Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2A regulatory subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HLA7_LEIBR

TriTrypDb:

LbrM.33.0710 , LBRM2903_330012500

Length:

848

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000159	protein phosphatase type 2A complex	5	8
GO:0008287	protein serine/threonine phosphatase complex	4	8
GO:0032991	protein-containing complex	1	8
GO:1902494	catalytic complex	2	8
GO:1903293	phosphatase complex	3	8
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HLA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLA7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0019208	phosphatase regulator activity	3	8
GO:0019888	protein phosphatase regulator activity	4	8
GO:0030234	enzyme regulator activity	2	8
GO:0098772	molecular function regulator activity	1	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.594
CLV_NRD_NRD_1	196	198	PF00675	0.749
CLV_NRD_NRD_1	28	30	PF00675	0.505
CLV_NRD_NRD_1	31	33	PF00675	0.477
CLV_NRD_NRD_1	396	398	PF00675	0.685
CLV_NRD_NRD_1	696	698	PF00675	0.826
CLV_NRD_NRD_1	715	717	PF00675	0.605
CLV_NRD_NRD_1	790	792	PF00675	0.667
CLV_PCSK_FUR_1	29	33	PF00082	0.416
CLV_PCSK_KEX2_1	195	197	PF00082	0.751
CLV_PCSK_KEX2_1	28	30	PF00082	0.505
CLV_PCSK_KEX2_1	31	33	PF00082	0.477
CLV_PCSK_KEX2_1	396	398	PF00082	0.685
CLV_PCSK_KEX2_1	416	418	PF00082	0.583
CLV_PCSK_KEX2_1	696	698	PF00082	0.784
CLV_PCSK_KEX2_1	715	717	PF00082	0.605
CLV_PCSK_KEX2_1	72	74	PF00082	0.652
CLV_PCSK_KEX2_1	790	792	PF00082	0.667
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.788
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.819
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.652
CLV_PCSK_SKI1_1	255	259	PF00082	0.721
CLV_PCSK_SKI1_1	31	35	PF00082	0.406
CLV_PCSK_SKI1_1	397	401	PF00082	0.693
CLV_PCSK_SKI1_1	433	437	PF00082	0.632
CLV_PCSK_SKI1_1	716	720	PF00082	0.650
DEG_APCC_DBOX_1	30	38	PF00400	0.642
DEG_APCC_DBOX_1	395	403	PF00400	0.486
DEG_SCF_FBW7_1	328	334	PF00400	0.473
DEG_SPOP_SBC_1	115	119	PF00917	0.439
DEG_SPOP_SBC_1	264	268	PF00917	0.455
DEG_SPOP_SBC_1	285	289	PF00917	0.475
DEG_SPOP_SBC_1	331	335	PF00917	0.537
DOC_CKS1_1	16	21	PF01111	0.643
DOC_CKS1_1	328	333	PF01111	0.472
DOC_CYCLIN_RxL_1	28	38	PF00134	0.604
DOC_CYCLIN_RxL_1	394	401	PF00134	0.482
DOC_CYCLIN_yClb1_LxF_4	54	60	PF00134	0.396
DOC_CYCLIN_yCln2_LP_2	307	313	PF00134	0.391
DOC_MAPK_gen_1	28	37	PF00069	0.648
DOC_MAPK_gen_1	396	402	PF00069	0.536
DOC_MAPK_gen_1	491	501	PF00069	0.372
DOC_MAPK_MEF2A_6	670	677	PF00069	0.376
DOC_PP2B_LxvP_1	103	106	PF13499	0.445
DOC_PP4_FxxP_1	122	125	PF00568	0.446
DOC_PP4_FxxP_1	5	8	PF00568	0.581
DOC_PP4_FxxP_1	59	62	PF00568	0.404
