Putative GPI transamidase component GAA1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI transamidase component GAA1, putative

Species:

Leishmania braziliensis

UniProt:

A4HLC3_LEIBR

TriTrypDb:

LbrM.33.0870 , LBRM2903_210026800

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0008303	caspase complex	5	11
GO:0032991	protein-containing complex	1	11
GO:0042765	GPI-anchor transamidase complex	3	11
GO:0098796	membrane protein complex	2	11
GO:0140534	endoplasmic reticulum protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1905368	peptidase complex	3	11
GO:1905369	endopeptidase complex	4	11

Expansion

Sequence features

A4HLC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLC3

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016255	attachment of GPI anchor to protein	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.551
CLV_NRD_NRD_1	3	5	PF00675	0.380
CLV_NRD_NRD_1	37	39	PF00675	0.608
CLV_NRD_NRD_1	77	79	PF00675	0.590
CLV_PCSK_FUR_1	75	79	PF00082	0.604
CLV_PCSK_KEX2_1	3	5	PF00082	0.405
CLV_PCSK_KEX2_1	77	79	PF00082	0.590
CLV_PCSK_SKI1_1	136	140	PF00082	0.482
CLV_PCSK_SKI1_1	3	7	PF00082	0.421
CLV_PCSK_SKI1_1	408	412	PF00082	0.449
DEG_APCC_DBOX_1	429	437	PF00400	0.528
DEG_COP1_1	243	253	PF00400	0.181
DEG_Nend_Nbox_1	1	3	PF02207	0.582
DEG_ODPH_VHL_1	17	28	PF01847	0.349
DOC_CDC14_PxL_1	29	37	PF14671	0.404
DOC_CKS1_1	327	332	PF01111	0.349
DOC_CYCLIN_yCln2_LP_2	327	333	PF00134	0.349
DOC_MAPK_DCC_7	315	324	PF00069	0.534
DOC_MAPK_MEF2A_6	136	143	PF00069	0.236
DOC_MAPK_MEF2A_6	16	24	PF00069	0.319
DOC_MAPK_MEF2A_6	364	371	PF00069	0.434
DOC_MAPK_NFAT4_5	136	144	PF00069	0.331
DOC_MAPK_NFAT4_5	364	372	PF00069	0.429
DOC_MAPK_RevD_3	24	39	PF00069	0.349
DOC_PP2B_LxvP_1	211	214	PF13499	0.193
DOC_PP2B_LxvP_1	429	432	PF13499	0.567
DOC_PP4_FxxP_1	245	248	PF00568	0.181
DOC_USP7_MATH_1	224	228	PF00917	0.300
DOC_USP7_MATH_1	232	236	PF00917	0.306
DOC_USP7_MATH_1	415	419	PF00917	0.356
DOC_USP7_MATH_1	95	99	PF00917	0.360
DOC_WW_Pin1_4	244	249	PF00397	0.181
DOC_WW_Pin1_4	280	285	PF00397	0.181
DOC_WW_Pin1_4	317	322	PF00397	0.271
DOC_WW_Pin1_4	326	331	PF00397	0.271
DOC_WW_Pin1_4	76	81	PF00397	0.456
LIG_14-3-3_CanoR_1	242	246	PF00244	0.375
LIG_14-3-3_CanoR_1	357	367	PF00244	0.296
LIG_14-3-3_CterR_2	458	463	PF00244	0.236
LIG_Actin_WH2_2	273	288	PF00022	0.181
LIG_BRCT_BRCA1_1	176	180	PF00533	0.196
