Coiled-coil domain-containing protein 40

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Coiled-coil domain-containing protein 40 homolog

Species:

Leishmania braziliensis

UniProt:

A4HL98_LEIBR

TriTrypDb:

LbrM.33.0620 , LBRM2903_330011700

Length:

875

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL98

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	12
GO:0001578	microtubule bundle formation	4	12
GO:0006996	organelle organization	4	12
GO:0007010	cytoskeleton organization	5	12
GO:0007017	microtubule-based process	2	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0035082	axoneme assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.489
CLV_C14_Caspase3-7	215	219	PF00656	0.531
CLV_C14_Caspase3-7	294	298	PF00656	0.391
CLV_C14_Caspase3-7	305	309	PF00656	0.411
CLV_C14_Caspase3-7	707	711	PF00656	0.356
CLV_NRD_NRD_1	121	123	PF00675	0.379
CLV_NRD_NRD_1	157	159	PF00675	0.440
CLV_NRD_NRD_1	246	248	PF00675	0.407
CLV_NRD_NRD_1	251	253	PF00675	0.405
CLV_NRD_NRD_1	276	278	PF00675	0.326
CLV_NRD_NRD_1	31	33	PF00675	0.493
CLV_NRD_NRD_1	334	336	PF00675	0.614
CLV_NRD_NRD_1	37	39	PF00675	0.458
CLV_NRD_NRD_1	391	393	PF00675	0.554
CLV_NRD_NRD_1	456	458	PF00675	0.444
CLV_NRD_NRD_1	462	464	PF00675	0.455
CLV_NRD_NRD_1	611	613	PF00675	0.254
CLV_NRD_NRD_1	615	617	PF00675	0.248
CLV_NRD_NRD_1	652	654	PF00675	0.392
CLV_NRD_NRD_1	702	704	PF00675	0.499
CLV_PCSK_KEX2_1	157	159	PF00082	0.440
CLV_PCSK_KEX2_1	210	212	PF00082	0.554
CLV_PCSK_KEX2_1	246	248	PF00082	0.407
CLV_PCSK_KEX2_1	276	278	PF00082	0.433
CLV_PCSK_KEX2_1	31	33	PF00082	0.530
CLV_PCSK_KEX2_1	455	457	PF00082	0.454
CLV_PCSK_KEX2_1	611	613	PF00082	0.251
CLV_PCSK_KEX2_1	617	619	PF00082	0.251
CLV_PCSK_KEX2_1	749	751	PF00082	0.447
CLV_PCSK_KEX2_1	809	811	PF00082	0.531
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.554
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.255
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.447
CLV_PCSK_PC1ET2_1	809	811	PF00082	0.516
CLV_PCSK_PC7_1	206	212	PF00082	0.551
CLV_PCSK_SKI1_1	147	151	PF00082	0.491
CLV_PCSK_SKI1_1	358	362	PF00082	0.566
CLV_PCSK_SKI1_1	392	396	PF00082	0.479
CLV_PCSK_SKI1_1	679	683	PF00082	0.610
CLV_PCSK_SKI1_1	741	745	PF00082	0.495
CLV_PCSK_SKI1_1	758	762	PF00082	0.388
DEG_APCC_DBOX_1	237	245	PF00400	0.523
DEG_APCC_DBOX_1	37	45	PF00400	0.473
DEG_APCC_KENBOX_2	736	740	PF00400	0.574
DOC_MAPK_gen_1	147	155	PF00069	0.319
DOC_MAPK_gen_1	174	182	PF00069	0.520
DOC_MAPK_gen_1	60	69	PF00069	0.431
DOC_MAPK_gen_1	616	623	PF00069	0.388
DOC_MAPK_gen_1	676	683	PF00069	0.470
DOC_MAPK_gen_1	713	721	PF00069	0.541
DOC_MAPK_MEF2A_6	176	184	PF00069	0.519
DOC_MAPK_MEF2A_6	573	581	PF00069	0.266
DOC_PP1_RVXF_1	644	651	PF00149	0.393
DOC_PP1_RVXF_1	677	684	PF00149	0.617
DOC_USP7_MATH_1	291	295	PF00917	0.550
DOC_USP7_MATH_1	4	8	PF00917	0.688
DOC_USP7_MATH_1	503	507	PF00917	0.448
DOC_USP7_MATH_1	833	837	PF00917	0.546
DOC_USP7_MATH_1	9	13	PF00917	0.656
DOC_USP7_UBL2_3	341	345	PF12436	0.622
DOC_USP7_UBL2_3	354	358	PF12436	0.465
LIG_14-3-3_CanoR_1	238	242	PF00244	0.507
