40S ribosomal protein S6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S6, putative

Species:

Leishmania braziliensis

UniProt:

A4HLC0_LEIBR

TriTrypDb:

LbrM.33.0840 , LBRM2903_210026500

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	19
GO:0032991	protein-containing complex	1	19
GO:0043226	organelle	2	19
GO:0043228	non-membrane-bounded organelle	3	19
GO:0043229	intracellular organelle	3	19
GO:0043232	intracellular non-membrane-bounded organelle	4	19
GO:0110165	cellular anatomical entity	1	19
GO:1990904	ribonucleoprotein complex	2	19
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HLC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLC0

PDB structure(s): 5osg_P

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	19
GO:0006518	peptide metabolic process	4	19
GO:0006807	nitrogen compound metabolic process	2	19
GO:0008152	metabolic process	1	19
GO:0009058	biosynthetic process	2	19
GO:0009059	macromolecule biosynthetic process	4	19
GO:0009987	cellular process	1	19
GO:0019538	protein metabolic process	3	19
GO:0034641	cellular nitrogen compound metabolic process	3	19
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	19
GO:0043043	peptide biosynthetic process	5	19
GO:0043170	macromolecule metabolic process	3	19
GO:0043603	amide metabolic process	3	19
GO:0043604	amide biosynthetic process	4	19
GO:0044237	cellular metabolic process	2	19
GO:0044238	primary metabolic process	2	19
GO:0044249	cellular biosynthetic process	3	19
GO:0044260	obsolete cellular macromolecule metabolic process	3	19
GO:0044271	cellular nitrogen compound biosynthetic process	4	19
GO:0071704	organic substance metabolic process	2	19
GO:1901564	organonitrogen compound metabolic process	3	19
GO:1901566	organonitrogen compound biosynthetic process	4	19
GO:1901576	organic substance biosynthetic process	3	19

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	19
GO:0005198	structural molecule activity	1	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.352
CLV_NRD_NRD_1	134	136	PF00675	0.483
CLV_NRD_NRD_1	144	146	PF00675	0.394
CLV_NRD_NRD_1	157	159	PF00675	0.418
CLV_NRD_NRD_1	163	165	PF00675	0.418
CLV_NRD_NRD_1	190	192	PF00675	0.436
CLV_NRD_NRD_1	209	211	PF00675	0.418
CLV_NRD_NRD_1	220	222	PF00675	0.533
CLV_NRD_NRD_1	24	26	PF00675	0.304
CLV_NRD_NRD_1	96	98	PF00675	0.323
CLV_PCSK_KEX2_1	134	136	PF00082	0.483
CLV_PCSK_KEX2_1	139	141	PF00082	0.396
CLV_PCSK_KEX2_1	157	159	PF00082	0.418
CLV_PCSK_KEX2_1	162	164	PF00082	0.426
CLV_PCSK_KEX2_1	190	192	PF00082	0.436
CLV_PCSK_KEX2_1	209	211	PF00082	0.418
CLV_PCSK_KEX2_1	220	222	PF00082	0.463
CLV_PCSK_KEX2_1	24	26	PF00082	0.304
CLV_PCSK_KEX2_1	79	81	PF00082	0.295
CLV_PCSK_KEX2_1	95	97	PF00082	0.321
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.396
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.291
CLV_PCSK_PC7_1	135	141	PF00082	0.425
CLV_PCSK_PC7_1	158	164	PF00082	0.345
CLV_PCSK_SKI1_1	145	149	PF00082	0.416
CLV_PCSK_SKI1_1	163	167	PF00082	0.425
CLV_PCSK_SKI1_1	181	185	PF00082	0.364
CLV_PCSK_SKI1_1	190	194	PF00082	0.437
CLV_PCSK_SKI1_1	220	224	PF00082	0.617
CLV_Separin_Metazoa	21	25	PF03568	0.335
DEG_APCC_DBOX_1	209	217	PF00400	0.428
DEG_Nend_UBRbox_1	1	4	PF02207	0.311
DOC_CKS1_1	182	187	PF01111	0.562
DOC_CYCLIN_RxL_1	139	151	PF00134	0.502
DOC_MAPK_gen_1	209	215	PF00069	0.479
DOC_MAPK_gen_1	79	85	PF00069	0.314
DOC_MAPK_RevD_3	177	191	PF00069	0.436
DOC_PP2B_LxvP_1	174	177	PF13499	0.526
DOC_USP7_UBL2_3	139	143	PF12436	0.465
DOC_USP7_UBL2_3	167	171	PF12436	0.452
DOC_USP7_UBL2_3	231	235	PF12436	0.635
DOC_WW_Pin1_4	181	186	PF00397	0.544
LIG_14-3-3_CanoR_1	214	223	PF00244	0.432
LIG_14-3-3_CanoR_1	73	77	PF00244	0.311
LIG_Actin_WH2_2	153	169	PF00022	0.342
LIG_FHA_1	151	157	PF00498	0.527
LIG_FHA_1	182	188	PF00498	0.434
LIG_FHA_1	231	237	PF00498	0.591
LIG_LIR_Gen_1	211	217	PF02991	0.468
LIG_LIR_Nem_3	211	215	PF02991	0.472
LIG_LIR_Nem_3	45	49	PF02991	0.332
LIG_LIR_Nem_3	60	65	PF02991	0.299
LIG_LIR_Nem_3	87	91	PF02991	0.354
LIG_PCNA_APIM_2	156	162	PF02747	0.400
LIG_Pex14_2	42	46	PF04695	0.315
LIG_SH2_STAT5	159	162	PF00017	0.423
LIG_SH2_STAT5	212	215	PF00017	0.467
LIG_SH2_STAT5	49	52	PF00017	0.316
LIG_SH3_3	60	66	PF00018	0.322
LIG_SUMO_SIM_anti_2	107	113	PF11976	0.293
LIG_SUMO_SIM_anti_2	71	78	PF11976	0.321
LIG_WRC_WIRS_1	85	90	PF05994	0.355
MOD_CDK_SPK_2	181	186	PF00069	0.607
MOD_CDK_SPxxK_3	181	188	PF00069	0.567
MOD_CK1_1	72	78	PF00069	0.311
MOD_CK2_1	148	154	PF00069	0.493
MOD_CK2_1	202	208	PF00069	0.425
MOD_Cter_Amidation	168	171	PF01082	0.456
MOD_GlcNHglycan	167	170	PF01048	0.654
MOD_GlcNHglycan	204	207	PF01048	0.423
MOD_GSK3_1	226	233	PF00069	0.683
MOD_GSK3_1	68	75	PF00069	0.422
MOD_LATS_1	228	234	PF00433	0.654
MOD_N-GLC_1	112	117	PF02516	0.393
MOD_N-GLC_1	148	153	PF02516	0.441
MOD_N-GLC_1	9	14	PF02516	0.291
MOD_NEK2_1	148	153	PF00069	0.541
MOD_NEK2_1	215	220	PF00069	0.485
MOD_NEK2_1	69	74	PF00069	0.427
MOD_NEK2_2	84	89	PF00069	0.322
MOD_PIKK_1	235	241	PF00454	0.460
MOD_PKA_1	139	145	PF00069	0.562
MOD_PKA_1	230	236	PF00069	0.622
MOD_PKA_2	139	145	PF00069	0.562
MOD_PKA_2	202	208	PF00069	0.422
MOD_PKA_2	72	78	PF00069	0.311
MOD_PKB_1	224	232	PF00069	0.646
MOD_PKB_1	52	60	PF00069	0.458
MOD_Plk_1	112	118	PF00069	0.362
MOD_Plk_4	72	78	PF00069	0.325
MOD_ProDKin_1	181	187	PF00069	0.539
TRG_DiLeu_BaEn_1	211	216	PF01217	0.480
TRG_DiLeu_LyEn_5	211	216	PF01217	0.506
TRG_ENDOCYTIC_2	212	215	PF00928	0.467
TRG_ER_diArg_1	133	135	PF00400	0.486
TRG_ER_diArg_1	156	158	PF00400	0.401
TRG_ER_diArg_1	161	164	PF00400	0.423
TRG_ER_diArg_1	223	226	PF00400	0.498
TRG_ER_diArg_1	23	25	PF00400	0.302
TRG_ER_diArg_1	51	54	PF00400	0.458
TRG_ER_diArg_1	95	97	PF00400	0.291
TRG_NES_CRM1_1	17	30	PF08389	0.422
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.619