DOC_PP4_FxxP_1	637	640	PF00568	0.434
DOC_SPAK_OSR1_1	32	36	PF12202	0.600
DOC_USP7_MATH_1	115	119	PF00917	0.439
DOC_USP7_MATH_1	161	165	PF00917	0.536
DOC_USP7_MATH_1	264	268	PF00917	0.600
DOC_USP7_MATH_1	285	289	PF00917	0.574
DOC_USP7_MATH_1	291	295	PF00917	0.501
DOC_USP7_MATH_1	313	317	PF00917	0.589
DOC_USP7_MATH_1	409	413	PF00917	0.539
DOC_USP7_MATH_1	42	46	PF00917	0.312
DOC_USP7_MATH_1	48	52	PF00917	0.312
DOC_USP7_MATH_1	53	57	PF00917	0.565
DOC_USP7_MATH_1	575	579	PF00917	0.425
DOC_USP7_MATH_1	820	824	PF00917	0.423
DOC_USP7_UBL2_3	513	517	PF12436	0.459
DOC_WW_Pin1_4	130	135	PF00397	0.533
DOC_WW_Pin1_4	15	20	PF00397	0.616
DOC_WW_Pin1_4	169	174	PF00397	0.568
DOC_WW_Pin1_4	241	246	PF00397	0.624
DOC_WW_Pin1_4	260	265	PF00397	0.572
DOC_WW_Pin1_4	289	294	PF00397	0.475
DOC_WW_Pin1_4	324	329	PF00397	0.527
DOC_WW_Pin1_4	4	9	PF00397	0.609
DOC_WW_Pin1_4	424	429	PF00397	0.585
DOC_WW_Pin1_4	464	469	PF00397	0.376
DOC_WW_Pin1_4	583	588	PF00397	0.439
DOC_WW_Pin1_4	658	663	PF00397	0.366
DOC_WW_Pin1_4	688	693	PF00397	0.540
DOC_WW_Pin1_4	88	93	PF00397	0.548
LIG_14-3-3_CanoR_1	165	173	PF00244	0.529
LIG_14-3-3_CanoR_1	238	246	PF00244	0.557
LIG_14-3-3_CanoR_1	248	254	PF00244	0.591
LIG_14-3-3_CanoR_1	260	264	PF00244	0.495
LIG_14-3-3_CanoR_1	273	279	PF00244	0.416
LIG_14-3-3_CanoR_1	396	400	PF00244	0.477
LIG_14-3-3_CanoR_1	433	439	PF00244	0.548
LIG_14-3-3_CanoR_1	527	532	PF00244	0.430
LIG_14-3-3_CanoR_1	624	628	PF00244	0.460
LIG_14-3-3_CanoR_1	790	795	PF00244	0.472
LIG_14-3-3_CanoR_1	80	87	PF00244	0.583
LIG_14-3-3_CanoR_1	803	810	PF00244	0.528
LIG_14-3-3_CanoR_1	813	817	PF00244	0.388
LIG_14-3-3_CanoR_1	819	825	PF00244	0.389
LIG_14-3-3_CanoR_1	93	99	PF00244	0.543
LIG_Actin_WH2_2	614	630	PF00022	0.451
LIG_BIR_II_1	1	5	PF00653	0.589
LIG_BRCT_BRCA1_1	118	122	PF00533	0.443
LIG_BRCT_BRCA1_1	55	59	PF00533	0.395
LIG_BRCT_BRCA1_1	555	559	PF00533	0.389
LIG_BRCT_BRCA1_1	6	10	PF00533	0.586
LIG_Clathr_ClatBox_1	34	38	PF01394	0.412
LIG_EH_1	505	509	PF12763	0.537
LIG_eIF4E_1	731	737	PF01652	0.423
LIG_FHA_1	126	132	PF00498	0.623
LIG_FHA_1	273	279	PF00498	0.580
LIG_FHA_1	378	384	PF00498	0.419
LIG_FHA_1	480	486	PF00498	0.412
LIG_FHA_1	514	520	PF00498	0.493
LIG_FHA_1	52	58	PF00498	0.477
LIG_FHA_1	564	570	PF00498	0.347
LIG_FHA_1	579	585	PF00498	0.388
LIG_FHA_1	650	656	PF00498	0.416
LIG_FHA_1	72	78	PF00498	0.429
LIG_FHA_1	775	781	PF00498	0.392
LIG_FHA_1	98	104	PF00498	0.539
LIG_FHA_2	201	207	PF00498	0.583
LIG_FHA_2	298	304	PF00498	0.364
LIG_FHA_2	396	402	PF00498	0.484
LIG_FHA_2	485	491	PF00498	0.310
LIG_FHA_2	559	565	PF00498	0.367
LIG_FHA_2	575	581	PF00498	0.318
LIG_FHA_2	769	775	PF00498	0.458
LIG_LIR_Apic_2	119	125	PF02991	0.443
LIG_LIR_Apic_2	56	62	PF02991	0.398
