Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLB5_LEIBR

TriTrypDb:

LbrM.33.0790 , LBRM2903_330013400

Length:

771

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	469	473	PF00656	0.475
CLV_C14_Caspase3-7	49	53	PF00656	0.456
CLV_NRD_NRD_1	118	120	PF00675	0.456
CLV_NRD_NRD_1	19	21	PF00675	0.339
CLV_NRD_NRD_1	238	240	PF00675	0.646
CLV_NRD_NRD_1	275	277	PF00675	0.640
CLV_NRD_NRD_1	675	677	PF00675	0.572
CLV_NRD_NRD_1	683	685	PF00675	0.644
CLV_PCSK_FUR_1	233	237	PF00082	0.682
CLV_PCSK_KEX2_1	118	120	PF00082	0.456
CLV_PCSK_KEX2_1	19	21	PF00082	0.339
CLV_PCSK_KEX2_1	235	237	PF00082	0.630
CLV_PCSK_KEX2_1	238	240	PF00082	0.635
CLV_PCSK_KEX2_1	275	277	PF00082	0.722
CLV_PCSK_KEX2_1	675	677	PF00082	0.567
CLV_PCSK_KEX2_1	682	684	PF00082	0.645
CLV_PCSK_PC7_1	233	239	PF00082	0.628
CLV_PCSK_PC7_1	679	685	PF00082	0.581
CLV_PCSK_SKI1_1	201	205	PF00082	0.564
CLV_PCSK_SKI1_1	238	242	PF00082	0.536
CLV_PCSK_SKI1_1	458	462	PF00082	0.529
CLV_PCSK_SKI1_1	604	608	PF00082	0.493
CLV_PCSK_SKI1_1	709	713	PF00082	0.553
CLV_PCSK_SKI1_1	757	761	PF00082	0.517
DEG_APCC_DBOX_1	603	611	PF00400	0.414
DEG_Nend_Nbox_1	1	3	PF02207	0.463
DEG_SPOP_SBC_1	243	247	PF00917	0.503
DEG_SPOP_SBC_1	490	494	PF00917	0.595
DEG_SPOP_SBC_1	710	714	PF00917	0.452
DOC_AGCK_PIF_3	768	771	PF00069	0.405
DOC_CDC14_PxL_1	566	574	PF14671	0.327
DOC_CYCLIN_RxL_1	233	245	PF00134	0.565
DOC_CYCLIN_yCln2_LP_2	417	420	PF00134	0.434
DOC_MAPK_gen_1	262	269	PF00069	0.584
DOC_MAPK_gen_1	275	282	PF00069	0.505
DOC_MAPK_gen_1	458	466	PF00069	0.387
DOC_MAPK_MEF2A_6	275	282	PF00069	0.737
DOC_MAPK_MEF2A_6	757	765	PF00069	0.514
DOC_MAPK_MEF2A_6	86	95	PF00069	0.307
DOC_MAPK_NFAT4_5	86	94	PF00069	0.301
DOC_PP1_RVXF_1	359	366	PF00149	0.397
DOC_PP1_RVXF_1	475	482	PF00149	0.447
DOC_PP1_RVXF_1	61	67	PF00149	0.514
DOC_PP2B_LxvP_1	417	420	PF13499	0.434
DOC_USP7_MATH_1	167	171	PF00917	0.667
DOC_USP7_MATH_1	212	216	PF00917	0.599
DOC_USP7_MATH_1	243	247	PF00917	0.676
DOC_USP7_MATH_1	258	262	PF00917	0.719
DOC_USP7_MATH_1	401	405	PF00917	0.341
DOC_USP7_MATH_1	504	508	PF00917	0.718
DOC_USP7_MATH_1	530	534	PF00917	0.651
DOC_USP7_MATH_1	536	540	PF00917	0.618
DOC_USP7_MATH_1	592	596	PF00917	0.468
DOC_USP7_MATH_1	710	714	PF00917	0.583
DOC_USP7_MATH_1	730	734	PF00917	0.742
DOC_USP7_MATH_1	753	757	PF00917	0.544
DOC_USP7_UBL2_3	514	518	PF12436	0.655
DOC_WW_Pin1_4	30	35	PF00397	0.634
