LeishMANIAdb
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Paraflagellar rod component

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Paraflagellar rod component
Gene product:
paraflagellar rod component, putative
Species:
Leishmania braziliensis
UniProt:
A4HLA1_LEIBR
TriTrypDb:
LbrM.33.0650 , LBRM2903_330011900
Length:
126

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 10
Silverman et al. no yes: 0
Pissara et al. yes yes: 30
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 32
NetGPI no yes: 0, no: 32
Cellular components
Term Name Level Count
GO:0005929 cilium 4 2
GO:0031514 motile cilium 5 2
GO:0042995 cell projection 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0110165 cellular anatomical entity 1 2
GO:0120025 plasma membrane bounded cell projection 3 2

Expansion

Sequence features

A4HLA1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLA1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 116 120 PF00082 0.458
DEG_SPOP_SBC_1 35 39 PF00917 0.430
DOC_PP2B_PxIxI_1 13 19 PF00149 0.416
DOC_PP4_FxxP_1 11 14 PF00568 0.416
DOC_WW_Pin1_4 10 15 PF00397 0.412
DOC_WW_Pin1_4 97 102 PF00397 0.559
LIG_14-3-3_CanoR_1 45 49 PF00244 0.501
LIG_BIR_II_1 1 5 PF00653 0.529
LIG_FHA_1 39 45 PF00498 0.575
LIG_LIR_Gen_1 88 98 PF02991 0.585
LIG_LIR_Nem_3 113 118 PF02991 0.505
LIG_LIR_Nem_3 88 94 PF02991 0.475
LIG_NRBOX 76 82 PF00104 0.450
LIG_PTB_Apo_2 111 118 PF02174 0.331
LIG_PTB_Apo_2 5 12 PF02174 0.428
LIG_REV1ctd_RIR_1 115 125 PF16727 0.500
LIG_SH2_STAT5 53 56 PF00017 0.486
LIG_SUMO_SIM_anti_2 75 81 PF11976 0.436
LIG_SUMO_SIM_par_1 77 83 PF11976 0.467
LIG_TRAF2_1 21 24 PF00917 0.563
LIG_TRAF2_1 84 87 PF00917 0.490
MOD_CK1_1 37 43 PF00069 0.539
MOD_CK1_1 96 102 PF00069 0.497
MOD_CK2_1 117 123 PF00069 0.477
MOD_GSK3_1 34 41 PF00069 0.453
MOD_GSK3_1 68 75 PF00069 0.507
MOD_GSK3_1 89 96 PF00069 0.489
MOD_NEK2_1 117 122 PF00069 0.536
MOD_NEK2_1 93 98 PF00069 0.515
MOD_PIKK_1 44 50 PF00454 0.559
MOD_PKA_2 44 50 PF00069 0.485
MOD_Plk_1 23 29 PF00069 0.485
MOD_ProDKin_1 10 16 PF00069 0.408
MOD_ProDKin_1 97 103 PF00069 0.572
MOD_SUMO_for_1 49 52 PF00179 0.601
TRG_ENDOCYTIC_2 115 118 PF00928 0.563

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3C7 Leptomonas seymouri 82% 100%
A0A0N1HW96 Leptomonas seymouri 36% 100%
A0A0N1IHI7 Leptomonas seymouri 44% 100%
A0A0S4IPF2 Bodo saltans 39% 100%
A0A0S4IRP9 Bodo saltans 45% 100%
A0A0S4JBB4 Bodo saltans 37% 100%
A0A0S4JFI1 Bodo saltans 36% 100%
A0A1X0P0Q8 Trypanosomatidae 59% 100%
A0A1X0P259 Trypanosomatidae 32% 100%
A0A1X0P760 Trypanosomatidae 41% 100%
A0A3Q8IB96 Leishmania donovani 41% 100%
A0A3R7K0R9 Trypanosoma rangeli 35% 100%
A0A3S7X3W3 Leishmania donovani 36% 100%
A0A3S7X6I1 Leishmania donovani 82% 75%
A0A422N867 Trypanosoma rangeli 53% 100%
A0A422NFX4 Trypanosoma rangeli 35% 100%
A0A422NPM1 Trypanosoma rangeli 40% 100%
A4H9R6 Leishmania braziliensis 40% 98%
A4HIL9 Leishmania braziliensis 34% 97%
A4HY35 Leishmania infantum 41% 100%
A4I5W4 Leishmania infantum 36% 100%
A4I8S7 Leishmania infantum 82% 100%
C9ZJ38 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZR85 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
D0A4S3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
E9ARU9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9B159 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B3P3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 78% 100%
Q4Q707 Leishmania major 37% 97%
Q4QDM4 Leishmania major 39% 97%
V5BMX8 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS