LeishMANIAdb
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Putative sterol C-24 reductase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative sterol C-24 reductase
Gene product:
sterol C-24 reductase, putative
Species:
Leishmania braziliensis
UniProt:
A4HLA8_LEIBR
TriTrypDb:
LbrM.33.0720 , LBRM2903_330012600
Length:
500

Annotations

LeishMANIAdb annotations

Related to both fungal ergosterol C-24 reductases and to a lesser extent, animal delta-14 lanosterol reductases (all preferentially ER-localized).. The highly changed Ser/Arg rich N-terminus might point to a mitochondrial transit signal (ergosterols are essential for Kinetoplastid mitochondria).. Localization: ER (by homology) / Mitochondrial (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

A4HLA8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLA8

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 9
GO:0006694 steroid biosynthetic process 5 9
GO:0008152 metabolic process 1 9
GO:0008202 steroid metabolic process 4 9
GO:0008610 lipid biosynthetic process 4 9
GO:0009058 biosynthetic process 2 9
GO:0016125 sterol metabolic process 4 9
GO:0016126 sterol biosynthetic process 5 9
GO:0044238 primary metabolic process 2 9
GO:0071704 organic substance metabolic process 2 9
GO:1901360 organic cyclic compound metabolic process 3 9
GO:1901362 organic cyclic compound biosynthetic process 4 9
GO:1901576 organic substance biosynthetic process 3 9
GO:1901615 organic hydroxy compound metabolic process 3 9
GO:1901617 organic hydroxy compound biosynthetic process 4 9
GO:0006066 alcohol metabolic process 3 1
GO:0006696 ergosterol biosynthetic process 5 1
GO:0008204 ergosterol metabolic process 4 1
GO:0009987 cellular process 1 1
GO:0016128 phytosteroid metabolic process 4 1
GO:0016129 phytosteroid biosynthetic process 5 1
GO:0044107 obsolete cellular alcohol metabolic process 3 1
GO:0044108 obsolete cellular alcohol biosynthetic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0044281 small molecule metabolic process 2 1
GO:0044283 small molecule biosynthetic process 3 1
GO:0046165 alcohol biosynthetic process 4 1
GO:0097384 cellular lipid biosynthetic process 4 1
GO:1902652 secondary alcohol metabolic process 4 1
GO:1902653 secondary alcohol biosynthetic process 5 1
Molecular functions
Term Name Level Count
GO:0000246 delta24(24-1) sterol reductase activity 5 7
GO:0003824 catalytic activity 1 9
GO:0016491 oxidoreductase activity 2 9
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 3 9
GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 4 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 197 199 PF00675 0.481
CLV_NRD_NRD_1 225 227 PF00675 0.214
CLV_NRD_NRD_1 23 25 PF00675 0.485
CLV_NRD_NRD_1 35 37 PF00675 0.430
CLV_NRD_NRD_1 384 386 PF00675 0.277
CLV_NRD_NRD_1 428 430 PF00675 0.231
CLV_NRD_NRD_1 470 472 PF00675 0.279
CLV_NRD_NRD_1 51 53 PF00675 0.349
CLV_PCSK_FUR_1 382 386 PF00082 0.234
CLV_PCSK_FUR_1 468 472 PF00082 0.256
CLV_PCSK_KEX2_1 197 199 PF00082 0.481
CLV_PCSK_KEX2_1 224 226 PF00082 0.232
CLV_PCSK_KEX2_1 35 37 PF00082 0.437
CLV_PCSK_KEX2_1 384 386 PF00082 0.234
CLV_PCSK_KEX2_1 470 472 PF00082 0.279
CLV_PCSK_PC1ET2_1 224 226 PF00082 0.257
CLV_PCSK_SKI1_1 354 358 PF00082 0.406
CLV_PCSK_SKI1_1 38 42 PF00082 0.408
CLV_PCSK_SKI1_1 410 414 PF00082 0.279
CLV_PCSK_SKI1_1 52 56 PF00082 0.281
DEG_APCC_DBOX_1 353 361 PF00400 0.349
DOC_AGCK_PIF_1 455 460 PF00069 0.186
DOC_CKS1_1 39 44 PF01111 0.643
DOC_CYCLIN_RxL_1 150 160 PF00134 0.498
DOC_CYCLIN_yCln2_LP_2 145 151 PF00134 0.333
DOC_MAPK_gen_1 109 116 PF00069 0.277
DOC_MAPK_gen_1 382 392 PF00069 0.498
DOC_MAPK_HePTP_8 243 255 PF00069 0.456
DOC_MAPK_MEF2A_6 128 136 PF00069 0.249
DOC_MAPK_MEF2A_6 246 255 PF00069 0.454
DOC_MAPK_MEF2A_6 260 268 PF00069 0.288
DOC_MAPK_MEF2A_6 354 363 PF00069 0.225
DOC_MAPK_NFAT4_5 354 362 PF00069 0.212
DOC_PP2B_LxvP_1 145 148 PF13499 0.345
DOC_PP2B_LxvP_1 155 158 PF13499 0.421
DOC_PP2B_LxvP_1 245 248 PF13499 0.372
DOC_PP2B_PxIxI_1 147 153 PF00149 0.186
DOC_PP4_FxxP_1 67 70 PF00568 0.456
DOC_USP7_MATH_1 156 160 PF00917 0.431
DOC_USP7_UBL2_3 105 109 PF12436 0.172
DOC_WW_Pin1_4 30 35 PF00397 0.643
DOC_WW_Pin1_4 38 43 PF00397 0.565
DOC_WW_Pin1_4 52 57 PF00397 0.464
LIG_14-3-3_CanoR_1 164 168 PF00244 0.517
LIG_14-3-3_CanoR_1 260 264 PF00244 0.269
LIG_14-3-3_CanoR_1 394 402 PF00244 0.390
LIG_14-3-3_CanoR_1 410 420 PF00244 0.478
LIG_AP2alpha_1 420 424 PF02296 0.477
LIG_APCC_ABBA_1 253 258 PF00400 0.431
LIG_BH_BH3_1 423 439 PF00452 0.372
LIG_BRCT_BRCA1_1 394 398 PF00533 0.372
LIG_deltaCOP1_diTrp_1 59 67 PF00928 0.424
LIG_EH1_1 175 183 PF00400 0.269
LIG_FHA_1 127 133 PF00498 0.224
LIG_FHA_1 208 214 PF00498 0.186
LIG_FHA_1 310 316 PF00498 0.438
LIG_FHA_1 327 333 PF00498 0.269
LIG_FHA_1 35 41 PF00498 0.527
LIG_FHA_1 414 420 PF00498 0.551
LIG_FHA_1 432 438 PF00498 0.351
LIG_FHA_1 461 467 PF00498 0.245
LIG_FHA_2 309 315 PF00498 0.466
LIG_FHA_2 39 45 PF00498 0.551
LIG_LIR_Apic_2 64 70 PF02991 0.454
LIG_LIR_Gen_1 113 123 PF02991 0.207
LIG_LIR_Gen_1 129 138 PF02991 0.386
LIG_LIR_Gen_1 140 150 PF02991 0.294
LIG_LIR_Gen_1 173 184 PF02991 0.409
LIG_LIR_Gen_1 215 223 PF02991 0.192
LIG_LIR_Gen_1 262 271 PF02991 0.275
LIG_LIR_Gen_1 276 284 PF02991 0.287
LIG_LIR_Gen_1 314 325 PF02991 0.437
LIG_LIR_Gen_1 44 54 PF02991 0.473
LIG_LIR_Gen_1 485 495 PF02991 0.456
LIG_LIR_Nem_3 113 119 PF02991 0.202
LIG_LIR_Nem_3 129 133 PF02991 0.412
LIG_LIR_Nem_3 140 145 PF02991 0.325
LIG_LIR_Nem_3 173 179 PF02991 0.408
LIG_LIR_Nem_3 215 220 PF02991 0.290
LIG_LIR_Nem_3 262 266 PF02991 0.275
LIG_LIR_Nem_3 276 281 PF02991 0.287
LIG_LIR_Nem_3 311 316 PF02991 0.445
LIG_LIR_Nem_3 422 427 PF02991 0.431
LIG_LIR_Nem_3 44 50 PF02991 0.553
LIG_LIR_Nem_3 451 455 PF02991 0.276
LIG_LIR_Nem_3 485 490 PF02991 0.436
LIG_NRBOX 133 139 PF00104 0.362
LIG_NRBOX 264 270 PF00104 0.186
LIG_Pex14_1 313 317 PF04695 0.457
LIG_Pex14_1 322 326 PF04695 0.305
LIG_Pex14_2 233 237 PF04695 0.551
LIG_Pex14_2 420 424 PF04695 0.412
LIG_Pex14_2 452 456 PF04695 0.269
LIG_SH2_CRK 176 180 PF00017 0.306
LIG_SH2_CRK 493 497 PF00017 0.431
LIG_SH2_GRB2like 298 301 PF00017 0.269
LIG_SH2_GRB2like 326 329 PF00017 0.269
LIG_SH2_NCK_1 47 51 PF00017 0.565
LIG_SH2_PTP2 487 490 PF00017 0.488