LIG_LIR_Gen_1	372	378	PF02991	0.368
LIG_LIR_Gen_1	605	612	PF02991	0.363
LIG_LIR_Gen_1	645	655	PF02991	0.434
LIG_LIR_Gen_1	671	680	PF02991	0.382
LIG_LIR_Gen_1	777	786	PF02991	0.515
LIG_LIR_Nem_3	372	376	PF02991	0.369
LIG_LIR_Nem_3	443	448	PF02991	0.489
LIG_LIR_Nem_3	605	610	PF02991	0.369
LIG_LIR_Nem_3	645	651	PF02991	0.453
LIG_LIR_Nem_3	671	675	PF02991	0.377
LIG_LIR_Nem_3	7	13	PF02991	0.595
LIG_LIR_Nem_3	777	781	PF02991	0.488
LIG_LIR_Nem_3	842	846	PF02991	0.401
LIG_LYPXL_SIV_4	453	461	PF13949	0.430
LIG_MLH1_MIPbox_1	6	10	PF16413	0.586
LIG_Pex14_1	570	574	PF04695	0.416
LIG_Pex14_2	5	9	PF04695	0.584
LIG_Pex14_2	740	744	PF04695	0.321
LIG_PTB_Apo_2	754	761	PF02174	0.397
LIG_PTB_Phospho_1	754	760	PF10480	0.399
LIG_Rb_LxCxE_1	564	583	PF01857	0.410
LIG_SH2_CRK	16	20	PF00017	0.609
LIG_SH2_CRK	843	847	PF00017	0.420
LIG_SH2_NCK_1	190	194	PF00017	0.485
LIG_SH2_PTP2	454	457	PF00017	0.419
LIG_SH2_SRC	454	457	PF00017	0.419
LIG_SH2_SRC	588	591	PF00017	0.500
LIG_SH2_STAP1	445	449	PF00017	0.422
LIG_SH2_STAP1	555	559	PF00017	0.478
LIG_SH2_STAP1	760	764	PF00017	0.352
LIG_SH2_STAT3	448	451	PF00017	0.462
LIG_SH2_STAT3	555	558	PF00017	0.491
LIG_SH2_STAT5	305	308	PF00017	0.447
LIG_SH2_STAT5	363	366	PF00017	0.400
LIG_SH2_STAT5	448	451	PF00017	0.393
LIG_SH2_STAT5	454	457	PF00017	0.358
LIG_SH2_STAT5	46	49	PF00017	0.229
LIG_SH2_STAT5	484	487	PF00017	0.400
LIG_SH2_STAT5	666	669	PF00017	0.376
LIG_SH3_1	600	606	PF00018	0.429
LIG_SH3_1	689	695	PF00018	0.585
LIG_SH3_2	692	697	PF14604	0.591
LIG_SH3_3	131	137	PF00018	0.457
LIG_SH3_3	325	331	PF00018	0.470
LIG_SH3_3	438	444	PF00018	0.450
LIG_SH3_3	600	606	PF00018	0.429
LIG_SH3_3	635	641	PF00018	0.310
LIG_SH3_3	689	695	PF00018	0.550
LIG_SUMO_SIM_anti_2	140	146	PF11976	0.643
LIG_SUMO_SIM_anti_2	294	300	PF11976	0.530
LIG_SUMO_SIM_anti_2	398	404	PF11976	0.538
LIG_SUMO_SIM_par_1	33	38	PF11976	0.611
LIG_SUMO_SIM_par_1	39	45	PF11976	0.250
LIG_TRAF2_1	300	303	PF00917	0.368
LIG_TRAF2_1	641	644	PF00917	0.481
LIG_WRC_WIRS_1	775	780	PF05994	0.423
LIG_WW_3	639	643	PF00397	0.514
MOD_CDC14_SPxK_1	694	697	PF00782	0.507
MOD_CDK_SPK_2	15	20	PF00069	0.609
MOD_CDK_SPK_2	428	433	PF00069	0.495
MOD_CDK_SPK_2	691	696	PF00069	0.590
MOD_CDK_SPK_2	88	93	PF00069	0.548
MOD_CDK_SPxK_1	691	697	PF00069	0.590
MOD_CDK_SPxxK_3	241	248	PF00069	0.612
MOD_CDK_SPxxK_3	658	665	PF00069	0.372
MOD_CK1_1	111	117	PF00069	0.558
MOD_CK1_1	118	124	PF00069	0.607
MOD_CK1_1	164	170	PF00069	0.489
MOD_CK1_1	191	197	PF00069	0.645
MOD_CK1_1	23	29	PF00069	0.636
MOD_CK1_1	263	269	PF00069	0.647
MOD_CK1_1	271	277	PF00069	0.561
MOD_CK1_1	289	295	PF00069	0.537
MOD_CK1_1	297	303	PF00069	0.457
MOD_CK1_1	316	322	PF00069	0.432
MOD_CK1_1	324	330	PF00069	0.574
