Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL95_LEIBR

TriTrypDb:

LbrM.33.0590 , LBRM2903_330011400

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032991	protein-containing complex	1	1
GO:0034708	methyltransferase complex	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0043527	tRNA methyltransferase complex	5	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HL95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL95

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	11
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0032259	methylation	2	12
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	11
GO:0036265	RNA (guanine-N7)-methylation	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006400	tRNA modification	6	1
GO:0030488	tRNA methylation	5	1
GO:0106004	tRNA (guanine-N7)-methylation	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.747
CLV_C14_Caspase3-7	368	372	PF00656	0.592
CLV_C14_Caspase3-7	536	540	PF00656	0.719
CLV_NRD_NRD_1	120	122	PF00675	0.752
CLV_NRD_NRD_1	17	19	PF00675	0.510
CLV_NRD_NRD_1	236	238	PF00675	0.359
CLV_NRD_NRD_1	531	533	PF00675	0.654
CLV_NRD_NRD_1	559	561	PF00675	0.540
CLV_NRD_NRD_1	87	89	PF00675	0.564
CLV_PCSK_FUR_1	529	533	PF00082	0.689
CLV_PCSK_KEX2_1	120	122	PF00082	0.754
CLV_PCSK_KEX2_1	154	156	PF00082	0.418
CLV_PCSK_KEX2_1	236	238	PF00082	0.358
CLV_PCSK_KEX2_1	299	301	PF00082	0.606
CLV_PCSK_KEX2_1	438	440	PF00082	0.439
CLV_PCSK_KEX2_1	531	533	PF00082	0.678
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.418
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.483
CLV_PCSK_PC1ET2_1	438	440	PF00082	0.466
CLV_PCSK_SKI1_1	154	158	PF00082	0.435
CLV_PCSK_SKI1_1	236	240	PF00082	0.358
CLV_PCSK_SKI1_1	381	385	PF00082	0.435
DEG_SPOP_SBC_1	365	369	PF00917	0.387
DOC_CYCLIN_RxL_1	230	242	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	305	311	PF00134	0.599
DOC_MAPK_gen_1	18	25	PF00069	0.433
DOC_MAPK_gen_1	438	448	PF00069	0.411
DOC_MAPK_MEF2A_6	442	450	PF00069	0.278
DOC_PP1_RVXF_1	178	184	PF00149	0.505
DOC_PP1_RVXF_1	440	446	PF00149	0.267
DOC_PP1_RVXF_1	55	62	PF00149	0.440
DOC_PP2B_LxvP_1	214	217	PF13499	0.477
DOC_PP2B_LxvP_1	305	308	PF13499	0.644
DOC_PP2B_LxvP_1	62	65	PF13499	0.465
DOC_PP4_FxxP_1	373	376	PF00568	0.564
DOC_PP4_FxxP_1	394	397	PF00568	0.432
DOC_PP4_FxxP_1	556	559	PF00568	0.541
DOC_USP7_MATH_1	160	164	PF00917	0.342
DOC_USP7_MATH_1	301	305	PF00917	0.477
DOC_USP7_MATH_1	331	335	PF00917	0.527
DOC_USP7_MATH_1	410	414	PF00917	0.603
DOC_USP7_MATH_1	425	429	PF00917	0.360
DOC_USP7_MATH_1	44	48	PF00917	0.599
DOC_USP7_MATH_2	331	337	PF00917	0.360
DOC_USP7_UBL2_3	299	303	PF12436	0.477
DOC_USP7_UBL2_3	561	565	PF12436	0.784
DOC_WW_Pin1_4	181	186	PF00397	0.510
DOC_WW_Pin1_4	267	272	PF00397	0.399
DOC_WW_Pin1_4	38	43	PF00397	0.689
DOC_WW_Pin1_4	414	419	PF00397	0.382
DOC_WW_Pin1_4	450	455	PF00397	0.577
DOC_WW_Pin1_4	555	560	PF00397	0.542
LIG_14-3-3_CanoR_1	120	129	PF00244	0.517
LIG_14-3-3_CanoR_1	155	160	PF00244	0.463
LIG_14-3-3_CanoR_1	178	184	PF00244	0.470
LIG_14-3-3_CanoR_1	300	306	PF00244	0.573
LIG_14-3-3_CanoR_1	389	397	PF00244	0.500
LIG_14-3-3_CanoR_1	442	446	PF00244	0.263
LIG_BIR_III_2	420	424	PF00653	0.575
LIG_BRCT_BRCA1_1	335	339	PF00533	0.424
LIG_BRCT_BRCA1_1	390	394	PF00533	0.508
LIG_FHA_1	109	115	PF00498	0.790
LIG_FHA_1	151	157	PF00498	0.433
LIG_FHA_1	186	192	PF00498	0.544
LIG_FHA_1	209	215	PF00498	0.387
LIG_FHA_1	25	31	PF00498	0.329
LIG_FHA_1	253	259	PF00498	0.444
LIG_FHA_1	336	342	PF00498	0.549
LIG_FHA_1	365	371	PF00498	0.420
LIG_FHA_1	431	437	PF00498	0.491
LIG_FHA_1	453	459	PF00498	0.549
LIG_FHA_2	159	165	PF00498	0.486
LIG_FHA_2	415	421	PF00498	0.465
LIG_Integrin_isoDGR_2	440	442	PF01839	0.422
LIG_LIR_Apic_2	141	145	PF02991	0.580
LIG_LIR_Apic_2	371	376	PF02991	0.581
LIG_LIR_Apic_2	391	397	PF02991	0.445
LIG_LIR_Apic_2	554	559	PF02991	0.545
LIG_LIR_Gen_1	336	347	PF02991	0.448
LIG_LIR_Gen_1	444	452	PF02991	0.521
LIG_LIR_Gen_1	520	528	PF02991	0.680
LIG_LIR_Gen_1	76	85	PF02991	0.505
LIG_LIR_Nem_3	141	146	PF02991	0.350
LIG_LIR_Nem_3	171	176	PF02991	0.363
LIG_LIR_Nem_3	306	312	PF02991	0.368
LIG_LIR_Nem_3	336	342	PF02991	0.435
LIG_LIR_Nem_3	355	360	PF02991	0.579
LIG_LIR_Nem_3	392	398	PF02991	0.363
LIG_LIR_Nem_3	444	448	PF02991	0.487
LIG_LIR_Nem_3	520	526	PF02991	0.673
LIG_LIR_Nem_3	76	82	PF02991	0.500
LIG_MYND_3	479	483	PF01753	0.534
LIG_PDZ_Class_2	567	572	PF00595	0.528
LIG_Pex14_1	143	147	PF04695	0.578
LIG_Pex14_2	395	399	PF04695	0.255
LIG_Rb_LxCxE_1	273	296	PF01857	0.386
LIG_SH2_NCK_1	523	527	PF00017	0.570
LIG_SH2_SRC	147	150	PF00017	0.561
LIG_SH2_STAP1	169	173	PF00017	0.267
LIG_SH2_STAP1	309	313	PF00017	0.461
LIG_SH2_STAT5	213	216	PF00017	0.517
LIG_SH2_STAT5	256	259	PF00017	0.493
LIG_SH2_STAT5	481	484	PF00017	0.508
LIG_SH3_3	265	271	PF00018	0.469
LIG_SH3_3	295	301	PF00018	0.479
LIG_SH3_3	344	350	PF00018	0.539
LIG_SH3_3	448	454	PF00018	0.505
LIG_SH3_3	62	68	PF00018	0.540
LIG_SH3_4	144	151	PF00018	0.551
LIG_SUMO_SIM_par_1	186	192	PF11976	0.567
LIG_SUMO_SIM_par_1	468	474	PF11976	0.544
LIG_TRAF2_1	226	229	PF00917	0.686
LIG_TRAF2_1	494	497	PF00917	0.741
LIG_TRAF2_1	99	102	PF00917	0.544
LIG_WRC_WIRS_1	342	347	PF05994	0.536
MOD_CDC14_SPxK_1	558	561	PF00782	0.537
MOD_CDK_SPK_2	555	560	PF00069	0.542
MOD_CDK_SPxK_1	555	561	PF00069	0.541
MOD_CK1_1	108	114	PF00069	0.784
MOD_CK1_1	158	164	PF00069	0.524
MOD_CK1_1	207	213	PF00069	0.381
MOD_CK1_1	270	276	PF00069	0.378
MOD_CK1_1	429	435	PF00069	0.485
MOD_CK1_1	453	459	PF00069	0.564
MOD_CK1_1	9	15	PF00069	0.420
MOD_CK2_1	158	164	PF00069	0.524
MOD_CK2_1	331	337	PF00069	0.516
MOD_CK2_1	425	431	PF00069	0.503
MOD_CK2_1	507	513	PF00069	0.573
MOD_CK2_1	96	102	PF00069	0.725