DOC_WW_Pin1_4	308	313	PF00397	0.481
DOC_WW_Pin1_4	326	331	PF00397	0.509
DOC_WW_Pin1_4	41	46	PF00397	0.587
DOC_WW_Pin1_4	424	429	PF00397	0.504
DOC_WW_Pin1_4	496	501	PF00397	0.541
DOC_WW_Pin1_4	588	593	PF00397	0.354
DOC_WW_Pin1_4	595	600	PF00397	0.341
DOC_WW_Pin1_4	619	624	PF00397	0.421
DOC_WW_Pin1_4	694	699	PF00397	0.612
DOC_WW_Pin1_4	714	719	PF00397	0.422
LIG_14-3-3_CanoR_1	10	17	PF00244	0.476
LIG_14-3-3_CanoR_1	132	138	PF00244	0.450
LIG_14-3-3_CanoR_1	213	220	PF00244	0.590
LIG_14-3-3_CanoR_1	223	230	PF00244	0.578
LIG_14-3-3_CanoR_1	242	252	PF00244	0.471
LIG_14-3-3_CanoR_1	262	268	PF00244	0.570
LIG_14-3-3_CanoR_1	334	342	PF00244	0.344
LIG_14-3-3_CanoR_1	387	394	PF00244	0.277
LIG_14-3-3_CanoR_1	582	590	PF00244	0.354
LIG_14-3-3_CanoR_1	65	69	PF00244	0.461
LIG_14-3-3_CanoR_1	668	677	PF00244	0.500
LIG_14-3-3_CanoR_1	709	718	PF00244	0.520
LIG_Actin_WH2_2	227	244	PF00022	0.490
LIG_Actin_WH2_2	539	556	PF00022	0.479
LIG_Actin_WH2_2	87	103	PF00022	0.276
LIG_APCC_ABBA_1	720	725	PF00400	0.478
LIG_BRCT_BRCA1_1	265	269	PF00533	0.673
LIG_BRCT_BRCA1_1	353	357	PF00533	0.400
LIG_FHA_1	10	16	PF00498	0.380
LIG_FHA_1	179	185	PF00498	0.678
LIG_FHA_1	474	480	PF00498	0.426
LIG_FHA_1	485	491	PF00498	0.729
LIG_FHA_1	540	546	PF00498	0.420
LIG_FHA_1	583	589	PF00498	0.358
LIG_FHA_1	619	625	PF00498	0.383
LIG_FHA_1	715	721	PF00498	0.546
LIG_FHA_2	170	176	PF00498	0.669
LIG_FHA_2	334	340	PF00498	0.490
LIG_FHA_2	450	456	PF00498	0.345
LIG_FHA_2	47	53	PF00498	0.509
LIG_FHA_2	491	497	PF00498	0.701
LIG_GBD_Chelix_1	545	553	PF00786	0.418
LIG_Integrin_RGD_1	684	686	PF01839	0.576
LIG_LIR_Apic_2	404	408	PF02991	0.417
LIG_LIR_Apic_2	625	631	PF02991	0.382
LIG_LIR_Gen_1	480	489	PF02991	0.379
LIG_LIR_Gen_1	540	549	PF02991	0.418
LIG_LIR_Gen_1	9	17	PF02991	0.403
LIG_LIR_Nem_3	400	405	PF02991	0.555
LIG_LIR_Nem_3	41	46	PF02991	0.493
LIG_LIR_Nem_3	424	429	PF02991	0.314
LIG_LIR_Nem_3	480	484	PF02991	0.317
LIG_LIR_Nem_3	540	546	PF02991	0.420
LIG_LIR_Nem_3	9	14	PF02991	0.404
LIG_MAD2	615	623	PF02301	0.420
LIG_NRBOX	90	96	PF00104	0.461
LIG_PCNA_yPIPBox_3	377	387	PF02747	0.269
LIG_PDZ_Class_2	766	771	PF00595	0.468
LIG_REV1ctd_RIR_1	766	771	PF16727	0.585
LIG_SH2_CRK	426	430	PF00017	0.320
LIG_SH2_NCK_1	123	127	PF00017	0.517
LIG_SH2_PTP2	318	321	PF00017	0.396
LIG_SH2_SRC	318	321	PF00017	0.314
LIG_SH2_STAP1	584	588	PF00017	0.369