LIG_BRCT_BRCA1_1	348	352	PF00533	0.388
LIG_BRCT_BRCA1_1	439	443	PF00533	0.360
LIG_CSL_BTD_1	278	281	PF09270	0.236
LIG_deltaCOP1_diTrp_1	199	204	PF00928	0.181
LIG_eIF4E_1	134	140	PF01652	0.282
LIG_eIF4E_1	428	434	PF01652	0.421
LIG_FHA_1	191	197	PF00498	0.221
LIG_FHA_1	223	229	PF00498	0.314
LIG_FHA_1	254	260	PF00498	0.277
LIG_FHA_1	35	41	PF00498	0.503
LIG_FHA_1	399	405	PF00498	0.259
LIG_FHA_1	58	64	PF00498	0.435
LIG_GBD_Chelix_1	374	382	PF00786	0.314
LIG_IRF3_LxIS_1	139	144	PF10401	0.181
LIG_LIR_Apic_2	125	131	PF02991	0.314
LIG_LIR_Apic_2	243	248	PF02991	0.267
LIG_LIR_Gen_1	252	262	PF02991	0.339
LIG_LIR_Gen_1	275	285	PF02991	0.317
LIG_LIR_Gen_1	320	331	PF02991	0.404
LIG_LIR_Gen_1	349	360	PF02991	0.358
LIG_LIR_Gen_1	365	376	PF02991	0.385
LIG_LIR_Gen_1	440	450	PF02991	0.404
LIG_LIR_Nem_3	116	122	PF02991	0.274
LIG_LIR_Nem_3	144	150	PF02991	0.229
LIG_LIR_Nem_3	275	280	PF02991	0.239
LIG_LIR_Nem_3	306	312	PF02991	0.271
LIG_LIR_Nem_3	320	326	PF02991	0.271
LIG_LIR_Nem_3	349	355	PF02991	0.320
LIG_LIR_Nem_3	365	371	PF02991	0.432
LIG_LIR_Nem_3	440	446	PF02991	0.365
LIG_LYPXL_SIV_4	133	141	PF13949	0.282
LIG_LYPXL_SIV_4	205	213	PF13949	0.282
LIG_Pex14_2	352	356	PF04695	0.335
LIG_PTB_Apo_2	87	94	PF02174	0.337
LIG_PTB_Phospho_1	87	93	PF10480	0.372
LIG_SH2_GRB2like	167	170	PF00017	0.282
LIG_SH2_GRB2like	88	91	PF00017	0.270
LIG_SH2_NCK_1	134	138	PF00017	0.397
LIG_SH2_NCK_1	290	294	PF00017	0.236
LIG_SH2_PTP2	150	153	PF00017	0.173
LIG_SH2_SRC	206	209	PF00017	0.331
LIG_SH2_SRC	290	293	PF00017	0.267
LIG_SH2_STAP1	134	138	PF00017	0.387
LIG_SH2_STAP1	167	171	PF00017	0.379
LIG_SH2_STAT3	184	187	PF00017	0.282
LIG_SH2_STAT5	120	123	PF00017	0.272
LIG_SH2_STAT5	134	137	PF00017	0.327
LIG_SH2_STAT5	150	153	PF00017	0.381
LIG_SH2_STAT5	167	170	PF00017	0.386
LIG_SH2_STAT5	184	187	PF00017	0.202
LIG_SH2_STAT5	206	209	PF00017	0.265
LIG_SH2_STAT5	287	290	PF00017	0.236
LIG_SH2_STAT5	41	44	PF00017	0.415
LIG_SH2_STAT5	424	427	PF00017	0.311
LIG_SH2_STAT5	428	431	PF00017	0.496
LIG_SH2_STAT5	88	91	PF00017	0.275
LIG_SH3_2	281	286	PF14604	0.181
LIG_SH3_3	211	217	PF00018	0.263
LIG_SH3_3	245	251	PF00018	0.181
LIG_SH3_3	275	281	PF00018	0.236
LIG_SH3_3	444	450	PF00018	0.404
LIG_SH3_3	64	70	PF00018	0.419
LIG_SH3_5	163	167	PF00018	0.282
LIG_SUMO_SIM_par_1	229	236	PF11976	0.249
LIG_SUMO_SIM_par_1	323	329	PF11976	0.381
LIG_TRAF2_1	124	127	PF00917	0.428
LIG_TYR_ITIM	421	426	PF00017	0.404
