Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLB7_LEIBR

TriTrypDb:

LbrM.33.0810 , LBRM2903_330013600

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLB7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.703
CLV_C14_Caspase3-7	227	231	PF00656	0.598
CLV_C14_Caspase3-7	267	271	PF00656	0.578
CLV_NRD_NRD_1	161	163	PF00675	0.697
CLV_NRD_NRD_1	168	170	PF00675	0.643
CLV_NRD_NRD_1	275	277	PF00675	0.604
CLV_PCSK_FUR_1	159	163	PF00082	0.692
CLV_PCSK_FUR_1	273	277	PF00082	0.506
CLV_PCSK_KEX2_1	161	163	PF00082	0.697
CLV_PCSK_KEX2_1	168	170	PF00082	0.643
CLV_PCSK_KEX2_1	275	277	PF00082	0.600
DEG_Nend_Nbox_1	1	3	PF02207	0.570
DEG_SCF_FBW7_1	10	17	PF00400	0.499
DEG_SCF_FBW7_1	200	207	PF00400	0.697
DOC_CKS1_1	255	260	PF01111	0.586
DOC_MAPK_DCC_7	168	177	PF00069	0.547
DOC_MAPK_MEF2A_6	168	177	PF00069	0.547
DOC_PP4_FxxP_1	2	5	PF00568	0.668
DOC_USP7_MATH_1	120	124	PF00917	0.639
DOC_USP7_MATH_1	128	132	PF00917	0.722
DOC_USP7_MATH_1	14	18	PF00917	0.510
DOC_USP7_MATH_1	176	180	PF00917	0.806
DOC_USP7_MATH_1	188	192	PF00917	0.608
DOC_USP7_MATH_1	204	208	PF00917	0.596
DOC_USP7_MATH_1	218	222	PF00917	0.630
DOC_USP7_MATH_1	228	232	PF00917	0.535
DOC_USP7_MATH_1	297	301	PF00917	0.767
DOC_USP7_MATH_1	341	345	PF00917	0.485
DOC_USP7_MATH_1	375	379	PF00917	0.634
DOC_USP7_MATH_1	390	394	PF00917	0.686
DOC_USP7_MATH_1	81	85	PF00917	0.617
DOC_USP7_MATH_1	99	103	PF00917	0.659
DOC_WW_Pin1_4	10	15	PF00397	0.548
DOC_WW_Pin1_4	150	155	PF00397	0.725
DOC_WW_Pin1_4	167	172	PF00397	0.577
DOC_WW_Pin1_4	192	197	PF00397	0.611
DOC_WW_Pin1_4	200	205	PF00397	0.592
DOC_WW_Pin1_4	25	30	PF00397	0.726
DOC_WW_Pin1_4	254	259	PF00397	0.586
DOC_WW_Pin1_4	302	307	PF00397	0.529
DOC_WW_Pin1_4	357	362	PF00397	0.671
DOC_WW_Pin1_4	371	376	PF00397	0.601
DOC_WW_Pin1_4	83	88	PF00397	0.748
LIG_14-3-3_CanoR_1	273	281	PF00244	0.501
LIG_14-3-3_CanoR_1	298	302	PF00244	0.630
LIG_14-3-3_CanoR_1	369	373	PF00244	0.625
LIG_FHA_1	291	297	PF00498	0.517
LIG_FHA_1	312	318	PF00498	0.428
LIG_FHA_1	93	99	PF00498	0.541
LIG_FHA_2	11	17	PF00498	0.500
LIG_FHA_2	137	143	PF00498	0.711
LIG_FHA_2	225	231	PF00498	0.578
LIG_FHA_2	314	320	PF00498	0.555
LIG_LIR_Gen_1	4	15	PF02991	0.483
LIG_LIR_Nem_3	4	10	PF02991	0.475
LIG_LIR_Nem_3	71	77	PF02991	0.559
LIG_LYPXL_yS_3	74	77	PF13949	0.573
LIG_PCNA_yPIPBox_3	31	41	PF02747	0.652
LIG_RPA_C_Fungi	156	168	PF08784	0.532
LIG_SH2_CRK	7	11	PF00017	0.486
LIG_SH2_STAT5	263	266	PF00017	0.592
LIG_SH3_3	252	258	PF00018	0.586
LIG_SH3_3	369	375	PF00018	0.535
LIG_SH3_3	394	400	PF00018	0.541
LIG_SUMO_SIM_par_1	60	66	PF11976	0.650
LIG_TRAF2_1	33	36	PF00917	0.563
LIG_TYR_ITIM	72	77	PF00017	0.561
MOD_CDK_SPK_2	200	205	PF00069	0.602
MOD_CK1_1	131	137	PF00069	0.662
MOD_CK1_1	150	156	PF00069	0.678
MOD_CK1_1	17	23	PF00069	0.734
MOD_CK1_1	191	197	PF00069	0.621
