Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLB6_LEIBR

TriTrypDb:

LbrM.33.0800 , LBRM2903_330013500

Length:

396

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.567
CLV_C14_Caspase3-7	148	152	PF00656	0.472
CLV_C14_Caspase3-7	206	210	PF00656	0.521
CLV_C14_Caspase3-7	272	276	PF00656	0.660
CLV_NRD_NRD_1	127	129	PF00675	0.483
CLV_NRD_NRD_1	142	144	PF00675	0.454
CLV_NRD_NRD_1	175	177	PF00675	0.401
CLV_NRD_NRD_1	381	383	PF00675	0.537
CLV_NRD_NRD_1	62	64	PF00675	0.496
CLV_PCSK_KEX2_1	127	129	PF00082	0.580
CLV_PCSK_KEX2_1	137	139	PF00082	0.466
CLV_PCSK_KEX2_1	175	177	PF00082	0.470
CLV_PCSK_KEX2_1	381	383	PF00082	0.537
CLV_PCSK_KEX2_1	62	64	PF00082	0.495
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.570
CLV_PCSK_SKI1_1	133	137	PF00082	0.517
CLV_PCSK_SKI1_1	171	175	PF00082	0.445
CLV_PCSK_SKI1_1	357	361	PF00082	0.476
CLV_PCSK_SKI1_1	76	80	PF00082	0.427
DEG_SPOP_SBC_1	15	19	PF00917	0.554
DEG_SPOP_SBC_1	312	316	PF00917	0.526
DOC_CDC14_PxL_1	248	256	PF14671	0.588
DOC_CYCLIN_RxL_1	354	361	PF00134	0.366
DOC_MAPK_MEF2A_6	158	166	PF00069	0.482
DOC_PP1_RVXF_1	355	361	PF00149	0.426
DOC_PP1_RVXF_1	74	81	PF00149	0.431
DOC_PP2B_LxvP_1	295	298	PF13499	0.663
DOC_PP2B_LxvP_1	321	324	PF13499	0.701
DOC_USP7_MATH_1	16	20	PF00917	0.661
DOC_USP7_MATH_1	234	238	PF00917	0.684
DOC_USP7_MATH_1	311	315	PF00917	0.677
DOC_USP7_MATH_1	362	366	PF00917	0.454
DOC_USP7_MATH_1	97	101	PF00917	0.589
DOC_USP7_UBL2_3	133	137	PF12436	0.553
DOC_USP7_UBL2_3	332	336	PF12436	0.562
DOC_WW_Pin1_4	314	319	PF00397	0.782
DOC_WW_Pin1_4	84	89	PF00397	0.445
LIG_14-3-3_CanoR_1	106	116	PF00244	0.480
LIG_14-3-3_CanoR_1	386	392	PF00244	0.486
LIG_Actin_WH2_2	288	303	PF00022	0.500
LIG_BIR_II_1	1	5	PF00653	0.479
LIG_Clathr_ClatBox_1	3	7	PF01394	0.496
LIG_FHA_1	275	281	PF00498	0.740
LIG_FHA_1	301	307	PF00498	0.519
LIG_FHA_2	238	244	PF00498	0.467
LIG_FHA_2	297	303	PF00498	0.563
LIG_FHA_2	324	330	PF00498	0.622
LIG_FHA_2	339	345	PF00498	0.628
LIG_LIR_Gen_1	243	253	PF02991	0.514
LIG_LIR_Gen_1	36	44	PF02991	0.504
LIG_LIR_Nem_3	167	173	PF02991	0.530
LIG_LIR_Nem_3	243	248	PF02991	0.503
LIG_LIR_Nem_3	36	40	PF02991	0.516
LIG_LIR_Nem_3	365	371	PF02991	0.432
LIG_LIR_Nem_3	389	395	PF02991	0.656
LIG_SH2_CRK	170	174	PF00017	0.509
LIG_SH2_CRK	368	372	PF00017	0.433
LIG_SH2_CRK	37	41	PF00017	0.507
LIG_SH2_SRC	198	201	PF00017	0.549
LIG_SH2_STAP1	245	249	PF00017	0.501
LIG_SH2_STAT3	215	218	PF00017	0.499
