Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HLB3_LEIBR

TriTrypDb:

LbrM.33.0770 , LBRM2903_330013200

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0005840	ribosome	5	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HLB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLB3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006356	regulation of transcription by RNA polymerase I	7	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045943	positive regulation of transcription by RNA polymerase I	8	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.414
CLV_C14_Caspase3-7	304	308	PF00656	0.375
CLV_C14_Caspase3-7	407	411	PF00656	0.500
CLV_C14_Caspase3-7	497	501	PF00656	0.487
CLV_NRD_NRD_1	12	14	PF00675	0.436
CLV_NRD_NRD_1	404	406	PF00675	0.392
CLV_PCSK_KEX2_1	12	14	PF00082	0.436
CLV_PCSK_KEX2_1	404	406	PF00082	0.552
CLV_PCSK_SKI1_1	142	146	PF00082	0.342
CLV_PCSK_SKI1_1	180	184	PF00082	0.350
CLV_PCSK_SKI1_1	456	460	PF00082	0.326
DEG_SCF_FBW7_1	111	116	PF00400	0.532
DEG_SCF_FBW7_1	26	31	PF00400	0.493
DEG_SPOP_SBC_1	72	76	PF00917	0.481
DOC_CKS1_1	181	186	PF01111	0.342
DOC_CYCLIN_RxL_1	138	149	PF00134	0.452
DOC_MAPK_gen_1	138	146	PF00069	0.518
DOC_MAPK_RevD_3	390	405	PF00069	0.426
DOC_PP2B_LxvP_1	3	6	PF13499	0.442
DOC_PP4_FxxP_1	167	170	PF00568	0.340
DOC_USP7_MATH_1	113	117	PF00917	0.553
DOC_USP7_MATH_1	170	174	PF00917	0.350
DOC_USP7_MATH_1	379	383	PF00917	0.533
DOC_USP7_MATH_1	414	418	PF00917	0.406
DOC_USP7_MATH_1	494	498	PF00917	0.383
DOC_USP7_MATH_1	517	521	PF00917	0.539
DOC_USP7_MATH_1	63	67	PF00917	0.662
DOC_USP7_MATH_1	71	75	PF00917	0.704
DOC_WW_Pin1_4	109	114	PF00397	0.685
DOC_WW_Pin1_4	18	23	PF00397	0.483
DOC_WW_Pin1_4	180	185	PF00397	0.360
DOC_WW_Pin1_4	212	217	PF00397	0.328
DOC_WW_Pin1_4	24	29	PF00397	0.483
DOC_WW_Pin1_4	30	35	PF00397	0.482
DOC_WW_Pin1_4	37	42	PF00397	0.486
LIG_14-3-3_CanoR_1	12	19	PF00244	0.460
LIG_14-3-3_CanoR_1	142	147	PF00244	0.441
LIG_14-3-3_CanoR_1	272	282	PF00244	0.456
LIG_14-3-3_CanoR_1	94	101	PF00244	0.642
LIG_AP2alpha_2	361	363	PF02296	0.528
LIG_BRCT_BRCA1_1	275	279	PF00533	0.449
LIG_FHA_1	106	112	PF00498	0.639
LIG_FHA_1	166	172	PF00498	0.407
LIG_FHA_1	177	183	PF00498	0.307
LIG_FHA_1	268	274	PF00498	0.434
LIG_FHA_1	295	301	PF00498	0.370
LIG_FHA_1	33	39	PF00498	0.511
LIG_FHA_1	430	436	PF00498	0.368
LIG_FHA_2	302	308	PF00498	0.476
LIG_GSK3_LRP6_1	28	33	PF00069	0.496
LIG_LIR_Apic_2	16	22	PF02991	0.474
LIG_LIR_Apic_2	166	170	PF02991	0.332
LIG_LIR_Nem_3	276	282	PF02991	0.266
LIG_PDZ_Class_1	559	564	PF00595	0.419
LIG_SH2_CRK	19	23	PF00017	0.490
LIG_SH2_CRK	228	232	PF00017	0.355
LIG_SH2_NCK_1	19	23	PF00017	0.484
LIG_SH2_NCK_1	60	64	PF00017	0.563
LIG_SH2_SRC	468	471	PF00017	0.544
LIG_SH2_SRC	60	63	PF00017	0.540
LIG_SH2_STAT5	206	209	PF00017	0.352
LIG_SH2_STAT5	228	231	PF00017	0.316
LIG_SH2_STAT5	468	471	PF00017	0.534
LIG_SH3_2	352	357	PF14604	0.544
LIG_SH3_3	178	184	PF00018	0.378
LIG_SH3_3	23	29	PF00018	0.493
LIG_SH3_3	346	352	PF00018	0.623
LIG_SUMO_SIM_anti_2	553	562	PF11976	0.413
LIG_SUMO_SIM_par_1	194	199	PF11976	0.304
LIG_TYR_ITIM	226	231	PF00017	0.355
