POT_family_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

POT family, putative

Species:

Leishmania braziliensis

UniProt:

A4HLB1_LEIBR

TriTrypDb:

LbrM.33.0750 , LBRM2903_330012900

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HLB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLB1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	10
GO:0022857	transmembrane transporter activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.633
CLV_C14_Caspase3-7	399	403	PF00656	0.487
CLV_NRD_NRD_1	190	192	PF00675	0.340
CLV_NRD_NRD_1	266	268	PF00675	0.504
CLV_NRD_NRD_1	534	536	PF00675	0.441
CLV_PCSK_KEX2_1	266	268	PF00082	0.407
CLV_PCSK_SKI1_1	114	118	PF00082	0.525
CLV_PCSK_SKI1_1	148	152	PF00082	0.346
CLV_PCSK_SKI1_1	312	316	PF00082	0.262
CLV_PCSK_SKI1_1	457	461	PF00082	0.386
CLV_PCSK_SKI1_1	482	486	PF00082	0.200
DEG_APCC_DBOX_1	481	489	PF00400	0.386
DEG_MDM2_SWIB_1	471	479	PF02201	0.341
DOC_AGCK_PIF_1	30	35	PF00069	0.393
DOC_CYCLIN_yCln2_LP_2	449	455	PF00134	0.288
DOC_CYCLIN_yCln2_LP_2	542	548	PF00134	0.276
DOC_MAPK_gen_1	420	430	PF00069	0.525
DOC_MAPK_gen_1	571	579	PF00069	0.525
DOC_MAPK_gen_1	72	81	PF00069	0.490
DOC_MAPK_MEF2A_6	312	320	PF00069	0.464
DOC_MAPK_MEF2A_6	423	430	PF00069	0.300
DOC_MAPK_MEF2A_6	75	83	PF00069	0.419
DOC_MAPK_NFAT4_5	423	431	PF00069	0.335
DOC_PP2B_LxvP_1	449	452	PF13499	0.284
DOC_PP2B_LxvP_1	5	8	PF13499	0.605
DOC_PP2B_LxvP_1	542	545	PF13499	0.276
DOC_PP4_FxxP_1	255	258	PF00568	0.300
DOC_PP4_FxxP_1	555	558	PF00568	0.383
DOC_USP7_MATH_1	200	204	PF00917	0.673
DOC_USP7_MATH_1	360	364	PF00917	0.472
DOC_WW_Pin1_4	565	570	PF00397	0.386
DOC_WW_Pin1_4	95	100	PF00397	0.492
LIG_14-3-3_CanoR_1	416	420	PF00244	0.594
LIG_14-3-3_CanoR_1	535	544	PF00244	0.264
LIG_APCC_ABBA_1	1	6	PF00400	0.522
LIG_BIR_II_1	1	5	PF00653	0.530
LIG_BRCT_BRCA1_1	235	239	PF00533	0.442
LIG_CSL_BTD_1	302	305	PF09270	0.386
LIG_EH1_1	609	617	PF00400	0.199
LIG_eIF4E_1	279	285	PF01652	0.284
LIG_eIF4E_1	86	92	PF01652	0.379
LIG_FHA_1	147	153	PF00498	0.565
LIG_FHA_1	178	184	PF00498	0.657
LIG_FHA_1	230	236	PF00498	0.460
LIG_FHA_1	240	246	PF00498	0.305
LIG_FHA_1	35	41	PF00498	0.365
LIG_FHA_1	363	369	PF00498	0.462
LIG_FHA_1	384	390	PF00498	0.386
LIG_FHA_1	465	471	PF00498	0.337
LIG_FHA_1	58	64	PF00498	0.199
LIG_FHA_1	85	91	PF00498	0.340
LIG_FHA_1	96	102	PF00498	0.393
LIG_FHA_2	154	160	PF00498	0.657
LIG_FHA_2	215	221	PF00498	0.611
LIG_FHA_2	394	400	PF00498	0.454
LIG_FHA_2	513	519	PF00498	0.259
LIG_FHA_2	557	563	PF00498	0.442
LIG_HP1_1	481	485	PF01393	0.386
LIG_LIR_Apic_2	254	258	PF02991	0.305
LIG_LIR_Apic_2	476	481	PF02991	0.518
LIG_LIR_Apic_2	553	558	PF02991	0.387
LIG_LIR_Gen_1	2	11	PF02991	0.555
LIG_LIR_Gen_1	211	220	PF02991	0.663
LIG_LIR_Gen_1	34	42	PF02991	0.344
LIG_LIR_Gen_1	352	361	PF02991	0.586
LIG_LIR_Gen_1	458	468	PF02991	0.241
LIG_LIR_Gen_1	538	548	PF02991	0.274
LIG_LIR_Nem_3	149	154	PF02991	0.502
LIG_LIR_Nem_3	2	7	PF02991	0.568
LIG_LIR_Nem_3	211	216	PF02991	0.676
LIG_LIR_Nem_3	277	283	PF02991	0.242
LIG_LIR_Nem_3	34	38	PF02991	0.317
LIG_LIR_Nem_3	349	353	PF02991	0.458
LIG_LIR_Nem_3	458	463	PF02991	0.241
LIG_LIR_Nem_3	505	511	PF02991	0.300
LIG_LIR_Nem_3	538	544	PF02991	0.214
LIG_LIR_Nem_3	587	592	PF02991	0.329
LIG_LIR_Nem_3	9	15	PF02991	0.513
LIG_PCNA_PIPBox_1	614	623	PF02747	0.272
LIG_PCNA_yPIPBox_3	614	623	PF02747	0.272
LIG_PDZ_Class_1	623	628	PF00595	0.485
LIG_Pex14_2	471	475	PF04695	0.385
LIG_PTB_Apo_2	49	56	PF02174	0.276
LIG_PTB_Phospho_1	49	55	PF10480	0.276
LIG_RPA_C_Fungi	72	84	PF08784	0.199
LIG_SH2_CRK	213	217	PF00017	0.531
LIG_SH2_CRK	281	285	PF00017	0.335
LIG_SH2_CRK	35	39	PF00017	0.335
LIG_SH2_CRK	353	357	PF00017	0.253
LIG_SH2_NCK_1	213	217	PF00017	0.600
LIG_SH2_NCK_1	26	30	PF00017	0.393
LIG_SH2_PTP2	55	58	PF00017	0.393
LIG_SH2_STAP1	241	245	PF00017	0.429
LIG_SH2_STAP1	26	30	PF00017	0.393
LIG_SH2_STAP1	281	285	PF00017	0.383
LIG_SH2_STAP1	86	90	PF00017	0.331
LIG_SH2_STAT3	546	549	PF00017	0.276
LIG_SH2_STAT5	102	105	PF00017	0.473
LIG_SH2_STAT5	241	244	PF00017	0.395
LIG_SH2_STAT5	275	278	PF00017	0.209
LIG_SH2_STAT5	35	38	PF00017	0.276
LIG_SH2_STAT5	528	531	PF00017	0.327
LIG_SH2_STAT5	546	549	PF00017	0.186
LIG_SH2_STAT5	55	58	PF00017	0.155
LIG_SH2_STAT5	86	89	PF00017	0.393
LIG_SH3_3	450	456	PF00018	0.272
LIG_SH3_3	594	600	PF00018	0.368
LIG_SUMO_SIM_anti_2	89	94	PF11976	0.393
LIG_SUMO_SIM_par_1	13	18	PF11976	0.227
LIG_TRFH_1	55	59	PF08558	0.300
LIG_TYR_ITIM	23	28	PF00017	0.365
LIG_TYR_ITIM	351	356	PF00017	0.253
LIG_TYR_ITIM	53	58	PF00017	0.365
LIG_WRC_WIRS_1	252	257	PF05994	0.305
LIG_WRC_WIRS_1	280	285	PF05994	0.383
LIG_WRC_WIRS_1	607	612	PF05994	0.341
MOD_CDK_SPxK_1	565	571	PF00069	0.199
MOD_CK1_1	187	193	PF00069	0.407
MOD_CK1_1	203	209	PF00069	0.501
MOD_CK1_1	212	218	PF00069	0.507
MOD_CK1_1	31	37	PF00069	0.393
MOD_CK1_1	362	368	PF00069	0.339
MOD_CK1_1	385	391	PF00069	0.409
MOD_CK1_1	392	398	PF00069	0.322
MOD_CK1_1	406	412	PF00069	0.277
MOD_CK1_1	584	590	PF00069	0.276
MOD_CK2_1	212	218	PF00069	0.464
MOD_CK2_1	221	227	PF00069	0.583
MOD_CK2_1	556	562	PF00069	0.276
MOD_CMANNOS	475	478	PF00535	0.383
MOD_GlcNHglycan	124	127	PF01048	0.306
MOD_GlcNHglycan	186	189	PF01048	0.407
MOD_GlcNHglycan	362	365	PF01048	0.360
MOD_GlcNHglycan	368	371	PF01048	0.357
MOD_GlcNHglycan	489	492	PF01048	0.341
MOD_GlcNHglycan	537	540	PF01048	0.337
MOD_GlcNHglycan	552	555	PF01048	0.155
MOD_GlcNHglycan	584	587	PF01048	0.282
MOD_GlcNHglycan	625	628	PF01048	0.458
MOD_GlcNHglycan	65	68	PF01048	0.307
