TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLB0_LEIBR

TriTrypDb:

LbrM.33.0740 , LBRM2903_330012800

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HLB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLB0

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0005515	protein binding	2	4
GO:0030544	Hsp70 protein binding	4	1
GO:0031072	heat shock protein binding	3	4
GO:0051879	Hsp90 protein binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.452
CLV_NRD_NRD_1	162	164	PF00675	0.469
CLV_NRD_NRD_1	318	320	PF00675	0.334
CLV_NRD_NRD_1	32	34	PF00675	0.534
CLV_NRD_NRD_1	83	85	PF00675	0.451
CLV_PCSK_KEX2_1	102	104	PF00082	0.552
CLV_PCSK_KEX2_1	32	34	PF00082	0.534
CLV_PCSK_KEX2_1	320	322	PF00082	0.284
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.284
CLV_PCSK_SKI1_1	171	175	PF00082	0.461
CLV_PCSK_SKI1_1	233	237	PF00082	0.483
CLV_PCSK_SKI1_1	242	246	PF00082	0.403
CLV_PCSK_SKI1_1	357	361	PF00082	0.287
DEG_Nend_Nbox_1	1	3	PF02207	0.595
DOC_CDC14_PxL_1	277	285	PF14671	0.360
DOC_CYCLIN_yCln2_LP_2	278	284	PF00134	0.350
DOC_MAPK_gen_1	168	176	PF00069	0.340
DOC_MAPK_gen_1	177	185	PF00069	0.391
DOC_MAPK_gen_1	188	195	PF00069	0.456
DOC_MAPK_gen_1	319	331	PF00069	0.422
DOC_MAPK_HePTP_8	185	197	PF00069	0.312
DOC_MAPK_MEF2A_6	177	185	PF00069	0.385
DOC_MAPK_MEF2A_6	188	197	PF00069	0.434
DOC_MAPK_MEF2A_6	242	251	PF00069	0.300
DOC_MAPK_NFAT4_5	178	186	PF00069	0.399
DOC_PP2B_LxvP_1	278	281	PF13499	0.353
DOC_USP7_MATH_1	133	137	PF00917	0.343
DOC_USP7_MATH_1	152	156	PF00917	0.376
DOC_USP7_MATH_1	200	204	PF00917	0.323
DOC_USP7_MATH_1	235	239	PF00917	0.433
DOC_USP7_MATH_1	243	247	PF00917	0.309
DOC_USP7_MATH_1	66	70	PF00917	0.458
DOC_USP7_UBL2_3	250	254	PF12436	0.321
DOC_USP7_UBL2_3	320	324	PF12436	0.297
DOC_WW_Pin1_4	249	254	PF00397	0.353
LIG_14-3-3_CanoR_1	242	248	PF00244	0.332
LIG_14-3-3_CanoR_1	3	11	PF00244	0.408
LIG_14-3-3_CanoR_1	357	362	PF00244	0.287
LIG_APCC_ABBA_1	283	288	PF00400	0.369
LIG_deltaCOP1_diTrp_1	347	356	PF00928	0.431
LIG_deltaCOP1_diTrp_1	41	49	PF00928	0.493
LIG_eIF4E_1	361	367	PF01652	0.372
LIG_FHA_1	113	119	PF00498	0.387
LIG_FHA_1	374	380	PF00498	0.425
LIG_FHA_2	10	16	PF00498	0.452
LIG_FHA_2	199	205	PF00498	0.326
LIG_FHA_2	218	224	PF00498	0.419
LIG_FHA_2	52	58	PF00498	0.485
LIG_LIR_Apic_2	360	364	PF02991	0.370
LIG_LIR_Gen_1	203	213	PF02991	0.416
LIG_LIR_Gen_1	41	50	PF02991	0.489
LIG_LIR_Gen_1	69	80	PF02991	0.478
LIG_LIR_Nem_3	347	353	PF02991	0.394
LIG_LIR_Nem_3	69	75	PF02991	0.491
LIG_MYND_1	364	368	PF01753	0.372
LIG_PTB_Apo_2	156	163	PF02174	0.305
LIG_PTB_Phospho_1	156	162	PF10480	0.308
LIG_Rb_pABgroove_1	280	288	PF01858	0.323
LIG_RPA_C_Fungi	130	142	PF08784	0.356
LIG_SH2_GRB2like	132	135	PF00017	0.352
LIG_SH2_NCK_1	361	365	PF00017	0.481
LIG_SH2_NCK_1	72	76	PF00017	0.488
LIG_SH2_SRC	72	75	PF00017	0.520
LIG_SH2_STAP1	114	118	PF00017	0.480
LIG_SH2_STAT5	114	117	PF00017	0.380
LIG_SH2_STAT5	271	274	PF00017	0.484
LIG_SH3_3	190	196	PF00018	0.582
LIG_SH3_3	335	341	PF00018	0.383
LIG_TRAF2_1	12	15	PF00917	0.576
LIG_TRAF2_1	220	223	PF00917	0.546
LIG_TRAF2_1	98	101	PF00917	0.584
LIG_TYR_ITIM	70	75	PF00017	0.496
LIG_UBA3_1	366	375	PF00899	0.382
MOD_CDK_SPK_2	249	254	PF00069	0.450
MOD_CK1_1	203	209	PF00069	0.299
MOD_CK2_1	110	116	PF00069	0.483
MOD_CK2_1	203	209	PF00069	0.373
MOD_CK2_1	217	223	PF00069	0.412
MOD_CK2_1	9	15	PF00069	0.506
MOD_GlcNHglycan	6	9	PF01048	0.551
MOD_GSK3_1	122	129	PF00069	0.555
MOD_N-GLC_1	133	138	PF02516	0.350
MOD_NEK2_1	49	54	PF00069	0.468
MOD_PIKK_1	198	204	PF00454	0.512
MOD_PIKK_1	51	57	PF00454	0.361
MOD_PK_1	126	132	PF00069	0.273
MOD_PKA_1	32	38	PF00069	0.426
MOD_PKA_2	32	38	PF00069	0.426
MOD_Plk_1	133	139	PF00069	0.343
MOD_Plk_4	126	132	PF00069	0.484
MOD_Plk_4	66	72	PF00069	0.572
MOD_ProDKin_1	249	255	PF00069	0.357
MOD_SUMO_for_1	253	256	PF00179	0.341
TRG_DiLeu_BaEn_1	362	367	PF01217	0.517
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.450
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.484
TRG_ENDOCYTIC_2	322	325	PF00928	0.400
TRG_ENDOCYTIC_2	72	75	PF00928	0.496
TRG_ER_diArg_1	319	322	PF00400	0.432
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R4	Leptomonas seymouri	76%	100%
A0A1X0P0Q3	Trypanosomatidae	60%	100%
A0A3S7X6F2	Leishmania donovani	86%	100%
A0A422P2K3	Trypanosoma rangeli	59%	100%
A1Z6M6	Drosophila melanogaster	29%	98%
A4I8T6	Leishmania infantum	85%	100%
D0A4T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	90%
E9B3Q2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O13754	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
O95801	Homo sapiens	27%	100%
P33313	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q4Q4D5	Leishmania major	85%	100%
Q54M20	Dictyostelium discoideum	25%	98%
Q5EA11	Bos taurus	29%	100%
Q8R3H9	Mus musculus	26%	100%