LIG_UBA3_1	103	111	PF00899	0.292
LIG_UBA3_1	31	39	PF00899	0.419
LIG_WRC_WIRS_1	443	448	PF05994	0.289
MOD_CDC14_SPxK_1	283	286	PF00782	0.181
MOD_CDK_SPxK_1	280	286	PF00069	0.181
MOD_CK1_1	227	233	PF00069	0.311
MOD_CK1_1	303	309	PF00069	0.271
MOD_CK1_1	79	85	PF00069	0.346
MOD_CK2_1	121	127	PF00069	0.407
MOD_CMANNOS	201	204	PF00535	0.531
MOD_Cter_Amidation	75	78	PF01082	0.580
MOD_GlcNHglycan	348	351	PF01048	0.329
MOD_GlcNHglycan	364	367	PF01048	0.277
MOD_GlcNHglycan	417	420	PF01048	0.328
MOD_GSK3_1	227	234	PF00069	0.264
MOD_GSK3_1	237	244	PF00069	0.315
MOD_GSK3_1	300	307	PF00069	0.276
MOD_GSK3_1	346	353	PF00069	0.339
MOD_GSK3_1	358	365	PF00069	0.400
MOD_GSK3_1	51	58	PF00069	0.341
MOD_N-GLC_1	122	127	PF02516	0.525
MOD_N-GLC_1	141	146	PF02516	0.350
MOD_NEK2_1	141	146	PF00069	0.306
MOD_NEK2_1	174	179	PF00069	0.395
MOD_NEK2_1	207	212	PF00069	0.302
MOD_NEK2_1	272	277	PF00069	0.261
MOD_NEK2_1	300	305	PF00069	0.287
MOD_NEK2_1	360	365	PF00069	0.569
MOD_NEK2_1	367	372	PF00069	0.527
MOD_NEK2_1	400	405	PF00069	0.283
MOD_NEK2_1	442	447	PF00069	0.309
MOD_NEK2_2	237	242	PF00069	0.339
MOD_PK_1	315	321	PF00069	0.482
MOD_PKA_2	190	196	PF00069	0.347
MOD_PKA_2	241	247	PF00069	0.317
MOD_Plk_1	141	147	PF00069	0.236
MOD_Plk_1	207	213	PF00069	0.333
MOD_Plk_4	142	148	PF00069	0.296
MOD_Plk_4	180	186	PF00069	0.331
MOD_Plk_4	253	259	PF00069	0.248
MOD_Plk_4	273	279	PF00069	0.281
MOD_Plk_4	300	306	PF00069	0.190
MOD_Plk_4	400	406	PF00069	0.320
MOD_Plk_4	442	448	PF00069	0.349
MOD_ProDKin_1	244	250	PF00069	0.181
MOD_ProDKin_1	280	286	PF00069	0.181
MOD_ProDKin_1	317	323	PF00069	0.271
MOD_ProDKin_1	326	332	PF00069	0.271
MOD_ProDKin_1	76	82	PF00069	0.457
MOD_SUMO_rev_2	264	272	PF00179	0.327
TRG_ENDOCYTIC_2	150	153	PF00928	0.252
TRG_ENDOCYTIC_2	423	426	PF00928	0.404
TRG_ENDOCYTIC_2	428	431	PF00928	0.533
TRG_ER_diArg_1	107	110	PF00400	0.350
TRG_ER_diArg_1	2	4	PF00400	0.627
TRG_ER_diArg_1	35	38	PF00400	0.405
TRG_ER_diArg_1	74	77	PF00400	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2W7	Leptomonas seymouri	65%	100%
A0A1X0NIY4	Trypanosomatidae	40%	100%
A0A3R7N823	Trypanosoma rangeli	39%	99%
A0A3S7WWY8	Leishmania donovani	83%	100%
A4HZI7	Leishmania infantum	83%	100%
D0A0Y9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AVH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QC02	Leishmania major	85%	100%
V5DID2	Trypanosoma cruzi	38%	96%