LeishMANIAdb
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C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
C2H2-type domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HL94_LEIBR
TriTrypDb:
LbrM.33.0580 , LBRM2903_330011200
Length:
138

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HL94
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL94

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 86 88 PF00675 0.441
CLV_NRD_NRD_1 93 95 PF00675 0.417
CLV_PCSK_KEX2_1 93 95 PF00082 0.413
CLV_PCSK_SKI1_1 73 77 PF00082 0.320
CLV_PCSK_SKI1_1 87 91 PF00082 0.483
DOC_USP7_MATH_1 125 129 PF00917 0.703
DOC_USP7_MATH_1 31 35 PF00917 0.619
LIG_FHA_2 54 60 PF00498 0.418
LIG_FHA_2 8 14 PF00498 0.573
LIG_LIR_Nem_3 47 52 PF02991 0.429
LIG_SH2_STAT5 48 51 PF00017 0.456
LIG_SH3_3 18 24 PF00018 0.462
LIG_SH3_3 25 31 PF00018 0.382
LIG_TRAF2_1 30 33 PF00917 0.575
MOD_CK1_1 121 127 PF00069 0.731
MOD_CK2_1 7 13 PF00069 0.592
MOD_GlcNHglycan 125 128 PF01048 0.680
MOD_GSK3_1 121 128 PF00069 0.721
MOD_NEK2_1 1 6 PF00069 0.525
MOD_NEK2_1 52 57 PF00069 0.478
MOD_PK_1 113 119 PF00069 0.478
MOD_Plk_1 113 119 PF00069 0.478
MOD_SUMO_rev_2 12 21 PF00179 0.599
TRG_ER_diArg_1 92 94 PF00400 0.521
TRG_Pf-PMV_PEXEL_1 39 43 PF00026 0.459

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6M0 Leptomonas seymouri 64% 99%
A0A1X0P0N5 Trypanosomatidae 56% 100%
A0A3Q8IJY7 Leishmania donovani 76% 96%
A0A422N525 Trypanosoma rangeli 56% 100%
A4I8S0 Leishmania infantum 76% 96%
D0A4R2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9B3N6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 96%
Q4Q4F1 Leishmania major 74% 100%
V5BBJ7 Trypanosoma cruzi 58% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS