Putative G1 cyclin CycE4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

G1 cyclin CycE4, putative

Species:

Leishmania braziliensis

UniProt:

A4HLB8_LEIBR

TriTrypDb:

LbrM.33.0820 , LBRM2903_330014400

Length:

881

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLB8

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	7
GO:0001932	regulation of protein phosphorylation	7	7
GO:0019220	regulation of phosphate metabolic process	6	7
GO:0019222	regulation of metabolic process	3	7
GO:0031323	regulation of cellular metabolic process	4	7
GO:0031399	regulation of protein modification process	6	7
GO:0042325	regulation of phosphorylation	7	7
GO:0043549	regulation of kinase activity	5	7
GO:0045859	regulation of protein kinase activity	6	7
GO:0050789	regulation of biological process	2	7
GO:0050790	regulation of catalytic activity	3	7
GO:0050794	regulation of cellular process	3	7
GO:0051171	regulation of nitrogen compound metabolic process	4	7
GO:0051174	regulation of phosphorus metabolic process	5	7
GO:0051246	regulation of protein metabolic process	5	7
GO:0051338	regulation of transferase activity	4	7
GO:0051726	regulation of cell cycle	4	7
GO:0060255	regulation of macromolecule metabolic process	4	7
GO:0065007	biological regulation	1	7
GO:0065009	regulation of molecular function	2	7
GO:0071900	regulation of protein serine/threonine kinase activity	7	7
GO:0080090	regulation of primary metabolic process	4	7
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	7

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0019899	enzyme binding	3	7
GO:0019900	kinase binding	4	7
GO:0019901	protein kinase binding	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	441	445	PF00656	0.627
CLV_NRD_NRD_1	296	298	PF00675	0.488
CLV_NRD_NRD_1	466	468	PF00675	0.767
CLV_NRD_NRD_1	52	54	PF00675	0.512
CLV_NRD_NRD_1	527	529	PF00675	0.513
CLV_NRD_NRD_1	758	760	PF00675	0.696
CLV_NRD_NRD_1	871	873	PF00675	0.500
CLV_PCSK_FUR_1	577	581	PF00082	0.517
CLV_PCSK_FUR_1	869	873	PF00082	0.494
CLV_PCSK_KEX2_1	296	298	PF00082	0.488
CLV_PCSK_KEX2_1	466	468	PF00082	0.767
CLV_PCSK_KEX2_1	52	54	PF00082	0.512
CLV_PCSK_KEX2_1	527	529	PF00082	0.513
CLV_PCSK_KEX2_1	579	581	PF00082	0.587
CLV_PCSK_KEX2_1	612	614	PF00082	0.628
CLV_PCSK_KEX2_1	758	760	PF00082	0.696
CLV_PCSK_KEX2_1	871	873	PF00082	0.500
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.520
CLV_PCSK_PC1ET2_1	612	614	PF00082	0.628
CLV_PCSK_SKI1_1	324	328	PF00082	0.524
CLV_PCSK_SKI1_1	403	407	PF00082	0.514
CLV_PCSK_SKI1_1	466	470	PF00082	0.725
CLV_PCSK_SKI1_1	52	56	PF00082	0.391
CLV_PCSK_SKI1_1	532	536	PF00082	0.659
CLV_PCSK_SKI1_1	568	572	PF00082	0.493
CLV_PCSK_SKI1_1	624	628	PF00082	0.583
CLV_PCSK_SKI1_1	872	876	PF00082	0.489
DEG_APCC_DBOX_1	262	270	PF00400	0.303
DEG_APCC_DBOX_1	486	494	PF00400	0.489
DEG_APCC_DBOX_1	634	642	PF00400	0.629
DEG_SCF_FBW7_1	299	305	PF00400	0.464
DEG_SPOP_SBC_1	366	370	PF00917	0.533
DOC_CKS1_1	299	304	PF01111	0.458
DOC_CKS1_1	689	694	PF01111	0.540
DOC_CYCLIN_yCln2_LP_2	417	423	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	437	440	PF00134	0.447
DOC_CYCLIN_yCln2_LP_2	516	522	PF00134	0.518
DOC_MAPK_DCC_7	140	150	PF00069	0.531
DOC_MAPK_DCC_7	466	475	PF00069	0.556
DOC_MAPK_gen_1	527	533	PF00069	0.515
DOC_MAPK_HePTP_8	463	475	PF00069	0.578
DOC_MAPK_MEF2A_6	191	198	PF00069	0.365
DOC_MAPK_MEF2A_6	466	475	PF00069	0.556
DOC_PP2B_LxvP_1	10	13	PF13499	0.609
DOC_PP2B_LxvP_1	417	420	PF13499	0.601
DOC_PP2B_LxvP_1	437	440	PF13499	0.447
DOC_PP2B_LxvP_1	481	484	PF13499	0.592
DOC_PP2B_LxvP_1	520	523	PF13499	0.807
DOC_PP2B_LxvP_1	653	656	PF13499	0.710
DOC_PP4_FxxP_1	115	118	PF00568	0.610
DOC_PP4_FxxP_1	469	472	PF00568	0.623
DOC_PP4_FxxP_1	689	692	PF00568	0.537
DOC_PP4_FxxP_1	84	87	PF00568	0.652
DOC_USP7_MATH_1	251	255	PF00917	0.370
DOC_USP7_MATH_1	302	306	PF00917	0.487
DOC_USP7_MATH_1	326	330	PF00917	0.598
DOC_USP7_MATH_1	385	389	PF00917	0.555
DOC_USP7_MATH_1	399	403	PF00917	0.555
DOC_USP7_MATH_1	428	432	PF00917	0.616
DOC_USP7_MATH_1	551	555	PF00917	0.521
DOC_USP7_MATH_1	693	697	PF00917	0.620
DOC_USP7_MATH_1	753	757	PF00917	0.578
DOC_USP7_MATH_1	772	776	PF00917	0.602
DOC_USP7_MATH_1	780	784	PF00917	0.576
DOC_USP7_MATH_1	87	91	PF00917	0.717
DOC_WW_Pin1_4	138	143	PF00397	0.739
DOC_WW_Pin1_4	298	303	PF00397	0.455
DOC_WW_Pin1_4	318	323	PF00397	0.553
DOC_WW_Pin1_4	348	353	PF00397	0.635
DOC_WW_Pin1_4	499	504	PF00397	0.562
DOC_WW_Pin1_4	515	520	PF00397	0.586
DOC_WW_Pin1_4	688	693	PF00397	0.536
