EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLA4_LEIBR

TriTrypDb:

LbrM.33.0680 , LBRM2903_330012200

Length:

117

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLA4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0005509	calcium ion binding	5	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	56	60	PF00082	0.484
DOC_PP1_RVXF_1	35	42	PF00149	0.536
DOC_USP7_MATH_1	21	25	PF00917	0.528
DOC_USP7_MATH_1	77	81	PF00917	0.411
LIG_14-3-3_CanoR_1	23	32	PF00244	0.535
LIG_14-3-3_CanoR_1	37	42	PF00244	0.483
LIG_FHA_1	1	7	PF00498	0.771
LIG_FHA_2	8	14	PF00498	0.490
LIG_LIR_Gen_1	109	115	PF02991	0.512
LIG_LIR_Gen_1	91	100	PF02991	0.512
LIG_LIR_Nem_3	109	113	PF02991	0.599
LIG_SH2_STAT5	107	110	PF00017	0.528
LIG_SH2_STAT5	68	71	PF00017	0.499
LIG_SUMO_SIM_anti_2	49	56	PF11976	0.544
LIG_TRAF2_1	86	89	PF00917	0.526
LIG_UBA3_1	54	59	PF00899	0.399
LIG_WRC_WIRS_1	38	43	PF05994	0.440
MOD_CK2_1	7	13	PF00069	0.487
MOD_CK2_1	77	83	PF00069	0.519
MOD_GlcNHglycan	23	26	PF01048	0.647
MOD_GlcNHglycan	33	36	PF01048	0.505
MOD_GlcNHglycan	75	78	PF01048	0.389
MOD_GlcNHglycan	79	82	PF01048	0.446
MOD_GlcNHglycan	85	88	PF01048	0.383
MOD_GSK3_1	37	44	PF00069	0.443
MOD_GSK3_1	73	80	PF00069	0.395
MOD_NEK2_1	2	7	PF00069	0.617
MOD_Plk_1	50	56	PF00069	0.539
TRG_DiLeu_BaEn_1	50	55	PF01217	0.537
TRG_DiLeu_BaEn_4	50	56	PF01217	0.539
TRG_ENDOCYTIC_2	107	110	PF00928	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IER1	Leishmania donovani	74%	100%
A4I8T0	Leishmania infantum	74%	100%
Q4Q4E1	Leishmania major	74%	100%