LIG_SH2_PTP2 88 91 PF00017 0.362
LIG_SH2_SRC 298 301 PF00017 0.269
LIG_SH2_STAP1 235 239 PF00017 0.431
LIG_SH2_STAP1 433 437 PF00017 0.269
LIG_SH2_STAT3 336 339 PF00017 0.269
LIG_SH2_STAT5 141 144 PF00017 0.303
LIG_SH2_STAT5 151 154 PF00017 0.456
LIG_SH2_STAT5 176 179 PF00017 0.286
LIG_SH2_STAT5 203 206 PF00017 0.222
LIG_SH2_STAT5 219 222 PF00017 0.386
LIG_SH2_STAT5 283 286 PF00017 0.238
LIG_SH2_STAT5 298 301 PF00017 0.366
LIG_SH2_STAT5 336 339 PF00017 0.277
LIG_SH2_STAT5 342 345 PF00017 0.223
LIG_SH2_STAT5 369 372 PF00017 0.287
LIG_SH2_STAT5 405 408 PF00017 0.456
LIG_SH2_STAT5 433 436 PF00017 0.273
LIG_SH2_STAT5 457 460 PF00017 0.289
LIG_SH2_STAT5 487 490 PF00017 0.431
LIG_SH2_STAT5 86 89 PF00017 0.269
LIG_SH3_3 36 42 PF00018 0.660
LIG_SH3_3 396 402 PF00018 0.431
LIG_SH3_3 98 104 PF00018 0.256
LIG_Sin3_3 142 149 PF02671 0.212
LIG_SUMO_SIM_anti_2 262 268 PF11976 0.269
LIG_SUMO_SIM_par_1 264 270 PF11976 0.263
LIG_SxIP_EBH_1 450 459 PF03271 0.172
LIG_TRAF2_1 41 44 PF00917 0.545
LIG_TYR_ITIM 185 190 PF00017 0.303
LIG_TYR_ITIM 491 496 PF00017 0.431
LIG_TYR_ITIM 84 89 PF00017 0.269
LIG_WRC_WIRS_1 115 120 PF05994 0.288
LIG_WRC_WIRS_1 127 132 PF05994 0.197
LIG_WRC_WIRS_1 449 454 PF05994 0.231
LIG_WRC_WIRS_1 457 462 PF05994 0.269
MOD_CDK_SPK_2 30 35 PF00069 0.598
MOD_CDK_SPxK_1 30 36 PF00069 0.663
MOD_CDK_SPxK_1 52 58 PF00069 0.496
MOD_CK1_1 376 382 PF00069 0.420
MOD_CK2_1 38 44 PF00069 0.560
MOD_Cter_Amidation 107 110 PF01082 0.372
MOD_Cter_Amidation 427 430 PF01082 0.231
MOD_DYRK1A_RPxSP_1 30 34 PF00069 0.664
MOD_GlcNHglycan 172 175 PF01048 0.402
MOD_GlcNHglycan 240 243 PF01048 0.231
MOD_GlcNHglycan 385 388 PF01048 0.247
MOD_GlcNHglycan 413 416 PF01048 0.365
MOD_GSK3_1 110 117 PF00069 0.172
MOD_GSK3_1 12 19 PF00069 0.671
MOD_GSK3_1 20 27 PF00069 0.704
MOD_GSK3_1 30 37 PF00069 0.660
MOD_GSK3_1 456 463 PF00069 0.186
MOD_N-GLC_1 4 9 PF02516 0.403
MOD_N-GLC_2 328 330 PF02516 0.269
MOD_NEK2_1 238 243 PF00069 0.443
MOD_NEK2_1 267 272 PF00069 0.337
MOD_NEK2_1 370 375 PF00069 0.299
MOD_NEK2_1 383 388 PF00069 0.421
MOD_NEK2_1 456 461 PF00069 0.263
MOD_NEK2_1 77 82 PF00069 0.294
MOD_NEK2_1 94 99 PF00069 0.180
MOD_NEK2_2 337 342 PF00069 0.362
MOD_PIKK_1 373 379 PF00454 0.431
MOD_PKA_1 24 30 PF00069 0.722
MOD_PKA_2 163 169 PF00069 0.517
MOD_PKA_2 227 233 PF00069 0.431
MOD_PKA_2 259 265 PF00069 0.269
MOD_PKA_2 34 40 PF00069 0.641
MOD_PKA_2 383 389 PF00069 0.444
MOD_PKA_2 393 399 PF00069 0.390
MOD_PKA_2 5 11 PF00069 0.602
MOD_PKB_1 14 22 PF00069 0.686
MOD_Plk_4 110 116 PF00069 0.231
MOD_Plk_4 259 265 PF00069 0.275
MOD_Plk_4 337 343 PF00069 0.276
MOD_Plk_4 448 454 PF00069 0.301
MOD_Plk_4 94 100 PF00069 0.248
MOD_ProDKin_1 30 36 PF00069 0.642
MOD_ProDKin_1 38 44 PF00069 0.560
MOD_ProDKin_1 52 58 PF00069 0.467
MOD_SUMO_for_1 104 107 PF00179 0.232
MOD_SUMO_for_1 303 306 PF00179 0.372
TRG_DiLeu_BaEn_1 486 491 PF01217 0.488
TRG_ENDOCYTIC_2 176 179 PF00928 0.318
TRG_ENDOCYTIC_2 187 190 PF00928 0.276
TRG_ENDOCYTIC_2 203 206 PF00928 0.339
TRG_ENDOCYTIC_2 235 238 PF00928 0.431
TRG_ENDOCYTIC_2 278 281 PF00928 0.256
TRG_ENDOCYTIC_2 317 320 PF00928 0.431