LIG_14-3-3_CanoR_1	252	258	PF00244	0.432
LIG_14-3-3_CanoR_1	520	528	PF00244	0.394
LIG_14-3-3_CanoR_1	596	605	PF00244	0.414
LIG_14-3-3_CanoR_1	631	641	PF00244	0.439
LIG_APCC_ABBAyCdc20_2	646	652	PF00400	0.398
LIG_BRCT_BRCA1_1	857	861	PF00533	0.569
LIG_Clathr_ClatBox_1	139	143	PF01394	0.538
LIG_Clathr_ClatBox_1	265	269	PF01394	0.527
LIG_DLG_GKlike_1	176	184	PF00625	0.428
LIG_FHA_1	134	140	PF00498	0.435
LIG_FHA_1	521	527	PF00498	0.281
LIG_FHA_1	824	830	PF00498	0.477
LIG_FHA_2	161	167	PF00498	0.443
LIG_FHA_2	195	201	PF00498	0.569
LIG_FHA_2	213	219	PF00498	0.483
LIG_FHA_2	303	309	PF00498	0.400
LIG_FHA_2	310	316	PF00498	0.418
LIG_FHA_2	329	335	PF00498	0.328
LIG_FHA_2	404	410	PF00498	0.568
LIG_FHA_2	49	55	PF00498	0.538
LIG_FHA_2	529	535	PF00498	0.315
LIG_FHA_2	680	686	PF00498	0.551
LIG_FHA_2	775	781	PF00498	0.465
LIG_FHA_2	801	807	PF00498	0.431
LIG_LIR_Gen_1	318	329	PF02991	0.443
LIG_LIR_Gen_1	517	526	PF02991	0.251
LIG_LIR_Nem_3	318	324	PF02991	0.437
LIG_LIR_Nem_3	517	521	PF02991	0.371
LIG_LIR_Nem_3	740	746	PF02991	0.374
LIG_LIR_Nem_3	826	830	PF02991	0.438
LIG_LIR_Nem_3	858	864	PF02991	0.457
LIG_MYND_1	862	866	PF01753	0.596
LIG_PCNA_yPIPBox_3	280	293	PF02747	0.540
LIG_PDZ_Class_1	870	875	PF00595	0.492
LIG_Rb_LxCxE_1	666	685	PF01857	0.552
LIG_SH2_CRK	827	831	PF00017	0.562
LIG_SH2_STAP1	475	479	PF00017	0.539
LIG_SH2_STAT3	70	73	PF00017	0.417
LIG_SH2_STAT5	125	128	PF00017	0.490
LIG_SUMO_SIM_anti_2	264	269	PF11976	0.529
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.402
LIG_SUMO_SIM_par_1	264	269	PF11976	0.529
LIG_SUMO_SIM_par_1	299	305	PF11976	0.480
LIG_TRAF2_1	103	106	PF00917	0.582
LIG_TRAF2_1	183	186	PF00917	0.410
LIG_TRAF2_1	331	334	PF00917	0.599
LIG_UBA3_1	180	189	PF00899	0.412
LIG_UBA3_1	388	395	PF00899	0.615
LIG_UBA3_1	556	564	PF00899	0.285
LIG_UBA3_1	698	704	PF00899	0.508
LIG_UBA3_1	742	749	PF00899	0.442
MOD_CK1_1	14	20	PF00069	0.563
MOD_CK1_1	327	333	PF00069	0.557
MOD_CK1_1	506	512	PF00069	0.310
MOD_CK2_1	165	171	PF00069	0.436
MOD_CK2_1	180	186	PF00069	0.411
MOD_CK2_1	194	200	PF00069	0.413
MOD_CK2_1	201	207	PF00069	0.449
MOD_CK2_1	218	224	PF00069	0.411
MOD_CK2_1	309	315	PF00069	0.478
MOD_CK2_1	328	334	PF00069	0.423
MOD_CK2_1	347	353	PF00069	0.393
MOD_CK2_1	403	409	PF00069	0.561
MOD_CK2_1	48	54	PF00069	0.538
MOD_CK2_1	506	512	PF00069	0.485
MOD_CK2_1	679	685	PF00069	0.550
MOD_CK2_1	760	766	PF00069	0.463
MOD_CK2_1	774	780	PF00069	0.371
MOD_CK2_1	800	806	PF00069	0.430
MOD_CK2_1	833	839	PF00069	0.399
MOD_GlcNHglycan	105	110	PF01048	0.578
MOD_GlcNHglycan	194	197	PF01048	0.493
MOD_GlcNHglycan	443	446	PF01048	0.476
MOD_GlcNHglycan	54	58	PF01048	0.504
MOD_GlcNHglycan	834	838	PF01048	0.438
MOD_GlcNHglycan	855	860	PF01048	0.536
MOD_GSK3_1	176	183	PF00069	0.564
MOD_GSK3_1	287	294	PF00069	0.457
MOD_GSK3_1	324	331	PF00069	0.501
MOD_GSK3_1	372	379	PF00069	0.559
MOD_GSK3_1	425	432	PF00069	0.442
MOD_GSK3_1	75	82	PF00069	0.488
MOD_N-GLC_1	192	197	PF02516	0.519
MOD_N-GLC_1	4	9	PF02516	0.624
MOD_N-GLC_1	425	430	PF02516	0.434
