Putative 60S ribosomal protein L6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L6, putative

Species:

Leishmania braziliensis

UniProt:

A4HLB2_LEIBR

TriTrypDb:

LbrM.33.0760 , LBRM2903_330013000

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	15
GO:0032991	protein-containing complex	1	17
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	16
GO:1990904	ribonucleoprotein complex	2	17
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	2
GO:0022625	cytosolic large ribosomal subunit	5	2
GO:0044391	ribosomal subunit	3	2

Expansion

Sequence features

A4HLB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLB2

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	17
GO:0006518	peptide metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009058	biosynthetic process	2	17
GO:0009059	macromolecule biosynthetic process	4	17
GO:0009987	cellular process	1	17
GO:0019538	protein metabolic process	3	17
GO:0034641	cellular nitrogen compound metabolic process	3	17
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	17
GO:0043043	peptide biosynthetic process	5	17
GO:0043170	macromolecule metabolic process	3	17
GO:0043603	amide metabolic process	3	17
GO:0043604	amide biosynthetic process	4	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0044249	cellular biosynthetic process	3	17
GO:0044260	obsolete cellular macromolecule metabolic process	3	17
GO:0044271	cellular nitrogen compound biosynthetic process	4	17
GO:0071704	organic substance metabolic process	2	17
GO:1901564	organonitrogen compound metabolic process	3	17
GO:1901566	organonitrogen compound biosynthetic process	4	17
GO:1901576	organic substance biosynthetic process	3	17
GO:0000027	ribosomal large subunit assembly	7	2
GO:0002181	cytoplasmic translation	5	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	17
GO:0005198	structural molecule activity	1	17
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.415
CLV_NRD_NRD_1	26	28	PF00675	0.481
CLV_NRD_NRD_1	46	48	PF00675	0.407
CLV_NRD_NRD_1	74	76	PF00675	0.290
CLV_NRD_NRD_1	9	11	PF00675	0.699
CLV_PCSK_FUR_1	44	48	PF00082	0.413
CLV_PCSK_KEX2_1	46	48	PF00082	0.407
CLV_PCSK_KEX2_1	74	76	PF00082	0.290
CLV_PCSK_KEX2_1	9	11	PF00082	0.708
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.708
CLV_PCSK_PC7_1	42	48	PF00082	0.417
CLV_PCSK_SKI1_1	11	15	PF00082	0.594
CLV_PCSK_SKI1_1	129	133	PF00082	0.401
CLV_PCSK_SKI1_1	176	180	PF00082	0.346
DEG_SPOP_SBC_1	93	97	PF00917	0.465
DOC_MAPK_gen_1	42	51	PF00069	0.411
DOC_MAPK_RevD_3	60	75	PF00069	0.421
DOC_PP4_FxxP_1	103	106	PF00568	0.498
DOC_USP7_UBL2_3	11	15	PF12436	0.596
DOC_USP7_UBL2_3	122	126	PF12436	0.525
DOC_USP7_UBL2_3	129	133	PF12436	0.484
DOC_USP7_UBL2_3	136	140	PF12436	0.454
DOC_USP7_UBL2_3	5	9	PF12436	0.596
DOC_WW_Pin1_4	17	22	PF00397	0.537
DOC_WW_Pin1_4	96	101	PF00397	0.524
LIG_14-3-3_CanoR_1	176	182	PF00244	0.585