LIG_SH2_STAP1	83	87	PF00017	0.581
LIG_SH2_STAT3	456	459	PF00017	0.484
LIG_SH2_STAT5	23	26	PF00017	0.461
LIG_SH2_STAT5	318	321	PF00017	0.503
LIG_SH2_STAT5	344	347	PF00017	0.431
LIG_SH2_STAT5	375	378	PF00017	0.332
LIG_SH2_STAT5	456	459	PF00017	0.426
LIG_SH2_STAT5	584	587	PF00017	0.426
LIG_SH2_STAT5	600	603	PF00017	0.384
LIG_SH2_STAT5	628	631	PF00017	0.393
LIG_SH2_STAT5	669	672	PF00017	0.455
LIG_SH2_STAT5	751	754	PF00017	0.462
LIG_SH3_3	107	113	PF00018	0.632
LIG_SH3_3	114	120	PF00018	0.631
LIG_SH3_3	413	419	PF00018	0.319
LIG_SUMO_SIM_anti_2	412	418	PF11976	0.354
LIG_SUMO_SIM_anti_2	52	58	PF11976	0.382
LIG_SUMO_SIM_anti_2	621	628	PF11976	0.416
LIG_SUMO_SIM_par_1	278	283	PF11976	0.566
LIG_SUMO_SIM_par_1	427	433	PF11976	0.527
LIG_TRAF2_1	574	577	PF00917	0.285
LIG_TRAF2_1	734	737	PF00917	0.562
MOD_CDK_SPxxK_3	30	37	PF00069	0.708
MOD_CK1_1	244	250	PF00069	0.660
MOD_CK1_1	253	259	PF00069	0.616
MOD_CK1_1	424	430	PF00069	0.450
MOD_CK1_1	539	545	PF00069	0.627
MOD_CK1_1	555	561	PF00069	0.453
MOD_CK1_1	595	601	PF00069	0.451
MOD_CK1_1	714	720	PF00069	0.676
MOD_CK2_1	151	157	PF00069	0.542
MOD_CK2_1	262	268	PF00069	0.490
MOD_CK2_1	333	339	PF00069	0.500
MOD_CK2_1	449	455	PF00069	0.348
MOD_CK2_1	490	496	PF00069	0.697
MOD_CK2_1	730	736	PF00069	0.574
MOD_Cter_Amidation	17	20	PF01082	0.341
MOD_Cter_Amidation	199	202	PF01082	0.462
MOD_GlcNHglycan	148	151	PF01048	0.534
MOD_GlcNHglycan	214	217	PF01048	0.679
MOD_GlcNHglycan	246	249	PF01048	0.542
MOD_GlcNHglycan	255	258	PF01048	0.672
MOD_GlcNHglycan	389	392	PF01048	0.338
MOD_GlcNHglycan	452	455	PF01048	0.412
MOD_GlcNHglycan	468	471	PF01048	0.615
MOD_GlcNHglycan	484	487	PF01048	0.448
MOD_GlcNHglycan	496	499	PF01048	0.623
MOD_GlcNHglycan	554	557	PF01048	0.532
MOD_GlcNHglycan	689	692	PF01048	0.600
MOD_GlcNHglycan	732	735	PF01048	0.743
MOD_GSK3_1	139	146	PF00069	0.494
MOD_GSK3_1	222	229	PF00069	0.612
MOD_GSK3_1	253	260	PF00069	0.632
MOD_GSK3_1	397	404	PF00069	0.425
MOD_GSK3_1	480	487	PF00069	0.365
MOD_GSK3_1	490	497	PF00069	0.501
MOD_GSK3_1	526	533	PF00069	0.655
MOD_GSK3_1	554	561	PF00069	0.520
MOD_GSK3_1	588	595	PF00069	0.397
MOD_GSK3_1	64	71	PF00069	0.444
MOD_GSK3_1	710	717	PF00069	0.554
MOD_N-GLC_1	152	157	PF02516	0.521
MOD_N-GLC_1	52	57	PF02516	0.507
MOD_N-GLC_1	619	624	PF02516	0.477
MOD_N-GLC_1	737	742	PF02516	0.520
MOD_NEK2_1	178	183	PF00069	0.580