TRG_ENDOCYTIC_2 457 460 PF00928 0.269
TRG_ENDOCYTIC_2 47 50 PF00928 0.563
TRG_ENDOCYTIC_2 480 483 PF00928 0.441
TRG_ENDOCYTIC_2 487 490 PF00928 0.459
TRG_ENDOCYTIC_2 493 496 PF00928 0.488
TRG_ENDOCYTIC_2 86 89 PF00928 0.270
TRG_ER_diArg_1 13 16 PF00400 0.607
TRG_ER_diArg_1 196 198 PF00400 0.262
TRG_ER_diArg_1 225 228 PF00400 0.415
TRG_ER_diArg_1 34 36 PF00400 0.662
TRG_ER_diArg_1 381 384 PF00400 0.517
TRG_NLS_MonoExtC_3 223 228 PF00514 0.434

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3C6 Leptomonas seymouri 75% 99%
A0A0N1PBH8 Leptomonas seymouri 29% 100%
A0A0S4IS37 Bodo saltans 27% 100%
A0A0S4KLN5 Bodo saltans 29% 100%
A0A1D8PIC7 Candida albicans (strain SC5314 / ATCC MYA-2876) 29% 100%
A0A1D8PJ25 Candida albicans (strain SC5314 / ATCC MYA-2876) 38% 100%
A0A1X0NRH6 Trypanosomatidae 28% 100%
A0A1X0P0Q6 Trypanosomatidae 64% 100%
A0A3Q8IM20 Leishmania donovani 86% 100%
A0A3R7KUI7 Trypanosoma rangeli 64% 100%
A0A3R7N804 Trypanosoma rangeli 29% 100%
A0A3S7X5R0 Leishmania donovani 26% 100%
A4HKM3 Leishmania braziliensis 27% 100%
A4I855 Leishmania infantum 26% 100%
A4I8T4 Leishmania infantum 86% 100%
D0AAC2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
E9B312 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B3Q0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
G4SW86 Methylotuvimicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z) 32% 100%
I1RF79 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 27% 100%
I1RR90 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 26% 100%
I1RZZ3 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 40% 84%
O08984 Rattus norvegicus 31% 81%
O13597 Septoria lycopersici 26% 98%
O76062 Homo sapiens 33% 100%
O88455 Mus musculus 26% 100%
P23913 Gallus gallus 29% 78%
P25340 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 100%
P32462 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 100%
P36209 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 38% 100%
P38670 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 27% 100%
P78575 Ascobolus immersus 28% 100%
Q01447 Fusarium vanettenii 27% 100%
Q09195 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 100%
Q14739 Homo sapiens 31% 81%
Q3U9G9 Mus musculus 31% 80%
Q4Q4D7 Leishmania major 85% 100%
Q4Q543 Leishmania major 26% 95%
Q4WJ59 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 36% 88%
Q4WJJ9 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 28% 97%
Q4WKA5 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 26% 100%
Q4WW43 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 42% 100%
Q54PP1 Dictyostelium discoideum 30% 100%
Q5E9J5 Bos taurus 26% 100%
Q5R7H4 Pongo abelii 31% 81%
Q5UQI4 Acanthamoeba polyphaga mimivirus 31% 100%
Q6P4M0 Xenopus tropicalis 27% 100%
Q71KT5 Mus musculus 33% 100%
Q7SXF1 Danio rerio 27% 100%
Q7ZXH1 Xenopus laevis 27% 100%
Q8WMV1 Bos taurus 33% 100%
Q9LDR4 Arabidopsis thaliana 29% 100%
Q9LDU6 Arabidopsis thaliana 25% 100%
Q9UBM7 Homo sapiens 26% 100%
Q9Z2Z8 Rattus norvegicus 27% 100%
V5BKN3 Trypanosoma cruzi 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS