SCF_FBW7_1	352	359	PF00400	0.514
DEG_SPOP_SBC_1	213	217	PF00917	0.505
DEG_SPOP_SBC_1	329	333	PF00917	0.481
DOC_ANK_TNKS_1	152	159	PF00023	0.454
DOC_CKS1_1	240	245	PF01111	0.710
DOC_MAPK_gen_1	268	276	PF00069	0.425
DOC_PP1_RVXF_1	146	153	PF00149	0.500
DOC_USP7_MATH_1	23	27	PF00917	0.478
DOC_USP7_MATH_1	322	326	PF00917	0.490
DOC_USP7_MATH_1	328	332	PF00917	0.539
DOC_USP7_MATH_1	356	360	PF00917	0.655
DOC_USP7_MATH_1	420	424	PF00917	0.505
DOC_USP7_MATH_1	430	434	PF00917	0.483
DOC_USP7_MATH_1	443	447	PF00917	0.586
DOC_USP7_MATH_1	50	54	PF00917	0.400
DOC_USP7_MATH_1	6	10	PF00917	0.717
DOC_USP7_UBL2_3	184	188	PF12436	0.612
DOC_WW_Pin1_4	103	108	PF00397	0.601
DOC_WW_Pin1_4	134	139	PF00397	0.550
DOC_WW_Pin1_4	174	179	PF00397	0.461
DOC_WW_Pin1_4	225	230	PF00397	0.529
DOC_WW_Pin1_4	239	244	PF00397	0.735
DOC_WW_Pin1_4	348	353	PF00397	0.633
DOC_WW_Pin1_4	394	399	PF00397	0.570
DOC_WW_Pin1_4	407	412	PF00397	0.715
DOC_WW_Pin1_4	453	458	PF00397	0.750
DOC_WW_Pin1_4	46	51	PF00397	0.283
DOC_WW_Pin1_4	87	92	PF00397	0.557
LIG_14-3-3_CanoR_1	145	151	PF00244	0.563
LIG_14-3-3_CanoR_1	182	191	PF00244	0.665
LIG_14-3-3_CanoR_1	294	302	PF00244	0.531
LIG_14-3-3_CanoR_1	77	87	PF00244	0.538
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_BIR_III_3	1	5	PF00653	0.544
LIG_BRCT_BRCA1_1	334	338	PF00533	0.633
LIG_CtBP_PxDLS_1	244	248	PF00389	0.405
LIG_FHA_1	128	134	PF00498	0.604
LIG_FHA_1	294	300	PF00498	0.530
LIG_FHA_1	433	439	PF00498	0.538
LIG_FHA_1	79	85	PF00498	0.450
LIG_FHA_1	98	104	PF00498	0.601
LIG_LIR_Nem_3	149	155	PF02991	0.452
LIG_LIR_Nem_3	168	173	PF02991	0.381
LIG_LIR_Nem_3	335	341	PF02991	0.635
LIG_MLH1_MIPbox_1	334	338	PF16413	0.633
LIG_MYND_1	223	227	PF01753	0.535
LIG_SH2_CRK	136	140	PF00017	0.436
LIG_SH2_STAP1	129	133	PF00017	0.554
LIG_SH2_STAT5	129	132	PF00017	0.634
LIG_SH2_STAT5	337	340	PF00017	0.638
LIG_SH2_STAT6	169	173	PF00017	0.393
LIG_SH3_1	221	227	PF00018	0.538
LIG_SH3_3	104	110	PF00018	0.677
LIG_SH3_3	132	138	PF00018	0.600
LIG_SH3_3	17	23	PF00018	0.638
LIG_SH3_3	220	226	PF00018	0.562
LIG_SH3_3	228	234	PF00018	0.565
LIG_SH3_3	237	243	PF00018	0.525
LIG_SH3_3	357	363	PF00018	0.657
LIG_SH3_3	366	372	PF00018	0.732
LIG_SH3_3	395	401	PF00018	0.552
LIG_UBA3_1	163	171	PF00899	0.335
LIG_UBA3_1	253	261	PF00899	0.345
LIG_WW_2	223	226	PF00397	0.536
MOD_CK1_1	206	212	PF00069	0.651
MOD_CK1_1	316	322	PF00069	0.476
MOD_CK1_1	331	337	PF00069	0.560
MOD_CK1_1	376	382	PF00069	0.501
MOD_CK1_1	400	406	PF00069	0.505
MOD_CK2_1	174	180	PF00069	0.505
MOD_CK2_1	204	210	PF00069	0.613
MOD_CK2_1	21	27	PF00069	0.622