LIG_TYR_ITIM	464	469	PF00017	0.277
LIG_UBA3_1	371	377	PF00899	0.420
MOD_CK1_1	122	128	PF00069	0.572
MOD_CK1_1	20	26	PF00069	0.488
MOD_CK1_1	275	281	PF00069	0.291
MOD_CK1_1	302	308	PF00069	0.456
MOD_CK1_1	381	387	PF00069	0.603
MOD_CK1_1	409	415	PF00069	0.685
MOD_CK1_1	66	72	PF00069	0.732
MOD_CK1_1	74	80	PF00069	0.682
MOD_CK1_1	87	93	PF00069	0.571
MOD_CK1_1	96	102	PF00069	0.591
MOD_CK2_1	53	59	PF00069	0.665
MOD_DYRK1A_RPxSP_1	180	184	PF00069	0.381
MOD_GlcNHglycan	121	124	PF01048	0.621
MOD_GlcNHglycan	189	192	PF01048	0.419
MOD_GlcNHglycan	221	224	PF01048	0.374
MOD_GlcNHglycan	290	293	PF01048	0.442
MOD_GlcNHglycan	318	321	PF01048	0.290
MOD_GlcNHglycan	384	387	PF01048	0.481
MOD_GlcNHglycan	406	409	PF01048	0.421
MOD_GlcNHglycan	423	426	PF01048	0.444
MOD_GlcNHglycan	508	511	PF01048	0.421
MOD_GlcNHglycan	519	522	PF01048	0.485
MOD_GlcNHglycan	55	58	PF01048	0.595
MOD_GlcNHglycan	82	85	PF01048	0.598
MOD_GlcNHglycan	89	92	PF01048	0.552
MOD_GlcNHglycan	95	98	PF01048	0.517
MOD_GSK3_1	105	112	PF00069	0.597
MOD_GSK3_1	13	20	PF00069	0.468
MOD_GSK3_1	142	149	PF00069	0.489
MOD_GSK3_1	176	183	PF00069	0.379
MOD_GSK3_1	24	31	PF00069	0.481
MOD_GSK3_1	263	270	PF00069	0.473
MOD_GSK3_1	288	295	PF00069	0.567
MOD_GSK3_1	378	385	PF00069	0.506
MOD_GSK3_1	406	413	PF00069	0.580
MOD_GSK3_1	429	436	PF00069	0.449
MOD_GSK3_1	441	448	PF00069	0.338
MOD_GSK3_1	80	87	PF00069	0.539
MOD_N-GLC_1	52	57	PF02516	0.596
MOD_NEK2_1	273	278	PF00069	0.497
MOD_NEK2_1	294	299	PF00069	0.538
MOD_NEK2_1	328	333	PF00069	0.446
MOD_NEK2_1	430	435	PF00069	0.558
MOD_NEK2_1	447	452	PF00069	0.373
MOD_NEK2_1	51	56	PF00069	0.600
MOD_NEK2_1	559	564	PF00069	0.419
MOD_NEK2_2	63	68	PF00069	0.543
MOD_NEK2_2	84	89	PF00069	0.478
MOD_PIKK_1	263	269	PF00454	0.434
MOD_PIKK_1	522	528	PF00454	0.322
MOD_PK_1	280	286	PF00069	0.360
MOD_PK_1	393	399	PF00069	0.285
MOD_PKA_1	404	410	PF00069	0.505
MOD_PKA_2	11	17	PF00069	0.449
MOD_PKA_2	187	193	PF00069	0.431
MOD_PKA_2	219	225	PF00069	0.460
MOD_PKA_2	404	410	PF00069	0.598
MOD_PKA_2	93	99	PF00069	0.539
MOD_PKB_1	140	148	PF00069	0.439
MOD_Plk_1	165	171	PF00069	0.568
MOD_Plk_1	430	436	PF00069	0.509
MOD_Plk_1	63	69	PF00069	0.686
MOD_Plk_4	202	208	PF00069	0.307
MOD_Plk_4	280	286	PF00069	0.266
MOD_Plk_4	393	399	PF00069	0.278
MOD_Plk_4	414	420	PF00069	0.428
MOD_Plk_4	442	448	PF00069	0.362
MOD_Plk_4	474	480	PF00069	0.375
MOD_ProDKin_1	109	115	PF00069	0.685
MOD_ProDKin_1	18	24	PF00069	0.484
MOD_ProDKin_1	180	186	PF00069	0.370
MOD_ProDKin_1	212	218	PF00069	0.324
MOD_ProDKin_1	28	34	PF00069	0.478
MOD_ProDKin_1	37	43	PF00069	0.489
TRG_ENDOCYTIC_2	228	231	PF00928	0.316
TRG_ENDOCYTIC_2	466	469	PF00928	0.318
TRG_ER_diArg_1	403	405	PF00400	0.545
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT4	Leptomonas seymouri	62%	100%
A0A1X0P1X3	Trypanosomatidae	44%	100%
A0A3Q8IGG9	Leishmania donovani	81%	100%
A0A422P2K2	Trypanosoma rangeli	46%	100%
A4I8T9	Leishmania infantum	80%	100%
D0A4T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B3Q5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q4D2	Leishmania major	80%	100%
V5DG89	Trypanosoma cruzi	44%	100%