MOD_CK1_1	420	426	PF00069	0.628
MOD_CK1_1	427	433	PF00069	0.542
MOD_CK1_1	479	485	PF00069	0.438
MOD_CK1_1	51	57	PF00069	0.554
MOD_CK1_1	526	532	PF00069	0.463
MOD_CK1_1	578	584	PF00069	0.386
MOD_CK1_1	614	620	PF00069	0.402
MOD_CK1_1	649	655	PF00069	0.452
MOD_CK1_1	709	715	PF00069	0.319
MOD_CK1_1	768	774	PF00069	0.430
MOD_CK1_1	812	818	PF00069	0.428
MOD_CK1_1	97	103	PF00069	0.585
MOD_CK2_1	139	145	PF00069	0.599
MOD_CK2_1	149	155	PF00069	0.569
MOD_CK2_1	164	170	PF00069	0.588
MOD_CK2_1	226	232	PF00069	0.477
MOD_CK2_1	297	303	PF00069	0.369
MOD_CK2_1	459	465	PF00069	0.322
MOD_CK2_1	484	490	PF00069	0.360
MOD_CK2_1	497	503	PF00069	0.472
MOD_CK2_1	574	580	PF00069	0.426
MOD_CK2_1	583	589	PF00069	0.478
MOD_DYRK1A_RPxSP_1	260	264	PF00069	0.456
MOD_GlcNHglycan	110	113	PF01048	0.730
MOD_GlcNHglycan	122	125	PF01048	0.756
MOD_GlcNHglycan	167	170	PF01048	0.787
MOD_GlcNHglycan	270	273	PF01048	0.805
MOD_GlcNHglycan	275	278	PF01048	0.758
MOD_GlcNHglycan	288	291	PF01048	0.708
MOD_GlcNHglycan	293	296	PF01048	0.536
MOD_GlcNHglycan	323	326	PF01048	0.826
MOD_GlcNHglycan	334	337	PF01048	0.729
MOD_GlcNHglycan	347	350	PF01048	0.824
MOD_GlcNHglycan	364	367	PF01048	0.476
MOD_GlcNHglycan	405	408	PF01048	0.765
MOD_GlcNHglycan	420	423	PF01048	0.774
MOD_GlcNHglycan	478	481	PF01048	0.720
MOD_GlcNHglycan	50	53	PF01048	0.254
MOD_GlcNHglycan	503	506	PF01048	0.618
MOD_GlcNHglycan	613	616	PF01048	0.605
MOD_GlcNHglycan	662	665	PF01048	0.634
MOD_GlcNHglycan	767	770	PF01048	0.672
MOD_GlcNHglycan	794	797	PF01048	0.639
MOD_GlcNHglycan	824	827	PF01048	0.644
MOD_GSK3_1	104	111	PF00069	0.553
MOD_GSK3_1	114	121	PF00069	0.609
MOD_GSK3_1	125	132	PF00069	0.583
MOD_GSK3_1	161	168	PF00069	0.522
MOD_GSK3_1	237	244	PF00069	0.590
MOD_GSK3_1	259	266	PF00069	0.564
MOD_GSK3_1	268	275	PF00069	0.547
MOD_GSK3_1	279	286	PF00069	0.512
MOD_GSK3_1	313	320	PF00069	0.519
MOD_GSK3_1	327	334	PF00069	0.546
MOD_GSK3_1	347	354	PF00069	0.597
MOD_GSK3_1	358	365	PF00069	0.454
MOD_GSK3_1	416	423	PF00069	0.575
MOD_GSK3_1	424	431	PF00069	0.539
MOD_GSK3_1	460	467	PF00069	0.403
MOD_GSK3_1	476	483	PF00069	0.405
MOD_GSK3_1	497	504	PF00069	0.444
MOD_GSK3_1	522	529	PF00069	0.492
MOD_GSK3_1	574	581	PF00069	0.386
MOD_GSK3_1	610	617	PF00069	0.396
MOD_GSK3_1	705	712	PF00069	0.487
MOD_GSK3_1	726	733	PF00069	0.423
MOD_GSK3_1	770	777	PF00069	0.435
MOD_GSK3_1	780	787	PF00069	0.428
MOD_GSK3_1	820	827	PF00069	0.341
MOD_GSK3_1	93	100	PF00069	0.469
MOD_N-GLC_1	649	654	PF02516	0.627
MOD_N-GLC_1	755	760	PF02516	0.601
MOD_NEK2_1	283	288	PF00069	0.548
MOD_NEK2_1	522	527	PF00069	0.468
MOD_NEK2_1	610	615	PF00069	0.359
MOD_NEK2_1	744	749	PF00069	0.408
MOD_NEK2_1	755	760	PF00069	0.313
MOD_NEK2_1	789	794	PF00069	0.444
