Intraflagellar transport protein 57 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intraflagellar transport protein 57/55, putative

Species:

Leishmania braziliensis

UniProt:

A4HLA2_LEIBR

TriTrypDb:

LbrM.33.0660 , LBRM2903_330012000

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0042995	cell projection	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005794	Golgi apparatus	5	1
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	4
GO:0030990	intraciliary transport particle	2	1
GO:0030992	intraciliary transport particle B	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0120025	plasma membrane bounded cell projection	3	4
GO:0031514	motile cilium	5	3

Expansion

Sequence features

A4HLA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLA2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0010970	transport along microtubule	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0035735	intraciliary transport involved in cilium assembly	4	1
GO:0042073	intraciliary transport	3	1
GO:0044782	cilium organization	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0099111	microtubule-based transport	4	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1
GO:1905515	non-motile cilium assembly	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.409
CLV_NRD_NRD_1	283	285	PF00675	0.597
CLV_PCSK_KEX2_1	173	175	PF00082	0.209
CLV_PCSK_KEX2_1	228	230	PF00082	0.209
CLV_PCSK_KEX2_1	283	285	PF00082	0.482
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.209
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.209
CLV_PCSK_SKI1_1	154	158	PF00082	0.209
CLV_PCSK_SKI1_1	92	96	PF00082	0.227
DEG_APCC_DBOX_1	189	197	PF00400	0.409
DEG_Nend_UBRbox_3	1	3	PF02207	0.301
DOC_CKS1_1	101	106	PF01111	0.505
DOC_MAPK_MEF2A_6	100	108	PF00069	0.456
DOC_MAPK_MEF2A_6	117	124	PF00069	0.380
DOC_MAPK_MEF2A_6	259	267	PF00069	0.409
DOC_PP2B_PxIxI_1	242	248	PF00149	0.505
DOC_WW_Pin1_4	100	105	PF00397	0.505
DOC_WW_Pin1_4	239	244	PF00397	0.409
LIG_14-3-3_CanoR_1	125	130	PF00244	0.451
LIG_14-3-3_CanoR_1	237	245	PF00244	0.360
LIG_14-3-3_CanoR_1	92	102	PF00244	0.428
LIG_Actin_WH2_2	251	266	PF00022	0.409
LIG_CaM_IQ_9	251	266	PF13499	0.505
LIG_CaM_NSCaTE_8	132	139	PF13499	0.440
LIG_FHA_1	101	107	PF00498	0.505
LIG_FHA_1	239	245	PF00498	0.409
LIG_FHA_2	196	202	PF00498	0.422
LIG_FHA_2	225	231	PF00498	0.505
LIG_LIR_Gen_1	44	51	PF02991	0.382
LIG_LIR_Nem_3	140	146	PF02991	0.417
LIG_LIR_Nem_3	147	153	PF02991	0.404
LIG_LIR_Nem_3	39	43	PF02991	0.437
LIG_LIR_Nem_3	44	48	PF02991	0.431
LIG_LIR_Nem_3	49	54	PF02991	0.447
LIG_LYPXL_S_1	149	153	PF13949	0.209
LIG_LYPXL_yS_3	150	153	PF13949	0.409
LIG_PCNA_yPIPBox_3	264	277	PF02747	0.497
LIG_RPA_C_Fungi	195	207	PF08784	0.301
LIG_SH2_CRK	45	49	PF00017	0.341
LIG_SH2_NCK_1	45	49	PF00017	0.168
LIG_SH2_STAP1	51	55	PF00017	0.399
LIG_SH2_STAT3	38	41	PF00017	0.301
LIG_SH2_STAT5	84	87	PF00017	0.243
LIG_SH3_3	98	104	PF00018	0.376
LIG_SUMO_SIM_par_1	19	26	PF11976	0.243
LIG_TYR_ITIM	43	48	PF00017	0.260
MOD_CDK_SPK_2	100	105	PF00069	0.376
MOD_CK1_1	199	205	PF00069	0.285
MOD_CK1_1	239	245	PF00069	0.243
MOD_CK1_1	46	52	PF00069	0.182
MOD_CK2_1	131	137	PF00069	0.260
MOD_DYRK1A_RPxSP_1	100	104	PF00069	0.376
MOD_GlcNHglycan	137	140	PF01048	0.260
MOD_GlcNHglycan	16	19	PF01048	0.284
MOD_GlcNHglycan	201	204	PF01048	0.274
MOD_GlcNHglycan	25	28	PF01048	0.285
MOD_GlcNHglycan	33	36	PF01048	0.285
MOD_GlcNHglycan	88	91	PF01048	0.301
MOD_GSK3_1	131	138	PF00069	0.285
MOD_GSK3_1	195	202	PF00069	0.285
MOD_N-GLC_1	196	201	PF02516	0.243
MOD_NEK2_1	224	229	PF00069	0.356
MOD_NEK2_1	277	282	PF00069	0.446
MOD_PIKK_1	43	49	PF00454	0.179
MOD_PKA_2	124	130	PF00069	0.301
MOD_PKA_2	199	205	PF00069	0.301
MOD_PKA_2	236	242	PF00069	0.282
MOD_PKB_1	133	141	PF00069	0.260
MOD_Plk_1	174	180	PF00069	0.243
MOD_Plk_1	43	49	PF00069	0.213
MOD_Plk_4	137	143	PF00069	0.285
MOD_ProDKin_1	100	106	PF00069	0.376
MOD_ProDKin_1	239	245	PF00069	0.243
MOD_SUMO_rev_2	107	113	PF00179	0.301
MOD_SUMO_rev_2	147	156	PF00179	0.320
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.260
TRG_DiLeu_BaLyEn_6	240	245	PF01217	0.376
TRG_ENDOCYTIC_2	150	153	PF00928	0.243
TRG_ENDOCYTIC_2	45	48	PF00928	0.284
TRG_ENDOCYTIC_2	51	54	PF00928	0.313
TRG_ER_diArg_1	132	135	PF00400	0.243
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.243

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAC0	Leptomonas seymouri	82%	72%
A0A1X0P107	Trypanosomatidae	64%	73%
A0A3R7LQW1	Trypanosoma rangeli	64%	74%
A0A3S7X6J3	Leishmania donovani	92%	100%
A4I8S8	Leishmania infantum	92%	100%
A9ULY7	Xenopus laevis	26%	73%
D0A4S4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	73%
E9B3P4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q28HX4	Xenopus tropicalis	26%	73%
Q4Q4E3	Leishmania major	92%	100%
Q5EA95	Bos taurus	25%	70%
Q6IVW0	Danio rerio	30%	74%
Q8BXG3	Mus musculus	25%	70%
Q93833	Caenorhabditis elegans	29%	73%
Q9NWB7	Homo sapiens	23%	70%
Q9VQS5	Drosophila melanogaster	25%	75%
V5BPF5	Trypanosoma cruzi	64%	73%