DOC_WW_Pin1_4	759	764	PF00397	0.619
DOC_WW_Pin1_4	83	88	PF00397	0.727
DOC_WW_Pin1_4	874	879	PF00397	0.565
DOC_WW_Pin1_4	90	95	PF00397	0.802
LIG_14-3-3_CanoR_1	206	210	PF00244	0.226
LIG_14-3-3_CanoR_1	225	233	PF00244	0.494
LIG_14-3-3_CanoR_1	367	376	PF00244	0.531
LIG_14-3-3_CanoR_1	377	384	PF00244	0.527
LIG_14-3-3_CanoR_1	430	440	PF00244	0.633
LIG_14-3-3_CanoR_1	489	494	PF00244	0.566
LIG_14-3-3_CanoR_1	5	11	PF00244	0.566
LIG_14-3-3_CanoR_1	532	541	PF00244	0.526
LIG_14-3-3_CanoR_1	589	593	PF00244	0.540
LIG_14-3-3_CanoR_1	661	667	PF00244	0.589
LIG_14-3-3_CanoR_1	681	685	PF00244	0.614
LIG_14-3-3_CanoR_1	694	703	PF00244	0.516
LIG_14-3-3_CanoR_1	761	767	PF00244	0.544
LIG_14-3-3_CanoR_1	871	881	PF00244	0.638
LIG_14-3-3_CanoR_1	88	95	PF00244	0.713
LIG_14-3-3_CanoR_1	97	103	PF00244	0.575
LIG_Actin_WH2_2	264	281	PF00022	0.365
LIG_Actin_WH2_2	417	432	PF00022	0.489
LIG_Clathr_ClatBox_1	271	275	PF01394	0.365
LIG_Clathr_ClatBox_1	287	291	PF01394	0.287
LIG_deltaCOP1_diTrp_1	284	289	PF00928	0.437
LIG_EVH1_1	702	706	PF00568	0.655
LIG_EVH1_2	529	533	PF00568	0.512
LIG_FHA_1	114	120	PF00498	0.601
LIG_FHA_1	226	232	PF00498	0.303
LIG_FHA_1	290	296	PF00498	0.427
LIG_FHA_1	340	346	PF00498	0.750
LIG_FHA_1	349	355	PF00498	0.610
LIG_FHA_1	416	422	PF00498	0.628
LIG_FHA_1	628	634	PF00498	0.588
LIG_FHA_2	260	266	PF00498	0.394
LIG_FHA_2	330	336	PF00498	0.638
LIG_FHA_2	342	348	PF00498	0.533
LIG_FHA_2	643	649	PF00498	0.543
LIG_FXI_DFP_1	271	275	PF00024	0.303
LIG_LIR_Apic_2	688	692	PF02991	0.535
LIG_LIR_Apic_2	81	87	PF02991	0.616
LIG_LIR_Gen_1	213	221	PF02991	0.411
LIG_LIR_Gen_1	265	276	PF02991	0.303
LIG_LIR_Gen_1	33	43	PF02991	0.402
LIG_LIR_Gen_1	378	385	PF02991	0.530
LIG_LIR_Gen_1	444	455	PF02991	0.613
LIG_LIR_Gen_1	488	498	PF02991	0.488
LIG_LIR_Nem_3	154	159	PF02991	0.520
LIG_LIR_Nem_3	213	218	PF02991	0.336
LIG_LIR_Nem_3	265	271	PF02991	0.307
LIG_LIR_Nem_3	273	277	PF02991	0.342
LIG_LIR_Nem_3	33	38	PF02991	0.418
LIG_LIR_Nem_3	378	382	PF02991	0.530
LIG_LIR_Nem_3	444	450	PF02991	0.634
LIG_LIR_Nem_3	488	494	PF02991	0.486
LIG_LIR_Nem_3	701	705	PF02991	0.662
LIG_LIR_Nem_3	819	825	PF02991	0.623
LIG_LIR_Nem_3	827	833	PF02991	0.525
LIG_LIR_Nem_3	840	846	PF02991	0.528
LIG_REV1ctd_RIR_1	531	539	PF16727	0.601
LIG_SH2_SRC	238	241	PF00017	0.303
LIG_SH2_SRC	423	426	PF00017	0.491
LIG_SH2_SRC	803	806	PF00017	0.692
LIG_SH2_SRC	825	828	PF00017	0.455
LIG_SH2_STAP1	39	43	PF00017	0.364
LIG_SH2_STAP1	781	785	PF00017	0.670
LIG_SH2_STAT5	203	206	PF00017	0.365
LIG_SH2_STAT5	270	273	PF00017	0.435
LIG_SH2_STAT5	306	309	PF00017	0.541
LIG_SH2_STAT5	383	386	PF00017	0.502
LIG_SH2_STAT5	423	426	PF00017	0.491
LIG_SH2_STAT5	600	603	PF00017	0.526
LIG_SH2_STAT5	830	833	PF00017	0.569
LIG_SH2_STAT5	846	849	PF00017	0.508
LIG_SH2_STAT5	866	869	PF00017	0.619
LIG_SH3_2	425	430	PF14604	0.569
LIG_SH3_2	541	546	PF14604	0.546
LIG_SH3_2	703	708	PF14604	0.517
LIG_SH3_3	107	113	PF00018	0.596
LIG_SH3_3	139	145	PF00018	0.624
LIG_SH3_3	296	302	PF00018	0.371