MOD_NEK2_1	241	246	PF00069	0.614
MOD_NEK2_1	466	471	PF00069	0.462
MOD_NEK2_1	484	489	PF00069	0.487
MOD_NEK2_1	667	672	PF00069	0.400
MOD_NEK2_1	704	709	PF00069	0.442
MOD_NEK2_1	89	94	PF00069	0.364
MOD_NEK2_2	562	567	PF00069	0.417
MOD_PIKK_1	590	596	PF00454	0.338
MOD_PIKK_1	634	640	PF00454	0.550
MOD_PIKK_1	669	675	PF00454	0.540
MOD_PKA_1	675	681	PF00069	0.592
MOD_PKA_2	131	137	PF00069	0.491
MOD_PKA_2	212	218	PF00069	0.535
MOD_PKA_2	222	228	PF00069	0.590
MOD_PKA_2	241	247	PF00069	0.544
MOD_PKA_2	263	269	PF00069	0.503
MOD_PKA_2	333	339	PF00069	0.358
MOD_PKA_2	494	500	PF00069	0.746
MOD_PKA_2	64	70	PF00069	0.588
MOD_PKA_2	667	673	PF00069	0.522
MOD_PKA_2	675	681	PF00069	0.620
MOD_PKA_2	9	15	PF00069	0.502
MOD_Plk_1	178	184	PF00069	0.675
MOD_Plk_1	397	403	PF00069	0.445
MOD_Plk_1	52	58	PF00069	0.404
MOD_Plk_1	539	545	PF00069	0.543
MOD_Plk_1	649	655	PF00069	0.487
MOD_Plk_4	352	358	PF00069	0.361
MOD_Plk_4	389	395	PF00069	0.450
MOD_Plk_4	442	448	PF00069	0.367
MOD_Plk_4	52	58	PF00069	0.667
MOD_Plk_4	89	95	PF00069	0.344
MOD_ProDKin_1	30	36	PF00069	0.638
MOD_ProDKin_1	308	314	PF00069	0.478
MOD_ProDKin_1	326	332	PF00069	0.510
MOD_ProDKin_1	41	47	PF00069	0.583
MOD_ProDKin_1	424	430	PF00069	0.499
MOD_ProDKin_1	496	502	PF00069	0.543
MOD_ProDKin_1	588	594	PF00069	0.357
MOD_ProDKin_1	595	601	PF00069	0.344
MOD_ProDKin_1	619	625	PF00069	0.422
MOD_ProDKin_1	694	700	PF00069	0.613
MOD_ProDKin_1	714	720	PF00069	0.424
MOD_SUMO_for_1	460	463	PF00179	0.479
MOD_SUMO_rev_2	55	64	PF00179	0.491
TRG_DiLeu_BaEn_1	337	342	PF01217	0.464
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.493
TRG_ENDOCYTIC_2	344	347	PF00928	0.449
TRG_ENDOCYTIC_2	426	429	PF00928	0.379
TRG_ENDOCYTIC_2	646	649	PF00928	0.437
TRG_ER_diArg_1	109	112	PF00400	0.510
TRG_ER_diArg_1	117	119	PF00400	0.430
TRG_ER_diArg_1	233	236	PF00400	0.609
TRG_ER_diArg_1	237	239	PF00400	0.625
TRG_ER_diArg_1	275	277	PF00400	0.478
TRG_ER_diArg_1	674	676	PF00400	0.569
TRG_ER_diArg_1	681	684	PF00400	0.641
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P467	Leptomonas seymouri	57%	89%
A0A1X0P116	Trypanosomatidae	36%	100%
A0A3Q8IGR5	Leishmania donovani	77%	100%
A4I8U1	Leishmania infantum	77%	100%
D0A4T7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B3Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q4D0	Leishmania major	76%	100%
V5BFB4	Trypanosoma cruzi	32%	100%