MOD_CK1_1	199	205	PF00069	0.643
MOD_CK1_1	212	218	PF00069	0.710
MOD_CK1_1	283	289	PF00069	0.600
MOD_CK1_1	371	377	PF00069	0.562
MOD_CK1_1	385	391	PF00069	0.634
MOD_CK1_1	63	69	PF00069	0.586
MOD_CK2_1	253	259	PF00069	0.542
MOD_CK2_1	297	303	PF00069	0.733
MOD_CK2_1	30	36	PF00069	0.617
MOD_CK2_1	313	319	PF00069	0.473
MOD_CK2_1	345	351	PF00069	0.516
MOD_GlcNHglycan	130	133	PF01048	0.767
MOD_GlcNHglycan	163	166	PF01048	0.684
MOD_GlcNHglycan	220	223	PF01048	0.734
MOD_GlcNHglycan	230	234	PF01048	0.560
MOD_GlcNHglycan	266	269	PF01048	0.695
MOD_GlcNHglycan	326	331	PF01048	0.609
MOD_GlcNHglycan	387	390	PF01048	0.706
MOD_GlcNHglycan	45	48	PF01048	0.645
MOD_GlcNHglycan	90	93	PF01048	0.755
MOD_GSK3_1	10	17	PF00069	0.640
MOD_GSK3_1	186	193	PF00069	0.652
MOD_GSK3_1	194	201	PF00069	0.663
MOD_GSK3_1	204	211	PF00069	0.593
MOD_GSK3_1	21	28	PF00069	0.795
MOD_GSK3_1	224	231	PF00069	0.531
MOD_GSK3_1	292	299	PF00069	0.529
MOD_GSK3_1	302	309	PF00069	0.597
MOD_GSK3_1	341	348	PF00069	0.466
MOD_GSK3_1	371	378	PF00069	0.626
MOD_GSK3_1	391	398	PF00069	0.480
MOD_GSK3_1	88	95	PF00069	0.742
MOD_N-GLC_1	281	286	PF02516	0.607
MOD_NEK2_1	186	191	PF00069	0.550
MOD_NEK2_1	213	218	PF00069	0.568
MOD_NEK2_1	229	234	PF00069	0.572
MOD_NEK2_1	264	269	PF00069	0.541
MOD_NEK2_1	280	285	PF00069	0.590
MOD_NEK2_1	342	347	PF00069	0.478
MOD_PIKK_1	213	219	PF00454	0.550
MOD_PIKK_1	290	296	PF00454	0.533
MOD_PKA_1	161	167	PF00069	0.709
MOD_PKA_1	275	281	PF00069	0.689
MOD_PKA_2	147	153	PF00069	0.571
MOD_PKA_2	161	167	PF00069	0.728
MOD_PKA_2	204	210	PF00069	0.763
MOD_PKA_2	274	280	PF00069	0.649
MOD_PKA_2	297	303	PF00069	0.766
MOD_PKA_2	368	374	PF00069	0.624
MOD_PKA_2	380	386	PF00069	0.633
MOD_PKA_2	390	396	PF00069	0.630
MOD_PKB_1	159	167	PF00069	0.624
MOD_PKB_1	273	281	PF00069	0.699
MOD_Plk_2-3	313	319	PF00069	0.473
MOD_Plk_4	120	126	PF00069	0.752
MOD_Plk_4	152	158	PF00069	0.503
MOD_Plk_4	275	281	PF00069	0.518
MOD_Plk_4	306	312	PF00069	0.539
MOD_Plk_4	313	319	PF00069	0.443
MOD_Plk_4	345	351	PF00069	0.491
MOD_ProDKin_1	10	16	PF00069	0.551
MOD_ProDKin_1	150	156	PF00069	0.727
MOD_ProDKin_1	167	173	PF00069	0.577
MOD_ProDKin_1	192	198	PF00069	0.612
MOD_ProDKin_1	200	206	PF00069	0.590
MOD_ProDKin_1	25	31	PF00069	0.728
MOD_ProDKin_1	254	260	PF00069	0.584
MOD_ProDKin_1	302	308	PF00069	0.529
MOD_ProDKin_1	357	363	PF00069	0.677
MOD_ProDKin_1	371	377	PF00069	0.601
MOD_ProDKin_1	83	89	PF00069	0.747
TRG_ENDOCYTIC_2	7	10	PF00928	0.485
TRG_ENDOCYTIC_2	74	77	PF00928	0.573
TRG_ER_diArg_1	159	162	PF00400	0.690
TRG_ER_diArg_1	272	275	PF00400	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S8	Leptomonas seymouri	39%	94%
A0A3Q8ITW3	Leishmania donovani	65%	96%
E9AEH0	Leishmania major	63%	100%
E9AHN3	Leishmania infantum	65%	96%
E9B3Q9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	96%