Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLA3_LEIBR

TriTrypDb:

LbrM.33.0670 , LBRM2903_330012100

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLA3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.619
CLV_C14_Caspase3-7	428	432	PF00656	0.641
CLV_NRD_NRD_1	166	168	PF00675	0.579
CLV_NRD_NRD_1	187	189	PF00675	0.660
CLV_NRD_NRD_1	193	195	PF00675	0.676
CLV_NRD_NRD_1	217	219	PF00675	0.695
CLV_NRD_NRD_1	277	279	PF00675	0.599
CLV_NRD_NRD_1	29	31	PF00675	0.615
CLV_PCSK_FUR_1	164	168	PF00082	0.574
CLV_PCSK_FUR_1	274	278	PF00082	0.352
CLV_PCSK_KEX2_1	166	168	PF00082	0.565
CLV_PCSK_KEX2_1	187	189	PF00082	0.665
CLV_PCSK_KEX2_1	193	195	PF00082	0.680
CLV_PCSK_KEX2_1	217	219	PF00082	0.695
CLV_PCSK_KEX2_1	276	278	PF00082	0.592
CLV_PCSK_KEX2_1	29	31	PF00082	0.585
CLV_PCSK_SKI1_1	120	124	PF00082	0.371
CLV_PCSK_SKI1_1	13	17	PF00082	0.603
CLV_PCSK_SKI1_1	167	171	PF00082	0.604
CLV_PCSK_SKI1_1	218	222	PF00082	0.545
CLV_PCSK_SKI1_1	227	231	PF00082	0.442
CLV_PCSK_SKI1_1	282	286	PF00082	0.682
CLV_PCSK_SKI1_1	345	349	PF00082	0.403
CLV_PCSK_SKI1_1	35	39	PF00082	0.647
CLV_PCSK_SKI1_1	384	388	PF00082	0.437
CLV_PCSK_SKI1_1	396	400	PF00082	0.432
DEG_APCC_DBOX_1	119	127	PF00400	0.354
DEG_APCC_DBOX_1	166	174	PF00400	0.623
DEG_APCC_DBOX_1	383	391	PF00400	0.438
DEG_Nend_UBRbox_2	1	3	PF02207	0.455
DOC_CDC14_PxL_1	450	458	PF14671	0.345
DOC_CKS1_1	346	351	PF01111	0.545
DOC_CYCLIN_RxL_1	381	391	PF00134	0.436
DOC_CYCLIN_yCln2_LP_2	143	149	PF00134	0.504
DOC_MAPK_gen_1	193	201	PF00069	0.711
DOC_MAPK_gen_1	26	34	PF00069	0.494
DOC_MAPK_gen_1	382	389	PF00069	0.351
DOC_MAPK_gen_1	466	476	PF00069	0.406
DOC_MAPK_MEF2A_6	466	474	PF00069	0.495
DOC_PP1_RVXF_1	11	17	PF00149	0.387
DOC_PP2B_LxvP_1	199	202	PF13499	0.705
DOC_USP7_MATH_1	370	374	PF00917	0.562
DOC_USP7_MATH_1	413	417	PF00917	0.711
DOC_USP7_MATH_1	99	103	PF00917	0.512
DOC_USP7_UBL2_3	469	473	PF12436	0.426
DOC_WW_Pin1_4	296	301	PF00397	0.786
DOC_WW_Pin1_4	320	325	PF00397	0.669
DOC_WW_Pin1_4	345	350	PF00397	0.549
DOC_WW_Pin1_4	459	464	PF00397	0.405
LIG_14-3-3_CanoR_1	194	200	PF00244	0.684
LIG_BIR_III_4	106	110	PF00653	0.712
LIG_BRCT_BRCA1_1	263	267	PF00533	0.551
LIG_BRCT_BRCA1_1	280	284	PF00533	0.591
LIG_eIF4E_1	450	456	PF01652	0.378
LIG_FHA_1	152	158	PF00498	0.512
LIG_FHA_1	196	202	PF00498	0.746
LIG_FHA_1	346	352	PF00498	0.504
LIG_FHA_1	424	430	PF00498	0.553
LIG_FHA_1	437	443	PF00498	0.380
LIG_FHA_1	45	51	PF00498	0.600
LIG_FHA_1	68	74	PF00498	0.554
LIG_FHA_1	86	92	PF00498	0.476
LIG_FHA_2	16	22	PF00498	0.636
LIG_FHA_2	214	220	PF00498	0.595
LIG_FHA_2	228	234	PF00498	0.554
LIG_FHA_2	324	330	PF00498	0.478
LIG_FHA_2	426	432	PF00498	0.663
LIG_LIR_Apic_2	458	463	PF02991	0.537
LIG_LIR_Gen_1	172	183	PF02991	0.326
LIG_LIR_Gen_1	462	472	PF02991	0.430
LIG_LIR_Nem_3	127	133	PF02991	0.415
LIG_LIR_Nem_3	142	148	PF02991	0.444
LIG_LIR_Nem_3	172	178	PF02991	0.309
LIG_LIR_Nem_3	208	214	PF02991	0.689
LIG_LIR_Nem_3	258	262	PF02991	0.434
LIG_LIR_Nem_3	462	467	PF02991	0.298
LIG_LIR_Nem_3	92	96	PF02991	0.718
LIG_LYPXL_S_1	144	148	PF13949	0.621
LIG_LYPXL_yS_3	145	148	PF13949	0.604
LIG_LYPXL_yS_3	93	96	PF13949	0.757
LIG_PAM2_1	434	446	PF00658	0.273
LIG_PDZ_Class_2	472	477	PF00595	0.539
LIG_PTAP_UEV_1	294	299	PF05743	0.617