MOD_GlcNHglycan	8	11	PF01048	0.334
MOD_GlcNHglycan	95	98	PF01048	0.430
MOD_GSK3_1	153	160	PF00069	0.419
MOD_GSK3_1	196	203	PF00069	0.706
MOD_GSK3_1	204	211	PF00069	0.684
MOD_GSK3_1	212	219	PF00069	0.623
MOD_GSK3_1	229	236	PF00069	0.386
MOD_GSK3_1	269	276	PF00069	0.270
MOD_GSK3_1	362	369	PF00069	0.293
MOD_GSK3_1	385	392	PF00069	0.332
MOD_N-GLC_1	196	201	PF02516	0.428
MOD_N-GLC_1	406	411	PF02516	0.316
MOD_NEK2_1	101	106	PF00069	0.412
MOD_NEK2_1	239	244	PF00069	0.328
MOD_NEK2_1	251	256	PF00069	0.305
MOD_NEK2_1	330	335	PF00069	0.372
MOD_NEK2_1	382	387	PF00069	0.285
MOD_NEK2_1	502	507	PF00069	0.276
MOD_NEK2_1	512	517	PF00069	0.276
MOD_NEK2_1	572	577	PF00069	0.363
MOD_NEK2_1	582	587	PF00069	0.249
MOD_NEK2_1	592	597	PF00069	0.155
MOD_NEK2_1	606	611	PF00069	0.288
MOD_NEK2_1	63	68	PF00069	0.375
MOD_NEK2_1	93	98	PF00069	0.311
MOD_NEK2_2	127	132	PF00069	0.393
MOD_NEK2_2	415	420	PF00069	0.393
MOD_PKA_1	535	541	PF00069	0.275
MOD_PKA_2	330	336	PF00069	0.329
MOD_PKA_2	415	421	PF00069	0.393
MOD_Plk_1	208	214	PF00069	0.713
MOD_Plk_1	406	412	PF00069	0.272
MOD_Plk_1	524	530	PF00069	0.375
MOD_Plk_2-3	209	215	PF00069	0.474
MOD_Plk_4	153	159	PF00069	0.560
MOD_Plk_4	168	174	PF00069	0.443
MOD_Plk_4	221	227	PF00069	0.496
MOD_Plk_4	239	245	PF00069	0.222
MOD_Plk_4	251	257	PF00069	0.218
MOD_Plk_4	279	285	PF00069	0.320
MOD_Plk_4	34	40	PF00069	0.306
MOD_Plk_4	385	391	PF00069	0.199
MOD_Plk_4	406	412	PF00069	0.316
MOD_Plk_4	464	470	PF00069	0.301
MOD_Plk_4	502	508	PF00069	0.344
MOD_Plk_4	524	530	PF00069	0.213
MOD_Plk_4	556	562	PF00069	0.276
MOD_Plk_4	572	578	PF00069	0.276
MOD_Plk_4	592	598	PF00069	0.155
MOD_Plk_4	86	92	PF00069	0.344
MOD_ProDKin_1	565	571	PF00069	0.199
MOD_ProDKin_1	95	101	PF00069	0.491
TRG_DiLeu_BaEn_1	264	269	PF01217	0.199
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.276
TRG_ENDOCYTIC_2	102	105	PF00928	0.360
TRG_ENDOCYTIC_2	128	131	PF00928	0.276
TRG_ENDOCYTIC_2	213	216	PF00928	0.662
TRG_ENDOCYTIC_2	25	28	PF00928	0.360
TRG_ENDOCYTIC_2	280	283	PF00928	0.276
TRG_ENDOCYTIC_2	298	301	PF00928	0.276
TRG_ENDOCYTIC_2	35	38	PF00928	0.300
TRG_ENDOCYTIC_2	353	356	PF00928	0.354
TRG_ENDOCYTIC_2	431	434	PF00928	0.276
TRG_ENDOCYTIC_2	55	58	PF00928	0.155
TRG_ER_diArg_1	266	268	PF00400	0.199
TRG_ER_diArg_1	75	78	PF00400	0.384
TRG_NES_CRM1_1	6	21	PF08389	0.250
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.199

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C4	Leptomonas seymouri	59%	96%
A0A1X0P0R8	Trypanosomatidae	39%	95%
A0A3S7X6J4	Leishmania donovani	75%	100%
A0A422P2J5	Trypanosoma rangeli	39%	99%
A4I8T7	Leishmania infantum	75%	100%
E9B3Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q4D4	Leishmania major	74%	100%
V5BPE7	Trypanosoma cruzi	37%	100%