Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL97_LEIBR

TriTrypDb:

LbrM.33.0610 , LBRM2903_330011600

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL97

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.616
CLV_C14_Caspase3-7	309	313	PF00656	0.506
CLV_C14_Caspase3-7	377	381	PF00656	0.552
CLV_NRD_NRD_1	118	120	PF00675	0.642
CLV_NRD_NRD_1	205	207	PF00675	0.570
CLV_NRD_NRD_1	400	402	PF00675	0.629
CLV_NRD_NRD_1	476	478	PF00675	0.575
CLV_NRD_NRD_1	638	640	PF00675	0.638
CLV_PCSK_KEX2_1	118	120	PF00082	0.642
CLV_PCSK_KEX2_1	205	207	PF00082	0.570
CLV_PCSK_KEX2_1	400	402	PF00082	0.567
CLV_PCSK_KEX2_1	417	419	PF00082	0.514
CLV_PCSK_KEX2_1	555	557	PF00082	0.633
CLV_PCSK_KEX2_1	638	640	PF00082	0.571
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.559
CLV_PCSK_PC1ET2_1	555	557	PF00082	0.633
CLV_PCSK_SKI1_1	181	185	PF00082	0.642
CLV_PCSK_SKI1_1	217	221	PF00082	0.596
CLV_PCSK_SKI1_1	414	418	PF00082	0.555
CLV_PCSK_SKI1_1	519	523	PF00082	0.556
CLV_PCSK_SKI1_1	638	642	PF00082	0.518
DEG_APCC_DBOX_1	638	646	PF00400	0.528
DEG_Nend_Nbox_1	1	3	PF02207	0.580
DEG_SCF_FBW7_1	271	278	PF00400	0.524
DEG_SPOP_SBC_1	245	249	PF00917	0.577
DOC_CKS1_1	8	13	PF01111	0.511
DOC_MAPK_gen_1	638	645	PF00069	0.525
DOC_MAPK_MEF2A_6	638	645	PF00069	0.526
DOC_PP1_SILK_1	217	222	PF00149	0.512
DOC_PP2B_LxvP_1	220	223	PF13499	0.599
DOC_PP4_FxxP_1	164	167	PF00568	0.523
DOC_USP7_MATH_1	124	128	PF00917	0.587
DOC_USP7_MATH_1	139	143	PF00917	0.637
DOC_USP7_MATH_1	189	193	PF00917	0.588
DOC_USP7_MATH_1	199	203	PF00917	0.560
DOC_USP7_MATH_1	257	261	PF00917	0.617
DOC_USP7_MATH_1	33	37	PF00917	0.561
DOC_USP7_MATH_1	412	416	PF00917	0.540
DOC_USP7_MATH_1	540	544	PF00917	0.682
DOC_USP7_MATH_1	554	558	PF00917	0.688
DOC_USP7_MATH_1	598	602	PF00917	0.711
DOC_USP7_MATH_1	646	650	PF00917	0.481
DOC_USP7_UBL2_3	407	411	PF12436	0.547
DOC_WW_Pin1_4	234	239	PF00397	0.633
DOC_WW_Pin1_4	255	260	PF00397	0.711
DOC_WW_Pin1_4	271	276	PF00397	0.628
DOC_WW_Pin1_4	655	660	PF00397	0.640
DOC_WW_Pin1_4	7	12	PF00397	0.515
DOC_WW_Pin1_4	86	91	PF00397	0.516
LIG_14-3-3_CanoR_1	108	117	PF00244	0.460
LIG_14-3-3_CanoR_1	394	399	PF00244	0.652
LIG_14-3-3_CanoR_1	4	12	PF00244	0.470
LIG_14-3-3_CanoR_1	439	446	PF00244	0.582
LIG_14-3-3_CanoR_1	52	60	PF00244	0.460
LIG_14-3-3_CanoR_1	618	625	PF00244	0.579
LIG_Actin_WH2_2	624	640	PF00022	0.522
LIG_Clathr_ClatBox_1	279	283	PF01394	0.707
LIG_deltaCOP1_diTrp_1	382	391	PF00928	0.627
LIG_FHA_1	110	116	PF00498	0.533
LIG_FHA_1	132	138	PF00498	0.538
LIG_FHA_1	356	362	PF00498	0.560
