Protein ZIP4 homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HLA0_LEIBR

TriTrypDb:

LbrM.33.0640

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HLA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HLA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.440
CLV_NRD_NRD_1	35	37	PF00675	0.505
CLV_PCSK_KEX2_1	162	164	PF00082	0.433
CLV_PCSK_KEX2_1	200	202	PF00082	0.593
CLV_PCSK_KEX2_1	35	37	PF00082	0.527
CLV_PCSK_KEX2_1	68	70	PF00082	0.525
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.433
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.432
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.525
CLV_PCSK_SKI1_1	261	265	PF00082	0.358
CLV_PCSK_SKI1_1	325	329	PF00082	0.353
CLV_PCSK_SKI1_1	35	39	PF00082	0.386
DEG_Nend_UBRbox_1	1	4	PF02207	0.458
DOC_CKS1_1	366	371	PF01111	0.407
DOC_CYCLIN_RxL_1	32	43	PF00134	0.412
DOC_CYCLIN_RxL_1	97	108	PF00134	0.492
DOC_MAPK_gen_1	200	209	PF00069	0.403
DOC_PP1_RVXF_1	247	254	PF00149	0.308
DOC_PP1_RVXF_1	425	432	PF00149	0.486
DOC_PP2B_LxvP_1	347	350	PF13499	0.512
DOC_PP4_FxxP_1	431	434	PF00568	0.302
DOC_USP7_MATH_1	17	21	PF00917	0.452
DOC_USP7_MATH_1	196	200	PF00917	0.329
DOC_USP7_UBL2_3	200	204	PF12436	0.519
DOC_WW_Pin1_4	253	258	PF00397	0.482
DOC_WW_Pin1_4	365	370	PF00397	0.567
DOC_WW_Pin1_4	40	45	PF00397	0.514
LIG_14-3-3_CanoR_1	208	214	PF00244	0.285
LIG_14-3-3_CanoR_1	301	311	PF00244	0.466
LIG_14-3-3_CanoR_1	380	386	PF00244	0.409
LIG_CaM_NSCaTE_8	391	398	PF13499	0.310
LIG_EH1_1	227	235	PF00400	0.451
LIG_eIF4E_1	228	234	PF01652	0.445
LIG_FHA_1	129	135	PF00498	0.376
LIG_FHA_1	155	161	PF00498	0.598
LIG_FHA_1	62	68	PF00498	0.445
LIG_FHA_1	80	86	PF00498	0.221
LIG_FHA_2	23	29	PF00498	0.479
LIG_FHA_2	307	313	PF00498	0.544
LIG_FHA_2	374	380	PF00498	0.373
LIG_GBD_Chelix_1	110	118	PF00786	0.474
LIG_LIR_Apic_2	428	434	PF02991	0.287
LIG_LIR_Gen_1	238	244	PF02991	0.319
LIG_LIR_Gen_1	270	280	PF02991	0.331
LIG_LIR_Nem_3	238	243	PF02991	0.378
LIG_LIR_Nem_3	270	276	PF02991	0.469
LIG_Pex14_1	70	74	PF04695	0.334
LIG_PTB_Apo_2	171	178	PF02174	0.531
LIG_SH2_CRK	156	160	PF00017	0.459
LIG_SH2_CRK	273	277	PF00017	0.366
LIG_SH2_SRC	240	243	PF00017	0.334
LIG_SH2_STAP1	156	160	PF00017	0.459
LIG_SH2_STAP1	226	230	PF00017	0.374
LIG_SH2_STAP1	240	244	PF00017	0.284
LIG_SH2_STAP1	273	277	PF00017	0.392
LIG_SH2_STAP1	345	349	PF00017	0.433
LIG_SH2_STAT5	156	159	PF00017	0.462
LIG_SH2_STAT5	186	189	PF00017	0.466
LIG_SH3_3	363	369	PF00018	0.493
LIG_Sin3_3	81	88	PF02671	0.310
LIG_SUMO_SIM_anti_2	278	285	PF11976	0.286
LIG_SUMO_SIM_anti_2	354	363	PF11976	0.438
LIG_SUMO_SIM_par_1	43	48	PF11976	0.417
LIG_TRAF2_1	179	182	PF00917	0.387
LIG_UBA3_1	101	106	PF00899	0.401
LIG_WRC_WIRS_1	283	288	PF05994	0.397
LIG_WRC_WIRS_1	349	354	PF05994	0.484
MOD_CK1_1	15	21	PF00069	0.650
MOD_CK1_1	158	164	PF00069	0.600
MOD_CK1_1	271	277	PF00069	0.454
MOD_CK1_1	306	312	PF00069	0.502
MOD_CK1_1	354	360	PF00069	0.565
MOD_CK2_1	158	164	PF00069	0.578
MOD_CK2_1	196	202	PF00069	0.277
MOD_CK2_1	22	28	PF00069	0.534
MOD_CK2_1	244	250	PF00069	0.550
MOD_CK2_1	275	281	PF00069	0.226
MOD_GlcNHglycan	107	110	PF01048	0.444
MOD_GlcNHglycan	190	193	PF01048	0.408
MOD_GlcNHglycan	297	300	PF01048	0.275
MOD_GlcNHglycan	338	341	PF01048	0.553
MOD_GSK3_1	154	161	PF00069	0.654
MOD_GSK3_1	255	262	PF00069	0.372
MOD_GSK3_1	267	274	PF00069	0.375
MOD_GSK3_1	302	309	PF00069	0.392
MOD_GSK3_1	348	355	PF00069	0.447
MOD_GSK3_1	367	374	PF00069	0.480
MOD_GSK3_1	380	387	PF00069	0.417
MOD_GSK3_1	421	428	PF00069	0.599
MOD_GSK3_1	7	14	PF00069	0.584
MOD_GSK3_1	90	97	PF00069	0.465
MOD_N-GLC_1	165	170	PF02516	0.497
MOD_N-GLC_1	90	95	PF02516	0.240
MOD_NEK2_1	1	6	PF00069	0.631
MOD_NEK2_1	16	21	PF00069	0.589
MOD_NEK2_1	22	27	PF00069	0.559
MOD_NEK2_1	259	264	PF00069	0.325
MOD_NEK2_1	275	280	PF00069	0.290
MOD_NEK2_1	282	287	PF00069	0.362
MOD_NEK2_1	295	300	PF00069	0.387
MOD_NEK2_1	352	357	PF00069	0.493
MOD_NEK2_1	359	364	PF00069	0.564
MOD_NEK2_1	381	386	PF00069	0.453
MOD_NEK2_1	418	423	PF00069	0.432
MOD_NEK2_1	55	60	PF00069	0.466
MOD_NEK2_1	8	13	PF00069	0.613
MOD_NEK2_2	289	294	PF00069	0.361
MOD_PIKK_1	384	390	PF00454	0.570
MOD_PIKK_1	47	53	PF00454	0.403
MOD_PIKK_1	90	96	PF00454	0.246
MOD_PK_1	69	75	PF00069	0.475
MOD_PKA_1	68	74	PF00069	0.267
MOD_PKA_2	218	224	PF00069	0.359
MOD_PKA_2	418	424	PF00069	0.414
MOD_PKA_2	68	74	PF00069	0.267
MOD_Plk_1	148	154	PF00069	0.501
MOD_Plk_1	271	277	PF00069	0.484
MOD_Plk_1	306	312	PF00069	0.427
MOD_Plk_1	90	96	PF00069	0.246
MOD_Plk_4	155	161	PF00069	0.720
MOD_Plk_4	255	261	PF00069	0.418
MOD_Plk_4	271	277	PF00069	0.444
MOD_Plk_4	306	312	PF00069	0.408
MOD_Plk_4	348	354	PF00069	0.380
MOD_Plk_4	367	373	PF00069	0.545
MOD_Plk_4	381	387	PF00069	0.298
MOD_Plk_4	396	402	PF00069	0.450
MOD_Plk_4	69	75	PF00069	0.423
MOD_ProDKin_1	253	259	PF00069	0.473
MOD_ProDKin_1	365	371	PF00069	0.560
MOD_ProDKin_1	40	46	PF00069	0.510
MOD_SUMO_for_1	179	182	PF00179	0.309
MOD_SUMO_rev_2	199	206	PF00179	0.489
MOD_SUMO_rev_2	344	350	PF00179	0.485
TRG_DiLeu_BaEn_1	324	329	PF01217	0.521
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.362
TRG_ENDOCYTIC_2	156	159	PF00928	0.462
TRG_ENDOCYTIC_2	186	189	PF00928	0.466
TRG_ENDOCYTIC_2	240	243	PF00928	0.463
TRG_ENDOCYTIC_2	273	276	PF00928	0.230
TRG_ER_diArg_1	34	36	PF00400	0.521
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R7	Leptomonas seymouri	52%	100%
A0A1X0P0P1	Trypanosomatidae	31%	99%
A0A3Q8IHM8	Leishmania donovani	79%	100%
A0A3S5IQQ0	Trypanosoma rangeli	28%	100%
A4I8S6	Leishmania infantum	79%	100%
D0A4S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B3P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q4E5	Leishmania major	77%	100%
V5BFC5	Trypanosoma cruzi	27%	100%