Protein FYV4, mitochondrial

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL99_LEIBR

TriTrypDb:

LbrM.33.0630 , LBRM2903_330011800

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HL99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL99

PDB structure(s): 7ane_w

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.532
CLV_NRD_NRD_1	188	190	PF00675	0.483
CLV_NRD_NRD_1	26	28	PF00675	0.469
CLV_PCSK_KEX2_1	101	103	PF00082	0.532
CLV_PCSK_KEX2_1	179	181	PF00082	0.532
CLV_PCSK_KEX2_1	88	90	PF00082	0.453
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.563
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.453
CLV_PCSK_SKI1_1	130	134	PF00082	0.404
DEG_COP1_1	136	145	PF00400	0.593
DEG_Nend_UBRbox_1	1	4	PF02207	0.664
DOC_CDC14_PxL_1	139	147	PF14671	0.475
DOC_MAPK_DCC_7	37	45	PF00069	0.498
DOC_MAPK_gen_1	101	111	PF00069	0.529
DOC_MAPK_gen_1	88	98	PF00069	0.525
DOC_MAPK_MEF2A_6	37	45	PF00069	0.498
DOC_USP7_MATH_1	182	186	PF00917	0.424
DOC_USP7_UBL2_3	74	78	PF12436	0.425
LIG_14-3-3_CanoR_1	2	8	PF00244	0.617
LIG_14-3-3_CanoR_1	46	52	PF00244	0.430
LIG_deltaCOP1_diTrp_1	124	132	PF00928	0.420
LIG_EVH1_2	116	120	PF00568	0.449
LIG_FHA_1	2	8	PF00498	0.564
LIG_FHA_1	47	53	PF00498	0.467
LIG_FHA_1	91	97	PF00498	0.550
LIG_FHA_2	120	126	PF00498	0.431
LIG_FHA_2	74	80	PF00498	0.472
LIG_LIR_Gen_1	79	84	PF02991	0.414
LIG_LIR_Nem_3	124	129	PF02991	0.414
LIG_LIR_Nem_3	136	142	PF02991	0.419
LIG_LIR_Nem_3	79	83	PF02991	0.402
LIG_MAD2	6	14	PF02301	0.399
LIG_Pex14_2	73	77	PF04695	0.411
LIG_SH2_CRK	139	143	PF00017	0.466
LIG_SH2_NCK_1	164	168	PF00017	0.526
LIG_SH2_STAP1	137	141	PF00017	0.460
LIG_SH2_STAP1	3	7	PF00017	0.706
LIG_SH2_STAT3	128	131	PF00017	0.416
LIG_SH2_STAT5	20	23	PF00017	0.350
LIG_SH2_STAT5	3	6	PF00017	0.700
LIG_SH2_STAT5	51	54	PF00017	0.419
LIG_SH3_1	140	146	PF00018	0.459
LIG_SH3_2	143	148	PF14604	0.469
LIG_SH3_3	140	146	PF00018	0.459
LIG_SH3_3	41	47	PF00018	0.514
LIG_TRAF2_1	122	125	PF00917	0.447
MOD_CK1_1	35	41	PF00069	0.568
MOD_CK2_1	119	125	PF00069	0.431
MOD_CK2_1	84	90	PF00069	0.492
MOD_GlcNHglycan	183	187	PF01048	0.629
MOD_GSK3_1	131	138	PF00069	0.417
MOD_GSK3_1	31	38	PF00069	0.497
MOD_NEK2_1	1	6	PF00069	0.614
MOD_NEK2_1	73	78	PF00069	0.420
MOD_NEK2_1	8	13	PF00069	0.515
MOD_NEK2_1	84	89	PF00069	0.490
MOD_PKA_2	1	7	PF00069	0.654
MOD_Plk_1	135	141	PF00069	0.453
MOD_Plk_1	32	38	PF00069	0.590
MOD_Plk_4	18	24	PF00069	0.515
MOD_Plk_4	47	53	PF00069	0.431
MOD_SUMO_for_1	175	178	PF00179	0.428
MOD_SUMO_rev_2	172	181	PF00179	0.540
MOD_SUMO_rev_2	71	76	PF00179	0.423
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.579
TRG_ENDOCYTIC_2	129	132	PF00928	0.419
TRG_ENDOCYTIC_2	139	142	PF00928	0.461
TRG_ENDOCYTIC_2	164	167	PF00928	0.476
TRG_ENDOCYTIC_2	20	23	PF00928	0.499
TRG_ER_diArg_1	91	94	PF00400	0.451
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.651

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCZ6	Leptomonas seymouri	92%	100%
A0A0S4JIZ9	Bodo saltans	70%	99%
A0A1X0P0P2	Trypanosomatidae	82%	100%
A0A3Q8IDM0	Leishmania donovani	94%	100%
A0A3R7N7M2	Trypanosoma rangeli	80%	100%
A4I8S5	Leishmania infantum	95%	100%
D0A4R9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9B3P1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q4E6	Leishmania major	94%	100%
V5DGB2	Trypanosoma cruzi	81%	100%