LIG_FHA_1	439	445	PF00498	0.718
LIG_FHA_1	488	494	PF00498	0.735
LIG_FHA_1	506	512	PF00498	0.600
LIG_FHA_1	611	617	PF00498	0.691
LIG_FHA_1	87	93	PF00498	0.515
LIG_FHA_2	101	107	PF00498	0.542
LIG_FHA_2	401	407	PF00498	0.586
LIG_FHA_2	419	425	PF00498	0.529
LIG_FHA_2	533	539	PF00498	0.552
LIG_FHA_2	598	604	PF00498	0.540
LIG_FHA_2	659	665	PF00498	0.555
LIG_LIR_Apic_2	10	15	PF02991	0.540
LIG_LIR_Apic_2	163	167	PF02991	0.525
LIG_MYND_1	277	281	PF01753	0.699
LIG_PCNA_yPIPBox_3	614	628	PF02747	0.617
LIG_Pex14_2	160	164	PF04695	0.533
LIG_SH2_NCK_1	340	344	PF00017	0.639
LIG_SH2_NCK_1	531	535	PF00017	0.689
LIG_SH2_SRC	104	107	PF00017	0.520
LIG_SH2_STAP1	300	304	PF00017	0.622
LIG_SH3_2	576	581	PF14604	0.549
LIG_SH3_3	220	226	PF00018	0.645
LIG_SH3_3	281	287	PF00018	0.662
LIG_SH3_3	5	11	PF00018	0.482
LIG_SH3_3	570	576	PF00018	0.572
LIG_SH3_3	653	659	PF00018	0.659
LIG_SH3_3	87	93	PF00018	0.515
LIG_TRAF2_1	620	623	PF00917	0.601
LIG_TRAF2_1	672	675	PF00917	0.547
MOD_CK1_1	192	198	PF00069	0.648
MOD_CK1_1	236	242	PF00069	0.766
MOD_CK1_1	246	252	PF00069	0.606
MOD_CK1_1	260	266	PF00069	0.581
MOD_CK1_1	27	33	PF00069	0.514
MOD_CK1_1	386	392	PF00069	0.633
MOD_CK1_1	393	399	PF00069	0.637
MOD_CK1_1	505	511	PF00069	0.584
MOD_CK1_1	512	518	PF00069	0.574
MOD_CK1_1	523	529	PF00069	0.695
MOD_CK1_1	557	563	PF00069	0.711
MOD_CK1_1	605	611	PF00069	0.598
MOD_CK1_1	658	664	PF00069	0.561
MOD_CK1_1	78	84	PF00069	0.604
MOD_CK1_1	98	104	PF00069	0.507
MOD_CK2_1	300	306	PF00069	0.573
MOD_CK2_1	322	328	PF00069	0.568
MOD_CK2_1	392	398	PF00069	0.684
MOD_CK2_1	423	429	PF00069	0.555
MOD_CK2_1	597	603	PF00069	0.576
MOD_CK2_1	617	623	PF00069	0.542
MOD_CK2_1	646	652	PF00069	0.490
MOD_CK2_1	658	664	PF00069	0.526
MOD_CK2_1	669	675	PF00069	0.522
MOD_GlcNHglycan	194	197	PF01048	0.718
MOD_GlcNHglycan	201	204	PF01048	0.666
MOD_GlcNHglycan	24	27	PF01048	0.560
MOD_GlcNHglycan	259	262	PF01048	0.614
MOD_GlcNHglycan	302	305	PF01048	0.620
MOD_GlcNHglycan	343	346	PF01048	0.622
MOD_GlcNHglycan	347	350	PF01048	0.643
MOD_GlcNHglycan	35	38	PF01048	0.615
MOD_GlcNHglycan	486	490	PF01048	0.573
MOD_GlcNHglycan	497	500	PF01048	0.530
MOD_GlcNHglycan	511	514	PF01048	0.511
MOD_GlcNHglycan	523	526	PF01048	0.730
MOD_GlcNHglycan	541	545	PF01048	0.615
MOD_GlcNHglycan	563	566	PF01048	0.717
MOD_GlcNHglycan	583	586	PF01048	0.518
MOD_GSK3_1	139	146	PF00069	0.616
MOD_GSK3_1	233	240	PF00069	0.679
MOD_GSK3_1	271	278	PF00069	0.776
MOD_GSK3_1	3	10	PF00069	0.481
MOD_GSK3_1	33	40	PF00069	0.659
MOD_GSK3_1	341	348	PF00069	0.603