MOD_NEK2_1	822	827	PF00069	0.448
MOD_NEK2_1	839	844	PF00069	0.316
MOD_NEK2_1	9	14	PF00069	0.677
MOD_NEK2_2	592	597	PF00069	0.428
MOD_OFUCOSY	821	828	PF10250	0.569
MOD_PIKK_1	104	110	PF00454	0.510
MOD_PIKK_1	358	364	PF00454	0.485
MOD_PIKK_1	94	100	PF00454	0.551
MOD_PK_1	177	183	PF00069	0.460
MOD_PK_1	497	503	PF00069	0.439
MOD_PKA_1	416	422	PF00069	0.626
MOD_PKA_1	790	796	PF00069	0.470
MOD_PKA_2	164	170	PF00069	0.554
MOD_PKA_2	237	243	PF00069	0.465
MOD_PKA_2	259	265	PF00069	0.484
MOD_PKA_2	268	274	PF00069	0.605
MOD_PKA_2	320	326	PF00069	0.643
MOD_PKA_2	395	401	PF00069	0.482
MOD_PKA_2	416	422	PF00069	0.577
MOD_PKA_2	501	507	PF00069	0.473
MOD_PKA_2	526	532	PF00069	0.433
MOD_PKA_2	592	598	PF00069	0.492
MOD_PKA_2	623	629	PF00069	0.450
MOD_PKA_2	789	795	PF00069	0.462
MOD_PKA_2	79	85	PF00069	0.565
MOD_PKA_2	802	808	PF00069	0.412
MOD_PKA_2	812	818	PF00069	0.374
MOD_Plk_1	139	145	PF00069	0.591
MOD_Plk_1	279	285	PF00069	0.455
MOD_Plk_1	563	569	PF00069	0.346
MOD_Plk_1	575	581	PF00069	0.384
MOD_Plk_1	709	715	PF00069	0.499
MOD_Plk_1	755	761	PF00069	0.388
MOD_Plk_2-3	79	85	PF00069	0.559
MOD_Plk_4	200	206	PF00069	0.515
MOD_Plk_4	351	357	PF00069	0.434
MOD_Plk_4	42	48	PF00069	0.295
MOD_Plk_4	466	472	PF00069	0.385
MOD_Plk_4	480	486	PF00069	0.374
MOD_Plk_4	563	569	PF00069	0.384
MOD_Plk_4	709	715	PF00069	0.504
MOD_Plk_4	726	732	PF00069	0.292
MOD_Plk_4	755	761	PF00069	0.399
MOD_Plk_4	812	818	PF00069	0.415
MOD_ProDKin_1	130	136	PF00069	0.531
MOD_ProDKin_1	15	21	PF00069	0.616
MOD_ProDKin_1	169	175	PF00069	0.570
MOD_ProDKin_1	241	247	PF00069	0.618
MOD_ProDKin_1	260	266	PF00069	0.573
MOD_ProDKin_1	289	295	PF00069	0.462
MOD_ProDKin_1	324	330	PF00069	0.527
MOD_ProDKin_1	4	10	PF00069	0.611
MOD_ProDKin_1	424	430	PF00069	0.586
MOD_ProDKin_1	464	470	PF00069	0.372
MOD_ProDKin_1	583	589	PF00069	0.440
MOD_ProDKin_1	658	664	PF00069	0.370
MOD_ProDKin_1	688	694	PF00069	0.541
MOD_ProDKin_1	88	94	PF00069	0.548
TRG_DiLeu_BaEn_4	302	308	PF01217	0.341
TRG_ENDOCYTIC_2	454	457	PF00928	0.381
TRG_ENDOCYTIC_2	496	499	PF00928	0.393
TRG_ENDOCYTIC_2	843	846	PF00928	0.410
TRG_ER_diArg_1	27	29	PF00400	0.714
TRG_ER_diArg_1	31	33	PF00400	0.688
TRG_ER_diArg_1	386	389	PF00400	0.458
TRG_ER_diArg_1	395	397	PF00400	0.484
TRG_ER_diArg_1	695	697	PF00400	0.582
TRG_ER_diArg_1	714	716	PF00400	0.424
TRG_ER_diArg_1	789	791	PF00400	0.481
TRG_NLS_MonoExtN_4	193	199	PF00514	0.524
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP1	Leptomonas seymouri	63%	100%
A0A3R7NES5	Trypanosoma rangeli	34%	100%
A0A3S7X6D7	Leishmania donovani	78%	98%
A4I8T3	Leishmania infantum	78%	92%
E9B3P9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
Q4Q4D8	Leishmania major	78%	100%