MOD_GlcNHglycan	228	233	PF01048	0.561
MOD_GlcNHglycan	265	268	PF01048	0.578
MOD_GlcNHglycan	305	308	PF01048	0.607
MOD_GlcNHglycan	412	415	PF01048	0.586
MOD_GlcNHglycan	72	75	PF01048	0.403
MOD_GSK3_1	150	157	PF00069	0.437
MOD_GSK3_1	179	186	PF00069	0.459
MOD_GSK3_1	204	211	PF00069	0.391
MOD_GSK3_1	224	231	PF00069	0.612
MOD_GSK3_1	263	270	PF00069	0.392
MOD_GSK3_1	303	310	PF00069	0.551
MOD_GSK3_1	331	338	PF00069	0.499
MOD_GSK3_1	361	368	PF00069	0.523
MOD_GSK3_1	40	47	PF00069	0.624
MOD_GSK3_1	410	417	PF00069	0.456
MOD_GSK3_1	425	432	PF00069	0.395
MOD_LATS_1	152	158	PF00433	0.405
MOD_N-GLC_1	301	306	PF02516	0.705
MOD_N-GLC_1	429	434	PF02516	0.413
MOD_N-GLC_1	83	88	PF02516	0.547
MOD_N-GLC_1	97	102	PF02516	0.649
MOD_NEK2_1	132	137	PF00069	0.564
MOD_NEK2_1	212	217	PF00069	0.402
MOD_NEK2_1	261	266	PF00069	0.540
MOD_NEK2_1	286	291	PF00069	0.619
MOD_NEK2_1	341	346	PF00069	0.495
MOD_NEK2_1	517	522	PF00069	0.578
MOD_OFUCOSY	235	241	PF10250	0.418
MOD_PIKK_1	132	138	PF00454	0.461
MOD_PKA_1	120	126	PF00069	0.744
MOD_PKA_1	154	160	PF00069	0.396
MOD_PKA_2	120	126	PF00069	0.744
MOD_PKA_2	154	160	PF00069	0.412
MOD_PKA_2	179	185	PF00069	0.492
MOD_PKA_2	247	253	PF00069	0.361
MOD_PKA_2	388	394	PF00069	0.505
MOD_PKA_2	441	447	PF00069	0.266
MOD_Plk_1	301	307	PF00069	0.705
MOD_Plk_1	430	436	PF00069	0.473
MOD_Plk_1	6	12	PF00069	0.480
MOD_Plk_2-3	507	513	PF00069	0.643
MOD_Plk_4	163	169	PF00069	0.364
MOD_Plk_4	208	214	PF00069	0.338
MOD_Plk_4	252	258	PF00069	0.448
MOD_Plk_4	307	313	PF00069	0.473
MOD_Plk_4	361	367	PF00069	0.456
MOD_Plk_4	44	50	PF00069	0.582
MOD_Plk_4	441	447	PF00069	0.454
MOD_ProDKin_1	181	187	PF00069	0.518
MOD_ProDKin_1	267	273	PF00069	0.394
MOD_ProDKin_1	38	44	PF00069	0.684
MOD_ProDKin_1	414	420	PF00069	0.386
MOD_ProDKin_1	450	456	PF00069	0.587
MOD_ProDKin_1	555	561	PF00069	0.541
MOD_SUMO_for_1	138	141	PF00179	0.611
MOD_SUMO_rev_2	558	568	PF00179	0.655
MOD_SUMO_rev_2	73	80	PF00179	0.442
TRG_DiLeu_BaEn_1	337	342	PF01217	0.469
TRG_DiLeu_BaEn_2	430	436	PF01217	0.548
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.272
TRG_ENDOCYTIC_2	523	526	PF00928	0.572
TRG_ER_diArg_1	177	180	PF00400	0.493
TRG_ER_diArg_1	236	238	PF00400	0.360
TRG_ER_diArg_1	528	531	PF00400	0.597
TRG_NES_CRM1_1	54	66	PF08389	0.547
TRG_NLS_MonoExtC_3	565	571	PF00514	0.603
TRG_NLS_MonoExtN_4	565	570	PF00514	0.743
TRG_Pf-PMV_PEXEL_1	3	7	PF00026	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL73	Leptomonas seymouri	65%	100%
A0A0S4IWR1	Bodo saltans	22%	100%
A0A1X0P0S8	Trypanosomatidae	30%	100%
A0A3Q8IGQ7	Leishmania donovani	79%	99%
A0A422N539	Trypanosoma rangeli	32%	100%
A4I8S1	Leishmania infantum	79%	99%
D0A4R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B3N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
Q4Q4F0	Leishmania major	79%	100%
V5D2Q1	Trypanosoma cruzi	32%	100%