LIG_14-3-3_CanoR_1	27	35	PF00244	0.434
LIG_BIR_II_1	1	5	PF00653	0.690
LIG_BIR_III_4	165	169	PF00653	0.585
LIG_FHA_1	93	99	PF00498	0.496
LIG_FHA_2	110	116	PF00498	0.595
LIG_FHA_2	84	90	PF00498	0.490
LIG_LIR_Apic_2	101	106	PF02991	0.498
LIG_LIR_Gen_1	20	31	PF02991	0.550
LIG_LIR_Nem_3	20	26	PF02991	0.486
LIG_SH2_CRK	23	27	PF00017	0.516
LIG_SH2_CRK	68	72	PF00017	0.341
LIG_SH2_SRC	80	83	PF00017	0.490
LIG_SH2_STAT5	174	177	PF00017	0.490
LIG_SH2_STAT5	23	26	PF00017	0.581
LIG_SH2_STAT5	80	83	PF00017	0.488
LIG_SH3_3	59	65	PF00018	0.543
LIG_SUMO_SIM_par_1	58	63	PF11976	0.440
MOD_CK1_1	17	23	PF00069	0.531
MOD_CK1_1	177	183	PF00069	0.490
MOD_CK1_1	92	98	PF00069	0.502
MOD_CK2_1	109	115	PF00069	0.505
MOD_CK2_1	132	138	PF00069	0.561
MOD_Cter_Amidation	44	47	PF01082	0.420
MOD_GlcNHglycan	62	65	PF01048	0.400
MOD_GlcNHglycan	68	71	PF01048	0.329
MOD_GSK3_1	17	24	PF00069	0.504
MOD_GSK3_1	88	95	PF00069	0.507
MOD_NEK2_1	1	6	PF00069	0.641
MOD_NEK2_1	26	31	PF00069	0.514
MOD_NEK2_1	60	65	PF00069	0.401
MOD_NEK2_1	66	71	PF00069	0.430
MOD_NEK2_2	174	179	PF00069	0.490
MOD_PKA_1	132	138	PF00069	0.546
MOD_PKA_1	14	20	PF00069	0.555
MOD_PKA_2	26	32	PF00069	0.460
MOD_Plk_1	21	27	PF00069	0.514
MOD_Plk_1	88	94	PF00069	0.528
MOD_Plk_2-3	89	95	PF00069	0.564
MOD_Plk_4	138	144	PF00069	0.572
MOD_ProDKin_1	17	23	PF00069	0.531
MOD_ProDKin_1	96	102	PF00069	0.524
MOD_SUMO_for_1	106	109	PF00179	0.491
MOD_SUMO_for_1	125	128	PF00179	0.456
MOD_SUMO_rev_2	135	142	PF00179	0.523
TRG_ENDOCYTIC_2	23	26	PF00928	0.516
TRG_ENDOCYTIC_2	68	71	PF00928	0.341
TRG_ER_diArg_1	43	46	PF00400	0.415
TRG_ER_diArg_1	73	75	PF00400	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT06	Leptomonas seymouri	91%	99%
A0A0S4JL50	Bodo saltans	73%	97%
A0A0S4JLI9	Bodo saltans	73%	97%
A0A1D8PCX8	Candida albicans (strain SC5314 / ATCC MYA-2876)	47%	100%
A0A1X0NVD8	Trypanosomatidae	77%	100%
A0A1X0P118	Trypanosomatidae	79%	98%
A0A3Q8IAA6	Leishmania donovani	94%	98%
A0A3R7KR31	Trypanosoma rangeli	76%	100%
A0A3R7LKV1	Trypanosoma rangeli	77%	99%
A4H873	Leishmania braziliensis	99%	100%
A4HWJ8	Leishmania infantum	94%	98%
D0A4T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9AQ99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
E9B3Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	98%
P05739	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
P0DJ56	Tetrahymena thermophila (strain SB210)	41%	100%
P34091	Mesembryanthemum crystallinum	41%	82%
P47991	Caenorhabditis elegans	39%	88%
P79071	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	98%
Q02326	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
Q02878	Homo sapiens	40%	67%
Q2YGT9	Sus scrofa	40%	68%
Q4Q4D3	Leishmania major	92%	100%
Q4QF84	Leishmania major	93%	100%
Q54D63	Dictyostelium discoideum	42%	81%
Q58DQ3	Bos taurus	40%	67%
Q6QMZ4	Chinchilla lanigera	39%	67%
Q9C9C5	Arabidopsis thaliana	38%	82%
Q9C9C6	Arabidopsis thaliana	37%	82%