LIG_SH2_STAT5	215	218	PF00017	0.499
LIG_SH3_3	23	29	PF00018	0.611
LIG_TRAF2_1	145	148	PF00917	0.621
LIG_UBA3_1	135	144	PF00899	0.465
MOD_CK1_1	17	23	PF00069	0.600
MOD_CK1_1	237	243	PF00069	0.527
MOD_CK1_1	269	275	PF00069	0.576
MOD_CK1_1	290	296	PF00069	0.544
MOD_CK1_1	314	320	PF00069	0.533
MOD_CK1_1	338	344	PF00069	0.647
MOD_CK1_1	39	45	PF00069	0.588
MOD_CK1_1	8	14	PF00069	0.517
MOD_CK2_1	16	22	PF00069	0.561
MOD_CK2_1	296	302	PF00069	0.569
MOD_CK2_1	323	329	PF00069	0.622
MOD_CK2_1	338	344	PF00069	0.615
MOD_CK2_1	54	60	PF00069	0.506
MOD_GlcNHglycan	230	233	PF01048	0.609
MOD_GlcNHglycan	234	237	PF01048	0.590
MOD_GlcNHglycan	259	262	PF01048	0.696
MOD_GlcNHglycan	268	271	PF01048	0.600
MOD_GlcNHglycan	349	352	PF01048	0.472
MOD_GlcNHglycan	45	48	PF01048	0.555
MOD_GlcNHglycan	56	59	PF01048	0.443
MOD_GSK3_1	104	111	PF00069	0.627
MOD_GSK3_1	17	24	PF00069	0.640
MOD_GSK3_1	224	231	PF00069	0.625
MOD_GSK3_1	234	241	PF00069	0.641
MOD_GSK3_1	283	290	PF00069	0.629
MOD_GSK3_1	296	303	PF00069	0.495
MOD_GSK3_1	313	320	PF00069	0.563
MOD_GSK3_1	347	354	PF00069	0.575
MOD_GSK3_1	387	394	PF00069	0.493
MOD_GSK3_1	39	46	PF00069	0.572
MOD_GSK3_1	5	12	PF00069	0.501
MOD_N-GLC_1	257	262	PF02516	0.657
MOD_N-GLC_2	184	186	PF02516	0.492
MOD_NEK2_1	116	121	PF00069	0.503
MOD_NEK2_1	219	224	PF00069	0.518
MOD_NEK2_1	391	396	PF00069	0.523
MOD_PIKK_1	234	240	PF00454	0.622
MOD_PIKK_1	300	306	PF00454	0.478
MOD_PKA_2	300	306	PF00069	0.478
MOD_PKA_2	362	368	PF00069	0.409
MOD_Plk_1	104	110	PF00069	0.501
MOD_Plk_1	290	296	PF00069	0.517
MOD_Plk_4	372	378	PF00069	0.606
MOD_Plk_4	387	393	PF00069	0.457
MOD_ProDKin_1	314	320	PF00069	0.784
MOD_ProDKin_1	84	90	PF00069	0.446
MOD_SUMO_rev_2	329	338	PF00179	0.538
MOD_SUMO_rev_2	87	95	PF00179	0.470
TRG_DiLeu_BaEn_1	302	307	PF01217	0.548
TRG_DiLeu_BaEn_2	160	166	PF01217	0.481
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.609
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.359
TRG_ENDOCYTIC_2	170	173	PF00928	0.440
TRG_ENDOCYTIC_2	245	248	PF00928	0.499
TRG_ENDOCYTIC_2	368	371	PF00928	0.438
TRG_ENDOCYTIC_2	37	40	PF00928	0.517
TRG_ER_diArg_1	126	128	PF00400	0.556
TRG_ER_diArg_1	174	176	PF00400	0.440
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0S4	Leptomonas seymouri	40%	99%
A0A3S7X6J7	Leishmania donovani	65%	100%
A4I8U2	Leishmania infantum	65%	100%
E9B3Q8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q4Q4C9	Leishmania major	64%	100%