MOD_CK2_1	430	436	PF00069	0.643
MOD_CK2_1	46	52	PF00069	0.342
MOD_GlcNHglycan	167	170	PF01048	0.516
MOD_GlcNHglycan	23	26	PF01048	0.537
MOD_GlcNHglycan	276	279	PF01048	0.500
MOD_GlcNHglycan	35	38	PF01048	0.272
MOD_GlcNHglycan	360	363	PF01048	0.688
MOD_GlcNHglycan	423	426	PF01048	0.502
MOD_GlcNHglycan	432	435	PF01048	0.510
MOD_GlcNHglycan	445	448	PF01048	0.570
MOD_GlcNHglycan	458	461	PF01048	0.510
MOD_GSK3_1	182	189	PF00069	0.616
MOD_GSK3_1	328	335	PF00069	0.632
MOD_GSK3_1	348	355	PF00069	0.546
MOD_GSK3_1	373	380	PF00069	0.535
MOD_GSK3_1	46	53	PF00069	0.307
MOD_GSK3_1	83	90	PF00069	0.521
MOD_GSK3_1	91	98	PF00069	0.625
MOD_GSK3_1	99	106	PF00069	0.673
MOD_N-GLC_1	203	208	PF02516	0.525
MOD_N-GLC_1	257	262	PF02516	0.342
MOD_NEK2_1	127	132	PF00069	0.549
MOD_NEK2_1	214	219	PF00069	0.506
MOD_NEK2_1	274	279	PF00069	0.439
MOD_NEK2_2	129	134	PF00069	0.584
MOD_PIKK_1	127	133	PF00454	0.562
MOD_PIKK_1	214	220	PF00454	0.507
MOD_PIKK_1	293	299	PF00454	0.493
MOD_PIKK_1	316	322	PF00454	0.694
MOD_PIKK_1	50	56	PF00454	0.377
MOD_PIKK_1	6	12	PF00454	0.752
MOD_PK_1	59	65	PF00069	0.206
MOD_PK_1	83	89	PF00069	0.531
MOD_PKA_1	182	188	PF00069	0.579
MOD_PKA_2	182	188	PF00069	0.622
MOD_PKA_2	192	198	PF00069	0.611
MOD_PKA_2	293	299	PF00069	0.531
MOD_Plk_1	30	36	PF00069	0.326
MOD_Plk_1	316	322	PF00069	0.472
MOD_Plk_1	377	383	PF00069	0.572
MOD_Plk_4	129	135	PF00069	0.622
MOD_Plk_4	322	328	PF00069	0.490
MOD_Plk_4	333	339	PF00069	0.630
MOD_Plk_4	378	384	PF00069	0.496
MOD_ProDKin_1	103	109	PF00069	0.602
MOD_ProDKin_1	134	140	PF00069	0.550
MOD_ProDKin_1	174	180	PF00069	0.465
MOD_ProDKin_1	225	231	PF00069	0.534
MOD_ProDKin_1	239	245	PF00069	0.731
MOD_ProDKin_1	348	354	PF00069	0.635
MOD_ProDKin_1	394	400	PF00069	0.570
MOD_ProDKin_1	407	413	PF00069	0.711
MOD_ProDKin_1	453	459	PF00069	0.752
MOD_ProDKin_1	46	52	PF00069	0.283
MOD_ProDKin_1	87	93	PF00069	0.566
MOD_SUMO_rev_2	180	189	PF00179	0.560
MOD_SUMO_rev_2	246	253	PF00179	0.496
MOD_SUMO_rev_2	256	263	PF00179	0.400
TRG_DiLeu_BaEn_1	249	254	PF01217	0.366
TRG_DiLeu_BaLyEn_6	437	442	PF01217	0.627
TRG_ENDOCYTIC_2	136	139	PF00928	0.470
TRG_ENDOCYTIC_2	170	173	PF00928	0.517
TRG_ER_diArg_1	181	183	PF00400	0.523
TRG_ER_diArg_1	198	201	PF00400	0.567
TRG_ER_diArg_1	44	47	PF00400	0.291
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA53	Leptomonas seymouri	57%	94%
A0A1X0NHT0	Trypanosomatidae	34%	100%
A0A3S7WWU5	Leishmania donovani	71%	99%
A4HZJ0	Leishmania infantum	71%	99%
E9AVI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QBZ9	Leishmania major	71%	100%
V5BHE6	Trypanosoma cruzi	30%	100%