Nkap_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ras-induced vulval development antagonist, putative

Species:

Leishmania braziliensis

UniProt:

A4HL96_LEIBR

TriTrypDb:

LbrM.33.0600 , LBRM2903_330011500

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL96

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	8
GO:0005488	binding	1	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.622
CLV_C14_Caspase3-7	92	96	PF00656	0.692
CLV_C14_Caspase3-7	99	103	PF00656	0.686
CLV_NRD_NRD_1	141	143	PF00675	0.817
CLV_NRD_NRD_1	192	194	PF00675	0.846
CLV_NRD_NRD_1	206	208	PF00675	0.819
CLV_NRD_NRD_1	300	302	PF00675	0.376
CLV_NRD_NRD_1	32	34	PF00675	0.573
CLV_NRD_NRD_1	352	354	PF00675	0.387
CLV_NRD_NRD_1	374	376	PF00675	0.399
CLV_NRD_NRD_1	38	40	PF00675	0.655
CLV_PCSK_FUR_1	30	34	PF00082	0.689
CLV_PCSK_FUR_1	36	40	PF00082	0.664
CLV_PCSK_KEX2_1	192	194	PF00082	0.846
CLV_PCSK_KEX2_1	208	210	PF00082	0.818
CLV_PCSK_KEX2_1	296	298	PF00082	0.376
CLV_PCSK_KEX2_1	30	32	PF00082	0.569
CLV_PCSK_KEX2_1	300	302	PF00082	0.376
CLV_PCSK_KEX2_1	36	38	PF00082	0.615
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.818
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.376
CLV_PCSK_PC7_1	32	38	PF00082	0.599
CLV_PCSK_SKI1_1	161	165	PF00082	0.439
CLV_Separin_Metazoa	139	143	PF03568	0.833
DEG_Nend_UBRbox_2	1	3	PF02207	0.685
DEG_SCF_FBW7_1	57	62	PF00400	0.481
DOC_MAPK_MEF2A_6	359	368	PF00069	0.501
DOC_PP1_RVXF_1	206	213	PF00149	0.746
DOC_USP7_MATH_1	116	120	PF00917	0.649
DOC_USP7_MATH_1	134	138	PF00917	0.795
DOC_USP7_MATH_1	219	223	PF00917	0.664
DOC_USP7_MATH_1	251	255	PF00917	0.740
DOC_USP7_MATH_1	257	261	PF00917	0.766
DOC_USP7_MATH_1	87	91	PF00917	0.633
DOC_USP7_UBL2_3	166	170	PF12436	0.642
DOC_WW_Pin1_4	124	129	PF00397	0.800
DOC_WW_Pin1_4	153	158	PF00397	0.582
DOC_WW_Pin1_4	213	218	PF00397	0.709
DOC_WW_Pin1_4	55	60	PF00397	0.587
LIG_14-3-3_CanoR_1	192	196	PF00244	0.586
LIG_14-3-3_CanoR_1	89	98	PF00244	0.548
LIG_CaM_IQ_9	345	361	PF13499	0.430
LIG_FHA_1	154	160	PF00498	0.708
LIG_FHA_1	240	246	PF00498	0.738
LIG_FHA_1	60	66	PF00498	0.472
LIG_FHA_2	108	114	PF00498	0.672
LIG_FHA_2	192	198	PF00498	0.751
LIG_FHA_2	285	291	PF00498	0.684
LIG_FHA_2	305	311	PF00498	0.171
LIG_Integrin_isoDGR_2	373	375	PF01839	0.380
LIG_LIR_Nem_3	24	29	PF02991	0.634
LIG_MYND_1	104	108	PF01753	0.562
LIG_Pex14_1	22	26	PF04695	0.626
LIG_Pex14_2	291	295	PF04695	0.376
LIG_SH2_STAT3	14	17	PF00017	0.593
LIG_SH2_STAT5	319	322	PF00017	0.352
LIG_SH2_STAT5	332	335	PF00017	0.376
LIG_SH2_STAT5	76	79	PF00017	0.516
LIG_SH3_3	127	133	PF00018	0.774