MOD_GSK3_1	355	362	PF00069	0.615
MOD_GSK3_1	385	392	PF00069	0.633
MOD_GSK3_1	423	430	PF00069	0.570
MOD_GSK3_1	450	457	PF00069	0.640
MOD_GSK3_1	502	509	PF00069	0.602
MOD_GSK3_1	519	526	PF00069	0.694
MOD_GSK3_1	532	539	PF00069	0.579
MOD_GSK3_1	554	561	PF00069	0.672
MOD_GSK3_1	598	605	PF00069	0.675
MOD_GSK3_1	627	634	PF00069	0.441
MOD_GSK3_1	660	667	PF00069	0.576
MOD_GSK3_1	75	82	PF00069	0.605
MOD_GSK3_1	91	98	PF00069	0.533
MOD_N-GLC_1	79	84	PF02516	0.505
MOD_NEK2_1	110	115	PF00069	0.481
MOD_NEK2_1	21	26	PF00069	0.626
MOD_NEK2_1	212	217	PF00069	0.578
MOD_NEK2_1	231	236	PF00069	0.661
MOD_NEK2_1	310	315	PF00069	0.707
MOD_NEK2_1	487	492	PF00069	0.557
MOD_NEK2_1	506	511	PF00069	0.649
MOD_NEK2_1	521	526	PF00069	0.489
MOD_NEK2_1	591	596	PF00069	0.534
MOD_NEK2_1	627	632	PF00069	0.445
MOD_NEK2_1	75	80	PF00069	0.644
MOD_NEK2_2	412	417	PF00069	0.550
MOD_NEK2_2	472	477	PF00069	0.580
MOD_PIKK_1	52	58	PF00454	0.464
MOD_PIKK_1	617	623	PF00454	0.618
MOD_PK_1	221	227	PF00069	0.682
MOD_PKA_1	400	406	PF00069	0.561
MOD_PKA_2	27	33	PF00069	0.514
MOD_PKA_2	3	9	PF00069	0.481
MOD_PKA_2	393	399	PF00069	0.652
MOD_PKA_2	400	406	PF00069	0.678
MOD_PKA_2	438	444	PF00069	0.567
MOD_PKA_2	557	563	PF00069	0.711
MOD_PKA_2	617	623	PF00069	0.594
MOD_PKA_2	631	637	PF00069	0.423
MOD_PKB_1	556	564	PF00069	0.558
MOD_Plk_1	602	608	PF00069	0.543
MOD_Plk_1	669	675	PF00069	0.643
MOD_Plk_1	79	85	PF00069	0.507
MOD_Plk_2-3	664	670	PF00069	0.709
MOD_Plk_4	265	271	PF00069	0.699
MOD_Plk_4	275	281	PF00069	0.591
MOD_Plk_4	46	52	PF00069	0.547
MOD_Plk_4	492	498	PF00069	0.573
MOD_Plk_4	502	508	PF00069	0.645
MOD_Plk_4	612	618	PF00069	0.503
MOD_ProDKin_1	234	240	PF00069	0.633
MOD_ProDKin_1	255	261	PF00069	0.709
MOD_ProDKin_1	271	277	PF00069	0.630
MOD_ProDKin_1	655	661	PF00069	0.643
MOD_ProDKin_1	7	13	PF00069	0.512
MOD_ProDKin_1	86	92	PF00069	0.515
MOD_SUMO_rev_2	584	594	PF00179	0.748
TRG_DiLeu_BaEn_1	306	311	PF01217	0.616
TRG_DiLeu_BaEn_3	622	628	PF01217	0.592
TRG_ER_diArg_1	117	119	PF00400	0.634
TRG_ER_diArg_1	332	335	PF00400	0.575
TRG_ER_diArg_1	399	401	PF00400	0.560
TRG_ER_diArg_1	637	639	PF00400	0.592
TRG_NES_CRM1_1	623	635	PF08389	0.518
TRG_NLS_MonoCore_2	476	481	PF00514	0.560
TRG_NLS_MonoExtC_3	477	482	PF00514	0.605
TRG_NLS_MonoExtN_4	477	483	PF00514	0.609
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE04	Leptomonas seymouri	33%	100%
A0A3Q8ITV4	Leishmania donovani	69%	100%
A4I8S3	Leishmania infantum	69%	100%
E9B3N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q4E8	Leishmania major	69%	100%