MOD_N-GLC_1	558	563	PF02516	0.374
MOD_N-GLC_1	571	576	PF02516	0.285
MOD_N-GLC_1	596	601	PF02516	0.311
MOD_NEK2_1	135	140	PF00069	0.414
MOD_NEK2_1	180	185	PF00069	0.516
MOD_NEK2_1	324	329	PF00069	0.519
MOD_NEK2_1	429	434	PF00069	0.428
MOD_NEK2_1	493	498	PF00069	0.451
MOD_NEK2_1	588	593	PF00069	0.170
MOD_PIKK_1	201	207	PF00454	0.434
MOD_PIKK_1	302	308	PF00454	0.431
MOD_PIKK_1	381	387	PF00454	0.452
MOD_PIKK_1	403	409	PF00454	0.491
MOD_PIKK_1	42	48	PF00454	0.489
MOD_PIKK_1	686	692	PF00454	0.614
MOD_PIKK_1	720	726	PF00454	0.521
MOD_PIKK_1	774	780	PF00454	0.508
MOD_PKA_2	212	218	PF00069	0.519
MOD_PKA_2	237	243	PF00069	0.504
MOD_PKA_2	251	257	PF00069	0.433
MOD_PKA_2	61	67	PF00069	0.556
MOD_PKA_2	630	636	PF00069	0.444
MOD_PKA_2	658	664	PF00069	0.561
MOD_PKA_2	686	692	PF00069	0.505
MOD_PKB_1	414	422	PF00069	0.439
MOD_Plk_1	324	330	PF00069	0.517
MOD_Plk_1	376	382	PF00069	0.560
MOD_Plk_1	4	10	PF00069	0.747
MOD_Plk_1	425	431	PF00069	0.432
MOD_Plk_1	493	499	PF00069	0.447
MOD_Plk_1	679	685	PF00069	0.550
MOD_Plk_1	737	743	PF00069	0.378
MOD_Plk_2-3	194	200	PF00069	0.346
MOD_Plk_2-3	218	224	PF00069	0.487
MOD_Plk_4	135	141	PF00069	0.433
MOD_Plk_4	176	182	PF00069	0.427
MOD_Plk_4	237	243	PF00069	0.392
MOD_Plk_4	544	550	PF00069	0.251
MOD_Plk_4	583	589	PF00069	0.394
MOD_SUMO_for_1	140	143	PF00179	0.436
MOD_SUMO_for_1	149	152	PF00179	0.380
MOD_SUMO_for_1	380	383	PF00179	0.507
MOD_SUMO_for_1	677	680	PF00179	0.613
MOD_SUMO_for_1	798	801	PF00179	0.517
MOD_SUMO_rev_2	203	212	PF00179	0.499
MOD_SUMO_rev_2	224	233	PF00179	0.314
MOD_SUMO_rev_2	330	337	PF00179	0.470
MOD_SUMO_rev_2	574	584	PF00179	0.308
MOD_SUMO_rev_2	619	627	PF00179	0.395
MOD_SUMO_rev_2	647	655	PF00179	0.370
MOD_SUMO_rev_2	689	698	PF00179	0.542
MOD_SUMO_rev_2	801	811	PF00179	0.481
TRG_DiLeu_BaEn_1	229	234	PF01217	0.404
TRG_DiLeu_BaEn_1	367	372	PF01217	0.637
TRG_DiLeu_BaEn_1	694	699	PF01217	0.485
TRG_DiLeu_BaEn_3	700	706	PF01217	0.514
TRG_DiLeu_BaLyEn_6	552	557	PF01217	0.266
TRG_DiLeu_BaLyEn_6	825	830	PF01217	0.463
TRG_ENDOCYTIC_2	321	324	PF00928	0.452
TRG_ENDOCYTIC_2	475	478	PF00928	0.512
TRG_ENDOCYTIC_2	827	830	PF00928	0.640
TRG_ER_diArg_1	101	104	PF00400	0.570
TRG_ER_diArg_1	275	277	PF00400	0.322
TRG_ER_diArg_1	31	33	PF00400	0.580
TRG_ER_diArg_1	414	417	PF00400	0.430
TRG_ER_diArg_1	454	457	PF00400	0.479
TRG_ER_diArg_1	610	612	PF00400	0.266
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.313
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	611	615	PF00026	0.251
TRG_Pf-PMV_PEXEL_1	696	700	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I582	Leptomonas seymouri	81%	100%
A0A0S4JM03	Bodo saltans	50%	99%
A0A1X0P1D5	Trypanosomatidae	59%	100%
A0A3R7RFG2	Trypanosoma rangeli	58%	100%
A0A3S7X6D9	Leishmania donovani	91%	100%
A4I8S4	Leishmania infantum	91%	100%
D0A4R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9B3P0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4G0X9	Homo sapiens	24%	77%
Q4Q4E7	Leishmania major	91%	100%
Q56A40	Danio rerio	23%	93%
Q8BI79	Mus musculus	25%	73%
V5BJZ2	Trypanosoma cruzi	57%	100%