LIG_SH3_3	422	428	PF00018	0.581
LIG_SH3_3	468	474	PF00018	0.576
LIG_SH3_3	477	483	PF00018	0.560
LIG_SH3_3	495	501	PF00018	0.469
LIG_SH3_3	516	522	PF00018	0.534
LIG_SH3_3	538	544	PF00018	0.536
LIG_SH3_3	637	643	PF00018	0.630
LIG_SH3_3	700	706	PF00018	0.662
LIG_SH3_3	732	738	PF00018	0.644
LIG_SH3_3	746	752	PF00018	0.598
LIG_SH3_3	787	793	PF00018	0.527
LIG_SUMO_SIM_par_1	146	152	PF11976	0.520
LIG_TRAF2_1	163	166	PF00917	0.741
LIG_TRAF2_1	257	260	PF00917	0.225
LIG_TRAF2_1	42	45	PF00917	0.439
LIG_TRAF2_1	848	851	PF00917	0.536
LIG_WW_2	471	474	PF00397	0.500
LIG_WW_3	691	695	PF00397	0.676
MOD_CDC14_SPxK_1	321	324	PF00782	0.511
MOD_CDC14_SPxK_1	518	521	PF00782	0.665
MOD_CDC14_SPxK_1	766	769	PF00782	0.543
MOD_CDK_SPK_2	759	764	PF00069	0.549
MOD_CDK_SPK_2	83	88	PF00069	0.643
MOD_CDK_SPxK_1	318	324	PF00069	0.502
MOD_CDK_SPxK_1	515	521	PF00069	0.652
MOD_CDK_SPxK_1	688	694	PF00069	0.538
MOD_CDK_SPxK_1	763	769	PF00069	0.543
MOD_CDK_SPxxK_3	90	97	PF00069	0.526
MOD_CK1_1	149	155	PF00069	0.734
MOD_CK1_1	329	335	PF00069	0.560
MOD_CK1_1	369	375	PF00069	0.648
MOD_CK1_1	388	394	PF00069	0.470
MOD_CK1_1	398	404	PF00069	0.478
MOD_CK1_1	431	437	PF00069	0.614
MOD_CK1_1	448	454	PF00069	0.492
MOD_CK1_1	502	508	PF00069	0.616
MOD_CK1_1	515	521	PF00069	0.534
MOD_CK1_1	536	542	PF00069	0.615
MOD_CK1_1	604	610	PF00069	0.512
MOD_CK1_1	671	677	PF00069	0.714
MOD_CK1_1	688	694	PF00069	0.593
MOD_CK1_1	698	704	PF00069	0.578
MOD_CK1_1	775	781	PF00069	0.659
MOD_CK1_1	80	86	PF00069	0.588
MOD_CK1_1	90	96	PF00069	0.671
MOD_CK2_1	259	265	PF00069	0.414
MOD_CK2_1	278	284	PF00069	0.461
MOD_CK2_1	329	335	PF00069	0.641
MOD_CK2_1	341	347	PF00069	0.538
MOD_CK2_1	642	648	PF00069	0.537
MOD_CK2_1	806	812	PF00069	0.688
MOD_CK2_1	845	851	PF00069	0.531
MOD_CMANNOS	286	289	PF00535	0.364
MOD_DYRK1A_RPxSP_1	759	763	PF00069	0.545
MOD_GlcNHglycan	129	133	PF01048	0.579
MOD_GlcNHglycan	23	26	PF01048	0.582
MOD_GlcNHglycan	253	256	PF01048	0.372
MOD_GlcNHglycan	310	313	PF01048	0.713
MOD_GlcNHglycan	371	374	PF01048	0.575
MOD_GlcNHglycan	397	400	PF01048	0.570
MOD_GlcNHglycan	430	433	PF01048	0.657
MOD_GlcNHglycan	447	450	PF01048	0.495
MOD_GlcNHglycan	512	515	PF01048	0.483
MOD_GlcNHglycan	564	567	PF01048	0.510
MOD_GlcNHglycan	590	593	PF01048	0.609
MOD_GlcNHglycan	603	606	PF01048	0.522
MOD_GlcNHglycan	670	673	PF01048	0.673
MOD_GlcNHglycan	675	678	PF01048	0.707
MOD_GlcNHglycan	697	700	PF01048	0.598
MOD_GlcNHglycan	755	758	PF01048	0.564
MOD_GlcNHglycan	774	777	PF01048	0.618
MOD_GlcNHglycan	89	92	PF01048	0.735
MOD_GSK3_1	1	8	PF00069	0.652
MOD_GSK3_1	151	158	PF00069	0.587
MOD_GSK3_1	210	217	PF00069	0.335
MOD_GSK3_1	298	305	PF00069	0.503
MOD_GSK3_1	325	332	PF00069	0.571
MOD_GSK3_1	337	344	PF00069	0.503
MOD_GSK3_1	348	355	PF00069	0.616
MOD_GSK3_1	362	369	PF00069	0.536
MOD_GSK3_1	395	402	PF00069	0.544
MOD_GSK3_1	428	435	PF00069	0.522
MOD_GSK3_1	485	492	PF00069	0.491
MOD_GSK3_1	671	678	PF00069	0.753
MOD_GSK3_1	694	701	PF00069	0.539
MOD_GSK3_1	721	728	PF00069	0.671
MOD_GSK3_1	753	760	PF00069	0.594
MOD_GSK3_1	76	83	PF00069	0.679
MOD_GSK3_1	771	778	PF00069	0.610
MOD_GSK3_1	86	93	PF00069	0.674
MOD_LATS_1	126	132	PF00433	0.658
MOD_N-GLC_1	786	791	PF02516	0.531
MOD_N-GLC_2	247	249	PF02516	0.365
MOD_NEK2_1	119	124	PF00069	0.649
MOD_NEK2_1	176	181	PF00069	0.410
MOD_NEK2_1	216	221	PF00069	0.338
MOD_NEK2_1	226	231	PF00069	0.405
MOD_NEK2_1	250	255	PF00069	0.489
MOD_NEK2_1	308	313	PF00069	0.520
MOD_NEK2_1	443	448	PF00069	0.595
MOD_NEK2_1	485	490	PF00069	0.486
MOD_NEK2_1	512	517	PF00069	0.546
MOD_NEK2_1	533	538	PF00069	0.603
MOD_NEK2_1	627	632	PF00069	0.583
MOD_NEK2_1	77	82	PF00069	0.566
MOD_PIKK_1	377	383	PF00454	0.510
MOD_PIKK_1	533	539	PF00454	0.635
MOD_PIKK_1	61	67	PF00454	0.584
MOD_PIKK_1	662	668	PF00454	0.698
MOD_PIKK_1	775	781	PF00454	0.668
MOD_PK_1	489	495	PF00069	0.571
MOD_PK_1	521	527	PF00069	0.662
MOD_PKA_1	52	58	PF00069	0.392
MOD_PKA_2	205	211	PF00069	0.327
MOD_PKA_2	224	230	PF00069	0.368
MOD_PKA_2	251	257	PF00069	0.309
MOD_PKA_2	329	335	PF00069	0.529
MOD_PKA_2	366	372	PF00069	0.529
MOD_PKA_2	510	516	PF00069	0.487
MOD_PKA_2	52	58	PF00069	0.462
MOD_PKA_2	588	594	PF00069	0.552
MOD_PKA_2	61	67	PF00069	0.563
MOD_PKA_2	660	666	PF00069	0.630
MOD_PKA_2	680	686	PF00069	0.573
MOD_PKA_2	693	699	PF00069	0.679
MOD_PKA_2	757	763	PF00069	0.549
MOD_PKA_2	87	93	PF00069	0.674
MOD_PKB_1	487	495	PF00069	0.493
MOD_Plk_1	168	174	PF00069	0.593
MOD_Plk_1	259	265	PF00069	0.365
MOD_Plk_1	362	368	PF00069	0.578
MOD_Plk_1	648	654	PF00069	0.699
MOD_Plk_1	786	792	PF00069	0.531
MOD_Plk_2-3	28	34	PF00069	0.512
MOD_Plk_2-3	845	851	PF00069	0.531
MOD_Plk_4	177	183	PF00069	0.402
MOD_Plk_4	302	308	PF00069	0.561
MOD_Plk_4	310	316	PF00069	0.479
MOD_Plk_4	353	359	PF00069	0.542
MOD_Plk_4	432	438	PF00069	0.638
MOD_Plk_4	629	635	PF00069	0.594
MOD_Plk_4	722	728	PF00069	0.577
MOD_ProDKin_1	138	144	PF00069	0.739
MOD_ProDKin_1	298	304	PF00069	0.460
MOD_ProDKin_1	318	324	PF00069	0.557
MOD_ProDKin_1	348	354	PF00069	0.638
MOD_ProDKin_1	499	505	PF00069	0.557
MOD_ProDKin_1	515	521	PF00069	0.590
MOD_ProDKin_1	688	694	PF00069	0.538
MOD_ProDKin_1	759	765	PF00069	0.620
MOD_ProDKin_1	83	89	PF00069	0.731
MOD_ProDKin_1	874	880	PF00069	0.568
MOD_ProDKin_1	90	96	PF00069	0.798
TRG_DiLeu_BaEn_4	259	265	PF01217	0.225
TRG_DiLeu_BaEn_4	648	654	PF01217	0.699
TRG_ENDOCYTIC_2	560	563	PF00928	0.515
TRG_ENDOCYTIC_2	702	705	PF00928	0.656
TRG_ER_diArg_1	295	297	PF00400	0.470
TRG_ER_diArg_1	487	490	PF00400	0.574
TRG_ER_diArg_1	52	54	PF00400	0.510
TRG_ER_diArg_1	527	529	PF00400	0.513
TRG_ER_diArg_1	758	761	PF00400	0.560
TRG_ER_diArg_1	869	872	PF00400	0.576
TRG_NES_CRM1_1	267	282	PF08389	0.311
TRG_NES_CRM1_1	285	298	PF08389	0.286
TRG_Pf-PMV_PEXEL_1	128	133	PF00026	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P0V4	Trypanosomatidae	30%	73%
A0A3Q8IDM6	Leishmania donovani	71%	100%
A4I8U4	Leishmania infantum	71%	100%
E9B3R0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	99%
Q4Q4C8	Leishmania major	70%	100%