LIG_TRAF2_1	307	310	PF00917	0.501
LIG_TRAF2_1	47	50	PF00917	0.706
LIG_TRAF2_1	8	11	PF00917	0.619
LIG_WW_3	139	143	PF00397	0.833
MOD_CK1_1	147	153	PF00069	0.759
MOD_CK1_1	222	228	PF00069	0.640
MOD_CK1_1	274	280	PF00069	0.666
MOD_CK1_1	284	290	PF00069	0.566
MOD_CK1_1	326	332	PF00069	0.430
MOD_CK1_1	52	58	PF00069	0.731
MOD_CK1_1	90	96	PF00069	0.747
MOD_CK2_1	107	113	PF00069	0.654
MOD_CK2_1	234	240	PF00069	0.650
MOD_CK2_1	284	290	PF00069	0.615
MOD_CK2_1	304	310	PF00069	0.171
MOD_CK2_1	43	49	PF00069	0.773
MOD_CK2_1	5	11	PF00069	0.633
MOD_CK2_1	57	63	PF00069	0.578
MOD_CK2_1	93	99	PF00069	0.601
MOD_Cter_Amidation	205	208	PF01082	0.822
MOD_Cter_Amidation	373	376	PF01082	0.507
MOD_GlcNHglycan	118	121	PF01048	0.658
MOD_GlcNHglycan	135	139	PF01048	0.667
MOD_GlcNHglycan	161	164	PF01048	0.617
MOD_GlcNHglycan	253	256	PF01048	0.751
MOD_GlcNHglycan	258	262	PF01048	0.785
MOD_GlcNHglycan	273	276	PF01048	0.529
MOD_GlcNHglycan	321	324	PF01048	0.376
MOD_GlcNHglycan	77	80	PF01048	0.522
MOD_GlcNHglycan	89	92	PF01048	0.638
MOD_GlcNHglycan	95	98	PF01048	0.618
MOD_GSK3_1	319	326	PF00069	0.430
MOD_GSK3_1	41	48	PF00069	0.704
MOD_GSK3_1	49	56	PF00069	0.693
MOD_GSK3_1	59	66	PF00069	0.515
MOD_GSK3_1	87	94	PF00069	0.674
MOD_N-GLC_1	144	149	PF02516	0.591
MOD_N-GLC_1	219	224	PF02516	0.593
MOD_N-GLC_1	41	46	PF02516	0.561
MOD_NEK2_1	115	120	PF00069	0.587
MOD_NEK2_1	122	127	PF00069	0.568
MOD_NEK2_1	21	26	PF00069	0.559
MOD_NEK2_1	321	326	PF00069	0.376
MOD_NEK2_1	81	86	PF00069	0.568
MOD_PIKK_1	191	197	PF00454	0.749
MOD_PIKK_1	219	225	PF00454	0.565
MOD_PIKK_1	281	287	PF00454	0.573
MOD_PIKK_1	290	296	PF00454	0.376
MOD_PIKK_1	57	63	PF00454	0.731
MOD_PKA_2	141	147	PF00069	0.682
MOD_PKA_2	191	197	PF00069	0.585
MOD_PKA_2	251	257	PF00069	0.819
MOD_PKB_1	39	47	PF00069	0.661
MOD_Plk_1	10	16	PF00069	0.429
MOD_Plk_1	219	225	PF00069	0.565
MOD_Plk_1	239	245	PF00069	0.738
MOD_Plk_1	52	58	PF00069	0.642
MOD_ProDKin_1	124	130	PF00069	0.802
MOD_ProDKin_1	153	159	PF00069	0.574
MOD_ProDKin_1	213	219	PF00069	0.707
MOD_ProDKin_1	55	61	PF00069	0.581
TRG_DiLeu_BaEn_1	367	372	PF01217	0.249
TRG_ER_diArg_1	207	210	PF00400	0.819
TRG_ER_diArg_1	29	32	PF00400	0.567
TRG_ER_diArg_1	299	301	PF00400	0.376
TRG_ER_diArg_1	36	39	PF00400	0.614
TRG_NLS_Bipartite_1	192	211	PF00514	0.831
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYC1	Leptomonas seymouri	49%	90%
A0A3S7X6H7	Leishmania donovani	76%	100%
A0A422N868	Trypanosoma rangeli	34%	100%
A4I8S2	Leishmania infantum	76%	100%
E9B3N8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%
Q4Q4E9	Leishmania major	76%	100%