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6J8	Leptomonas seymouri	91%	100%
A0A0S4IXL4	Bodo saltans	73%	100%
A0A0S4JEL0	Bodo saltans	70%	94%
A0A1D8PL99	Candida albicans (strain SC5314 / ATCC MYA-2876)	51%	100%
A0A1X0NHJ4	Trypanosomatidae	74%	100%
A0A1X0P5W5	Trypanosomatidae	71%	100%
A0A3R7K8Y0	Trypanosoma rangeli	74%	100%
A0A3S7WWY7	Leishmania donovani	96%	100%
A0A3S7X972	Leishmania donovani	96%	100%
A0A422NNU2	Trypanosoma rangeli	73%	100%
A4HMM1	Leishmania braziliensis	100%	100%
A4HZI4	Leishmania infantum	96%	100%
C9ZZM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
D0A0Y7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	91%
E9AF23	Leishmania major	96%	100%
E9AVH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O01727	Branchiostoma floridae	45%	100%
O44012	Leishmania infantum	96%	100%
O48549	Arabidopsis thaliana	43%	100%
P05752	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
P0CX37	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	100%
P0CX38	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	53%	100%
P29327	Drosophila melanogaster	48%	100%
P29345	Nicotiana tabacum	40%	100%
P39017	Xenopus laevis	46%	100%
P41798	Kluyveromyces marxianus	54%	100%
P47838	Gallus gallus	48%	100%
P51430	Arabidopsis thaliana	47%	100%
P62753	Homo sapiens	49%	100%
P62754	Mus musculus	49%	100%
P62755	Rattus norvegicus	49%	100%
Q2PQM1	Glossina morsitans morsitans	46%	100%
Q4R4K6	Macaca fascicularis	49%	100%
Q54UU3	Dictyostelium discoideum	48%	100%
Q5E995	Bos taurus	49%	100%
Q6BXH8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	48%	100%
Q6C169	Yarrowia lipolytica (strain CLIB 122 / E 150)	48%	100%
Q6CM04	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	49%	100%
Q6FJH3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	53%	100%
Q74ZK3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	52%	100%
Q8SRY0	Encephalitozoon cuniculi (strain GB-M1)	38%	100%
Q90YR8	Ictalurus punctatus	45%	100%
Q94624	Manduca sexta	45%	98%
Q95V32	Spodoptera frugiperda	45%	98%
Q9BMX5	Aplysia californica	46%	100%
Q9C0Z7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	100%
Q9M3V8	Asparagus officinalis	46%	99%
Q9NE83	Leishmania major	96%	100%
Q9NEN6	Caenorhabditis elegans	42%	100%
Q9U761	Aedes aegypti	44%	72%
Q9U762	Aedes albopictus	44%	71%
Q9YGF2	Oncorhynchus mykiss	46%	100%
V5B8X2	Trypanosoma cruzi	73%	100%