Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLA9_LEIBR

TriTrypDb:

LbrM.33.0730 , LBRM2903_330012700

Length:

154

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLA9

PDB structure(s): 7aih_BB , 7am2_BB , 7ane_BB

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.435
CLV_PCSK_FUR_1	86	90	PF00082	0.583
CLV_PCSK_KEX2_1	23	25	PF00082	0.435
CLV_PCSK_KEX2_1	32	34	PF00082	0.456
CLV_PCSK_KEX2_1	88	90	PF00082	0.478
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.585
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.478
CLV_PCSK_SKI1_1	128	132	PF00082	0.461
CLV_PCSK_SKI1_1	24	28	PF00082	0.425
DEG_APCC_DBOX_1	88	96	PF00400	0.498
DEG_Nend_Nbox_1	1	3	PF02207	0.568
DOC_MAPK_gen_1	86	94	PF00069	0.587
DOC_PP4_FxxP_1	108	111	PF00568	0.446
DOC_PP4_FxxP_1	129	132	PF00568	0.453
DOC_USP7_MATH_1	47	51	PF00917	0.616
DOC_USP7_UBL2_3	40	44	PF12436	0.593
LIG_14-3-3_CanoR_1	89	93	PF00244	0.567
LIG_deltaCOP1_diTrp_1	98	108	PF00928	0.461
LIG_FHA_1	105	111	PF00498	0.411
LIG_FHA_1	125	131	PF00498	0.281
LIG_FHA_1	143	149	PF00498	0.453
LIG_FHA_1	89	95	PF00498	0.576
LIG_LIR_Apic_2	107	111	PF02991	0.430
LIG_LIR_Apic_2	126	132	PF02991	0.458
LIG_LIR_Apic_2	98	104	PF02991	0.442
LIG_LIR_Gen_1	14	22	PF02991	0.418
LIG_LIR_Nem_3	107	112	PF02991	0.413
LIG_LIR_Nem_3	14	19	PF02991	0.429
LIG_MAD2	117	125	PF02301	0.473
LIG_Pex14_2	108	112	PF04695	0.441
LIG_Pex14_2	72	76	PF04695	0.524
LIG_SH2_CRK	16	20	PF00017	0.422
LIG_SH3_1	144	150	PF00018	0.439
LIG_SH3_3	108	114	PF00018	0.464
LIG_SH3_3	130	136	PF00018	0.443
LIG_SH3_3	144	150	PF00018	0.439
LIG_SH3_3	16	22	PF00018	0.444
LIG_SH3_3	76	82	PF00018	0.456
MOD_CK2_1	8	14	PF00069	0.471
MOD_GlcNHglycan	49	52	PF01048	0.607
MOD_NEK2_1	142	147	PF00069	0.440
MOD_NEK2_1	2	7	PF00069	0.614
MOD_NEK2_1	8	13	PF00069	0.560
MOD_NEK2_2	104	109	PF00069	0.483
MOD_PIKK_1	93	99	PF00454	0.360
MOD_PKA_1	88	94	PF00069	0.553
MOD_PKA_2	36	42	PF00069	0.558
MOD_PKA_2	88	94	PF00069	0.553
MOD_Plk_4	104	110	PF00069	0.455
MOD_SUMO_for_1	31	34	PF00179	0.601
MOD_SUMO_rev_2	120	130	PF00179	0.462
TRG_ENDOCYTIC_2	16	19	PF00928	0.416
TRG_ER_diArg_1	22	24	PF00400	0.435
TRG_Pf-PMV_PEXEL_1	23	28	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN7	Leptomonas seymouri	88%	99%
A0A0S4IVK6	Bodo saltans	62%	100%
A0A1X0P0U6	Trypanosomatidae	70%	100%
A0A3S7X6H2	Leishmania donovani	92%	100%
A0A422P2L4	Trypanosoma rangeli	69%	100%
A4I8T5	Leishmania infantum	92%	100%
D0A4T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9B3Q1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4D6	Leishmania major	89%	100%