LIG_SH2_CRK	460	464	PF00017	0.573
LIG_SH2_GRB2like	334	337	PF00017	0.341
LIG_SH2_NCK_1	460	464	PF00017	0.320
LIG_SH2_STAT3	262	265	PF00017	0.308
LIG_SH2_STAT5	239	242	PF00017	0.379
LIG_SH2_STAT5	262	265	PF00017	0.484
LIG_SH2_STAT5	443	446	PF00017	0.433
LIG_SH3_1	292	298	PF00018	0.510
LIG_SH3_2	298	303	PF14604	0.533
LIG_SH3_3	165	171	PF00018	0.608
LIG_SH3_3	292	298	PF00018	0.732
LIG_SH3_3	301	307	PF00018	0.796
LIG_SH3_3	319	325	PF00018	0.663
LIG_SH3_3	88	94	PF00018	0.698
LIG_SUMO_SIM_par_1	425	432	PF11976	0.583
LIG_TYR_ITIM	143	148	PF00017	0.376
LIG_TYR_ITIM	91	96	PF00017	0.505
MOD_CDK_SPxxK_3	296	303	PF00069	0.531
MOD_CDK_SPxxK_3	345	352	PF00069	0.553
MOD_CDK_SPxxK_3	459	466	PF00069	0.395
MOD_CK1_1	296	302	PF00069	0.759
MOD_CK1_1	323	329	PF00069	0.437
MOD_CK1_1	335	341	PF00069	0.331
MOD_CK1_1	85	91	PF00069	0.718
MOD_CK1_1	95	101	PF00069	0.705
MOD_CK2_1	227	233	PF00069	0.576
MOD_CK2_1	73	79	PF00069	0.777
MOD_Cter_Amidation	164	167	PF01082	0.445
MOD_Cter_Amidation	185	188	PF01082	0.484
MOD_GlcNHglycan	101	104	PF01048	0.723
MOD_GlcNHglycan	113	116	PF01048	0.358
MOD_GlcNHglycan	159	162	PF01048	0.456
MOD_GlcNHglycan	251	254	PF01048	0.492
MOD_GlcNHglycan	295	298	PF01048	0.762
MOD_GlcNHglycan	408	411	PF01048	0.638
MOD_GlcNHglycan	415	418	PF01048	0.669
MOD_GlcNHglycan	74	78	PF01048	0.651
MOD_GlcNHglycan	97	100	PF01048	0.698
MOD_GSK3_1	225	232	PF00069	0.555
MOD_GSK3_1	251	258	PF00069	0.389
MOD_GSK3_1	425	432	PF00069	0.505
MOD_GSK3_1	54	61	PF00069	0.551
MOD_GSK3_1	85	92	PF00069	0.728
MOD_GSK3_1	95	102	PF00069	0.749
MOD_LATS_1	223	229	PF00433	0.379
MOD_N-GLC_1	335	340	PF02516	0.464
MOD_NEK2_1	174	179	PF00069	0.472
MOD_NEK2_1	436	441	PF00069	0.319
MOD_NEK2_2	425	430	PF00069	0.438
MOD_PIKK_1	261	267	PF00454	0.544
MOD_PK_1	225	231	PF00069	0.358
MOD_PKA_1	278	284	PF00069	0.649
MOD_PKA_2	157	163	PF00069	0.354
MOD_PKA_2	370	376	PF00069	0.581
MOD_PKA_2	429	435	PF00069	0.518
MOD_PKA_2	465	471	PF00069	0.464
MOD_PKB_1	225	233	PF00069	0.508
MOD_PKB_1	276	284	PF00069	0.402
MOD_Plk_1	20	26	PF00069	0.636
MOD_Plk_1	206	212	PF00069	0.565
MOD_Plk_4	152	158	PF00069	0.448
MOD_Plk_4	174	180	PF00069	0.307
MOD_Plk_4	195	201	PF00069	0.678
MOD_Plk_4	206	212	PF00069	0.600
MOD_Plk_4	258	264	PF00069	0.317
MOD_Plk_4	92	98	PF00069	0.727
MOD_ProDKin_1	296	302	PF00069	0.787
MOD_ProDKin_1	320	326	PF00069	0.656
MOD_ProDKin_1	345	351	PF00069	0.539
MOD_ProDKin_1	459	465	PF00069	0.401
TRG_DiLeu_BaEn_1	415	420	PF01217	0.474
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.666
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.541
TRG_DiLeu_BaLyEn_6	451	456	PF01217	0.576
TRG_ENDOCYTIC_2	145	148	PF00928	0.534
TRG_ENDOCYTIC_2	239	242	PF00928	0.539
TRG_ENDOCYTIC_2	464	467	PF00928	0.292
TRG_ENDOCYTIC_2	93	96	PF00928	0.715
TRG_ER_diArg_1	164	167	PF00400	0.581
TRG_ER_diArg_1	274	277	PF00400	0.560
TRG_NES_CRM1_1	393	406	PF08389	0.567
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUL5	Leptomonas seymouri	36%	98%
A0A1X0P1W2	Trypanosomatidae	26%	100%
A0A3Q8IHD2	Leishmania donovani	72%	98%
A0A3R7K4P6	Trypanosoma rangeli	25%	100%
A4I8S9	Leishmania infantum	72%	98%
E9B3P5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	97%
Q4Q4E2	Leishmania major	73%	100%
V5BJY6	Trypanosoma cruzi	26%	100%